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Protein

Glutamate racemase

Gene

murI

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Provides the (R)-glutamate required for cell wall biosynthesis.UniRule annotation

Catalytic activityi

L-glutamate = D-glutamate.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei70Proton donor/acceptorUniRule annotation1
Active sitei181Proton donor/acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciHPY:HP0549-MONOMER.
SABIO-RKP56068.
UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate racemaseUniRule annotation (EC:5.1.1.3UniRule annotation)
Gene namesi
Name:murIUniRule annotation
Synonyms:glr
Ordered Locus Names:HP_0549
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi
  • UP000000429 Componenti: Chromosome

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL6078.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000954761 – 255Glutamate racemaseAdd BLAST255

Proteomic databases

PaxDbiP56068.

Interactioni

Protein-protein interaction databases

IntActiP56068. 1 interactor.
STRINGi85962.HP0549.

Chemistry databases

BindingDBiP56068.

Structurei

3D structure databases

ProteinModelPortaliP56068.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni7 – 8Substrate bindingUniRule annotation2
Regioni39 – 40Substrate bindingUniRule annotation2
Regioni71 – 72Substrate bindingUniRule annotation2
Regioni182 – 183Substrate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the aspartate/glutamate racemases family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105F03. Bacteria.
COG0796. LUCA.
KOiK01776.
OMAiELLETCM.

Family and domain databases

Gene3Di3.40.50.1860. 2 hits.
HAMAPiMF_00258. Glu_racemase. 1 hit.
InterProiIPR015942. Asp/Glu/hydantoin_racemase.
IPR001920. Asp/Glu_race.
IPR018187. Asp/Glu_racemase_AS_1.
IPR033134. Asp/Glu_racemase_AS_2.
IPR004391. Glu_race.
[Graphical view]
PfamiPF01177. Asp_Glu_race. 1 hit.
[Graphical view]
SUPFAMiSSF53681. SSF53681. 2 hits.
TIGRFAMsiTIGR00067. glut_race. 1 hit.
PROSITEiPS00923. ASP_GLU_RACEMASE_1. 1 hit.
PS00924. ASP_GLU_RACEMASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P56068-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIGVFDSGV GGFSVLKSLL KAQLFDEIIY YGDSARVPYG TKDPTTIKQF
60 70 80 90 100
GLEALDFFKP HQIKLLIVAC NTASALALEE MQKHSKIPVV GVIEPSILAI
110 120 130 140 150
KRQVKDKNAP ILVLGTKATI QSNAYDNALK QQGYLNVSHL ATSLFVPLIE
160 170 180 190 200
ESILEGELLE TCMRYYFTPL EILPEVVILG CTHFPLIAQK IEGYFMEHFA
210 220 230 240 250
LSTPPLLIHS GDAIVEYLQQ NYALKKNACA FPKVEFHASG DVVWLEKQAK

EWLKL
Length:255
Mass (Da):28,413
Last modified:November 1, 1997 - v1
Checksum:i7DC46DE96D9709E8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti64K → E in AAC44708 (PubMed:8962108).Curated1
Sequence conflicti89V → I in AAC44708 (PubMed:8962108).Curated1
Sequence conflicti171E → K in AAC44708 (PubMed:8962108).Curated1
Sequence conflicti177V → I in AAC44708 (PubMed:8962108).Curated1
Sequence conflicti216E → G in AAC44708 (PubMed:8962108).Curated1
Sequence conflicti221N → K in AAC44708 (PubMed:8962108).Curated1
Sequence conflicti229C → H in AAC44708 (PubMed:8962108).Curated1
Sequence conflicti243V → I in AAC44708 (PubMed:8962108).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF282853 Genomic DNA. Translation: AAC44708.1.
AE000511 Genomic DNA. Translation: AAD07615.1.
PIRiE64588.
RefSeqiNP_207344.1. NC_000915.1.
WP_000690349.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD07615; AAD07615; HP_0549.
GeneIDi900031.
KEGGiheo:C694_02840.
hpy:HP0549.
PATRICi20592373. VBIHelPyl33062_0575.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF282853 Genomic DNA. Translation: AAC44708.1.
AE000511 Genomic DNA. Translation: AAD07615.1.
PIRiE64588.
RefSeqiNP_207344.1. NC_000915.1.
WP_000690349.1. NC_018939.1.

3D structure databases

ProteinModelPortaliP56068.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP56068. 1 interactor.
STRINGi85962.HP0549.

Chemistry databases

BindingDBiP56068.
ChEMBLiCHEMBL6078.

Proteomic databases

PaxDbiP56068.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD07615; AAD07615; HP_0549.
GeneIDi900031.
KEGGiheo:C694_02840.
hpy:HP0549.
PATRICi20592373. VBIHelPyl33062_0575.

Phylogenomic databases

eggNOGiENOG4105F03. Bacteria.
COG0796. LUCA.
KOiK01776.
OMAiELLETCM.

Enzyme and pathway databases

UniPathwayiUPA00219.
BioCyciHPY:HP0549-MONOMER.
SABIO-RKP56068.

Family and domain databases

Gene3Di3.40.50.1860. 2 hits.
HAMAPiMF_00258. Glu_racemase. 1 hit.
InterProiIPR015942. Asp/Glu/hydantoin_racemase.
IPR001920. Asp/Glu_race.
IPR018187. Asp/Glu_racemase_AS_1.
IPR033134. Asp/Glu_racemase_AS_2.
IPR004391. Glu_race.
[Graphical view]
PfamiPF01177. Asp_Glu_race. 1 hit.
[Graphical view]
SUPFAMiSSF53681. SSF53681. 2 hits.
TIGRFAMsiTIGR00067. glut_race. 1 hit.
PROSITEiPS00923. ASP_GLU_RACEMASE_1. 1 hit.
PS00924. ASP_GLU_RACEMASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMURI_HELPY
AccessioniPrimary (citable) accession number: P56068
Secondary accession number(s): P94841
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: October 5, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.