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P56103 (KGUA_HELPY) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Guanylate kinase

EC=2.7.4.8
Alternative name(s):
GMP kinase
Gene names
Name:gmk
Ordered Locus Names:HP_0321
OrganismHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) [Reference proteome] [HAMAP]
Taxonomic identifier85962 [NCBI]
Taxonomic lineageBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter

Protein attributes

Sequence length206 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Essential for recycling GMP and indirectly, cGMP By similarity. HAMAP-Rule MF_00328

Catalytic activity

ATP + GMP = ADP + GDP. HAMAP-Rule MF_00328

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00328.

Sequence similarities

Belongs to the guanylate kinase family.

Contains 1 guanylate kinase-like domain.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processpurine nucleotide metabolic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

guanylate kinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 206206Guanylate kinase HAMAP-Rule MF_00328
PRO_0000170547

Regions

Domain5 – 183179Guanylate kinase-like
Nucleotide binding12 – 198ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
P56103 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: AED9253D02C36A13

FASTA20623,830
        10         20         30         40         50         60 
MHNDFNLLIL SGPSGAGKST LTKYLQEKIP KTHFSLSTTT RKPREGEVDG LHYNFVSEEE 

        70         80         90        100        110        120 
FKQGIEKGQF LEWAIVHNHY YGTSKIPVEK ALKEGKIVIF DIDVQGHEIL KKHYPNACSV 

       130        140        150        160        170        180 
FISTKNQEIL KERLLLRGTD SKETIEKRLI NAYKEMQCLE SFDYLIINED LEKSKEIILS 

       190        200 
IAKTLVHRLK AFNFEKICKA WKNETL 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE000511 Genomic DNA. Translation: AAD07389.1.
PIRA64560.
RefSeqNP_207119.1. NC_000915.1.
YP_006934249.1. NC_018939.1.

3D structure databases

ProteinModelPortalP56103.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-3426N.
IntActP56103. 3 interactions.
MINTMINT-185893.
STRING85962.HP0321.

Proteomic databases

PRIDEP56103.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAD07389; AAD07389; HP_0321.
GeneID900200.
KEGGheo:C694_01625.
hpy:HP0321.
PATRIC20591873. VBIHelPyl33062_0334.

Phylogenomic databases

eggNOGCOG0194.
KOK00942.
OMADAVFSIS.
OrthoDBEOG6CP410.

Enzyme and pathway databases

BioCycHPY:HP0321-MONOMER.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
HAMAPMF_00328. Guanylate_kinase.
InterProIPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like.
IPR017665. Guanylate_kinase.
IPR020590. Guanylate_kinase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF00625. Guanylate_kin. 1 hit.
[Graphical view]
SMARTSM00072. GuKc. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR03263. guanyl_kin. 1 hit.
PROSITEPS00856. GUANYLATE_KINASE_1. 1 hit.
PS50052. GUANYLATE_KINASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKGUA_HELPY
AccessionPrimary (citable) accession number: P56103
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: July 9, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Helicobacter pylori

Helicobacter pylori (strain 26695): entries and gene names