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Protein

Cytochrome bd-I ubiquinol oxidase subunit X

Gene

cydX

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for correct functioning of cytochrome bd-I oxidase. This protein and AppX may have some functional overlap.

Catalytic activityi

2 ubiquinol + O2(Side 2) + 4 H+(Side 2) = 2 ubiquinone + 2 H2O(Side 2) + 4 H+(Side 1).

Pathwayi: oxidative phosphorylation

This protein is involved in the pathway oxidative phosphorylation, which is part of Energy metabolism.
View all proteins of this organism that are known to be involved in the pathway oxidative phosphorylation and in Energy metabolism.

GO - Molecular functioni

  • oxidoreductase activity, acting on diphenols and related substances as donors Source: EcoCyc

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Stress response, Transport

Enzyme and pathway databases

BioCyciEcoCyc:MONOMER0-2663
MetaCyc:MONOMER0-2663
UniPathwayiUPA00705

Protein family/group databases

TCDBi3.D.4.3.2 the proton-translocating cytochrome oxidase (cox) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome bd-I ubiquinol oxidase subunit X (EC:1.10.3.14)
Alternative name(s):
Cytochrome bd-I oxidase subunit X
Cytochrome d ubiquinol oxidase subunit X
Gene namesi
Name:cydX
Synonyms:ybgT
Ordered Locus Names:b4515, JW0724
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG14329 cydX

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei4 – 24HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • integral component of plasma membrane Source: EcoCyc
  • membrane Source: EcoCyc
  • outer membrane Source: EcoCyc
  • plasma membrane Source: EcoCyc

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Slow growth in aerobic liquid culture, forms mixed colonies on aerobic solid media, increased sensitivity to reductant (beta-mercapoethanol). Reduced cytochrome bd-I oxidase activity.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi1M → Q: Does not restore reductant (beta-mercapoethanol) resistance. 1 Publication1
Mutagenesisi4F → A: Does not restore reductant (beta-mercapoethanol) resistance. 1 Publication1
Mutagenesisi7I → A: Does not restore reductant (beta-mercapoethanol) resistance. 1 Publication1
Mutagenesisi12L → A: Does not restore reductant (beta-mercapoethanol) resistance. 1 Publication1
Mutagenesisi14C → S: Restores reductant (beta-mercapoethanol) resistance. 1 Publication1
Mutagenesisi21A → G: Does not restore reductant (beta-mercapoethanol) resistance. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001687011 – 37Cytochrome bd-I ubiquinol oxidase subunit XAdd BLAST37

Proteomic databases

PaxDbiP56100
PRIDEiP56100

Expressioni

Inductioni

Constitutively expressed during aerobic growth (PubMed:19121005), induced in low oxygen, and maybe by SDS/EDTA (envelope stress) (PubMed:19734316) (at protein level).2 Publications

Interactioni

Subunit structurei

May be a subunit of cytochrome bd-I ubiquinol oxidase. Probably interacts with CydA and CydB.1 Publication

Protein-protein interaction databases

BioGridi4259450, 12 interactors
IntActiP56100, 2 interactors
MINTiP56100
STRINGi316385.ECDH10B_0801

Structurei

3D structure databases

SMRiP56100
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG4890 LUCA
HOGENOMiHOG000264864
KOiK00424

Family and domain databases

InterProiView protein in InterPro
IPR011724 Cyd_oper_YbgT
IPR012994 YbgT_YccB
PfamiView protein in Pfam
PF08173 YbgT_YccB, 1 hit
TIGRFAMsiTIGR02106 cyd_oper_ybgT, 1 hit

Sequencei

Sequence statusi: Complete.

P56100-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30 
MWYFAWILGT LLACSFGVIT ALALEHVESG KAGQEDI
Length:37
Mass (Da):4,042
Last modified:November 1, 1997 - v1
Checksum:iFCA4CC0A727F668B
GO

Sequence cautioni

The sequence J03939 differs from that shown. Reason: Frameshift at positions 22 and 27.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03939 Unassigned DNA No translation available.
U30934 Genomic DNA No translation available.
U00096 Genomic DNA Translation: ABD18645.1
AP009048 Genomic DNA Translation: BAE76359.1
RefSeqiWP_000270282.1, NZ_LN832404.1
YP_588444.1, NC_000913.3

Genome annotation databases

EnsemblBacteriaiABD18645; ABD18645; b4515
BAE76359; BAE76359; BAE76359
GeneIDi1450246
KEGGiecj:JW0724
eco:b4515
PATRICifig|511145.12.peg.766

Entry informationi

Entry nameiCYDX_ECOLI
AccessioniPrimary (citable) accession number: P56100
Secondary accession number(s): Q2EER0, Q2MBJ7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: May 23, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

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