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P56063 (IDH_HELPY) Reviewed, UniProtKB/Swiss-Prot

Last modified December 11, 2013. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Isocitrate dehydrogenase [NADP]

Short name=IDH
EC=1.1.1.42
Alternative name(s):
IDP
NADP(+)-specific ICDH
Oxalosuccinate decarboxylase
Gene names
Name:icd
Ordered Locus Names:HP_0027
OrganismHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) [Reference proteome] [HAMAP]
Taxonomic identifier85962 [NCBI]
Taxonomic lineageBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter

Protein attributes

Sequence length425 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity.

Sequence similarities

Belongs to the isocitrate and isopropylmalate dehydrogenases family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 425425Isocitrate dehydrogenase [NADP]
PRO_0000083552

Regions

Nucleotide binding348 – 3547NADP By similarity

Sites

Metal binding3161Magnesium or manganese By similarity
Binding site1141NADP By similarity
Binding site1231Substrate By similarity
Binding site1251Substrate By similarity
Binding site1291Substrate By similarity
Binding site1391Substrate By similarity
Binding site1621Substrate By similarity
Binding site3611NADP; via amide nitrogen and carbonyl oxygen By similarity
Binding site4001NADP By similarity
Binding site4041NADP By similarity
Site1691Critical for catalysis By similarity
Site2391Critical for catalysis By similarity

Amino acid modifications

Modified residue1231Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
P56063 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: 3741722B8818DC96

FASTA42547,531
        10         20         30         40         50         60 
MAYNPKILQK PKEGEEITIK DNKLHVPNHP IIPFIEGDGI GSDITPAMIK VVDSAVQKAY 

        70         80         90        100        110        120 
KGEKKIAWYE VFVGEKCYQK FKDYKELSPE EQWLLPDTIE AINHYKVSIK GPLTTPIGEG 

       130        140        150        160        170        180 
FRSLNVALRQ KMDLYVCLRP VRWYGSPSPV KEPQKVDMVI FRENSEDIYA GIEWQEGSAE 

       190        200        210        220        230        240 
AKKLIHFLQN ELKVKKIRFP ESSGIGVKPI SKEGTERLVR KAIEYAIDND KPSVTFVHKG 

       250        260        270        280        290        300 
NIMKYTEGAF MKWGYALAQK EFNAQVIDKG PWCSLKNPKN GKEIIIKDMI ADAFLQQILL 

       310        320        330        340        350        360 
RPSEYSVIAT MNLNGDYISD ALAAMVGGIG IAPGANLNDT VGMFEATHGT APKYAGLDKV 

       370        380        390        400        410        420 
NPGSIILSAE MMLRHMGWVE AADLIVSAME KAIKSKKVTY DFARLMDGAK EVKCSEFASV 


MIENM 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE000511 Genomic DNA. Translation: AAD07098.1.
PIRC64523.
RefSeqNP_206829.1. NC_000915.1.
YP_006933949.1. NC_018939.1.

3D structure databases

ProteinModelPortalP56063.
SMRP56063. Positions 11-425.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-3724N.
IntActP56063. 1 interaction.
MINTMINT-180352.
STRING85962.HP0027.

Proteomic databases

PRIDEP56063.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAD07098; AAD07098; HP_0027.
GeneID13869203.
899116.
KEGGheo:C694_00125.
hpy:HP0027.
PATRIC20591251. VBIHelPyl33062_0027.

Phylogenomic databases

eggNOGCOG0538.
KOK00031.
OMAFRDWGYE.
OrthoDBEOG6SNDTP.
ProtClustDBCLSK495824.

Enzyme and pathway databases

BioCycHPY:HP0027-MONOMER.

Family and domain databases

Gene3D3.40.718.10. 1 hit.
InterProIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERPTHR11835. PTHR11835. 1 hit.
PfamPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsTIGR00183. prok_nadp_idh. 1 hit.
PROSITEPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameIDH_HELPY
AccessionPrimary (citable) accession number: P56063
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: December 11, 2013
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Helicobacter pylori

Helicobacter pylori (strain 26695): entries and gene names