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Protein

Isocitrate dehydrogenase [NADP]

Gene

icd

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 1 Mg(2+) or Mn2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei114 – 1141NADPBy similarity
Binding sitei123 – 1231SubstrateBy similarity
Binding sitei125 – 1251SubstrateBy similarity
Binding sitei129 – 1291SubstrateBy similarity
Binding sitei139 – 1391SubstrateBy similarity
Binding sitei162 – 1621SubstrateBy similarity
Sitei169 – 1691Critical for catalysisBy similarity
Sitei239 – 2391Critical for catalysisBy similarity
Metal bindingi316 – 3161Magnesium or manganeseBy similarity
Binding sitei361 – 3611NADP; via amide nitrogen and carbonyl oxygenBy similarity
Binding sitei400 – 4001NADPBy similarity
Binding sitei404 – 4041NADPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi348 – 3547NADPBy similarity

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glyoxylate bypass, Tricarboxylic acid cycle

Keywords - Ligandi

Magnesium, Manganese, Metal-binding, NADP

Enzyme and pathway databases

BioCyciHPY:HP0027-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP] (EC:1.1.1.42)
Short name:
IDH
Alternative name(s):
IDP
NADP(+)-specific ICDH
Oxalosuccinate decarboxylase
Gene namesi
Name:icd
Ordered Locus Names:HP_0027
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000429 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 425425Isocitrate dehydrogenase [NADP]PRO_0000083552Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei123 – 1231PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiP56063.

Interactioni

Protein-protein interaction databases

DIPiDIP-3724N.
IntActiP56063. 1 interaction.
MINTiMINT-180352.
STRINGi85962.HP0027.

Structurei

3D structure databases

ProteinModelPortaliP56063.
SMRiP56063. Positions 11-425.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0538.
KOiK00031.
OMAiFRDWGYE.
OrthoDBiEOG6SNDTP.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P56063-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAYNPKILQK PKEGEEITIK DNKLHVPNHP IIPFIEGDGI GSDITPAMIK
60 70 80 90 100
VVDSAVQKAY KGEKKIAWYE VFVGEKCYQK FKDYKELSPE EQWLLPDTIE
110 120 130 140 150
AINHYKVSIK GPLTTPIGEG FRSLNVALRQ KMDLYVCLRP VRWYGSPSPV
160 170 180 190 200
KEPQKVDMVI FRENSEDIYA GIEWQEGSAE AKKLIHFLQN ELKVKKIRFP
210 220 230 240 250
ESSGIGVKPI SKEGTERLVR KAIEYAIDND KPSVTFVHKG NIMKYTEGAF
260 270 280 290 300
MKWGYALAQK EFNAQVIDKG PWCSLKNPKN GKEIIIKDMI ADAFLQQILL
310 320 330 340 350
RPSEYSVIAT MNLNGDYISD ALAAMVGGIG IAPGANLNDT VGMFEATHGT
360 370 380 390 400
APKYAGLDKV NPGSIILSAE MMLRHMGWVE AADLIVSAME KAIKSKKVTY
410 420
DFARLMDGAK EVKCSEFASV MIENM
Length:425
Mass (Da):47,531
Last modified:November 1, 1997 - v1
Checksum:i3741722B8818DC96
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD07098.1.
PIRiC64523.
RefSeqiNP_206829.1. NC_000915.1.
YP_006933949.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD07098; AAD07098; HP_0027.
GeneIDi899116.
KEGGiheo:C694_00125.
hpy:HP0027.
PATRICi20591251. VBIHelPyl33062_0027.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD07098.1.
PIRiC64523.
RefSeqiNP_206829.1. NC_000915.1.
YP_006933949.1. NC_018939.1.

3D structure databases

ProteinModelPortaliP56063.
SMRiP56063. Positions 11-425.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-3724N.
IntActiP56063. 1 interaction.
MINTiMINT-180352.
STRINGi85962.HP0027.

Proteomic databases

PRIDEiP56063.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD07098; AAD07098; HP_0027.
GeneIDi899116.
KEGGiheo:C694_00125.
hpy:HP0027.
PATRICi20591251. VBIHelPyl33062_0027.

Phylogenomic databases

eggNOGiCOG0538.
KOiK00031.
OMAiFRDWGYE.
OrthoDBiEOG6SNDTP.

Enzyme and pathway databases

BioCyciHPY:HP0027-MONOMER.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700392 / 26695.

Entry informationi

Entry nameiIDH_HELPY
AccessioniPrimary (citable) accession number: P56063
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: April 1, 2015
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.