P56080 (Y117_HELPY) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
UPF0026 protein HP_0117

Gene names

Ordered Locus Names:

HP_0117

Organism

Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) [Reference proteome] [HAMAP]

Taxonomic identifier

85962 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › delta/epsilon subdivisions › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter › Helicobacter pylori

Protein attributes

Sequence length	308 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Cofactor	Binds 1 4Fe-4S cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine Potential.
Sequence similarities	Belongs to the UPF0026 family.

Ontologies

Keywords
Ligand	4Fe-4S Iron Iron-sulfur Metal-binding S-adenosyl-L-methionine
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	metabolic process Inferred from electronic annotation. Source: GOC
Molecular_function	4 iron, 4 sulfur cluster binding Inferred from electronic annotation. Source: UniProtKB-KW catalytic activity Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 308	308	UPF0026 protein HP_0117		PRO_0000217864
Sites
	Metal binding	33	1	Iron-sulfur (4Fe-4S-S-AdoMet) Potential
	Metal binding	37	1	Iron-sulfur (4Fe-4S-S-AdoMet) Potential
	Metal binding	40	1	Iron-sulfur (4Fe-4S-S-AdoMet) Potential

Sequences

	Sequence		Length	Mass (Da)
	P56080 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: BBAA863283FBDF4B	FASTA	308	34,405
	10 20 30 40 50 60 MAKENPPIVF GPVLSRRFGK SLGVDLSPSK KQCNYNCIYC ELGKAKPIER MEEVIKVETL 70 80 90 100 110 120 INAIQNALNN LTTPIDVLTI TANGEPTLYP HLLELIQSIK PFLKGVKTLI LSNGSLFYEP 130 140 150 160 170 180 KVQQALKEFD IVKFSLDAID LKAFERVDKP YSKDINKILE GILRFSQIYQ GQLVAEVLLI 190 200 210 220 230 240 KGVNDSANNL KLIAAFLKQI NIARVDLSTI DRPSSFKAPK LSEDELLKCS LFFEGLCVSL 250 260 270 280 290 300 PKRSITQAKK LISCGIDELL ALISRRPLSA EEAPLILDSN AFKHLETLLN HKQITIKKVG SLEFYCAF

References

[1]

"The complete genome sequence of the gastric pathogen Helicobacter pylori." Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G., Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A., Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N., Loftus B.J., Richardson D.L., Dodson R.J. , Khalak H.G., Glodek A., McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E., Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D., Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S., Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C. Nature 388:539-547(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700392 / 26695.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE000511 Genomic DNA. Translation: AAD07185.1.
PIR	E64534.
RefSeq	NP_206917.1. NC_000915.1. YP_006934040.1. NC_018939.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-3297N.
MINT	MINT-175797.
STRING	85962.HP0117.
Proteomic databases
PRIDE	P56080.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAD07185; AAD07185; HP_0117.
GeneID	13869296. 900364.
KEGG	heo:C694_00580. hpy:HP0117.
PATRIC	20591449. VBIHelPyl33062_0124.
Phylogenomic databases
eggNOG	COG0731.
OMA	CGIDELL.
ProtClustDB	CLSK551645.
Family and domain databases
Gene3D	3.20.20.70. 1 hit.
InterPro	IPR013785. Aldolase_TIM. IPR007197. rSAM. [Graphical view]
Pfam	PF04055. Radical_SAM. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Y117_HELPY

Accession

Primary (citable) accession number: P56080

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	May 1, 2013
This is version 65 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program