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Reviewed, UniProtKB/Swiss-Prot P56075 (NDK_HELPY)

Last modified December 15, 2009. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Nucleoside diphosphate kinase
      Short name=NDK
      Short name=NDP kinase
    EC=2.7.4.6
Alternative name(s):
    Nucleoside-2-P kinase
Gene names
Name: ndk
Ordered Locus Names: HP_0198
OrganismHelicobacter pylori (Campylobacter pylori) [Complete proteome] [HAMAP]
Taxonomic identifier210 [NCBI]
Taxonomic lineageBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter

Protein attributes

Sequence length137 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Function

Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. HAMAP MF_00451

Catalytic activity

ATP + nucleoside diphosphate = ADP + nucleoside triphosphate. HAMAP MF_00451

Cofactor

Magnesium By similarity.

Subunit structure

Homotetramer By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the NDK family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 137137Nucleoside diphosphate kinase HAMAP MF_00451
PRO_0000136992

Sites

Active site1161Pros-phosphohistidine intermediate By similarity
Binding site101ATP By similarity
Binding site581ATP By similarity
Binding site861ATP By similarity
Binding site921ATP By similarity
Binding site1031ATP By similarity
Binding site1131ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
P56075-1 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: C103D5A7FAD42F63

FASTA13715,286
        10         20         30         40         50         60 
MKQRTLSIIK PDALKKKVVG KIIDRFESNG LEVVAMKRLH LSVKDAENFY AIHRERPFFK 

        70         80         90        100        110        120 
DLIEFMVSGP VVVMVLEGKD AVAKNRDLMG ATDPKLAQKG TIRADFAESI DANAVHGSDS 

       130 
LENAHNEIAF FFAARDL 

« Hide

Cross-references

Sequence databases

AE000511 Genomic DNA. Translation: AAD07268.1.
PIRF64544.
RefSeqNP_206997.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID899081.
GenomeReviewsGene locus HP_0198 in contig AE000511_GR.
KEGGhpy:HP0198.
NMPDRfig|85962.1.peg.195.
TIGRHP_0198.

Phylogenomic databases

HOGENOMHBG445152.
OMALTGAITK.

Enzyme and pathway databases

BRENDA2.7.4.6. 1131.

Family and domain databases

HAMAPMF_00451.
[Tree]
InterProIPR001564. Nuc_diP_kinase_core.
[Graphical view]
Gene3DG3DSA:3.30.70.141. NDK. 1 hit.
PANTHERPTHR11349. Nuc_diP_kinase_core. 1 hit.
PfamPF00334. NDK. 1 hit.
[Graphical view]
PRINTSPR01243. NUCDPKINASE.
SMARTSM00562. NDK. 1 hit.
[Graphical view]
PROSITEPS00469. NDP_KINASES. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNDK_HELPY
AccessionPrimary (citable) accession number: P56075
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: December 15, 2009
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

Helicobacter pylori

Helicobacter pylori (strain 26695): entries and gene names

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents