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P56105

- DPO1_HELPY

UniProt

P56105 - DPO1_HELPY

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Protein
DNA polymerase I
Gene
polA, HP_1470
Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

In addition to polymerase activity, this DNA polymerase exhibits 3' to 5' and 5' to 3' exonuclease activity By similarity.

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

GO - Molecular functioni

  1. 3'-5' exonuclease activity Source: InterPro
  2. DNA binding Source: UniProtKB-KW
  3. DNA-directed DNA polymerase activity Source: UniProtKB-KW

GO - Biological processi

  1. DNA repair Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

DNA-directed DNA polymerase, Exonuclease, Hydrolase, Nuclease, Nucleotidyltransferase, Transferase

Keywords - Biological processi

DNA damage, DNA repair, DNA replication

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase I (EC:2.7.7.7)
Short name:
POL I
Gene namesi
Name:polA
Ordered Locus Names:HP_1470
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000429: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 891891DNA polymerase I
PRO_0000101241Add
BLAST

Interactioni

Subunit structurei

Single-chain monomer with multiple functions.

Protein-protein interaction databases

DIPiDIP-3098N.
IntActiP56105. 5 interactions.
MINTiMINT-181017.
STRINGi85962.HP1470.

Structurei

3D structure databases

ProteinModelPortaliP56105.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 3133135'-3' exonuclease
Add
BLAST
Domaini314 – 4881753'-5' exonuclease
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni492 – 890399Polymerase
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0258.
KOiK02335.
OMAiKGGLEEN.
OrthoDBiEOG6SJJH7.

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
3.40.50.1010. 1 hit.
InterProiIPR002562. 3'-5'_exonuclease_dom.
IPR020046. 5-3_exonucl_a-hlix_arch_N.
IPR020045. 5-3_exonuclease_C.
IPR002421. 5-3_exonuclease_N.
IPR019760. DNA-dir_DNA_pol_A_CS.
IPR001098. DNA-dir_DNA_pol_A_palm_dom.
IPR018320. DNA_polymerase_1.
IPR002298. DNA_polymerase_A.
IPR008918. HhH2.
IPR029060. PIN_domain-like.
IPR012337. RNaseH-like_dom.
[Graphical view]
PfamiPF01367. 5_3_exonuc. 1 hit.
PF02739. 5_3_exonuc_N. 1 hit.
PF00476. DNA_pol_A. 1 hit.
[Graphical view]
PRINTSiPR00868. DNAPOLI.
SMARTiSM00474. 35EXOc. 1 hit.
SM00475. 53EXOc. 1 hit.
SM00279. HhH2. 1 hit.
SM00482. POLAc. 1 hit.
[Graphical view]
SUPFAMiSSF47807. SSF47807. 1 hit.
SSF53098. SSF53098. 1 hit.
SSF88723. SSF88723. 1 hit.
TIGRFAMsiTIGR00593. pola. 1 hit.
PROSITEiPS00447. DNA_POLYMERASE_A. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P56105-1 [UniParc]FASTAAdd to Basket

« Hide

MEQPVIKEGT LALIDTFAYL FRSYYMSAKN KPLTNDKGFP TGLLTGLVGM    50
VKKFYKDRKN MPFIVFALES QTKTKRAEKL GEYKQNRKDA PKEMLLQIPI 100
ALEWLQKMGF VCVEVNGFEA DDVIASLATL SPYKTRIYSK DKDFNQLLSD 150
KIALFDGKTE FLAKDCVEKY GILPSQFTDY QGIVGDSSDN YKGVKGIGSK 200
NAKELLQRLG SLEKIYENLD LAKNLLSPKM YRALIHDKAS AFLSKELATL 250
ERGCIKEFDF LSCAFPSENP LLKIKDELKE YGFISTLRDL ENSPTPLILD 300
NAPLLDNTPA LDNTPKKSCM IVLESAAPLS AFLEKLEKTN ARVFARLVLD 350
KEKKVLALAF LYEDQGYFLP LEEALFSPFS LEFLQNAFFK MLQHAQIIGH 400
DLKPLLSFLK AKYQVPLENI RIQDTQILAF LKNPEKVGFD EVLKEYLKEE 450
LIPHEKIKDF KTKAEKLELL SVELNALKRL CEYFEKGGLE ENLLSLAREI 500
ETPFMKVLMG MEFQGFKIDA PYFKRLEQEF KNELHVLERQ ILELIGVDFN 550
LNSPKQLSEV LYDKLGLPKN KSHSTDEKSL LKILDKHPSI ALILEYRELN 600
KLFNTYTTPL LRLKDKDDKI HTTFIQTGTA TGRLSSHSPN LQNIPVRSPK 650
GLLIRKGFIA SSKEYCLLGV DYSQIELRLL AHFSQDKDLM EAFLKGRDIH 700
LETSKALFGE YLAKEKRSIA KSINFGLVYG MGSKKLSETL NISLNEAKSY 750
IEAYFKRFPS IKDYLNRMKE EILKTSKAFT LLGRYRVFDF TGANDYVKGN 800
YLREGVNAIF QGSASDLLKL GMLKVSERFK NNPSVRLLLQ VHDELIFEIE 850
EKNAPELQQE IQRILNDEVY PLRVPLETSA FIAKRWNELK G 891
Length:891
Mass (Da):101,975
Last modified:December 1, 2000 - v2
Checksum:i3D6E7D8FF613EB88
GO

Sequence cautioni

The sequence AAD08510.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000511 Genomic DNA. Translation: AAD08510.1. Different initiation.
PIRiF64703.
RefSeqiNP_208261.1. NC_000915.1.
YP_006935394.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD08510; AAD08510; HP_1470.
GeneIDi13870684.
899822.
KEGGiheo:C694_07610.
hpy:HP1470.
PATRICi20594351. VBIHelPyl33062_1544.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000511 Genomic DNA. Translation: AAD08510.1 . Different initiation.
PIRi F64703.
RefSeqi NP_208261.1. NC_000915.1.
YP_006935394.1. NC_018939.1.

3D structure databases

ProteinModelPortali P56105.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-3098N.
IntActi P56105. 5 interactions.
MINTi MINT-181017.
STRINGi 85962.HP1470.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD08510 ; AAD08510 ; HP_1470 .
GeneIDi 13870684.
899822.
KEGGi heo:C694_07610.
hpy:HP1470.
PATRICi 20594351. VBIHelPyl33062_1544.

Phylogenomic databases

eggNOGi COG0258.
KOi K02335.
OMAi KGGLEEN.
OrthoDBi EOG6SJJH7.

Family and domain databases

Gene3Di 3.30.420.10. 1 hit.
3.40.50.1010. 1 hit.
InterProi IPR002562. 3'-5'_exonuclease_dom.
IPR020046. 5-3_exonucl_a-hlix_arch_N.
IPR020045. 5-3_exonuclease_C.
IPR002421. 5-3_exonuclease_N.
IPR019760. DNA-dir_DNA_pol_A_CS.
IPR001098. DNA-dir_DNA_pol_A_palm_dom.
IPR018320. DNA_polymerase_1.
IPR002298. DNA_polymerase_A.
IPR008918. HhH2.
IPR029060. PIN_domain-like.
IPR012337. RNaseH-like_dom.
[Graphical view ]
Pfami PF01367. 5_3_exonuc. 1 hit.
PF02739. 5_3_exonuc_N. 1 hit.
PF00476. DNA_pol_A. 1 hit.
[Graphical view ]
PRINTSi PR00868. DNAPOLI.
SMARTi SM00474. 35EXOc. 1 hit.
SM00475. 53EXOc. 1 hit.
SM00279. HhH2. 1 hit.
SM00482. POLAc. 1 hit.
[Graphical view ]
SUPFAMi SSF47807. SSF47807. 1 hit.
SSF53098. SSF53098. 1 hit.
SSF88723. SSF88723. 1 hit.
TIGRFAMsi TIGR00593. pola. 1 hit.
PROSITEi PS00447. DNA_POLYMERASE_A. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700392 / 26695.

Entry informationi

Entry nameiDPO1_HELPY
AccessioniPrimary (citable) accession number: P56105
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: December 1, 2000
Last modified: September 3, 2014
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi