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P56063

- IDH_HELPY

UniProt

P56063 - IDH_HELPY

Protein

Isocitrate dehydrogenase [NADP]

Gene

icd

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 1 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei114 – 1141NADPBy similarity
    Binding sitei123 – 1231SubstrateBy similarity
    Binding sitei125 – 1251SubstrateBy similarity
    Binding sitei129 – 1291SubstrateBy similarity
    Binding sitei139 – 1391SubstrateBy similarity
    Binding sitei162 – 1621SubstrateBy similarity
    Sitei169 – 1691Critical for catalysisBy similarity
    Sitei239 – 2391Critical for catalysisBy similarity
    Metal bindingi316 – 3161Magnesium or manganeseBy similarity
    Binding sitei361 – 3611NADP; via amide nitrogen and carbonyl oxygenBy similarity
    Binding sitei400 – 4001NADPBy similarity
    Binding sitei404 – 4041NADPBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi348 – 3547NADPBy similarity

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. magnesium ion binding Source: InterPro
    3. NAD binding Source: InterPro

    GO - Biological processi

    1. glyoxylate cycle Source: UniProtKB-KW
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Glyoxylate bypass, Tricarboxylic acid cycle

    Keywords - Ligandi

    Magnesium, Manganese, Metal-binding, NADP

    Enzyme and pathway databases

    BioCyciHPY:HP0027-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isocitrate dehydrogenase [NADP] (EC:1.1.1.42)
    Short name:
    IDH
    Alternative name(s):
    IDP
    NADP(+)-specific ICDH
    Oxalosuccinate decarboxylase
    Gene namesi
    Name:icd
    Ordered Locus Names:HP_0027
    OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
    Taxonomic identifieri85962 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
    ProteomesiUP000000429: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 425425Isocitrate dehydrogenase [NADP]PRO_0000083552Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei123 – 1231PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiP56063.

    Interactioni

    Protein-protein interaction databases

    DIPiDIP-3724N.
    IntActiP56063. 1 interaction.
    MINTiMINT-180352.
    STRINGi85962.HP0027.

    Structurei

    3D structure databases

    ProteinModelPortaliP56063.
    SMRiP56063. Positions 11-425.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0538.
    KOiK00031.
    OMAiRYAIDND.
    OrthoDBiEOG6SNDTP.

    Family and domain databases

    Gene3Di3.40.718.10. 1 hit.
    InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR001804. Isocitrate/isopropylmalate_DH.
    IPR004439. Isocitrate_DH_NADP_dimer_prok.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PANTHERiPTHR11835. PTHR11835. 1 hit.
    PfamiPF00180. Iso_dh. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
    PROSITEiPS00470. IDH_IMDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P56063-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAYNPKILQK PKEGEEITIK DNKLHVPNHP IIPFIEGDGI GSDITPAMIK    50
    VVDSAVQKAY KGEKKIAWYE VFVGEKCYQK FKDYKELSPE EQWLLPDTIE 100
    AINHYKVSIK GPLTTPIGEG FRSLNVALRQ KMDLYVCLRP VRWYGSPSPV 150
    KEPQKVDMVI FRENSEDIYA GIEWQEGSAE AKKLIHFLQN ELKVKKIRFP 200
    ESSGIGVKPI SKEGTERLVR KAIEYAIDND KPSVTFVHKG NIMKYTEGAF 250
    MKWGYALAQK EFNAQVIDKG PWCSLKNPKN GKEIIIKDMI ADAFLQQILL 300
    RPSEYSVIAT MNLNGDYISD ALAAMVGGIG IAPGANLNDT VGMFEATHGT 350
    APKYAGLDKV NPGSIILSAE MMLRHMGWVE AADLIVSAME KAIKSKKVTY 400
    DFARLMDGAK EVKCSEFASV MIENM 425
    Length:425
    Mass (Da):47,531
    Last modified:November 1, 1997 - v1
    Checksum:i3741722B8818DC96
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000511 Genomic DNA. Translation: AAD07098.1.
    PIRiC64523.
    RefSeqiNP_206829.1. NC_000915.1.
    YP_006933949.1. NC_018939.1.

    Genome annotation databases

    EnsemblBacteriaiAAD07098; AAD07098; HP_0027.
    GeneIDi13869203.
    899116.
    KEGGiheo:C694_00125.
    hpy:HP0027.
    PATRICi20591251. VBIHelPyl33062_0027.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000511 Genomic DNA. Translation: AAD07098.1 .
    PIRi C64523.
    RefSeqi NP_206829.1. NC_000915.1.
    YP_006933949.1. NC_018939.1.

    3D structure databases

    ProteinModelPortali P56063.
    SMRi P56063. Positions 11-425.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-3724N.
    IntActi P56063. 1 interaction.
    MINTi MINT-180352.
    STRINGi 85962.HP0027.

    Proteomic databases

    PRIDEi P56063.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD07098 ; AAD07098 ; HP_0027 .
    GeneIDi 13869203.
    899116.
    KEGGi heo:C694_00125.
    hpy:HP0027.
    PATRICi 20591251. VBIHelPyl33062_0027.

    Phylogenomic databases

    eggNOGi COG0538.
    KOi K00031.
    OMAi RYAIDND.
    OrthoDBi EOG6SNDTP.

    Enzyme and pathway databases

    BioCyci HPY:HP0027-MONOMER.

    Family and domain databases

    Gene3Di 3.40.718.10. 1 hit.
    InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR001804. Isocitrate/isopropylmalate_DH.
    IPR004439. Isocitrate_DH_NADP_dimer_prok.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    PANTHERi PTHR11835. PTHR11835. 1 hit.
    Pfami PF00180. Iso_dh. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00183. prok_nadp_idh. 1 hit.
    PROSITEi PS00470. IDH_IMDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700392 / 26695.

    Entry informationi

    Entry nameiIDH_HELPY
    AccessioniPrimary (citable) accession number: P56063
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 99 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Helicobacter pylori
      Helicobacter pylori (strain 26695): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3