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Protein

Ferrochelatase

Gene

hemH

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the ferrous insertion into protoporphyrin IX.By similarity

Catalytic activityi

Protoheme + 2 H+ = protoporphyrin + Fe2+.

Pathwayi: protoheme biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes protoheme from protoporphyrin-IX.
Proteins known to be involved in this subpathway in this organism are:
  1. Ferrochelatase (hemH)
This subpathway is part of the pathway protoheme biosynthesis, which is itself part of Porphyrin-containing compound metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes protoheme from protoporphyrin-IX, the pathway protoheme biosynthesis and in Porphyrin-containing compound metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi207IronBy similarity1
Metal bindingi288IronBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Heme biosynthesis, Porphyrin biosynthesis

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BioCyciHPY:HP0376-MONOMER.
UniPathwayiUPA00252; UER00325.

Names & Taxonomyi

Protein namesi
Recommended name:
Ferrochelatase (EC:4.99.1.1)
Alternative name(s):
Heme synthase
Protoheme ferro-lyase
Gene namesi
Name:hemH
Ordered Locus Names:HP_0376
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi
  • UP000000429 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001751491 – 334FerrochelataseAdd BLAST334

Proteomic databases

PaxDbiP56107.

Interactioni

Protein-protein interaction databases

IntActiP56107. 2 interactors.
STRINGi85962.HP0376.

Structurei

3D structure databases

ProteinModelPortaliP56107.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ferrochelatase family.Curated

Phylogenomic databases

eggNOGiENOG4105CFX. Bacteria.
COG0276. LUCA.
KOiK01772.
OMAiLPIQNKL.

Family and domain databases

CDDicd00419. Ferrochelatase_C. 1 hit.
cd03411. Ferrochelatase_N. 1 hit.
HAMAPiMF_00323. Ferrochelatase. 1 hit.
InterProiIPR001015. Ferrochelatase.
IPR019772. Ferrochelatase_AS.
IPR033644. Ferrochelatase_C.
IPR033659. Ferrochelatase_N.
[Graphical view]
PANTHERiPTHR11108. PTHR11108. 1 hit.
PfamiPF00762. Ferrochelatase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00109. hemH. 1 hit.
PROSITEiPS00534. FERROCHELATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P56107-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLINEKLNN LENNATKSPK EAVILLNMGG PNSLYEVGVF LKNMFDDPFI
60 70 80 90 100
LTIKNNFMRK MVGKMIVNSR IEKSKKIYEK LGGKSPLTPI TFALTERLNK
110 120 130 140 150
LDPSRFYTYA MRYTPPYASM VLQDLALKEV ESLVFFSMYP QYSSTTTLSS
160 170 180 190 200
FNDAFNALKS LETFRPKVRV IERFYASKKL NKIILNTILN TLNNRKSQDF
210 220 230 240 250
VLIFSVHGLP KSVIDAGDTY QQECEHHVSL LKELMQQKNT PFKEVLLSYQ
260 270 280 290 300
SKLGPMKWLE PSTEELIEKH RKSHIIIYPL AFTIDNSETL YELDMQYRLM
310 320 330
AERLAVKEYL VCPCLNDSIE FAQFIIERVK NLKE
Length:334
Mass (Da):38,735
Last modified:November 1, 1997 - v1
Checksum:iA955449996649B3E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD07444.1.
PIRiH64566.
RefSeqiNP_207174.1. NC_000915.1.
WP_000364269.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD07444; AAD07444; HP_0376.
GeneIDi898870.
KEGGiheo:C694_01910.
hpy:HP0376.
PATRICi20591989. VBIHelPyl33062_0388.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD07444.1.
PIRiH64566.
RefSeqiNP_207174.1. NC_000915.1.
WP_000364269.1. NC_018939.1.

3D structure databases

ProteinModelPortaliP56107.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP56107. 2 interactors.
STRINGi85962.HP0376.

Proteomic databases

PaxDbiP56107.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD07444; AAD07444; HP_0376.
GeneIDi898870.
KEGGiheo:C694_01910.
hpy:HP0376.
PATRICi20591989. VBIHelPyl33062_0388.

Phylogenomic databases

eggNOGiENOG4105CFX. Bacteria.
COG0276. LUCA.
KOiK01772.
OMAiLPIQNKL.

Enzyme and pathway databases

UniPathwayiUPA00252; UER00325.
BioCyciHPY:HP0376-MONOMER.

Family and domain databases

CDDicd00419. Ferrochelatase_C. 1 hit.
cd03411. Ferrochelatase_N. 1 hit.
HAMAPiMF_00323. Ferrochelatase. 1 hit.
InterProiIPR001015. Ferrochelatase.
IPR019772. Ferrochelatase_AS.
IPR033644. Ferrochelatase_C.
IPR033659. Ferrochelatase_N.
[Graphical view]
PANTHERiPTHR11108. PTHR11108. 1 hit.
PfamiPF00762. Ferrochelatase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00109. hemH. 1 hit.
PROSITEiPS00534. FERROCHELATASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHEMH_HELPY
AccessioniPrimary (citable) accession number: P56107
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: October 5, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.