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P56107

- HEMH_HELPY

UniProt

P56107 - HEMH_HELPY

Protein

Ferrochelatase

Gene

hemH

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 1 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Catalyzes the ferrous insertion into protoporphyrin IX.By similarity

    Catalytic activityi

    Protoheme + 2 H+ = protoporphyrin + Fe2+.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi207 – 2071IronBy similarity
    Metal bindingi288 – 2881IronBy similarity

    GO - Molecular functioni

    1. ferrochelatase activity Source: UniProtKB-HAMAP
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. heme biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Heme biosynthesis, Porphyrin biosynthesis

    Keywords - Ligandi

    Iron, Metal-binding

    Enzyme and pathway databases

    BioCyciHPY:HP0376-MONOMER.
    UniPathwayiUPA00252; UER00325.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ferrochelatase (EC:4.99.1.1)
    Alternative name(s):
    Heme synthase
    Protoheme ferro-lyase
    Gene namesi
    Name:hemH
    Ordered Locus Names:HP_0376
    OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
    Taxonomic identifieri85962 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
    ProteomesiUP000000429: Chromosome

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 334334FerrochelatasePRO_0000175149Add
    BLAST

    Proteomic databases

    PRIDEiP56107.

    Interactioni

    Protein-protein interaction databases

    IntActiP56107. 2 interactions.
    STRINGi85962.HP0376.

    Structurei

    3D structure databases

    ProteinModelPortaliP56107.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ferrochelatase family.Curated

    Phylogenomic databases

    eggNOGiCOG0276.
    KOiK01772.
    OMAiANDQLFR.
    OrthoDBiEOG6XHC5H.

    Family and domain databases

    HAMAPiMF_00323. Ferrochelatase.
    InterProiIPR001015. Ferrochelatase.
    IPR019772. Ferrochelatase_AS.
    [Graphical view]
    PANTHERiPTHR11108. PTHR11108. 1 hit.
    PfamiPF00762. Ferrochelatase. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00109. hemH. 1 hit.
    PROSITEiPS00534. FERROCHELATASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P56107-1 [UniParc]FASTAAdd to Basket

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    MDLINEKLNN LENNATKSPK EAVILLNMGG PNSLYEVGVF LKNMFDDPFI    50
    LTIKNNFMRK MVGKMIVNSR IEKSKKIYEK LGGKSPLTPI TFALTERLNK 100
    LDPSRFYTYA MRYTPPYASM VLQDLALKEV ESLVFFSMYP QYSSTTTLSS 150
    FNDAFNALKS LETFRPKVRV IERFYASKKL NKIILNTILN TLNNRKSQDF 200
    VLIFSVHGLP KSVIDAGDTY QQECEHHVSL LKELMQQKNT PFKEVLLSYQ 250
    SKLGPMKWLE PSTEELIEKH RKSHIIIYPL AFTIDNSETL YELDMQYRLM 300
    AERLAVKEYL VCPCLNDSIE FAQFIIERVK NLKE 334
    Length:334
    Mass (Da):38,735
    Last modified:November 1, 1997 - v1
    Checksum:iA955449996649B3E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000511 Genomic DNA. Translation: AAD07444.1.
    PIRiH64566.
    RefSeqiNP_207174.1. NC_000915.1.
    YP_006934300.1. NC_018939.1.

    Genome annotation databases

    EnsemblBacteriaiAAD07444; AAD07444; HP_0376.
    GeneIDi13869562.
    898870.
    KEGGiheo:C694_01910.
    hpy:HP0376.
    PATRICi20591989. VBIHelPyl33062_0388.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000511 Genomic DNA. Translation: AAD07444.1 .
    PIRi H64566.
    RefSeqi NP_207174.1. NC_000915.1.
    YP_006934300.1. NC_018939.1.

    3D structure databases

    ProteinModelPortali P56107.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P56107. 2 interactions.
    STRINGi 85962.HP0376.

    Proteomic databases

    PRIDEi P56107.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD07444 ; AAD07444 ; HP_0376 .
    GeneIDi 13869562.
    898870.
    KEGGi heo:C694_01910.
    hpy:HP0376.
    PATRICi 20591989. VBIHelPyl33062_0388.

    Phylogenomic databases

    eggNOGi COG0276.
    KOi K01772.
    OMAi ANDQLFR.
    OrthoDBi EOG6XHC5H.

    Enzyme and pathway databases

    UniPathwayi UPA00252 ; UER00325 .
    BioCyci HPY:HP0376-MONOMER.

    Family and domain databases

    HAMAPi MF_00323. Ferrochelatase.
    InterProi IPR001015. Ferrochelatase.
    IPR019772. Ferrochelatase_AS.
    [Graphical view ]
    PANTHERi PTHR11108. PTHR11108. 1 hit.
    Pfami PF00762. Ferrochelatase. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00109. hemH. 1 hit.
    PROSITEi PS00534. FERROCHELATASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700392 / 26695.

    Entry informationi

    Entry nameiHEMH_HELPY
    AccessioniPrimary (citable) accession number: P56107
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Helicobacter pylori
      Helicobacter pylori (strain 26695): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3