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Protein

UPF0026 protein HP_0117

Gene

HP_0117

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Cofactori

[4Fe-4S] clusterCuratedNote: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.Curated

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi33 – 331Iron-sulfur (4Fe-4S-S-AdoMet)Sequence Analysis
Metal bindingi37 – 371Iron-sulfur (4Fe-4S-S-AdoMet)Sequence Analysis
Metal bindingi40 – 401Iron-sulfur (4Fe-4S-S-AdoMet)Sequence Analysis

GO - Molecular functioni

  1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
  2. catalytic activity Source: InterPro
  3. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Ligandi

4Fe-4S, Iron, Iron-sulfur, Metal-binding, S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciHPY:HP0117-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
UPF0026 protein HP_0117
Gene namesi
Ordered Locus Names:HP_0117
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000429: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 308308UPF0026 protein HP_0117PRO_0000217864Add
BLAST

Proteomic databases

PRIDEiP56080.

Interactioni

Protein-protein interaction databases

DIPiDIP-3297N.
IntActiP56080. 2 interactions.
MINTiMINT-175797.
STRINGi85962.HP0117.

Family & Domainsi

Sequence similaritiesi

Belongs to the UPF0026 family.Curated

Phylogenomic databases

eggNOGiCOG0731.
OMAiSCGIDEL.
OrthoDBiEOG6TTVP9.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR007197. rSAM.
[Graphical view]
PfamiPF04055. Radical_SAM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P56080-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAKENPPIVF GPVLSRRFGK SLGVDLSPSK KQCNYNCIYC ELGKAKPIER
60 70 80 90 100
MEEVIKVETL INAIQNALNN LTTPIDVLTI TANGEPTLYP HLLELIQSIK
110 120 130 140 150
PFLKGVKTLI LSNGSLFYEP KVQQALKEFD IVKFSLDAID LKAFERVDKP
160 170 180 190 200
YSKDINKILE GILRFSQIYQ GQLVAEVLLI KGVNDSANNL KLIAAFLKQI
210 220 230 240 250
NIARVDLSTI DRPSSFKAPK LSEDELLKCS LFFEGLCVSL PKRSITQAKK
260 270 280 290 300
LISCGIDELL ALISRRPLSA EEAPLILDSN AFKHLETLLN HKQITIKKVG

SLEFYCAF
Length:308
Mass (Da):34,405
Last modified:November 1, 1997 - v1
Checksum:iBBAA863283FBDF4B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD07185.1.
PIRiE64534.
RefSeqiNP_206917.1. NC_000915.1.
YP_006934040.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD07185; AAD07185; HP_0117.
GeneIDi13869296.
900364.
KEGGiheo:C694_00580.
hpy:HP0117.
PATRICi20591449. VBIHelPyl33062_0124.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD07185.1.
PIRiE64534.
RefSeqiNP_206917.1. NC_000915.1.
YP_006934040.1. NC_018939.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-3297N.
IntActiP56080. 2 interactions.
MINTiMINT-175797.
STRINGi85962.HP0117.

Proteomic databases

PRIDEiP56080.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD07185; AAD07185; HP_0117.
GeneIDi13869296.
900364.
KEGGiheo:C694_00580.
hpy:HP0117.
PATRICi20591449. VBIHelPyl33062_0124.

Phylogenomic databases

eggNOGiCOG0731.
OMAiSCGIDEL.
OrthoDBiEOG6TTVP9.

Enzyme and pathway databases

BioCyciHPY:HP0117-MONOMER.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR007197. rSAM.
[Graphical view]
PfamiPF04055. Radical_SAM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700392 / 26695.

Entry informationi

Entry nameiY117_HELPY
AccessioniPrimary (citable) accession number: P56080
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: January 7, 2015
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families
  3. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.