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Protein

Cysteine synthase

Gene

cysM

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

O-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate.

Cofactori

Pathwayi: L-cysteine biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes L-cysteine from L-serine.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Serine acetyltransferase (cysE)
  2. Cysteine synthase (cysM)
This subpathway is part of the pathway L-cysteine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-cysteine from L-serine, the pathway L-cysteine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei76Pyridoxal phosphateBy similarity1
Binding sitei267Pyridoxal phosphateBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Cysteine biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciHPY:HP0107-MONOMER.
UniPathwayiUPA00136; UER00200.

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine synthase (EC:2.5.1.47)
Short name:
CSase
Alternative name(s):
O-acetylserine (thiol)-lyase
Short name:
OAS-TL
O-acetylserine sulfhydrylase
Gene namesi
Name:cysM
Synonyms:cysK
Ordered Locus Names:HP_0107
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi
  • UP000000429 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001671101 – 306Cysteine synthaseAdd BLAST306

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei46N6-(pyridoxal phosphate)lysineBy similarity1

Proteomic databases

PaxDbiP56067.
PRIDEiP56067.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

DIPiDIP-3738N.
IntActiP56067. 1 interactor.
MINTiMINT-168918.
STRINGi85962.HP0107.

Structurei

Secondary structure

1306
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 6Combined sources4
Helixi7 – 10Combined sources4
Beta strandi16 – 19Combined sources4
Turni21 – 23Combined sources3
Beta strandi31 – 36Combined sources6
Helixi37 – 39Combined sources3
Helixi46 – 60Combined sources15
Beta strandi68 – 72Combined sources5
Helixi76 – 85Combined sources10
Turni86 – 89Combined sources4
Beta strandi91 – 97Combined sources7
Helixi102 – 110Combined sources9
Beta strandi114 – 118Combined sources5
Helixi123 – 137Combined sources15
Turni146 – 148Combined sources3
Helixi151 – 158Combined sources8
Helixi160 – 168Combined sources9
Beta strandi174 – 178Combined sources5
Beta strandi180 – 182Combined sources3
Helixi183 – 195Combined sources13
Beta strandi200 – 206Combined sources7
Beta strandi240 – 244Combined sources5
Helixi246 – 260Combined sources15
Helixi266 – 281Combined sources16
Beta strandi287 – 292Combined sources6
Helixi296 – 299Combined sources4
Turni300 – 305Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4R2VX-ray1.90A/B1-306[»]
5HBGX-ray1.90A/B1-306[»]
ProteinModelPortaliP56067.
SMRiP56067.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni180 – 184Pyridoxal phosphate bindingBy similarity5

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105C6T. Bacteria.
COG0031. LUCA.
KOiK01738.
OMAiISEHEGV.

Family and domain databases

InterProiIPR001216. P-phosphate_BS.
IPR001926. TrpB-like_PLP-dep.
[Graphical view]
PfamiPF00291. PALP. 1 hit.
[Graphical view]
SUPFAMiSSF53686. SSF53686. 1 hit.
PROSITEiPS00901. CYS_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P56067-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMIITTMQDA IGRTPVFKFT NKDYPIPLNS AIYAKLEHLN PGGSVKDRLG
60 70 80 90 100
QYLIGEGFKT GKITSKTTII EPTAGNTGIA LALVAIKHHL KTIFVVPEKF
110 120 130 140 150
STEKQQIMRA LGALVINTPT SEGISGAIKK SKELAESIPD SYLPLQFENP
160 170 180 190 200
DNPAAYYHTL APEIVQELGT NLTSFVAGIG SGGTFAGTAR YLKERIPAIR
210 220 230 240 250
LIGVEPEGSI LNGGEPGPHE IEGIGVEFIP PFFENLDIDG FETISDEEGF
260 270 280 290 300
SYTRKLAKKN GLLVGSSSGA AFVAALKEAQ RLPEGSQVLT IFPDVADRYL

SKGIYL
Length:306
Mass (Da):32,942
Last modified:November 1, 1997 - v1
Checksum:iAE2FF7EE0373DA17
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD07177.1.
PIRiC64533.
RefSeqiNP_206907.1. NC_000915.1.
WP_000972731.1. NC_000915.1.

Genome annotation databases

EnsemblBacteriaiAAD07177; AAD07177; HP_0107.
GeneIDi899978.
KEGGihpy:HP0107.
PATRICi20591429. VBIHelPyl33062_0114.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD07177.1.
PIRiC64533.
RefSeqiNP_206907.1. NC_000915.1.
WP_000972731.1. NC_000915.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4R2VX-ray1.90A/B1-306[»]
5HBGX-ray1.90A/B1-306[»]
ProteinModelPortaliP56067.
SMRiP56067.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-3738N.
IntActiP56067. 1 interactor.
MINTiMINT-168918.
STRINGi85962.HP0107.

Proteomic databases

PaxDbiP56067.
PRIDEiP56067.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD07177; AAD07177; HP_0107.
GeneIDi899978.
KEGGihpy:HP0107.
PATRICi20591429. VBIHelPyl33062_0114.

Phylogenomic databases

eggNOGiENOG4105C6T. Bacteria.
COG0031. LUCA.
KOiK01738.
OMAiISEHEGV.

Enzyme and pathway databases

UniPathwayiUPA00136; UER00200.
BioCyciHPY:HP0107-MONOMER.

Family and domain databases

InterProiIPR001216. P-phosphate_BS.
IPR001926. TrpB-like_PLP-dep.
[Graphical view]
PfamiPF00291. PALP. 1 hit.
[Graphical view]
SUPFAMiSSF53686. SSF53686. 1 hit.
PROSITEiPS00901. CYS_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCYSM_HELPY
AccessioniPrimary (citable) accession number: P56067
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 2, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.