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P56107 (HEMH_HELPY) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ferrochelatase

EC=4.99.1.1
Alternative name(s):
Heme synthase
Protoheme ferro-lyase
Gene names
Name:hemH
Ordered Locus Names:HP_0376
OrganismHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) [Reference proteome] [HAMAP]
Taxonomic identifier85962 [NCBI]
Taxonomic lineageBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter

Protein attributes

Sequence length334 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the ferrous insertion into protoporphyrin IX By similarity. HAMAP-Rule MF_00323

Catalytic activity

Protoheme + 2 H+ = protoporphyrin + Fe2+. HAMAP-Rule MF_00323

Pathway

Porphyrin-containing compound metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1. HAMAP-Rule MF_00323

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00323.

Sequence similarities

Belongs to the ferrochelatase family.

Ontologies

Keywords
   Biological processHeme biosynthesis
Porphyrin biosynthesis
   Cellular componentCytoplasm
   LigandIron
Metal-binding
   Molecular functionLyase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processheme biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionferrochelatase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 334334Ferrochelatase HAMAP-Rule MF_00323
PRO_0000175149

Sites

Metal binding2071Iron By similarity
Metal binding2881Iron By similarity

Sequences

Sequence LengthMass (Da)Tools
P56107 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: A955449996649B3E

FASTA33438,735
        10         20         30         40         50         60 
MDLINEKLNN LENNATKSPK EAVILLNMGG PNSLYEVGVF LKNMFDDPFI LTIKNNFMRK 

        70         80         90        100        110        120 
MVGKMIVNSR IEKSKKIYEK LGGKSPLTPI TFALTERLNK LDPSRFYTYA MRYTPPYASM 

       130        140        150        160        170        180 
VLQDLALKEV ESLVFFSMYP QYSSTTTLSS FNDAFNALKS LETFRPKVRV IERFYASKKL 

       190        200        210        220        230        240 
NKIILNTILN TLNNRKSQDF VLIFSVHGLP KSVIDAGDTY QQECEHHVSL LKELMQQKNT 

       250        260        270        280        290        300 
PFKEVLLSYQ SKLGPMKWLE PSTEELIEKH RKSHIIIYPL AFTIDNSETL YELDMQYRLM 

       310        320        330 
AERLAVKEYL VCPCLNDSIE FAQFIIERVK NLKE 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE000511 Genomic DNA. Translation: AAD07444.1.
PIRH64566.
RefSeqNP_207174.1. NC_000915.1.
YP_006934300.1. NC_018939.1.

3D structure databases

ProteinModelPortalP56107.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING85962.HP0376.

Proteomic databases

PRIDEP56107.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAD07444; AAD07444; HP_0376.
GeneID13869562.
898870.
KEGGheo:C694_01910.
hpy:HP0376.
PATRIC20591989. VBIHelPyl33062_0388.

Phylogenomic databases

eggNOGCOG0276.
KOK01772.
OMALNMGGPN.
OrthoDBEOG6XHC5H.
ProtClustDBPRK00035.

Enzyme and pathway databases

BioCycHPY:HP0376-MONOMER.
UniPathwayUPA00252; UER00325.

Family and domain databases

HAMAPMF_00323. Ferrochelatase.
InterProIPR001015. Ferrochelatase.
IPR019772. Ferrochelatase_AS.
[Graphical view]
PANTHERPTHR11108. PTHR11108. 1 hit.
PfamPF00762. Ferrochelatase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00109. hemH. 1 hit.
PROSITEPS00534. FERROCHELATASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHEMH_HELPY
AccessionPrimary (citable) accession number: P56107
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: February 19, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Helicobacter pylori

Helicobacter pylori (strain 26695): entries and gene names