Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

General transcriptional corepressor TUP1

Gene

TUP1

Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Represses transcription by RNA polymerase II.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
General transcriptional corepressor TUP1
Gene namesi
Name:TUP1
Ordered Locus Names:KLLA0F10263g
OrganismiKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Taxonomic identifieri284590 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKluyveromyces
Proteomesi
  • UP000000598 Componenti: Chromosome F

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000513091 – 682General transcriptional corepressor TUP1Add BLAST682

Interactioni

Protein-protein interaction databases

STRINGi284590.XP_455547.1.

Structurei

3D structure databases

ProteinModelPortaliP56094.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati319 – 359WD 1Add BLAST41
Repeati404 – 443WD 2Add BLAST40
Repeati446 – 485WD 3Add BLAST40
Repeati487 – 527WD 4Add BLAST41
Repeati537 – 576WD 5Add BLAST40
Repeati586 – 625WD 6Add BLAST40
Repeati628 – 673WD 7Add BLAST46

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi172 – 180Poly-Gln9
Compositional biasi184 – 194Poly-GlnAdd BLAST11

Sequence similaritiesi

Belongs to the WD repeat TUP1 family.Curated
Contains 7 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0266. Eukaryota.
ENOG410XP3K. LUCA.
HOGENOMiHOG000200558.
InParanoidiP56094.
KOiK06666.
OMAiGKKSSCD.
OrthoDBiEOG092C21A7.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR013890. Tscrpt_rep_Tup1_N.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF08581. Tup_N. 1 hit.
PF00400. WD40. 7 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
ProDomiPD010558. Transcrip_repressor_Tup1_N. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 2 hits.
PROSITEiPS00678. WD_REPEATS_1. 5 hits.
PS50082. WD_REPEATS_2. 5 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P56094-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSVAASQNK INDLLEAIRQ EFANVSQEAN SYRLQNQKDY DFKINQQLAE
60 70 80 90 100
MQQVRNTVYE LELTHRKMKD AYEEEISRLK LELEQKDRQL ASIAHGSTVG
110 120 130 140 150
NVPGQVPQLS RNSGAQGNAN IAPPNIPQPM VSQTVGTGMA PQMAPLNTQH
160 170 180 190 200
PTQQTKSNAG EQAAANLAPV IQQQQQPQQQ LPPQQQQQQQ QQQQSNIPVT
210 220 230 240 250
TAAPVQPAGG NLDQTVPNSI SPQQQPTEQQ QPASTATTAP ATASTAPPTS
260 270 280 290 300
APSDQVGQDH YLVPADQRAV HAKPIPPFLL DLDSQLVPSH LKKQNNDYYV
310 320 330 340 350
LHNPALPTDL DVELHKSLEH SSVVCCVRFS SDGEFLATGC NKTTQVYKVS
360 370 380 390 400
TGELVARLSD DSASQPQPQP QNQTVTAETS TSNSNGSSAE DGTGNQNSAA
410 420 430 440 450
STASSDLYIR SVCFSPDGKF LATGAEDKLI RIWDLETKKI VMTLKGHEQD
460 470 480 490 500
IYSLDYFPSG NKLVSGSGDR TVRIWDLTTG TCSLTLSIED GVTTVAVSPG
510 520 530 540 550
EGKFIAAGSL DRTVRVWDSD TGFLVERLDS ENELGTGHRD SVYSVVFTRD
560 570 580 590 600
GKGVVSGSLD RSVKLWNLNG LSGQKSHAEC EVTYTGHKDF VLSVATTQND
610 620 630 640 650
EYILSGSKDR GVLFWDTKSG NPLLMLQGHR NSVISVTVAN GHPLGPEYGV
660 670 680
FATGSGDCKA RIWKYSKKNS QQNSTQIKEI KE
Length:682
Mass (Da):74,008
Last modified:September 27, 2004 - v2
Checksum:iDA119FC373764466
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti635S → Y in AAB63194 (Ref. 1) Curated1
Sequence conflicti670S → G in AAB63194 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF005740 Genomic DNA. Translation: AAB63194.1.
CR382126 Genomic DNA. Translation: CAG98255.1.
RefSeqiXP_455547.1. XM_455547.1.

Genome annotation databases

EnsemblFungiiCAG98255; CAG98255; KLLA0_F10263g.
GeneIDi2895005.
KEGGikla:KLLA0F10263g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF005740 Genomic DNA. Translation: AAB63194.1.
CR382126 Genomic DNA. Translation: CAG98255.1.
RefSeqiXP_455547.1. XM_455547.1.

3D structure databases

ProteinModelPortaliP56094.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi284590.XP_455547.1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCAG98255; CAG98255; KLLA0_F10263g.
GeneIDi2895005.
KEGGikla:KLLA0F10263g.

Phylogenomic databases

eggNOGiKOG0266. Eukaryota.
ENOG410XP3K. LUCA.
HOGENOMiHOG000200558.
InParanoidiP56094.
KOiK06666.
OMAiGKKSSCD.
OrthoDBiEOG092C21A7.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR013890. Tscrpt_rep_Tup1_N.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF08581. Tup_N. 1 hit.
PF00400. WD40. 7 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
ProDomiPD010558. Transcrip_repressor_Tup1_N. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 2 hits.
PROSITEiPS00678. WD_REPEATS_1. 5 hits.
PS50082. WD_REPEATS_2. 5 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTUP1_KLULA
AccessioniPrimary (citable) accession number: P56094
Secondary accession number(s): Q6CKJ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: September 27, 2004
Last modified: November 2, 2016
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.