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P56062

- CISY_HELPY

UniProt

P56062 - CISY_HELPY

Protein

Citrate synthase

Gene

gltA

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 1 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Acetyl-CoA + H2O + oxaloacetate = citrate + CoA.PROSITE-ProRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei314 – 3141PROSITE-ProRule annotation
    Active sitei372 – 3721PROSITE-ProRule annotation

    GO - Molecular functioni

    1. transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer Source: InterPro

    GO - Biological processi

    1. cellular carbohydrate metabolic process Source: InterPro
    2. tricarboxylic acid cycle Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Tricarboxylic acid cycle

    Enzyme and pathway databases

    BioCyciHPY:HP0026-MONOMER.
    UniPathwayiUPA00223; UER00717.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Citrate synthase (EC:2.3.3.16)
    Gene namesi
    Name:gltA
    Ordered Locus Names:HP_0026
    OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
    Taxonomic identifieri85962 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
    ProteomesiUP000000429: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 426426Citrate synthasePRO_0000169946Add
    BLAST

    Proteomic databases

    PRIDEiP56062.

    Interactioni

    Protein-protein interaction databases

    DIPiDIP-3680N.
    IntActiP56062. 2 interactions.
    MINTiMINT-170268.
    STRINGi85962.HP0026.

    Structurei

    3D structure databases

    ProteinModelPortaliP56062.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the citrate synthase family.Curated

    Phylogenomic databases

    eggNOGiCOG0372.
    KOiK01647.
    OMAiMAKTTHE.
    OrthoDBiEOG6P8TP4.

    Family and domain databases

    Gene3Di1.10.230.10. 1 hit.
    1.10.580.10. 1 hit.
    InterProiIPR016142. Citrate_synth-like_lrg_a-sub.
    IPR016143. Citrate_synth-like_sm_a-sub.
    IPR002020. Citrate_synthase-like.
    IPR016141. Citrate_synthase-like_core.
    IPR019810. Citrate_synthase_AS.
    IPR024176. Citrate_synthase_bac-typ.
    [Graphical view]
    PANTHERiPTHR11739. PTHR11739. 1 hit.
    PfamiPF00285. Citrate_synt. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001369. Citrate_synth. 1 hit.
    PRINTSiPR00143. CITRTSNTHASE.
    SUPFAMiSSF48256. SSF48256. 1 hit.
    PROSITEiPS00480. CITRATE_SYNTHASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P56062-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSVTLVNNEN NERYEFETIE STRGPKAVDF SKLFETTGFF SYDPGYSSTA    50
    GCQSKISYVN GKKGELYYRG HRIEDLVAKY KYVDVCKLLL TGELPKNQDE 100
    SLEFELELRH RSFVHESLLN MFSAFPSNAH PMAKLSSGVS ILSTLYSTHQ 150
    NMHTEEDYQT MARRIVAKIP TLAAICYRNE VGAPIIYPDI ARSYVENILF 200
    MLRGYPYSRL KHTTQGEVEI TPLEVEAFDK ILTLHADHSQ NASSTTVRNV 250
    ASTGVHPYAA ISAGISALWG HLHGGANEKV LLQLEEIGDV KNVDKYIARV 300
    KDKNDNFKLM GFGHRVYKSY DPRAKILKGL KDELHQKGVK MDERLSEIAA 350
    KVEEIALKDE YFIERNLYPN VDFYSGTILR ALKIPVRFFT PVFVIGRTVG 400
    WCAQLLEHVK SPQARITRPR QVYVGD 426
    Length:426
    Mass (Da):48,350
    Last modified:November 1, 1997 - v1
    Checksum:i7777B67DA74C7C1A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000511 Genomic DNA. Translation: AAD07097.1.
    PIRiB64523.
    RefSeqiNP_206828.1. NC_000915.1.
    YP_006933948.1. NC_018939.1.

    Genome annotation databases

    EnsemblBacteriaiAAD07097; AAD07097; HP_0026.
    GeneIDi13869202.
    899115.
    KEGGiheo:C694_00120.
    hpy:HP0026.
    PATRICi20591249. VBIHelPyl33062_0026.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000511 Genomic DNA. Translation: AAD07097.1 .
    PIRi B64523.
    RefSeqi NP_206828.1. NC_000915.1.
    YP_006933948.1. NC_018939.1.

    3D structure databases

    ProteinModelPortali P56062.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-3680N.
    IntActi P56062. 2 interactions.
    MINTi MINT-170268.
    STRINGi 85962.HP0026.

    Proteomic databases

    PRIDEi P56062.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD07097 ; AAD07097 ; HP_0026 .
    GeneIDi 13869202.
    899115.
    KEGGi heo:C694_00120.
    hpy:HP0026.
    PATRICi 20591249. VBIHelPyl33062_0026.

    Phylogenomic databases

    eggNOGi COG0372.
    KOi K01647.
    OMAi MAKTTHE.
    OrthoDBi EOG6P8TP4.

    Enzyme and pathway databases

    UniPathwayi UPA00223 ; UER00717 .
    BioCyci HPY:HP0026-MONOMER.

    Family and domain databases

    Gene3Di 1.10.230.10. 1 hit.
    1.10.580.10. 1 hit.
    InterProi IPR016142. Citrate_synth-like_lrg_a-sub.
    IPR016143. Citrate_synth-like_sm_a-sub.
    IPR002020. Citrate_synthase-like.
    IPR016141. Citrate_synthase-like_core.
    IPR019810. Citrate_synthase_AS.
    IPR024176. Citrate_synthase_bac-typ.
    [Graphical view ]
    PANTHERi PTHR11739. PTHR11739. 1 hit.
    Pfami PF00285. Citrate_synt. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001369. Citrate_synth. 1 hit.
    PRINTSi PR00143. CITRTSNTHASE.
    SUPFAMi SSF48256. SSF48256. 1 hit.
    PROSITEi PS00480. CITRATE_SYNTHASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700392 / 26695.

    Entry informationi

    Entry nameiCISY_HELPY
    AccessioniPrimary (citable) accession number: P56062
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 87 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Citrate synthase is found in nearly all cells capable of oxidative metabolism.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Helicobacter pylori
      Helicobacter pylori (strain 26695): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3