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P56102 (AMPM_HELPY) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Methionine aminopeptidase

Short name=MAP
EC=3.4.11.18
Alternative name(s):
Peptidase M
Gene names
Name:map
Ordered Locus Names:HP_1299
OrganismHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifier85962 [NCBI]
Taxonomic lineageBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter

Protein attributes

Sequence length253 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Removes the amino-terminal methionine from nascent proteins By similarity.

Catalytic activity

Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.

Cofactor

Binds 2 cobalt ions per subunit. The true nature of the physiological cofactor is under debate. The enzyme is also active with zinc, manganese or divalent iron ions By similarity.

Subunit structure

Monomer By similarity.

Sequence similarities

Belongs to the peptidase M24A family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 253253Methionine aminopeptidase
PRO_0000148941

Sites

Metal binding951Cobalt 1 By similarity
Metal binding1061Cobalt 1 By similarity
Metal binding1061Cobalt 2 By similarity
Metal binding1691Cobalt 2 By similarity
Metal binding2061Cobalt 2 By similarity
Metal binding2371Cobalt 1 By similarity
Metal binding2371Cobalt 2 By similarity
Binding site781Substrate By similarity
Binding site1761Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
P56102 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: C09772EB85A6A8DA

FASTA25327,577
        10         20         30         40         50         60 
MAISIKSPKE IKALRKAGEL TAQALALLER EVRPGVSLLE LDKMAEDFIK SSHARPAFKG 

        70         80         90        100        110        120 
LYGFPNSVCM SLNEVVIHGI PTDYVLQEGD IIGLDLGVEV DGYYGDSALT LPIGAISPQD 

       130        140        150        160        170        180 
EKLLACSKES LMHAINSIRV GMHFKELSQI LESTITERGF VPLKGFCGHG IGKKPHEEPE 

       190        200        210        220        230        240 
IPNYLEKGVK PNSGPKIKEG MVFCLEPMVC QKQGEPKILA DKWSVVSVDG LNTSHHEHTI 

       250 
AIVGNKAVIL TER 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE000511 Genomic DNA. Translation: AAD08340.1.
PIRC64682.
RefSeqNP_208091.1. NC_000915.1.

3D structure databases

ProteinModelPortalP56102.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-3487N.
MINTMINT-173189.

Protein family/group databases

MEROPSM24.001.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID898824.
GenomeReviewsGene locus HP_1299 in contig AE000511_GR.
KEGGhpy:HP1299.
NMPDRfig|85962.1.peg.1287.
PATRIC20593979. VBIHelPyl33062_1360.
TIGRHP_1299.

Phylogenomic databases

HOGENOMHBG299384.
OMAQDISHAV.
ProtClustDBPRK05716.

Family and domain databases

InterProIPR001714. Pept_M24_MAP.
IPR000994. Pept_M24_structural-domain.
IPR002467. Pept_M24A_MAP1.
[Graphical view]
Gene3DG3DSA:3.90.230.10. Peptidase_M24_cat_core. 1 hit.
KOK01265.
PfamPF00557. Peptidase_M24. 1 hit.
[Graphical view]
PRINTSPR00599. MAPEPTIDASE.
SUPFAMSSF55920. Peptidase_M24_cat_core. 1 hit.
TIGRFAMsTIGR00500. Met_pdase_I. 1 hit.
PROSITEPS00680. MAP_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameAMPM_HELPY
AccessionPrimary (citable) accession number: P56102
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: January 25, 2012
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Peptidase families

Classification of peptidase families and list of entries

Helicobacter pylori

Helicobacter pylori (strain 26695): entries and gene names

SIMILARITY comments

Index of protein domains and families