P56078 (RL25_HELPY) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
50S ribosomal protein L25

Alternative name(s):
General stress protein CTC

Gene names

Name:	rplY
Synonyms:	ctc
Ordered Locus Names:	HP_1496

Organism

Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) [Reference proteome] [HAMAP]

Taxonomic identifier

85962 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › delta/epsilon subdivisions › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter › Helicobacter pylori

Protein attributes

Sequence length	178 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance By similarity. HAMAP-Rule MF_01334
Subunit structure	Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18 By similarity.
Sequence similarities	Belongs to the ribosomal protein L25P family. Ctc subfamily.

Ontologies

Keywords
Ligand	RNA-binding rRNA-binding
Molecular function	Ribonucleoprotein Ribosomal protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	translation Inferred from electronic annotation. Source: HAMAP
Cellular_component	ribosome Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	5S rRNA binding Inferred from electronic annotation. Source: InterPro structural constituent of ribosome Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 178	178	50S ribosomal protein L25 HAMAP-Rule MF_01334		PRO_0000181554

Sequences

	Sequence		Length	Mass (Da)
	P56078 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: B66E5C13A5BD0B9B	FASTA	178	19,879
	10 20 30 40 50 60 MLEGVIRESI TKANAKALKK DGYLIANVYG KGIENVNGAF KLNPFIKYLK EKKHLIFPVK 70 80 90 100 110 120 LGDKTFEVVV QEYQKNPVTN ELIHVDLLAV TKGVKSKFKV PIKHQGTPVG LKNKGILMLS 130 140 150 160 170 KKRISVECAP EHLPDHYLVD VAPLDVNESI LVRDLEKHEN VKILDHDSIA VIGVIKAK

References

[1]

"The complete genome sequence of the gastric pathogen Helicobacter pylori." Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G., Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A., Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N., Loftus B.J., Richardson D.L., Dodson R.J. , Khalak H.G., Glodek A., McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E., Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D., Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S., Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C. Nature 388:539-547(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700392 / 26695.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE000511 Genomic DNA. Translation: AAD08537.1.
PIR	H64706.
RefSeq	NP_208287.1. NC_000915.1. YP_006935422.1. NC_018939.1.
3D structure databases
ProteinModelPortal	P56078.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-3750N.
MINT	MINT-179762.
STRING	85962.HP1496.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAD08537; AAD08537; HP_1496.
GeneID	13870712. 899795.
KEGG	heo:C694_07750. hpy:HP1496.
PATRIC	20594403. VBIHelPyl33062_1570.
Phylogenomic databases
eggNOG	COG1825.
KO	K02897.
OMA	LEIKNEY.
ProtClustDB	PRK05618.
Family and domain databases
Gene3D	2.170.120.20. 1 hit. 2.40.240.10. 1 hit.
HAMAP	MF_01334. Ribosomal_L25_CTC.
InterPro	IPR020056. Rbsml_L25/Gln-tRNA_synth_b-brl. IPR011035. Ribosomal_L25/Gln-tRNA_synth. IPR020057. Ribosomal_L25_b-dom. IPR001021. Ribosomal_L25_long. IPR020055. Ribosomal_L25_short. [Graphical view]
Pfam	PF01386. Ribosomal_L25p. 1 hit. [Graphical view]
ProDom	PD012503. Ribosomal_L25. 1 hit. [Graphical view] [Entries sharing at least one domain]
SUPFAM	SSF50715. Ribosomal_L25rel. 1 hit.
TIGRFAMs	TIGR00731. ctc_TL5. 1 hit.
ProtoNet	Search...

Entry information

Entry name

RL25_HELPY

Accession

Primary (citable) accession number: P56078

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	May 1, 2013
This is version 76 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program