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P56088

- IMDH_HELPY

UniProt

P56088 - IMDH_HELPY

Protein

Inosine-5'-monophosphate dehydrogenase

Gene

guaB

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 1 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.UniRule annotation

    Catalytic activityi

    Inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'-phosphate + NADH.UniRule annotation

    Cofactori

    Potassium.UniRule annotation

    Enzyme regulationi

    Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei244 – 2441NADUniRule annotation
    Metal bindingi295 – 2951Potassium; via carbonyl oxygenUniRule annotation
    Metal bindingi297 – 2971Potassium; via carbonyl oxygenUniRule annotation
    Binding sitei298 – 2981IMPUniRule annotation
    Active sitei300 – 3001Thioimidate intermediateUniRule annotation
    Metal bindingi300 – 3001Potassium; via carbonyl oxygenUniRule annotation
    Binding sitei410 – 4101IMPUniRule annotation
    Metal bindingi464 – 4641Potassium; via carbonyl oxygen; shared with tetrameric partnerUniRule annotation
    Metal bindingi465 – 4651Potassium; via carbonyl oxygen; shared with tetrameric partnerUniRule annotation
    Metal bindingi466 – 4661Potassium; via carbonyl oxygen; shared with tetrameric partnerUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi293 – 2953NADUniRule annotation

    GO - Molecular functioni

    1. adenyl nucleotide binding Source: InterPro
    2. IMP dehydrogenase activity Source: UniProtKB-HAMAP
    3. metal ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. GMP biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    GMP biosynthesis, Purine biosynthesis

    Keywords - Ligandi

    Metal-binding, NAD, Potassium

    Enzyme and pathway databases

    BioCyciHPY:HP0829-MONOMER.
    UniPathwayiUPA00601; UER00295.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Inosine-5'-monophosphate dehydrogenaseUniRule annotation (EC:1.1.1.205UniRule annotation)
    Short name:
    IMP dehydrogenaseUniRule annotation
    Short name:
    IMPDUniRule annotation
    Short name:
    IMPDHUniRule annotation
    Gene namesi
    Name:guaBUniRule annotation
    Ordered Locus Names:HP_0829
    OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
    Taxonomic identifieri85962 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
    ProteomesiUP000000429: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 481481Inosine-5'-monophosphate dehydrogenasePRO_0000093698Add
    BLAST

    Proteomic databases

    PRIDEiP56088.

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Protein-protein interaction databases

    STRINGi85962.HP0829.

    Structurei

    3D structure databases

    ProteinModelPortaliP56088.
    SMRiP56088. Positions 2-480.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini92 – 14857CBS 1UniRule annotationAdd
    BLAST
    Domaini152 – 20958CBS 2UniRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni333 – 3353IMP bindingUniRule annotation
    Regioni356 – 3572IMP bindingUniRule annotation
    Regioni380 – 3845IMP bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the IMPDH/GMPR family.UniRule annotation
    Contains 2 CBS domains.UniRule annotation

    Keywords - Domaini

    CBS domain, Repeat

    Phylogenomic databases

    eggNOGiCOG0517.
    KOiK00088.
    OMAiNNSQKRY.
    OrthoDBiEOG6GTZPV.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    HAMAPiMF_01964. IMPDH.
    InterProiIPR013785. Aldolase_TIM.
    IPR000644. CBS_dom.
    IPR005990. IMP_DH.
    IPR015875. IMP_DH/GMP_Rdtase_CS.
    IPR001093. IMP_DH_GMPRt.
    [Graphical view]
    PANTHERiPTHR11911:SF6. PTHR11911:SF6. 1 hit.
    PfamiPF00571. CBS. 2 hits.
    PF00478. IMPDH. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000130. IMPDH. 1 hit.
    SMARTiSM00116. CBS. 2 hits.
    [Graphical view]
    TIGRFAMsiTIGR01302. IMP_dehydrog. 1 hit.
    PROSITEiPS51371. CBS. 2 hits.
    PS00487. IMP_DH_GMP_RED. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P56088-1 [UniParc]FASTAAdd to Basket

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    MRILQRALTF EDVLMVPRKS SVLPKDVSLK SRLTKNIRLN IPFISAAMDT    50
    VTEHKTAIAM ARLGGIGIVH KNMDIQTQVK EITKVKKSES GVINDPIFIH 100
    AHRTLADAKV ITDNYKISGV PVVDDKGLLI GILTNRDVRF ETDLSKKVGD 150
    VMTKMPLVTA HVGISLDEAS DLMHKHKIEK LPIVDKDNVL KGLITIKDIQ 200
    KRIEYPEANK DDFGRLRVGA AIGVGQLDRA EMLVKAGVDA LVLDSAHGHS 250
    ANILHTLEEI KKSLVVDVIV GNVVTKEATS DLISAGADAI KVGIGPGSIC 300
    TTRIVAGVGM PQVSAIDNCV EVASKFDIPV IADGGIRYSG DVAKALALGA 350
    SSVMIGSLLA GTEESPGDFM IYQGRQYKSY RGMGSIGAMT KGSSDRYFQE 400
    GVASEKLVPE GIEGRVPYRG KVSDMIFQLV GGVRSSMGYQ GAKNILELYQ 450
    NAEFVEITSA GLKESHVHGV DITKEAPNYY G 481
    Length:481
    Mass (Da):51,802
    Last modified:November 1, 1997 - v1
    Checksum:i075A84B1F8AC9481
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000511 Genomic DNA. Translation: AAD07879.1.
    PIRiE64623.
    RefSeqiNP_207622.1. NC_000915.1.
    YP_006934744.1. NC_018939.1.

    Genome annotation databases

    EnsemblBacteriaiAAD07879; AAD07879; HP_0829.
    GeneIDi13870013.
    900202.
    KEGGiheo:C694_04250.
    hpy:HP0829.
    PATRICi20592949. VBIHelPyl33062_0863.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000511 Genomic DNA. Translation: AAD07879.1 .
    PIRi E64623.
    RefSeqi NP_207622.1. NC_000915.1.
    YP_006934744.1. NC_018939.1.

    3D structure databases

    ProteinModelPortali P56088.
    SMRi P56088. Positions 2-480.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 85962.HP0829.

    Proteomic databases

    PRIDEi P56088.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD07879 ; AAD07879 ; HP_0829 .
    GeneIDi 13870013.
    900202.
    KEGGi heo:C694_04250.
    hpy:HP0829.
    PATRICi 20592949. VBIHelPyl33062_0863.

    Phylogenomic databases

    eggNOGi COG0517.
    KOi K00088.
    OMAi NNSQKRY.
    OrthoDBi EOG6GTZPV.

    Enzyme and pathway databases

    UniPathwayi UPA00601 ; UER00295 .
    BioCyci HPY:HP0829-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    HAMAPi MF_01964. IMPDH.
    InterProi IPR013785. Aldolase_TIM.
    IPR000644. CBS_dom.
    IPR005990. IMP_DH.
    IPR015875. IMP_DH/GMP_Rdtase_CS.
    IPR001093. IMP_DH_GMPRt.
    [Graphical view ]
    PANTHERi PTHR11911:SF6. PTHR11911:SF6. 1 hit.
    Pfami PF00571. CBS. 2 hits.
    PF00478. IMPDH. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000130. IMPDH. 1 hit.
    SMARTi SM00116. CBS. 2 hits.
    [Graphical view ]
    TIGRFAMsi TIGR01302. IMP_dehydrog. 1 hit.
    PROSITEi PS51371. CBS. 2 hits.
    PS00487. IMP_DH_GMP_RED. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700392 / 26695.

    Entry informationi

    Entry nameiIMDH_HELPY
    AccessioniPrimary (citable) accession number: P56088
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 107 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Helicobacter pylori
      Helicobacter pylori (strain 26695): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3