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P56074

- HEM2_HELPY

UniProt

P56074 - HEM2_HELPY

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Protein

Delta-aminolevulinic acid dehydratase

Gene
hemB, HP_0163
Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen By similarity.

Catalytic activityi

2 5-aminolevulinate = porphobilinogen + 2 H2O.

Cofactori

Binds 1 zinc ion per monomer By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi118 – 1181Zinc; catalytic By similarity
Metal bindingi120 – 1201Zinc; catalytic By similarity
Metal bindingi128 – 1281Zinc; catalytic By similarity
Active sitei193 – 1931Schiff-base intermediate with substrate By similarity
Binding sitei203 – 2031Substrate 1 By similarity
Binding sitei215 – 2151Substrate 1 By similarity
Metal bindingi231 – 2311Magnesium By similarity
Active sitei246 – 2461Schiff-base intermediate with substrate By similarity
Binding sitei272 – 2721Substrate 2 By similarity
Binding sitei311 – 3111Substrate 2 By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. porphobilinogen synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Heme biosynthesis, Porphyrin biosynthesis

Keywords - Ligandi

Magnesium, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciHPY:HP0163-MONOMER.
UniPathwayiUPA00251; UER00318.

Names & Taxonomyi

Protein namesi
Recommended name:
Delta-aminolevulinic acid dehydratase (EC:4.2.1.24)
Short name:
ALAD
Short name:
ALADH
Alternative name(s):
Porphobilinogen synthase
Gene namesi
Name:hemB
Ordered Locus Names:HP_0163
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000429: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 323323Delta-aminolevulinic acid dehydratasePRO_0000140502Add
BLAST

Proteomic databases

PRIDEiP56074.

Interactioni

Subunit structurei

Homooctamer By similarity.

Protein-protein interaction databases

IntActiP56074. 1 interaction.
STRINGi85962.HP0163.

Structurei

3D structure databases

ProteinModelPortaliP56074.
SMRiP56074. Positions 1-318.

Family & Domainsi

Sequence similaritiesi

Belongs to the ALADH family.

Phylogenomic databases

eggNOGiCOG0113.
KOiK01698.
OMAiPRESIEP.
OrthoDBiEOG6VXFCB.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR001731. Porphobilinogen_synth.
[Graphical view]
PANTHERiPTHR11458. PTHR11458. 1 hit.
PfamiPF00490. ALAD. 1 hit.
[Graphical view]
PIRSFiPIRSF001415. Porphbilin_synth. 1 hit.
PRINTSiPR00144. DALDHYDRTASE.
SMARTiSM01004. ALAD. 1 hit.
[Graphical view]
PROSITEiPS00169. D_ALA_DEHYDRATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P56074-1 [UniParc]FASTAAdd to Basket

« Hide

MFKRLRRLRS SENLRAMLRE TRLNIDDFIA PLFVIESDSC IKNEISSMPG    50
VYQMSMEPLL KECEELVGLG VKAVLLFGIP KHKDATGSHA LNKDHIVAKA 100
AKEIKKRFKD LIVIADLCFC EYTDHGHCGI LENASVSNDK TLEILNLQGL 150
ILAESGVDIL APSNMMDGNV LSLRKTLDNA GYTHTPIMSY STKFASSYYG 200
PFRDVANSAP SFGDRKSYQM DYANQKEALL ESLEDEKQGA DILMVKPALA 250
YLDIVKEIRD HTLLPLALYN VSGEYAMLKL AQKHNLINYE SVLLETMTCF 300
KRAGADMIIS YHAKEVANLL QRN 323
Length:323
Mass (Da):36,203
Last modified:November 1, 1997 - v1
Checksum:iADB784A450856CA2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000511 Genomic DNA. Translation: AAD07232.1.
PIRiC64540.
RefSeqiNP_206962.1. NC_000915.1.
YP_006934086.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD07232; AAD07232; HP_0163.
GeneIDi13869342.
899142.
KEGGiheo:C694_00810.
hpy:HP0163.
PATRICi20591547. VBIHelPyl33062_0173.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000511 Genomic DNA. Translation: AAD07232.1 .
PIRi C64540.
RefSeqi NP_206962.1. NC_000915.1.
YP_006934086.1. NC_018939.1.

3D structure databases

ProteinModelPortali P56074.
SMRi P56074. Positions 1-318.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P56074. 1 interaction.
STRINGi 85962.HP0163.

Proteomic databases

PRIDEi P56074.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD07232 ; AAD07232 ; HP_0163 .
GeneIDi 13869342.
899142.
KEGGi heo:C694_00810.
hpy:HP0163.
PATRICi 20591547. VBIHelPyl33062_0173.

Phylogenomic databases

eggNOGi COG0113.
KOi K01698.
OMAi PRESIEP.
OrthoDBi EOG6VXFCB.

Enzyme and pathway databases

UniPathwayi UPA00251 ; UER00318 .
BioCyci HPY:HP0163-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR013785. Aldolase_TIM.
IPR001731. Porphobilinogen_synth.
[Graphical view ]
PANTHERi PTHR11458. PTHR11458. 1 hit.
Pfami PF00490. ALAD. 1 hit.
[Graphical view ]
PIRSFi PIRSF001415. Porphbilin_synth. 1 hit.
PRINTSi PR00144. DALDHYDRTASE.
SMARTi SM01004. ALAD. 1 hit.
[Graphical view ]
PROSITEi PS00169. D_ALA_DEHYDRATASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700392 / 26695.

Entry informationi

Entry nameiHEM2_HELPY
AccessioniPrimary (citable) accession number: P56074
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: September 3, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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