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P56105

- DPO1_HELPY

UniProt

P56105 - DPO1_HELPY

Protein

DNA polymerase I

Gene

polA

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 2 (01 Dec 2000)
      Previous versions | rss
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    Functioni

    In addition to polymerase activity, this DNA polymerase exhibits 3' to 5' and 5' to 3' exonuclease activity.By similarity

    Catalytic activityi

    Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

    GO - Molecular functioni

    1. 3'-5' exonuclease activity Source: InterPro
    2. DNA binding Source: UniProtKB-KW
    3. DNA-directed DNA polymerase activity Source: UniProtKB-KW

    GO - Biological processi

    1. DNA repair Source: UniProtKB-KW

    Keywords - Molecular functioni

    DNA-directed DNA polymerase, Exonuclease, Hydrolase, Nuclease, Nucleotidyltransferase, Transferase

    Keywords - Biological processi

    DNA damage, DNA repair, DNA replication

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA polymerase I (EC:2.7.7.7)
    Short name:
    POL I
    Gene namesi
    Name:polA
    Ordered Locus Names:HP_1470
    OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
    Taxonomic identifieri85962 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
    ProteomesiUP000000429: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 891891DNA polymerase IPRO_0000101241Add
    BLAST

    Interactioni

    Subunit structurei

    Single-chain monomer with multiple functions.

    Protein-protein interaction databases

    DIPiDIP-3098N.
    IntActiP56105. 5 interactions.
    MINTiMINT-181017.
    STRINGi85962.HP1470.

    Structurei

    3D structure databases

    ProteinModelPortaliP56105.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 3133135'-3' exonucleaseAdd
    BLAST
    Domaini314 – 4881753'-5' exonucleaseAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni492 – 890399PolymeraseAdd
    BLAST

    Sequence similaritiesi

    Belongs to the DNA polymerase type-A family.Curated
    Contains 1 3'-5' exonuclease domain.Curated
    Contains 1 5'-3' exonuclease domain.Curated

    Phylogenomic databases

    eggNOGiCOG0258.
    KOiK02335.
    OMAiKGGLEEN.
    OrthoDBiEOG6SJJH7.

    Family and domain databases

    Gene3Di3.30.420.10. 1 hit.
    3.40.50.1010. 1 hit.
    InterProiIPR002562. 3'-5'_exonuclease_dom.
    IPR020046. 5-3_exonucl_a-hlix_arch_N.
    IPR020045. 5-3_exonuclease_C.
    IPR002421. 5-3_exonuclease_N.
    IPR019760. DNA-dir_DNA_pol_A_CS.
    IPR001098. DNA-dir_DNA_pol_A_palm_dom.
    IPR018320. DNA_polymerase_1.
    IPR002298. DNA_polymerase_A.
    IPR008918. HhH2.
    IPR029060. PIN_domain-like.
    IPR012337. RNaseH-like_dom.
    [Graphical view]
    PfamiPF01367. 5_3_exonuc. 1 hit.
    PF02739. 5_3_exonuc_N. 1 hit.
    PF00476. DNA_pol_A. 1 hit.
    [Graphical view]
    PRINTSiPR00868. DNAPOLI.
    SMARTiSM00474. 35EXOc. 1 hit.
    SM00475. 53EXOc. 1 hit.
    SM00279. HhH2. 1 hit.
    SM00482. POLAc. 1 hit.
    [Graphical view]
    SUPFAMiSSF47807. SSF47807. 1 hit.
    SSF53098. SSF53098. 1 hit.
    SSF88723. SSF88723. 1 hit.
    TIGRFAMsiTIGR00593. pola. 1 hit.
    PROSITEiPS00447. DNA_POLYMERASE_A. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P56105-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEQPVIKEGT LALIDTFAYL FRSYYMSAKN KPLTNDKGFP TGLLTGLVGM    50
    VKKFYKDRKN MPFIVFALES QTKTKRAEKL GEYKQNRKDA PKEMLLQIPI 100
    ALEWLQKMGF VCVEVNGFEA DDVIASLATL SPYKTRIYSK DKDFNQLLSD 150
    KIALFDGKTE FLAKDCVEKY GILPSQFTDY QGIVGDSSDN YKGVKGIGSK 200
    NAKELLQRLG SLEKIYENLD LAKNLLSPKM YRALIHDKAS AFLSKELATL 250
    ERGCIKEFDF LSCAFPSENP LLKIKDELKE YGFISTLRDL ENSPTPLILD 300
    NAPLLDNTPA LDNTPKKSCM IVLESAAPLS AFLEKLEKTN ARVFARLVLD 350
    KEKKVLALAF LYEDQGYFLP LEEALFSPFS LEFLQNAFFK MLQHAQIIGH 400
    DLKPLLSFLK AKYQVPLENI RIQDTQILAF LKNPEKVGFD EVLKEYLKEE 450
    LIPHEKIKDF KTKAEKLELL SVELNALKRL CEYFEKGGLE ENLLSLAREI 500
    ETPFMKVLMG MEFQGFKIDA PYFKRLEQEF KNELHVLERQ ILELIGVDFN 550
    LNSPKQLSEV LYDKLGLPKN KSHSTDEKSL LKILDKHPSI ALILEYRELN 600
    KLFNTYTTPL LRLKDKDDKI HTTFIQTGTA TGRLSSHSPN LQNIPVRSPK 650
    GLLIRKGFIA SSKEYCLLGV DYSQIELRLL AHFSQDKDLM EAFLKGRDIH 700
    LETSKALFGE YLAKEKRSIA KSINFGLVYG MGSKKLSETL NISLNEAKSY 750
    IEAYFKRFPS IKDYLNRMKE EILKTSKAFT LLGRYRVFDF TGANDYVKGN 800
    YLREGVNAIF QGSASDLLKL GMLKVSERFK NNPSVRLLLQ VHDELIFEIE 850
    EKNAPELQQE IQRILNDEVY PLRVPLETSA FIAKRWNELK G 891
    Length:891
    Mass (Da):101,975
    Last modified:December 1, 2000 - v2
    Checksum:i3D6E7D8FF613EB88
    GO

    Sequence cautioni

    The sequence AAD08510.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000511 Genomic DNA. Translation: AAD08510.1. Different initiation.
    PIRiF64703.
    RefSeqiNP_208261.1. NC_000915.1.
    YP_006935394.1. NC_018939.1.

    Genome annotation databases

    EnsemblBacteriaiAAD08510; AAD08510; HP_1470.
    GeneIDi13870684.
    899822.
    KEGGiheo:C694_07610.
    hpy:HP1470.
    PATRICi20594351. VBIHelPyl33062_1544.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000511 Genomic DNA. Translation: AAD08510.1 . Different initiation.
    PIRi F64703.
    RefSeqi NP_208261.1. NC_000915.1.
    YP_006935394.1. NC_018939.1.

    3D structure databases

    ProteinModelPortali P56105.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-3098N.
    IntActi P56105. 5 interactions.
    MINTi MINT-181017.
    STRINGi 85962.HP1470.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD08510 ; AAD08510 ; HP_1470 .
    GeneIDi 13870684.
    899822.
    KEGGi heo:C694_07610.
    hpy:HP1470.
    PATRICi 20594351. VBIHelPyl33062_1544.

    Phylogenomic databases

    eggNOGi COG0258.
    KOi K02335.
    OMAi KGGLEEN.
    OrthoDBi EOG6SJJH7.

    Family and domain databases

    Gene3Di 3.30.420.10. 1 hit.
    3.40.50.1010. 1 hit.
    InterProi IPR002562. 3'-5'_exonuclease_dom.
    IPR020046. 5-3_exonucl_a-hlix_arch_N.
    IPR020045. 5-3_exonuclease_C.
    IPR002421. 5-3_exonuclease_N.
    IPR019760. DNA-dir_DNA_pol_A_CS.
    IPR001098. DNA-dir_DNA_pol_A_palm_dom.
    IPR018320. DNA_polymerase_1.
    IPR002298. DNA_polymerase_A.
    IPR008918. HhH2.
    IPR029060. PIN_domain-like.
    IPR012337. RNaseH-like_dom.
    [Graphical view ]
    Pfami PF01367. 5_3_exonuc. 1 hit.
    PF02739. 5_3_exonuc_N. 1 hit.
    PF00476. DNA_pol_A. 1 hit.
    [Graphical view ]
    PRINTSi PR00868. DNAPOLI.
    SMARTi SM00474. 35EXOc. 1 hit.
    SM00475. 53EXOc. 1 hit.
    SM00279. HhH2. 1 hit.
    SM00482. POLAc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47807. SSF47807. 1 hit.
    SSF53098. SSF53098. 1 hit.
    SSF88723. SSF88723. 1 hit.
    TIGRFAMsi TIGR00593. pola. 1 hit.
    PROSITEi PS00447. DNA_POLYMERASE_A. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700392 / 26695.

    Entry informationi

    Entry nameiDPO1_HELPY
    AccessioniPrimary (citable) accession number: P56105
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: December 1, 2000
    Last modified: October 1, 2014
    This is version 100 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Helicobacter pylori
      Helicobacter pylori (strain 26695): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3