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P56088

- IMDH_HELPY

UniProt

P56088 - IMDH_HELPY

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Protein
Inosine-5'-monophosphate dehydrogenase
Gene
guaB, HP_0829
Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth By similarity.UniRule annotation

Catalytic activityi

Inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'-phosphate + NADH.UniRule annotation

Cofactori

Potassium By similarity.UniRule annotation

Enzyme regulationi

Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei244 – 2441NAD By similarity
Metal bindingi295 – 2951Potassium; via carbonyl oxygen By similarity
Metal bindingi297 – 2971Potassium; via carbonyl oxygen By similarity
Binding sitei298 – 2981IMP By similarity
Active sitei300 – 3001Thioimidate intermediate By similarity
Metal bindingi300 – 3001Potassium; via carbonyl oxygen By similarity
Binding sitei410 – 4101IMP By similarity
Metal bindingi464 – 4641Potassium; via carbonyl oxygen; shared with tetrameric partner By similarity
Metal bindingi465 – 4651Potassium; via carbonyl oxygen; shared with tetrameric partner By similarity
Metal bindingi466 – 4661Potassium; via carbonyl oxygen; shared with tetrameric partner By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi293 – 2953NAD By similarity

GO - Molecular functioni

  1. IMP dehydrogenase activity Source: UniProtKB-HAMAP
  2. adenyl nucleotide binding Source: InterPro
  3. metal ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. GMP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

GMP biosynthesis, Purine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Potassium

Enzyme and pathway databases

BioCyciHPY:HP0829-MONOMER.
UniPathwayiUPA00601; UER00295.

Names & Taxonomyi

Protein namesi
Recommended name:
Inosine-5'-monophosphate dehydrogenase (EC:1.1.1.205)
Short name:
IMP dehydrogenase
Short name:
IMPD
Short name:
IMPDH
Gene namesi
Name:guaB
Ordered Locus Names:HP_0829
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000429: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 481481Inosine-5'-monophosphate dehydrogenaseUniRule annotation
PRO_0000093698Add
BLAST

Proteomic databases

PRIDEiP56088.

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi85962.HP0829.

Structurei

3D structure databases

ProteinModelPortaliP56088.
SMRiP56088. Positions 2-480.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini92 – 14857CBS 1
Add
BLAST
Domaini152 – 20958CBS 2
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni333 – 3353IMP binding By similarity
Regioni356 – 3572IMP binding By similarity
Regioni380 – 3845IMP binding By similarity

Sequence similaritiesi

Belongs to the IMPDH/GMPR family.
Contains 2 CBS domains.

Keywords - Domaini

CBS domain, Repeat

Phylogenomic databases

eggNOGiCOG0517.
KOiK00088.
OMAiNNSQKRY.
OrthoDBiEOG6GTZPV.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_01964. IMPDH.
InterProiIPR013785. Aldolase_TIM.
IPR000644. CBS_dom.
IPR005990. IMP_DH.
IPR015875. IMP_DH/GMP_Rdtase_CS.
IPR001093. IMP_DH_GMPRt.
[Graphical view]
PANTHERiPTHR11911:SF6. PTHR11911:SF6. 1 hit.
PfamiPF00571. CBS. 2 hits.
PF00478. IMPDH. 1 hit.
[Graphical view]
PIRSFiPIRSF000130. IMPDH. 1 hit.
SMARTiSM00116. CBS. 2 hits.
[Graphical view]
TIGRFAMsiTIGR01302. IMP_dehydrog. 1 hit.
PROSITEiPS51371. CBS. 2 hits.
PS00487. IMP_DH_GMP_RED. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P56088-1 [UniParc]FASTAAdd to Basket

« Hide

MRILQRALTF EDVLMVPRKS SVLPKDVSLK SRLTKNIRLN IPFISAAMDT    50
VTEHKTAIAM ARLGGIGIVH KNMDIQTQVK EITKVKKSES GVINDPIFIH 100
AHRTLADAKV ITDNYKISGV PVVDDKGLLI GILTNRDVRF ETDLSKKVGD 150
VMTKMPLVTA HVGISLDEAS DLMHKHKIEK LPIVDKDNVL KGLITIKDIQ 200
KRIEYPEANK DDFGRLRVGA AIGVGQLDRA EMLVKAGVDA LVLDSAHGHS 250
ANILHTLEEI KKSLVVDVIV GNVVTKEATS DLISAGADAI KVGIGPGSIC 300
TTRIVAGVGM PQVSAIDNCV EVASKFDIPV IADGGIRYSG DVAKALALGA 350
SSVMIGSLLA GTEESPGDFM IYQGRQYKSY RGMGSIGAMT KGSSDRYFQE 400
GVASEKLVPE GIEGRVPYRG KVSDMIFQLV GGVRSSMGYQ GAKNILELYQ 450
NAEFVEITSA GLKESHVHGV DITKEAPNYY G 481
Length:481
Mass (Da):51,802
Last modified:November 1, 1997 - v1
Checksum:i075A84B1F8AC9481
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000511 Genomic DNA. Translation: AAD07879.1.
PIRiE64623.
RefSeqiNP_207622.1. NC_000915.1.
YP_006934744.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD07879; AAD07879; HP_0829.
GeneIDi13870013.
900202.
KEGGiheo:C694_04250.
hpy:HP0829.
PATRICi20592949. VBIHelPyl33062_0863.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000511 Genomic DNA. Translation: AAD07879.1 .
PIRi E64623.
RefSeqi NP_207622.1. NC_000915.1.
YP_006934744.1. NC_018939.1.

3D structure databases

ProteinModelPortali P56088.
SMRi P56088. Positions 2-480.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 85962.HP0829.

Proteomic databases

PRIDEi P56088.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD07879 ; AAD07879 ; HP_0829 .
GeneIDi 13870013.
900202.
KEGGi heo:C694_04250.
hpy:HP0829.
PATRICi 20592949. VBIHelPyl33062_0863.

Phylogenomic databases

eggNOGi COG0517.
KOi K00088.
OMAi NNSQKRY.
OrthoDBi EOG6GTZPV.

Enzyme and pathway databases

UniPathwayi UPA00601 ; UER00295 .
BioCyci HPY:HP0829-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_01964. IMPDH.
InterProi IPR013785. Aldolase_TIM.
IPR000644. CBS_dom.
IPR005990. IMP_DH.
IPR015875. IMP_DH/GMP_Rdtase_CS.
IPR001093. IMP_DH_GMPRt.
[Graphical view ]
PANTHERi PTHR11911:SF6. PTHR11911:SF6. 1 hit.
Pfami PF00571. CBS. 2 hits.
PF00478. IMPDH. 1 hit.
[Graphical view ]
PIRSFi PIRSF000130. IMPDH. 1 hit.
SMARTi SM00116. CBS. 2 hits.
[Graphical view ]
TIGRFAMsi TIGR01302. IMP_dehydrog. 1 hit.
PROSITEi PS51371. CBS. 2 hits.
PS00487. IMP_DH_GMP_RED. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700392 / 26695.

Entry informationi

Entry nameiIMDH_HELPY
AccessioniPrimary (citable) accession number: P56088
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: September 3, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi