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Protein

DNA polymerase I

Gene

polA

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

In addition to polymerase activity, this DNA polymerase exhibits 3'-5' and 5'-3' exonuclease activity.By similarity

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, DNA-directed DNA polymerase, Exonuclease, Hydrolase, Nuclease, Nucleotidyltransferase, Transferase
Biological processDNA damage, DNA repair, DNA replication

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase I (EC:2.7.7.7)
Short name:
POL I
Gene namesi
Name:polA
Ordered Locus Names:HP_1470
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001012411 – 891DNA polymerase IAdd BLAST891

Proteomic databases

PaxDbiP56105
PRIDEiP56105

Interactioni

Subunit structurei

Single-chain monomer with multiple functions.

Protein-protein interaction databases

DIPiDIP-3098N
IntActiP56105, 5 interactors
MINTiP56105
STRINGi85962.HP1470

Structurei

3D structure databases

ProteinModelPortaliP56105
SMRiP56105
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 3135'-3' exonucleaseAdd BLAST313
Domaini314 – 4883'-5' exonucleaseAdd BLAST175

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni492 – 890PolymeraseAdd BLAST399

Sequence similaritiesi

Belongs to the DNA polymerase type-A family.Curated

Phylogenomic databases

eggNOGiENOG4105C2M Bacteria
COG0258 LUCA
COG0749 LUCA
KOiK02335
OMAiETGRVHT

Family and domain databases

CDDicd09898 H3TH_53EXO, 1 hit
Gene3Di3.30.420.10, 1 hit
InterProiView protein in InterPro
IPR002562 3'-5'_exonuclease_dom
IPR020046 5-3_exonucl_a-hlix_arch_N
IPR036279 5-3_exonuclease_C_sf
IPR002421 5-3_exonuclease_N
IPR019760 DNA-dir_DNA_pol_A_CS
IPR001098 DNA-dir_DNA_pol_A_palm_dom
IPR020045 DNA_polI_H3TH
IPR018320 DNA_polymerase_1
IPR002298 DNA_polymerase_A
IPR008918 HhH2
IPR029060 PIN-like_dom_sf
IPR012337 RNaseH-like_sf
IPR036397 RNaseH_sf
PANTHERiPTHR10133 PTHR10133, 1 hit
PfamiView protein in Pfam
PF01367 5_3_exonuc, 1 hit
PF02739 5_3_exonuc_N, 1 hit
PF00476 DNA_pol_A, 1 hit
PRINTSiPR00868 DNAPOLI
SMARTiView protein in SMART
SM00474 35EXOc, 1 hit
SM00475 53EXOc, 1 hit
SM00279 HhH2, 1 hit
SM00482 POLAc, 1 hit
SUPFAMiSSF47807 SSF47807, 1 hit
SSF53098 SSF53098, 1 hit
SSF88723 SSF88723, 1 hit
TIGRFAMsiTIGR00593 pola, 1 hit
PROSITEiView protein in PROSITE
PS00447 DNA_POLYMERASE_A, 1 hit

Sequencei

Sequence statusi: Complete.

P56105-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEQPVIKEGT LALIDTFAYL FRSYYMSAKN KPLTNDKGFP TGLLTGLVGM
60 70 80 90 100
VKKFYKDRKN MPFIVFALES QTKTKRAEKL GEYKQNRKDA PKEMLLQIPI
110 120 130 140 150
ALEWLQKMGF VCVEVNGFEA DDVIASLATL SPYKTRIYSK DKDFNQLLSD
160 170 180 190 200
KIALFDGKTE FLAKDCVEKY GILPSQFTDY QGIVGDSSDN YKGVKGIGSK
210 220 230 240 250
NAKELLQRLG SLEKIYENLD LAKNLLSPKM YRALIHDKAS AFLSKELATL
260 270 280 290 300
ERGCIKEFDF LSCAFPSENP LLKIKDELKE YGFISTLRDL ENSPTPLILD
310 320 330 340 350
NAPLLDNTPA LDNTPKKSCM IVLESAAPLS AFLEKLEKTN ARVFARLVLD
360 370 380 390 400
KEKKVLALAF LYEDQGYFLP LEEALFSPFS LEFLQNAFFK MLQHAQIIGH
410 420 430 440 450
DLKPLLSFLK AKYQVPLENI RIQDTQILAF LKNPEKVGFD EVLKEYLKEE
460 470 480 490 500
LIPHEKIKDF KTKAEKLELL SVELNALKRL CEYFEKGGLE ENLLSLAREI
510 520 530 540 550
ETPFMKVLMG MEFQGFKIDA PYFKRLEQEF KNELHVLERQ ILELIGVDFN
560 570 580 590 600
LNSPKQLSEV LYDKLGLPKN KSHSTDEKSL LKILDKHPSI ALILEYRELN
610 620 630 640 650
KLFNTYTTPL LRLKDKDDKI HTTFIQTGTA TGRLSSHSPN LQNIPVRSPK
660 670 680 690 700
GLLIRKGFIA SSKEYCLLGV DYSQIELRLL AHFSQDKDLM EAFLKGRDIH
710 720 730 740 750
LETSKALFGE YLAKEKRSIA KSINFGLVYG MGSKKLSETL NISLNEAKSY
760 770 780 790 800
IEAYFKRFPS IKDYLNRMKE EILKTSKAFT LLGRYRVFDF TGANDYVKGN
810 820 830 840 850
YLREGVNAIF QGSASDLLKL GMLKVSERFK NNPSVRLLLQ VHDELIFEIE
860 870 880 890
EKNAPELQQE IQRILNDEVY PLRVPLETSA FIAKRWNELK G
Length:891
Mass (Da):101,975
Last modified:December 1, 2000 - v2
Checksum:i3D6E7D8FF613EB88
GO

Sequence cautioni

The sequence AAD08510 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA Translation: AAD08510.1 Different initiation.
PIRiF64703
RefSeqiNP_208261.1, NC_000915.1

Genome annotation databases

EnsemblBacteriaiAAD08510; AAD08510; HP_1470
GeneIDi899822
KEGGiheo:C694_07610
hpy:HP1470
PATRICifig|85962.47.peg.1581

Entry informationi

Entry nameiDPO1_HELPY
AccessioniPrimary (citable) accession number: P56105
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: December 1, 2000
Last modified: May 23, 2018
This is version 120 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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