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P56105 (DPO1_HELPY) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
DNA polymerase I
Short name=POL I
EC=2.7.7.7
Gene names
Name:polA
Ordered Locus Names:HP_1470
OrganismHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) [Reference proteome] [HAMAP]
Taxonomic identifier85962 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter ›

Protein attributes

Sequence length891 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

In addition to polymerase activity, this DNA polymerase exhibits 3' to 5' and 5' to 3' exonuclease activity By similarity.

Catalytic activity

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

Subunit structure

Single-chain monomer with multiple functions.

Sequence similarities

Belongs to the DNA polymerase type-A family.

Contains 1 3'-5' exonuclease domain.

Contains 1 5'-3' exonuclease domain.

Sequence caution

The sequence AAD08510.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 891891DNA polymerase I
PRO_0000101241

Regions

Domain1 – 3133135'-3' exonuclease
Domain314 – 4881753'-5' exonuclease
Region492 – 890399Polymerase

Sequences

Sequence LengthMass (Da)Tools
P56105 [UniParc].

Last modified December 1, 2000. Version 2.
Checksum: 3D6E7D8FF613EB88

FASTA891101,975
        10         20         30         40         50         60 
MEQPVIKEGT LALIDTFAYL FRSYYMSAKN KPLTNDKGFP TGLLTGLVGM VKKFYKDRKN 

        70         80         90        100        110        120 
MPFIVFALES QTKTKRAEKL GEYKQNRKDA PKEMLLQIPI ALEWLQKMGF VCVEVNGFEA 

       130        140        150        160        170        180 
DDVIASLATL SPYKTRIYSK DKDFNQLLSD KIALFDGKTE FLAKDCVEKY GILPSQFTDY 

       190        200        210        220        230        240 
QGIVGDSSDN YKGVKGIGSK NAKELLQRLG SLEKIYENLD LAKNLLSPKM YRALIHDKAS 

       250        260        270        280        290        300 
AFLSKELATL ERGCIKEFDF LSCAFPSENP LLKIKDELKE YGFISTLRDL ENSPTPLILD 

       310        320        330        340        350        360 
NAPLLDNTPA LDNTPKKSCM IVLESAAPLS AFLEKLEKTN ARVFARLVLD KEKKVLALAF 

       370        380        390        400        410        420 
LYEDQGYFLP LEEALFSPFS LEFLQNAFFK MLQHAQIIGH DLKPLLSFLK AKYQVPLENI 

       430        440        450        460        470        480 
RIQDTQILAF LKNPEKVGFD EVLKEYLKEE LIPHEKIKDF KTKAEKLELL SVELNALKRL 

       490        500        510        520        530        540 
CEYFEKGGLE ENLLSLAREI ETPFMKVLMG MEFQGFKIDA PYFKRLEQEF KNELHVLERQ 

       550        560        570        580        590        600 
ILELIGVDFN LNSPKQLSEV LYDKLGLPKN KSHSTDEKSL LKILDKHPSI ALILEYRELN 

       610        620        630        640        650        660 
KLFNTYTTPL LRLKDKDDKI HTTFIQTGTA TGRLSSHSPN LQNIPVRSPK GLLIRKGFIA 

       670        680        690        700        710        720 
SSKEYCLLGV DYSQIELRLL AHFSQDKDLM EAFLKGRDIH LETSKALFGE YLAKEKRSIA 

       730        740        750        760        770        780 
KSINFGLVYG MGSKKLSETL NISLNEAKSY IEAYFKRFPS IKDYLNRMKE EILKTSKAFT 

       790        800        810        820        830        840 
LLGRYRVFDF TGANDYVKGN YLREGVNAIF QGSASDLLKL GMLKVSERFK NNPSVRLLLQ 

       850        860        870        880        890 
VHDELIFEIE EKNAPELQQE IQRILNDEVY PLRVPLETSA FIAKRWNELK G

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE000511 Genomic DNA. Translation: AAD08510.1. Different initiation.
PIRF64703.
RefSeqNP_208261.1. NC_000915.1.
YP_006935394.1. NC_018939.1.

3D structure databases

ProteinModelPortalP56105.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-3098N.
MINTMINT-181017.
STRING85962.HP1470.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAD08510; AAD08510; HP_1470.
GeneID13870684.
899822.
KEGGheo:C694_07610.
hpy:HP1470.
PATRIC20594351. VBIHelPyl33062_1544.

Phylogenomic databases

eggNOGCOG0258.
KOK02335.
OMAEQRRYAK.
ProtClustDBPRK05755.

Family and domain databases

InterProIPR002562. 3'-5'_exonuclease_dom.
IPR020046. 5-3_exonucl_a-hlix_arch_N.
IPR020045. 5-3_exonuclease_C.
IPR002421. 5-3_exonuclease_N.
IPR019760. DNA-dir_DNA_pol_A_CS.
IPR001098. DNA-dir_DNA_pol_A_palm_dom.
IPR018320. DNA_polymerase_1.
IPR002298. DNA_polymerase_A.
IPR008918. HhH2.
IPR012337. RNaseH-like_dom.
[Graphical view]
PfamPF01367. 5_3_exonuc. 1 hit.
PF02739. 5_3_exonuc_N. 1 hit.
PF00476. DNA_pol_A. 1 hit.
[Graphical view]
PRINTSPR00868. DNAPOLI.
SMARTSM00474. 35EXOc. 1 hit.
SM00475. 53EXOc. 1 hit.
SM00279. HhH2. 1 hit.
SM00482. POLAc. 1 hit.
[Graphical view]
SUPFAMSSF47807. 5_3_exo_C. 1 hit.
SSF53098. RNaseH_fold. 1 hit.
TIGRFAMsTIGR00593. pola. 1 hit.
PROSITEPS00447. DNA_POLYMERASE_A. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDPO1_HELPY
AccessionPrimary (citable) accession number: P56105
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: December 1, 2000
Last modified: May 29, 2013
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Helicobacter pylori

Helicobacter pylori (strain 26695): entries and gene names

SIMILARITY comments

Index of protein domains and families

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