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Protein

Uridylate kinase

Gene

pyrH

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the reversible phosphorylation of UMP to UDP.UniRule annotation

Catalytic activityi

ATP + UMP = ADP + UDP.UniRule annotation

Enzyme regulationi

Inhibited by UTP.UniRule annotation

Pathwayi: CTP biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes UDP from UMP (UMPK route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Uridylate kinase (pyrH)
This subpathway is part of the pathway CTP biosynthesis via de novo pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes UDP from UMP (UMPK route), the pathway CTP biosynthesis via de novo pathway and in Pyrimidine metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei55 – 551UMP; via amide nitrogenUniRule annotation
Binding sitei56 – 561ATP; via amide nitrogenUniRule annotation
Binding sitei60 – 601ATPUniRule annotation
Binding sitei76 – 761UMPUniRule annotation
Binding sitei164 – 1641ATPUniRule annotation
Binding sitei170 – 1701ATP; via amide nitrogen and carbonyl oxygenUniRule annotation
Binding sitei173 – 1731ATPUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi13 – 164ATPUniRule annotation
Nucleotide bindingi137 – 1448UMPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Pyrimidine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciHPY:HP0777-MONOMER.
BRENDAi2.7.4.22. 2604.
UniPathwayiUPA00159; UER00275.

Names & Taxonomyi

Protein namesi
Recommended name:
Uridylate kinaseUniRule annotation (EC:2.7.4.22UniRule annotation)
Short name:
UKUniRule annotation
Alternative name(s):
Uridine monophosphate kinaseUniRule annotation
Short name:
UMP kinaseUniRule annotation
Short name:
UMPKUniRule annotation
Gene namesi
Name:pyrHUniRule annotation
Ordered Locus Names:HP_0777
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi
  • UP000000429 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 240240Uridylate kinasePRO_0000143848Add
BLAST

Proteomic databases

PaxDbiP56106.
PRIDEiP56106.

Interactioni

Subunit structurei

Homohexamer.UniRule annotation

Protein-protein interaction databases

IntActiP56106. 3 interactions.
STRINGi85962.HP0777.

Structurei

Secondary structure

1
240
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi9 – 146Combined sources
Helixi16 – 205Combined sources
Beta strandi23 – 264Combined sources
Helixi29 – 4416Combined sources
Beta strandi48 – 536Combined sources
Turni56 – 583Combined sources
Helixi61 – 644Combined sources
Beta strandi68 – 703Combined sources
Helixi72 – 9625Combined sources
Beta strandi101 – 1077Combined sources
Turni110 – 1123Combined sources
Beta strandi113 – 1153Combined sources
Helixi118 – 1269Combined sources
Beta strandi130 – 1356Combined sources
Helixi144 – 15411Combined sources
Beta strandi158 – 17215Combined sources
Turni174 – 1763Combined sources
Beta strandi182 – 1876Combined sources
Helixi188 – 1936Combined sources
Helixi201 – 2099Combined sources
Beta strandi214 – 2218Combined sources
Helixi224 – 2318Combined sources
Beta strandi237 – 2404Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4A7WX-ray1.80A/B1-240[»]
4A7XX-ray2.49A/B/C/D/E/F1-240[»]
ProteinModelPortaliP56106.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UMP kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C41. Bacteria.
COG0528. LUCA.
KOiK09903.
OMAiIIVFDMN.
OrthoDBiEOG6M0T8S.

Family and domain databases

Gene3Di3.40.1160.10. 1 hit.
HAMAPiMF_01220_B. PyrH_B.
InterProiIPR001048. Asp/Glu/Uridylate_kinase.
IPR011817. Uridylate_kinase.
IPR015963. Uridylate_kinase_bac.
[Graphical view]
PANTHERiPTHR21499:SF23. PTHR21499:SF23. 1 hit.
PfamiPF00696. AA_kinase. 1 hit.
[Graphical view]
PIRSFiPIRSF005650. Uridylate_kin. 1 hit.
SUPFAMiSSF53633. SSF53633. 1 hit.
TIGRFAMsiTIGR02075. pyrH_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

P56106-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQAKIKNKRV LVKFSGEALA GDNQFGIDIH VLDHIAKEIK SLVENDIEVG
60 70 80 90 100
IVIGGGNIIR GVSAAQGGII RRTSGDYMGM LATVINAVAM QEALEHIGLD
110 120 130 140 150
TRVQSAIEIK EICESYIYRK AIRHLEKGRV VIFGAGTGNP FFTTDTAATL
160 170 180 190 200
RAIEIGSDLI IKATKVDGIY DKDPNKFKDA KKLDTLSYND ALIGDIEVMD
210 220 230 240
DTAISLAKDN KLPIVVCNMF KKGNLLQVIK HQQGVFSMVK
Length:240
Mass (Da):26,172
Last modified:November 1, 1997 - v1
Checksum:iF978BAD5BBCA5828
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD07823.1.
PIRiA64617.
RefSeqiNP_207570.1. NC_000915.1.
WP_001148056.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD07823; AAD07823; HP_0777.
GeneIDi900266.
KEGGiheo:C694_03990.
hpy:HP0777.
PATRICi20592843. VBIHelPyl33062_0810.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD07823.1.
PIRiA64617.
RefSeqiNP_207570.1. NC_000915.1.
WP_001148056.1. NC_018939.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4A7WX-ray1.80A/B1-240[»]
4A7XX-ray2.49A/B/C/D/E/F1-240[»]
ProteinModelPortaliP56106.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP56106. 3 interactions.
STRINGi85962.HP0777.

Proteomic databases

PaxDbiP56106.
PRIDEiP56106.

Protocols and materials databases

DNASUi900266.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD07823; AAD07823; HP_0777.
GeneIDi900266.
KEGGiheo:C694_03990.
hpy:HP0777.
PATRICi20592843. VBIHelPyl33062_0810.

Phylogenomic databases

eggNOGiENOG4105C41. Bacteria.
COG0528. LUCA.
KOiK09903.
OMAiIIVFDMN.
OrthoDBiEOG6M0T8S.

Enzyme and pathway databases

UniPathwayiUPA00159; UER00275.
BioCyciHPY:HP0777-MONOMER.
BRENDAi2.7.4.22. 2604.

Family and domain databases

Gene3Di3.40.1160.10. 1 hit.
HAMAPiMF_01220_B. PyrH_B.
InterProiIPR001048. Asp/Glu/Uridylate_kinase.
IPR011817. Uridylate_kinase.
IPR015963. Uridylate_kinase_bac.
[Graphical view]
PANTHERiPTHR21499:SF23. PTHR21499:SF23. 1 hit.
PfamiPF00696. AA_kinase. 1 hit.
[Graphical view]
PIRSFiPIRSF005650. Uridylate_kin. 1 hit.
SUPFAMiSSF53633. SSF53633. 1 hit.
TIGRFAMsiTIGR02075. pyrH_bact. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700392 / 26695.

Entry informationi

Entry nameiPYRH_HELPY
AccessioniPrimary (citable) accession number: P56106
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 11, 2015
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.