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P56067

- CYSM_HELPY

UniProt

P56067 - CYSM_HELPY

Protein

Cysteine synthase

Gene

cysM

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 1 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    O-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate.

    Cofactori

    Pyridoxal phosphate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei76 – 761Pyridoxal phosphateBy similarity
    Binding sitei267 – 2671Pyridoxal phosphateBy similarity

    GO - Molecular functioni

    1. cysteine synthase activity Source: UniProtKB-EC
    2. transferase activity Source: UniProtKB-KW

    GO - Biological processi

    1. cysteine biosynthetic process from serine Source: InterPro

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Amino-acid biosynthesis, Cysteine biosynthesis

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciHPY:HP0107-MONOMER.
    UniPathwayiUPA00136; UER00200.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cysteine synthase (EC:2.5.1.47)
    Short name:
    CSase
    Alternative name(s):
    O-acetylserine (thiol)-lyase
    Short name:
    OAS-TL
    O-acetylserine sulfhydrylase
    Gene namesi
    Name:cysM
    Synonyms:cysK
    Ordered Locus Names:HP_0107
    OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
    Taxonomic identifieri85962 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
    ProteomesiUP000000429: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 306306Cysteine synthasePRO_0000167110Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei46 – 461N6-(pyridoxal phosphate)lysineBy similarity

    Proteomic databases

    PRIDEiP56067.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    DIPiDIP-3738N.
    IntActiP56067. 1 interaction.
    MINTiMINT-168918.
    STRINGi85962.HP0107.

    Structurei

    Secondary structure

    1
    306
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi3 – 64
    Helixi7 – 104
    Beta strandi16 – 194
    Turni21 – 233
    Beta strandi31 – 366
    Helixi37 – 393
    Helixi46 – 6015
    Beta strandi68 – 725
    Helixi76 – 8510
    Turni86 – 894
    Beta strandi91 – 977
    Helixi102 – 1109
    Beta strandi113 – 1186
    Turni121 – 1244
    Helixi125 – 13713
    Beta strandi138 – 1425
    Turni146 – 1483
    Helixi151 – 1588
    Helixi160 – 1689
    Beta strandi174 – 1785
    Beta strandi180 – 1823
    Helixi183 – 19513
    Beta strandi200 – 2067
    Beta strandi240 – 2445
    Helixi246 – 26015
    Helixi266 – 28116
    Beta strandi287 – 2926
    Helixi296 – 2994
    Turni300 – 3056

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4I1XX-ray1.90A/B1-306[»]
    ProteinModelPortaliP56067.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni180 – 1845Pyridoxal phosphate bindingBy similarity

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0031.
    KOiK01738.
    OMAiTIFPDMA.
    OrthoDBiEOG6Q2SP8.

    Family and domain databases

    InterProiIPR001216. P-phosphate_BS.
    IPR001926. Trp_syn_b_sub_like_PLP_eny_SF.
    [Graphical view]
    PfamiPF00291. PALP. 1 hit.
    [Graphical view]
    SUPFAMiSSF53686. SSF53686. 1 hit.
    PROSITEiPS00901. CYS_SYNTHASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P56067-1 [UniParc]FASTAAdd to Basket

    « Hide

    MMIITTMQDA IGRTPVFKFT NKDYPIPLNS AIYAKLEHLN PGGSVKDRLG    50
    QYLIGEGFKT GKITSKTTII EPTAGNTGIA LALVAIKHHL KTIFVVPEKF 100
    STEKQQIMRA LGALVINTPT SEGISGAIKK SKELAESIPD SYLPLQFENP 150
    DNPAAYYHTL APEIVQELGT NLTSFVAGIG SGGTFAGTAR YLKERIPAIR 200
    LIGVEPEGSI LNGGEPGPHE IEGIGVEFIP PFFENLDIDG FETISDEEGF 250
    SYTRKLAKKN GLLVGSSSGA AFVAALKEAQ RLPEGSQVLT IFPDVADRYL 300
    SKGIYL 306
    Length:306
    Mass (Da):32,942
    Last modified:November 1, 1997 - v1
    Checksum:iAE2FF7EE0373DA17
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000511 Genomic DNA. Translation: AAD07177.1.
    PIRiC64533.
    RefSeqiNP_206907.1. NC_000915.1.
    WP_000972731.1. NC_000915.1.

    Genome annotation databases

    EnsemblBacteriaiAAD07177; AAD07177; HP_0107.
    GeneIDi899978.
    KEGGihpy:HP0107.
    PATRICi20591429. VBIHelPyl33062_0114.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000511 Genomic DNA. Translation: AAD07177.1 .
    PIRi C64533.
    RefSeqi NP_206907.1. NC_000915.1.
    WP_000972731.1. NC_000915.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4I1X X-ray 1.90 A/B 1-306 [» ]
    ProteinModelPortali P56067.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-3738N.
    IntActi P56067. 1 interaction.
    MINTi MINT-168918.
    STRINGi 85962.HP0107.

    Proteomic databases

    PRIDEi P56067.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD07177 ; AAD07177 ; HP_0107 .
    GeneIDi 899978.
    KEGGi hpy:HP0107.
    PATRICi 20591429. VBIHelPyl33062_0114.

    Phylogenomic databases

    eggNOGi COG0031.
    KOi K01738.
    OMAi TIFPDMA.
    OrthoDBi EOG6Q2SP8.

    Enzyme and pathway databases

    UniPathwayi UPA00136 ; UER00200 .
    BioCyci HPY:HP0107-MONOMER.

    Family and domain databases

    InterProi IPR001216. P-phosphate_BS.
    IPR001926. Trp_syn_b_sub_like_PLP_eny_SF.
    [Graphical view ]
    Pfami PF00291. PALP. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53686. SSF53686. 1 hit.
    PROSITEi PS00901. CYS_SYNTHASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700392 / 26695.

    Entry informationi

    Entry nameiCYSM_HELPY
    AccessioniPrimary (citable) accession number: P56067
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Helicobacter pylori
      Helicobacter pylori (strain 26695): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3