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P56067 (CYSM_HELPY) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cysteine synthase

Short name=CSase
EC=2.5.1.47
Alternative name(s):
O-acetylserine (thiol)-lyase
Short name=OAS-TL
O-acetylserine sulfhydrylase
Gene names
Name:cysM
Synonyms:cysK
Ordered Locus Names:HP_0107
OrganismHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) [Reference proteome] [HAMAP]
Taxonomic identifier85962 [NCBI]
Taxonomic lineageBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter

Protein attributes

Sequence length306 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

O(3)-acetyl-L-serine + H2S = L-cysteine + acetate.

Cofactor

Pyridoxal phosphate.

Pathway

Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-serine: step 2/2.

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the cysteine synthase/cystathionine beta-synthase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 306306Cysteine synthase
PRO_0000167110

Regions

Region180 – 1845Pyridoxal phosphate binding By similarity

Sites

Binding site761Pyridoxal phosphate By similarity
Binding site2671Pyridoxal phosphate By similarity

Amino acid modifications

Modified residue461N6-(pyridoxal phosphate)lysine By similarity

Secondary structure

.................................................... 306
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P56067 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: AE2FF7EE0373DA17

FASTA30632,942
        10         20         30         40         50         60 
MMIITTMQDA IGRTPVFKFT NKDYPIPLNS AIYAKLEHLN PGGSVKDRLG QYLIGEGFKT 

        70         80         90        100        110        120 
GKITSKTTII EPTAGNTGIA LALVAIKHHL KTIFVVPEKF STEKQQIMRA LGALVINTPT 

       130        140        150        160        170        180 
SEGISGAIKK SKELAESIPD SYLPLQFENP DNPAAYYHTL APEIVQELGT NLTSFVAGIG 

       190        200        210        220        230        240 
SGGTFAGTAR YLKERIPAIR LIGVEPEGSI LNGGEPGPHE IEGIGVEFIP PFFENLDIDG 

       250        260        270        280        290        300 
FETISDEEGF SYTRKLAKKN GLLVGSSSGA AFVAALKEAQ RLPEGSQVLT IFPDVADRYL 


SKGIYL 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE000511 Genomic DNA. Translation: AAD07177.1.
PIRC64533.
RefSeqNP_206907.1. NC_000915.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
4I1XX-ray1.90A/B1-306[»]
ProteinModelPortalP56067.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-3738N.
IntActP56067. 1 interaction.
MINTMINT-168918.
STRING85962.HP0107.

Proteomic databases

PRIDEP56067.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAD07177; AAD07177; HP_0107.
GeneID899978.
KEGGhpy:HP0107.
PATRIC20591429. VBIHelPyl33062_0114.

Phylogenomic databases

eggNOGCOG0031.
KOK01738.
OMALVAIKHH.
OrthoDBEOG6Q2SP8.
ProtClustDBCLSK495864.

Enzyme and pathway databases

BioCycHPY:HP0107-MONOMER.
UniPathwayUPA00136; UER00200.

Family and domain databases

InterProIPR001216. Cys_synth_BS.
IPR001926. Trp_syn_b_sub_like_PLP_eny_SF.
[Graphical view]
PfamPF00291. PALP. 1 hit.
[Graphical view]
SUPFAMSSF53686. SSF53686. 1 hit.
PROSITEPS00901. CYS_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCYSM_HELPY
AccessionPrimary (citable) accession number: P56067
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: March 19, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

PATHWAY comments

Index of metabolic and biosynthesis pathways

Helicobacter pylori

Helicobacter pylori (strain 26695): entries and gene names