Skip Header

Contribute Send feedback
Read comments (?) or add your own

P56076 (TPIS_HELPY) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Triosephosphate isomerase
Short name=TIM
EC=5.3.1.1
Alternative name(s):
Triose-phosphate isomerase
Gene names
Name:tpiA
Synonyms:tpi
Ordered Locus Names:HP_0194
OrganismHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) [Reference proteome] [HAMAP]
Taxonomic identifier85962 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter ›

Protein attributes

Sequence length234 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

D-glyceraldehyde 3-phosphate = glycerone phosphate. HAMAP-Rule MF_00147

Pathway

Carbohydrate biosynthesis; gluconeogenesis. HAMAP-Rule MF_00147

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1. HAMAP-Rule MF_00147

Subunit structure

Homodimer By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the triosephosphate isomerase family.

Ontologies

Keywords
   Biological processGluconeogenesis
Glycolysis
Pentose shunt
   Cellular componentCytoplasm
   Molecular functionIsomerase
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processgluconeogenesis

Inferred from electronic annotation. Source: HAMAP

glycolysis

Inferred from electronic annotation. Source: HAMAP

pentose-phosphate shunt

Inferred from electronic annotation. Source: HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functiontriose-phosphate isomerase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 234234Triosephosphate isomerase HAMAP-Rule MF_00147
PRO_0000090228

Sites

Active site901Electrophile By similarity
Active site1591Proton acceptor By similarity
Binding site81Substrate By similarity
Binding site101Substrate By similarity

Secondary structure

1 ............................................. 234
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P56076 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: AFEB4FF92D5BC4D3

FASTA23426,708
        10         20         30         40         50         60 
MTKIAMANFK SAMPIFKSHA YLKELEKTLK PQHFDRVFVF PDFFGLLPNS FLHFTLGVQN 

        70         80         90        100        110        120 
AYPRDCGAFT GEITSKHLEE LKIHTLLIGH SERRTLLKES PSFLKEKFDF FKSKNFKIVY 

       130        140        150        160        170        180 
CIGEELTTRE KGFKAVKEFL SEQLENIDLN YPNLVVAYEP IWAIGTKKSA SLEDIYLTHG 

       190        200        210        220        230 
FLKQILNQKT PLLYGGSVNT QNAKEILGID SVDGLLIGSA SWELENFKTI ISFL

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE000511 Genomic DNA. Translation: AAD07261.1.
PIRB64544.
RefSeqNP_206993.1. NC_000915.1.
YP_006934117.1. NC_018939.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2JGQX-ray2.30A/B2-234[»]
ProteinModelPortalP56076.
SMRP56076. Positions 2-234.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-3273N.
MINTMINT-166065.
STRING85962.HP0194.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAD07261; AAD07261; HP_0194.
GeneID13869373.
899983.
KEGGheo:C694_00965.
hpy:HP0194.
PATRIC20591609. VBIHelPyl33062_0204.

Phylogenomic databases

eggNOGCOG0149.
KOK01803.
OMAFFKDKNF.
ProtClustDBPRK00042.

Enzyme and pathway databases

SABIO-RKP56076.
UniPathwayUPA00109; UER00189.
UPA00138.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
HAMAPMF_00147_B. TIM_B.
InterProIPR013785. Aldolase_TIM.
IPR022896. TrioseP_Isoase_bac/euk.
IPR000652. Triosephosphate_isomerase.
IPR020861. Triosephosphate_isomerase_AS.
[Graphical view]
PANTHERPTHR21139. PTHR21139. 1 hit.
PfamPF00121. TIM. 1 hit.
[Graphical view]
SUPFAMSSF51351. Triophos_ismrse. 1 hit.
PROSITEPS00171. TIM_1. 1 hit.
PS51440. TIM_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP56076.

Entry information

Entry nameTPIS_HELPY
AccessionPrimary (citable) accession number: P56076
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: May 1, 2013
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Helicobacter pylori

Helicobacter pylori (strain 26695): entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents