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P56107

- HEMH_HELPY

UniProt

P56107 - HEMH_HELPY

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Protein

Ferrochelatase

Gene
hemH, HP_0376
Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the ferrous insertion into protoporphyrin IX By similarity.UniRule annotation

Catalytic activityi

Protoheme + 2 H+ = protoporphyrin + Fe2+.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi207 – 2071Iron By similarity
Metal bindingi288 – 2881Iron By similarity

GO - Molecular functioni

  1. ferrochelatase activity Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. heme biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Heme biosynthesis, Porphyrin biosynthesis

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BioCyciHPY:HP0376-MONOMER.
UniPathwayiUPA00252; UER00325.

Names & Taxonomyi

Protein namesi
Recommended name:
Ferrochelatase (EC:4.99.1.1)
Alternative name(s):
Heme synthase
Protoheme ferro-lyase
Gene namesi
Name:hemH
Ordered Locus Names:HP_0376
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000429: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 334334FerrochelataseUniRule annotationPRO_0000175149Add
BLAST

Proteomic databases

PRIDEiP56107.

Interactioni

Protein-protein interaction databases

IntActiP56107. 2 interactions.
STRINGi85962.HP0376.

Structurei

3D structure databases

ProteinModelPortaliP56107.

Family & Domainsi

Sequence similaritiesi

Belongs to the ferrochelatase family.

Phylogenomic databases

eggNOGiCOG0276.
KOiK01772.
OMAiANDQLFR.
OrthoDBiEOG6XHC5H.

Family and domain databases

HAMAPiMF_00323. Ferrochelatase.
InterProiIPR001015. Ferrochelatase.
IPR019772. Ferrochelatase_AS.
[Graphical view]
PANTHERiPTHR11108. PTHR11108. 1 hit.
PfamiPF00762. Ferrochelatase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00109. hemH. 1 hit.
PROSITEiPS00534. FERROCHELATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P56107-1 [UniParc]FASTAAdd to Basket

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MDLINEKLNN LENNATKSPK EAVILLNMGG PNSLYEVGVF LKNMFDDPFI    50
LTIKNNFMRK MVGKMIVNSR IEKSKKIYEK LGGKSPLTPI TFALTERLNK 100
LDPSRFYTYA MRYTPPYASM VLQDLALKEV ESLVFFSMYP QYSSTTTLSS 150
FNDAFNALKS LETFRPKVRV IERFYASKKL NKIILNTILN TLNNRKSQDF 200
VLIFSVHGLP KSVIDAGDTY QQECEHHVSL LKELMQQKNT PFKEVLLSYQ 250
SKLGPMKWLE PSTEELIEKH RKSHIIIYPL AFTIDNSETL YELDMQYRLM 300
AERLAVKEYL VCPCLNDSIE FAQFIIERVK NLKE 334
Length:334
Mass (Da):38,735
Last modified:November 1, 1997 - v1
Checksum:iA955449996649B3E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000511 Genomic DNA. Translation: AAD07444.1.
PIRiH64566.
RefSeqiNP_207174.1. NC_000915.1.
YP_006934300.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD07444; AAD07444; HP_0376.
GeneIDi13869562.
898870.
KEGGiheo:C694_01910.
hpy:HP0376.
PATRICi20591989. VBIHelPyl33062_0388.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000511 Genomic DNA. Translation: AAD07444.1 .
PIRi H64566.
RefSeqi NP_207174.1. NC_000915.1.
YP_006934300.1. NC_018939.1.

3D structure databases

ProteinModelPortali P56107.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P56107. 2 interactions.
STRINGi 85962.HP0376.

Proteomic databases

PRIDEi P56107.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD07444 ; AAD07444 ; HP_0376 .
GeneIDi 13869562.
898870.
KEGGi heo:C694_01910.
hpy:HP0376.
PATRICi 20591989. VBIHelPyl33062_0388.

Phylogenomic databases

eggNOGi COG0276.
KOi K01772.
OMAi ANDQLFR.
OrthoDBi EOG6XHC5H.

Enzyme and pathway databases

UniPathwayi UPA00252 ; UER00325 .
BioCyci HPY:HP0376-MONOMER.

Family and domain databases

HAMAPi MF_00323. Ferrochelatase.
InterProi IPR001015. Ferrochelatase.
IPR019772. Ferrochelatase_AS.
[Graphical view ]
PANTHERi PTHR11108. PTHR11108. 1 hit.
Pfami PF00762. Ferrochelatase. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00109. hemH. 1 hit.
PROSITEi PS00534. FERROCHELATASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700392 / 26695.

Entry informationi

Entry nameiHEMH_HELPY
AccessioniPrimary (citable) accession number: P56107
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: September 3, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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