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Protein

DNA polymerase I

Gene

polA

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

In addition to polymerase activity, this DNA polymerase exhibits 3' to 5' and 5' to 3' exonuclease activity.By similarity

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

DNA-directed DNA polymerase, Exonuclease, Hydrolase, Nuclease, Nucleotidyltransferase, Transferase

Keywords - Biological processi

DNA damage, DNA repair, DNA replication

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase I (EC:2.7.7.7)
Short name:
POL I
Gene namesi
Name:polA
Ordered Locus Names:HP_1470
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi
  • UP000000429 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001012411 – 891DNA polymerase IAdd BLAST891

Proteomic databases

PaxDbiP56105.

Interactioni

Subunit structurei

Single-chain monomer with multiple functions.

Protein-protein interaction databases

DIPiDIP-3098N.
IntActiP56105. 5 interactors.
MINTiMINT-181017.
STRINGi85962.HP1470.

Structurei

3D structure databases

ProteinModelPortaliP56105.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 3135'-3' exonucleaseAdd BLAST313
Domaini314 – 4883'-5' exonucleaseAdd BLAST175

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni492 – 890PolymeraseAdd BLAST399

Sequence similaritiesi

Belongs to the DNA polymerase type-A family.Curated
Contains 1 3'-5' exonuclease domain.Curated
Contains 1 5'-3' exonuclease domain.Curated

Phylogenomic databases

eggNOGiENOG4105C2M. Bacteria.
COG0258. LUCA.
COG0749. LUCA.
KOiK02335.
OMAiCFDTETT.

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
3.40.50.1010. 1 hit.
InterProiIPR002562. 3'-5'_exonuclease_dom.
IPR020046. 5-3_exonucl_a-hlix_arch_N.
IPR020045. 5-3_exonuclease_C.
IPR002421. 5-3_exonuclease_N.
IPR019760. DNA-dir_DNA_pol_A_CS.
IPR001098. DNA-dir_DNA_pol_A_palm_dom.
IPR018320. DNA_polymerase_1.
IPR002298. DNA_polymerase_A.
IPR008918. HhH2.
IPR029060. PIN_domain-like.
IPR012337. RNaseH-like_dom.
[Graphical view]
PfamiPF01367. 5_3_exonuc. 1 hit.
PF02739. 5_3_exonuc_N. 1 hit.
PF00476. DNA_pol_A. 1 hit.
[Graphical view]
PRINTSiPR00868. DNAPOLI.
SMARTiSM00474. 35EXOc. 1 hit.
SM00475. 53EXOc. 1 hit.
SM00279. HhH2. 1 hit.
SM00482. POLAc. 1 hit.
[Graphical view]
SUPFAMiSSF47807. SSF47807. 1 hit.
SSF53098. SSF53098. 1 hit.
SSF88723. SSF88723. 1 hit.
TIGRFAMsiTIGR00593. pola. 1 hit.
PROSITEiPS00447. DNA_POLYMERASE_A. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P56105-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEQPVIKEGT LALIDTFAYL FRSYYMSAKN KPLTNDKGFP TGLLTGLVGM
60 70 80 90 100
VKKFYKDRKN MPFIVFALES QTKTKRAEKL GEYKQNRKDA PKEMLLQIPI
110 120 130 140 150
ALEWLQKMGF VCVEVNGFEA DDVIASLATL SPYKTRIYSK DKDFNQLLSD
160 170 180 190 200
KIALFDGKTE FLAKDCVEKY GILPSQFTDY QGIVGDSSDN YKGVKGIGSK
210 220 230 240 250
NAKELLQRLG SLEKIYENLD LAKNLLSPKM YRALIHDKAS AFLSKELATL
260 270 280 290 300
ERGCIKEFDF LSCAFPSENP LLKIKDELKE YGFISTLRDL ENSPTPLILD
310 320 330 340 350
NAPLLDNTPA LDNTPKKSCM IVLESAAPLS AFLEKLEKTN ARVFARLVLD
360 370 380 390 400
KEKKVLALAF LYEDQGYFLP LEEALFSPFS LEFLQNAFFK MLQHAQIIGH
410 420 430 440 450
DLKPLLSFLK AKYQVPLENI RIQDTQILAF LKNPEKVGFD EVLKEYLKEE
460 470 480 490 500
LIPHEKIKDF KTKAEKLELL SVELNALKRL CEYFEKGGLE ENLLSLAREI
510 520 530 540 550
ETPFMKVLMG MEFQGFKIDA PYFKRLEQEF KNELHVLERQ ILELIGVDFN
560 570 580 590 600
LNSPKQLSEV LYDKLGLPKN KSHSTDEKSL LKILDKHPSI ALILEYRELN
610 620 630 640 650
KLFNTYTTPL LRLKDKDDKI HTTFIQTGTA TGRLSSHSPN LQNIPVRSPK
660 670 680 690 700
GLLIRKGFIA SSKEYCLLGV DYSQIELRLL AHFSQDKDLM EAFLKGRDIH
710 720 730 740 750
LETSKALFGE YLAKEKRSIA KSINFGLVYG MGSKKLSETL NISLNEAKSY
760 770 780 790 800
IEAYFKRFPS IKDYLNRMKE EILKTSKAFT LLGRYRVFDF TGANDYVKGN
810 820 830 840 850
YLREGVNAIF QGSASDLLKL GMLKVSERFK NNPSVRLLLQ VHDELIFEIE
860 870 880 890
EKNAPELQQE IQRILNDEVY PLRVPLETSA FIAKRWNELK G
Length:891
Mass (Da):101,975
Last modified:December 1, 2000 - v2
Checksum:i3D6E7D8FF613EB88
GO

Sequence cautioni

The sequence AAD08510 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD08510.1. Different initiation.
PIRiF64703.
RefSeqiNP_208261.1. NC_000915.1.
WP_000437576.1. NC_018939.1.
WP_010875630.1. NC_000915.1.

Genome annotation databases

EnsemblBacteriaiAAD08510; AAD08510; HP_1470.
GeneIDi899822.
KEGGiheo:C694_07610.
hpy:HP1470.
PATRICi20594351. VBIHelPyl33062_1544.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD08510.1. Different initiation.
PIRiF64703.
RefSeqiNP_208261.1. NC_000915.1.
WP_000437576.1. NC_018939.1.
WP_010875630.1. NC_000915.1.

3D structure databases

ProteinModelPortaliP56105.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-3098N.
IntActiP56105. 5 interactors.
MINTiMINT-181017.
STRINGi85962.HP1470.

Proteomic databases

PaxDbiP56105.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD08510; AAD08510; HP_1470.
GeneIDi899822.
KEGGiheo:C694_07610.
hpy:HP1470.
PATRICi20594351. VBIHelPyl33062_1544.

Phylogenomic databases

eggNOGiENOG4105C2M. Bacteria.
COG0258. LUCA.
COG0749. LUCA.
KOiK02335.
OMAiCFDTETT.

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
3.40.50.1010. 1 hit.
InterProiIPR002562. 3'-5'_exonuclease_dom.
IPR020046. 5-3_exonucl_a-hlix_arch_N.
IPR020045. 5-3_exonuclease_C.
IPR002421. 5-3_exonuclease_N.
IPR019760. DNA-dir_DNA_pol_A_CS.
IPR001098. DNA-dir_DNA_pol_A_palm_dom.
IPR018320. DNA_polymerase_1.
IPR002298. DNA_polymerase_A.
IPR008918. HhH2.
IPR029060. PIN_domain-like.
IPR012337. RNaseH-like_dom.
[Graphical view]
PfamiPF01367. 5_3_exonuc. 1 hit.
PF02739. 5_3_exonuc_N. 1 hit.
PF00476. DNA_pol_A. 1 hit.
[Graphical view]
PRINTSiPR00868. DNAPOLI.
SMARTiSM00474. 35EXOc. 1 hit.
SM00475. 53EXOc. 1 hit.
SM00279. HhH2. 1 hit.
SM00482. POLAc. 1 hit.
[Graphical view]
SUPFAMiSSF47807. SSF47807. 1 hit.
SSF53098. SSF53098. 1 hit.
SSF88723. SSF88723. 1 hit.
TIGRFAMsiTIGR00593. pola. 1 hit.
PROSITEiPS00447. DNA_POLYMERASE_A. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDPO1_HELPY
AccessioniPrimary (citable) accession number: P56105
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: December 1, 2000
Last modified: October 5, 2016
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.