Reviewed, UniProtKB/Swiss-Prot P56062 (CISY_HELPY)

Names and origin

Protein names

Recommended name:
    Citrate synthase
    EC=2.3.3.1

Gene names

Name:	gltA
Ordered Locus Names:	HP_0026

Organism

Helicobacter pylori (Campylobacter pylori) [Complete proteome] [HAMAP]

Taxonomic identifier

210 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter

Protein attributes

Sequence length	426 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Acetyl-CoA + H2O + oxaloacetate = citrate + CoA.
Pathway	Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 1/2.
Miscellaneous	Citrate synthase is found in nearly all cells capable of oxidative metabolism.
Sequence similarities	Belongs to the citrate synthase family.

Ontologies

Keywords
Biological process	Tricarboxylic acid cycle
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cellular carbohydrate metabolic process Inferred from electronic annotation. Source: InterPro tricarboxylic acid cycle Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	citrate (Si)-synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 426	426	Citrate synthase		PRO_0000169946
Sites
	Active site	314	1	By similarity
	Active site	372	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	P56062-1 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: 7777B67DA74C7C1A	FASTA	426	48,350
	10 20 30 40 50 60 MSVTLVNNEN NERYEFETIE STRGPKAVDF SKLFETTGFF SYDPGYSSTA GCQSKISYVN 70 80 90 100 110 120 GKKGELYYRG HRIEDLVAKY KYVDVCKLLL TGELPKNQDE SLEFELELRH RSFVHESLLN 130 140 150 160 170 180 MFSAFPSNAH PMAKLSSGVS ILSTLYSTHQ NMHTEEDYQT MARRIVAKIP TLAAICYRNE 190 200 210 220 230 240 VGAPIIYPDI ARSYVENILF MLRGYPYSRL KHTTQGEVEI TPLEVEAFDK ILTLHADHSQ 250 260 270 280 290 300 NASSTTVRNV ASTGVHPYAA ISAGISALWG HLHGGANEKV LLQLEEIGDV KNVDKYIARV 310 320 330 340 350 360 KDKNDNFKLM GFGHRVYKSY DPRAKILKGL KDELHQKGVK MDERLSEIAA KVEEIALKDE 370 380 390 400 410 420 YFIERNLYPN VDFYSGTILR ALKIPVRFFT PVFVIGRTVG WCAQLLEHVK SPQARITRPR QVYVGD

References

[1]

"The complete genome sequence of the gastric pathogen Helicobacter pylori." Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G., Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A., Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N., Loftus B.J., Richardson D.L., Dodson R.J. , Khalak H.G., Glodek A., McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E., Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D., Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S., Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C. Nature 388:539-547(1997) [PubMed: 9252185] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700392 / 26695.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE000511 Genomic DNA. Translation: AAD07097.1.
PIR	B64523.
RefSeq	NP_206828.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-3680N.
Genome annotation databases
GeneID	899115.
GenomeReviews	Gene locus HP_0026 in contig AE000511_GR.
KEGG	hpy:HP0026.
NMPDR	fig|85962.1.peg.26.
TIGR	HP_0026.
Phylogenomic databases
HOGENOM	HBG649489.
OMA	WCAQLLE.
Enzyme and pathway databases
BRENDA	2.3.3.1. 1131.
Family and domain databases
InterPro	IPR016142. Citrate_synth-like_lrg_a-sub. IPR002020. Citrate_synthase-like. IPR016141. Citrate_synthase-like_core. IPR019810. Citrate_synthase_AS. IPR010953. Citrate_synthase_typ-II. [Graphical view]
Gene3D	G3DSA:1.10.580.10. Citrate_synthase_lrg_a-sub. 1 hit.
PANTHER	PTHR11739. Citrate_synth. 1 hit.
Pfam	PF00285. Citrate_synt. 1 hit. [Graphical view]
PRINTS	PR00143. CITRTSNTHASE.
PROSITE	PS00480. CITRATE_SYNTHASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CISY_HELPY

Accession

Primary (citable) accession number: P56062

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	December 15, 2009
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)