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P56074

- HEM2_HELPY

UniProt

P56074 - HEM2_HELPY

Protein

Delta-aminolevulinic acid dehydratase

Gene

hemB

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 1 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen By similarity.By similarity

    Catalytic activityi

    2 5-aminolevulinate = porphobilinogen + 2 H2O.

    Cofactori

    Binds 1 zinc ion per monomer.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi118 – 1181Zinc; catalyticBy similarity
    Metal bindingi120 – 1201Zinc; catalyticBy similarity
    Metal bindingi128 – 1281Zinc; catalyticBy similarity
    Active sitei193 – 1931Schiff-base intermediate with substrateBy similarity
    Binding sitei203 – 2031Substrate 1By similarity
    Binding sitei215 – 2151Substrate 1By similarity
    Metal bindingi231 – 2311MagnesiumBy similarity
    Active sitei246 – 2461Schiff-base intermediate with substrateBy similarity
    Binding sitei272 – 2721Substrate 2By similarity
    Binding sitei311 – 3111Substrate 2By similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. porphobilinogen synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Heme biosynthesis, Porphyrin biosynthesis

    Keywords - Ligandi

    Magnesium, Metal-binding, Zinc

    Enzyme and pathway databases

    BioCyciHPY:HP0163-MONOMER.
    UniPathwayiUPA00251; UER00318.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Delta-aminolevulinic acid dehydratase (EC:4.2.1.24)
    Short name:
    ALAD
    Short name:
    ALADH
    Alternative name(s):
    Porphobilinogen synthase
    Gene namesi
    Name:hemB
    Ordered Locus Names:HP_0163
    OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
    Taxonomic identifieri85962 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
    ProteomesiUP000000429: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 323323Delta-aminolevulinic acid dehydratasePRO_0000140502Add
    BLAST

    Proteomic databases

    PRIDEiP56074.

    Interactioni

    Subunit structurei

    Homooctamer.By similarity

    Protein-protein interaction databases

    IntActiP56074. 1 interaction.
    STRINGi85962.HP0163.

    Structurei

    3D structure databases

    ProteinModelPortaliP56074.
    SMRiP56074. Positions 1-318.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ALADH family.Curated

    Phylogenomic databases

    eggNOGiCOG0113.
    KOiK01698.
    OMAiPRESIEP.
    OrthoDBiEOG6VXFCB.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    InterProiIPR013785. Aldolase_TIM.
    IPR001731. Porphobilinogen_synth.
    [Graphical view]
    PANTHERiPTHR11458. PTHR11458. 1 hit.
    PfamiPF00490. ALAD. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001415. Porphbilin_synth. 1 hit.
    PRINTSiPR00144. DALDHYDRTASE.
    SMARTiSM01004. ALAD. 1 hit.
    [Graphical view]
    PROSITEiPS00169. D_ALA_DEHYDRATASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P56074-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFKRLRRLRS SENLRAMLRE TRLNIDDFIA PLFVIESDSC IKNEISSMPG    50
    VYQMSMEPLL KECEELVGLG VKAVLLFGIP KHKDATGSHA LNKDHIVAKA 100
    AKEIKKRFKD LIVIADLCFC EYTDHGHCGI LENASVSNDK TLEILNLQGL 150
    ILAESGVDIL APSNMMDGNV LSLRKTLDNA GYTHTPIMSY STKFASSYYG 200
    PFRDVANSAP SFGDRKSYQM DYANQKEALL ESLEDEKQGA DILMVKPALA 250
    YLDIVKEIRD HTLLPLALYN VSGEYAMLKL AQKHNLINYE SVLLETMTCF 300
    KRAGADMIIS YHAKEVANLL QRN 323
    Length:323
    Mass (Da):36,203
    Last modified:November 1, 1997 - v1
    Checksum:iADB784A450856CA2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000511 Genomic DNA. Translation: AAD07232.1.
    PIRiC64540.
    RefSeqiNP_206962.1. NC_000915.1.
    YP_006934086.1. NC_018939.1.

    Genome annotation databases

    EnsemblBacteriaiAAD07232; AAD07232; HP_0163.
    GeneIDi13869342.
    899142.
    KEGGiheo:C694_00810.
    hpy:HP0163.
    PATRICi20591547. VBIHelPyl33062_0173.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000511 Genomic DNA. Translation: AAD07232.1 .
    PIRi C64540.
    RefSeqi NP_206962.1. NC_000915.1.
    YP_006934086.1. NC_018939.1.

    3D structure databases

    ProteinModelPortali P56074.
    SMRi P56074. Positions 1-318.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P56074. 1 interaction.
    STRINGi 85962.HP0163.

    Proteomic databases

    PRIDEi P56074.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD07232 ; AAD07232 ; HP_0163 .
    GeneIDi 13869342.
    899142.
    KEGGi heo:C694_00810.
    hpy:HP0163.
    PATRICi 20591547. VBIHelPyl33062_0173.

    Phylogenomic databases

    eggNOGi COG0113.
    KOi K01698.
    OMAi PRESIEP.
    OrthoDBi EOG6VXFCB.

    Enzyme and pathway databases

    UniPathwayi UPA00251 ; UER00318 .
    BioCyci HPY:HP0163-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    InterProi IPR013785. Aldolase_TIM.
    IPR001731. Porphobilinogen_synth.
    [Graphical view ]
    PANTHERi PTHR11458. PTHR11458. 1 hit.
    Pfami PF00490. ALAD. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001415. Porphbilin_synth. 1 hit.
    PRINTSi PR00144. DALDHYDRTASE.
    SMARTi SM01004. ALAD. 1 hit.
    [Graphical view ]
    PROSITEi PS00169. D_ALA_DEHYDRATASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700392 / 26695.

    Entry informationi

    Entry nameiHEM2_HELPY
    AccessioniPrimary (citable) accession number: P56074
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 88 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Helicobacter pylori
      Helicobacter pylori (strain 26695): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3