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Protein

Citrate synthase

Gene

gltA

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Acetyl-CoA + H2O + oxaloacetate = citrate + CoA.PROSITE-ProRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei314 – 3141PROSITE-ProRule annotation
Active sitei372 – 3721PROSITE-ProRule annotation

GO - Molecular functioni

  1. transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer Source: InterPro

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Tricarboxylic acid cycle

Enzyme and pathway databases

BioCyciHPY:HP0026-MONOMER.
UniPathwayiUPA00223; UER00717.

Names & Taxonomyi

Protein namesi
Recommended name:
Citrate synthase (EC:2.3.3.16)
Gene namesi
Name:gltA
Ordered Locus Names:HP_0026
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000429 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 426426Citrate synthasePRO_0000169946Add
BLAST

Proteomic databases

PRIDEiP56062.

Interactioni

Protein-protein interaction databases

DIPiDIP-3680N.
IntActiP56062. 2 interactions.
MINTiMINT-170268.
STRINGi85962.HP0026.

Structurei

3D structure databases

ProteinModelPortaliP56062.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the citrate synthase family.Curated

Phylogenomic databases

eggNOGiCOG0372.
KOiK01647.
OMAiNKEDGVR.
OrthoDBiEOG6P8TP4.

Family and domain databases

Gene3Di1.10.230.10. 1 hit.
1.10.580.10. 1 hit.
InterProiIPR016142. Citrate_synth-like_lrg_a-sub.
IPR016143. Citrate_synth-like_sm_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
IPR024176. Citrate_synthase_bac-typ.
[Graphical view]
PANTHERiPTHR11739. PTHR11739. 1 hit.
PfamiPF00285. Citrate_synt. 1 hit.
[Graphical view]
PIRSFiPIRSF001369. Citrate_synth. 1 hit.
PRINTSiPR00143. CITRTSNTHASE.
SUPFAMiSSF48256. SSF48256. 1 hit.
PROSITEiPS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P56062-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVTLVNNEN NERYEFETIE STRGPKAVDF SKLFETTGFF SYDPGYSSTA
60 70 80 90 100
GCQSKISYVN GKKGELYYRG HRIEDLVAKY KYVDVCKLLL TGELPKNQDE
110 120 130 140 150
SLEFELELRH RSFVHESLLN MFSAFPSNAH PMAKLSSGVS ILSTLYSTHQ
160 170 180 190 200
NMHTEEDYQT MARRIVAKIP TLAAICYRNE VGAPIIYPDI ARSYVENILF
210 220 230 240 250
MLRGYPYSRL KHTTQGEVEI TPLEVEAFDK ILTLHADHSQ NASSTTVRNV
260 270 280 290 300
ASTGVHPYAA ISAGISALWG HLHGGANEKV LLQLEEIGDV KNVDKYIARV
310 320 330 340 350
KDKNDNFKLM GFGHRVYKSY DPRAKILKGL KDELHQKGVK MDERLSEIAA
360 370 380 390 400
KVEEIALKDE YFIERNLYPN VDFYSGTILR ALKIPVRFFT PVFVIGRTVG
410 420
WCAQLLEHVK SPQARITRPR QVYVGD
Length:426
Mass (Da):48,350
Last modified:October 31, 1997 - v1
Checksum:i7777B67DA74C7C1A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD07097.1.
PIRiB64523.
RefSeqiNP_206828.1. NC_000915.1.
YP_006933948.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD07097; AAD07097; HP_0026.
GeneIDi13869202.
899115.
KEGGiheo:C694_00120.
hpy:HP0026.
PATRICi20591249. VBIHelPyl33062_0026.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD07097.1.
PIRiB64523.
RefSeqiNP_206828.1. NC_000915.1.
YP_006933948.1. NC_018939.1.

3D structure databases

ProteinModelPortaliP56062.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-3680N.
IntActiP56062. 2 interactions.
MINTiMINT-170268.
STRINGi85962.HP0026.

Proteomic databases

PRIDEiP56062.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD07097; AAD07097; HP_0026.
GeneIDi13869202.
899115.
KEGGiheo:C694_00120.
hpy:HP0026.
PATRICi20591249. VBIHelPyl33062_0026.

Phylogenomic databases

eggNOGiCOG0372.
KOiK01647.
OMAiNKEDGVR.
OrthoDBiEOG6P8TP4.

Enzyme and pathway databases

UniPathwayiUPA00223; UER00717.
BioCyciHPY:HP0026-MONOMER.

Family and domain databases

Gene3Di1.10.230.10. 1 hit.
1.10.580.10. 1 hit.
InterProiIPR016142. Citrate_synth-like_lrg_a-sub.
IPR016143. Citrate_synth-like_sm_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
IPR024176. Citrate_synthase_bac-typ.
[Graphical view]
PANTHERiPTHR11739. PTHR11739. 1 hit.
PfamiPF00285. Citrate_synt. 1 hit.
[Graphical view]
PIRSFiPIRSF001369. Citrate_synth. 1 hit.
PRINTSiPR00143. CITRTSNTHASE.
SUPFAMiSSF48256. SSF48256. 1 hit.
PROSITEiPS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700392 / 26695.

Entry informationi

Entry nameiCISY_HELPY
AccessioniPrimary (citable) accession number: P56062
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 1997
Last sequence update: October 31, 1997
Last modified: January 6, 2015
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Citrate synthase is found in nearly all cells capable of oxidative metabolism.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.