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P56074

- HEM2_HELPY

UniProt

P56074 - HEM2_HELPY

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Protein

Delta-aminolevulinic acid dehydratase

Gene

hemB

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen (By similarity).By similarity

Catalytic activityi

2 5-aminolevulinate = porphobilinogen + 2 H2O.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per monomer.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi118 – 1181Zinc; catalyticBy similarity
Metal bindingi120 – 1201Zinc; catalyticBy similarity
Metal bindingi128 – 1281Zinc; catalyticBy similarity
Active sitei193 – 1931Schiff-base intermediate with substrateBy similarity
Binding sitei203 – 2031Substrate 1By similarity
Binding sitei215 – 2151Substrate 1By similarity
Metal bindingi231 – 2311MagnesiumBy similarity
Active sitei246 – 2461Schiff-base intermediate with substrateBy similarity
Binding sitei272 – 2721Substrate 2By similarity
Binding sitei311 – 3111Substrate 2By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. porphobilinogen synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Heme biosynthesis, Porphyrin biosynthesis

Keywords - Ligandi

Magnesium, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciHPY:HP0163-MONOMER.
UniPathwayiUPA00251; UER00318.

Names & Taxonomyi

Protein namesi
Recommended name:
Delta-aminolevulinic acid dehydratase (EC:4.2.1.24)
Short name:
ALAD
Short name:
ALADH
Alternative name(s):
Porphobilinogen synthase
Gene namesi
Name:hemB
Ordered Locus Names:HP_0163
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000429: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 323323Delta-aminolevulinic acid dehydratasePRO_0000140502Add
BLAST

Proteomic databases

PRIDEiP56074.

Interactioni

Subunit structurei

Homooctamer.By similarity

Protein-protein interaction databases

IntActiP56074. 1 interaction.
STRINGi85962.HP0163.

Structurei

3D structure databases

ProteinModelPortaliP56074.
SMRiP56074. Positions 1-318.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ALAD family.Curated

Phylogenomic databases

eggNOGiCOG0113.
KOiK01698.
OMAiPRESIEP.
OrthoDBiEOG6VXFCB.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR001731. Porphobilinogen_synth.
[Graphical view]
PANTHERiPTHR11458. PTHR11458. 1 hit.
PfamiPF00490. ALAD. 1 hit.
[Graphical view]
PIRSFiPIRSF001415. Porphbilin_synth. 1 hit.
PRINTSiPR00144. DALDHYDRTASE.
SMARTiSM01004. ALAD. 1 hit.
[Graphical view]
PROSITEiPS00169. D_ALA_DEHYDRATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P56074-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFKRLRRLRS SENLRAMLRE TRLNIDDFIA PLFVIESDSC IKNEISSMPG
60 70 80 90 100
VYQMSMEPLL KECEELVGLG VKAVLLFGIP KHKDATGSHA LNKDHIVAKA
110 120 130 140 150
AKEIKKRFKD LIVIADLCFC EYTDHGHCGI LENASVSNDK TLEILNLQGL
160 170 180 190 200
ILAESGVDIL APSNMMDGNV LSLRKTLDNA GYTHTPIMSY STKFASSYYG
210 220 230 240 250
PFRDVANSAP SFGDRKSYQM DYANQKEALL ESLEDEKQGA DILMVKPALA
260 270 280 290 300
YLDIVKEIRD HTLLPLALYN VSGEYAMLKL AQKHNLINYE SVLLETMTCF
310 320
KRAGADMIIS YHAKEVANLL QRN
Length:323
Mass (Da):36,203
Last modified:November 1, 1997 - v1
Checksum:iADB784A450856CA2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD07232.1.
PIRiC64540.
RefSeqiNP_206962.1. NC_000915.1.
YP_006934086.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD07232; AAD07232; HP_0163.
GeneIDi13869342.
899142.
KEGGiheo:C694_00810.
hpy:HP0163.
PATRICi20591547. VBIHelPyl33062_0173.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD07232.1 .
PIRi C64540.
RefSeqi NP_206962.1. NC_000915.1.
YP_006934086.1. NC_018939.1.

3D structure databases

ProteinModelPortali P56074.
SMRi P56074. Positions 1-318.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P56074. 1 interaction.
STRINGi 85962.HP0163.

Proteomic databases

PRIDEi P56074.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD07232 ; AAD07232 ; HP_0163 .
GeneIDi 13869342.
899142.
KEGGi heo:C694_00810.
hpy:HP0163.
PATRICi 20591547. VBIHelPyl33062_0173.

Phylogenomic databases

eggNOGi COG0113.
KOi K01698.
OMAi PRESIEP.
OrthoDBi EOG6VXFCB.

Enzyme and pathway databases

UniPathwayi UPA00251 ; UER00318 .
BioCyci HPY:HP0163-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR013785. Aldolase_TIM.
IPR001731. Porphobilinogen_synth.
[Graphical view ]
PANTHERi PTHR11458. PTHR11458. 1 hit.
Pfami PF00490. ALAD. 1 hit.
[Graphical view ]
PIRSFi PIRSF001415. Porphbilin_synth. 1 hit.
PRINTSi PR00144. DALDHYDRTASE.
SMARTi SM01004. ALAD. 1 hit.
[Graphical view ]
PROSITEi PS00169. D_ALA_DEHYDRATASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700392 / 26695.

Entry informationi

Entry nameiHEM2_HELPY
AccessioniPrimary (citable) accession number: P56074
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 26, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3