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P56067

- CYSM_HELPY

UniProt

P56067 - CYSM_HELPY

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Protein
Cysteine synthase
Gene
cysM, cysK, HP_0107
Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

O-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate.

Cofactori

Pyridoxal phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei76 – 761Pyridoxal phosphate By similarity
Binding sitei267 – 2671Pyridoxal phosphate By similarity

GO - Molecular functioni

  1. cysteine synthase activity Source: UniProtKB-EC
  2. transferase activity Source: UniProtKB-KW

GO - Biological processi

  1. cysteine biosynthetic process from serine Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Cysteine biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciHPY:HP0107-MONOMER.
UniPathwayiUPA00136; UER00200.

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine synthase (EC:2.5.1.47)
Short name:
CSase
Alternative name(s):
O-acetylserine (thiol)-lyase
Short name:
OAS-TL
O-acetylserine sulfhydrylase
Gene namesi
Name:cysM
Synonyms:cysK
Ordered Locus Names:HP_0107
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000429: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 306306Cysteine synthase
PRO_0000167110Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei46 – 461N6-(pyridoxal phosphate)lysine By similarity

Proteomic databases

PRIDEiP56067.

Interactioni

Subunit structurei

Homodimer By similarity.

Protein-protein interaction databases

DIPiDIP-3738N.
IntActiP56067. 1 interaction.
MINTiMINT-168918.
STRINGi85962.HP0107.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi3 – 64
Helixi7 – 104
Beta strandi16 – 194
Turni21 – 233
Beta strandi31 – 366
Helixi37 – 393
Helixi46 – 6015
Beta strandi68 – 725
Helixi76 – 8510
Turni86 – 894
Beta strandi91 – 977
Helixi102 – 1109
Beta strandi113 – 1186
Turni121 – 1244
Helixi125 – 13713
Beta strandi138 – 1425
Turni146 – 1483
Helixi151 – 1588
Helixi160 – 1689
Beta strandi174 – 1785
Beta strandi180 – 1823
Helixi183 – 19513
Beta strandi200 – 2067
Beta strandi240 – 2445
Helixi246 – 26015
Helixi266 – 28116
Beta strandi287 – 2926
Helixi296 – 2994
Turni300 – 3056

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4I1XX-ray1.90A/B1-306[»]
ProteinModelPortaliP56067.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni180 – 1845Pyridoxal phosphate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0031.
KOiK01738.
OMAiTIFPDMA.
OrthoDBiEOG6Q2SP8.

Family and domain databases

InterProiIPR001216. P-phosphate_BS.
IPR001926. Trp_syn_b_sub_like_PLP_eny_SF.
[Graphical view]
PfamiPF00291. PALP. 1 hit.
[Graphical view]
SUPFAMiSSF53686. SSF53686. 1 hit.
PROSITEiPS00901. CYS_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P56067-1 [UniParc]FASTAAdd to Basket

« Hide

MMIITTMQDA IGRTPVFKFT NKDYPIPLNS AIYAKLEHLN PGGSVKDRLG    50
QYLIGEGFKT GKITSKTTII EPTAGNTGIA LALVAIKHHL KTIFVVPEKF 100
STEKQQIMRA LGALVINTPT SEGISGAIKK SKELAESIPD SYLPLQFENP 150
DNPAAYYHTL APEIVQELGT NLTSFVAGIG SGGTFAGTAR YLKERIPAIR 200
LIGVEPEGSI LNGGEPGPHE IEGIGVEFIP PFFENLDIDG FETISDEEGF 250
SYTRKLAKKN GLLVGSSSGA AFVAALKEAQ RLPEGSQVLT IFPDVADRYL 300
SKGIYL 306
Length:306
Mass (Da):32,942
Last modified:November 1, 1997 - v1
Checksum:iAE2FF7EE0373DA17
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000511 Genomic DNA. Translation: AAD07177.1.
PIRiC64533.
RefSeqiNP_206907.1. NC_000915.1.
WP_000972731.1. NC_000915.1.

Genome annotation databases

EnsemblBacteriaiAAD07177; AAD07177; HP_0107.
GeneIDi899978.
KEGGihpy:HP0107.
PATRICi20591429. VBIHelPyl33062_0114.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000511 Genomic DNA. Translation: AAD07177.1 .
PIRi C64533.
RefSeqi NP_206907.1. NC_000915.1.
WP_000972731.1. NC_000915.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4I1X X-ray 1.90 A/B 1-306 [» ]
ProteinModelPortali P56067.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-3738N.
IntActi P56067. 1 interaction.
MINTi MINT-168918.
STRINGi 85962.HP0107.

Proteomic databases

PRIDEi P56067.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD07177 ; AAD07177 ; HP_0107 .
GeneIDi 899978.
KEGGi hpy:HP0107.
PATRICi 20591429. VBIHelPyl33062_0114.

Phylogenomic databases

eggNOGi COG0031.
KOi K01738.
OMAi TIFPDMA.
OrthoDBi EOG6Q2SP8.

Enzyme and pathway databases

UniPathwayi UPA00136 ; UER00200 .
BioCyci HPY:HP0107-MONOMER.

Family and domain databases

InterProi IPR001216. P-phosphate_BS.
IPR001926. Trp_syn_b_sub_like_PLP_eny_SF.
[Graphical view ]
Pfami PF00291. PALP. 1 hit.
[Graphical view ]
SUPFAMi SSF53686. SSF53686. 1 hit.
PROSITEi PS00901. CYS_SYNTHASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700392 / 26695.

Entry informationi

Entry nameiCYSM_HELPY
AccessioniPrimary (citable) accession number: P56067
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: September 3, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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