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P56062 (CISY_HELPY) Reviewed, UniProtKB/Swiss-Prot

Last modified December 11, 2013. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Citrate synthase

EC=2.3.3.1
Gene names
Name:gltA
Ordered Locus Names:HP_0026
OrganismHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) [Reference proteome] [HAMAP]
Taxonomic identifier85962 [NCBI]
Taxonomic lineageBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter

Protein attributes

Sequence length426 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Acetyl-CoA + H2O + oxaloacetate = citrate + CoA.

Pathway

Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 1/2.

Miscellaneous

Citrate synthase is found in nearly all cells capable of oxidative metabolism.

Sequence similarities

Belongs to the citrate synthase family.

Ontologies

Keywords
   Biological processTricarboxylic acid cycle
   Molecular functionTransferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcellular carbohydrate metabolic process

Inferred from electronic annotation. Source: InterPro

tricarboxylic acid cycle

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functioncitrate (Si)-synthase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 426426Citrate synthase
PRO_0000169946

Sites

Active site3141 By similarity
Active site3721 By similarity

Sequences

Sequence LengthMass (Da)Tools
P56062 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: 7777B67DA74C7C1A

FASTA42648,350
        10         20         30         40         50         60 
MSVTLVNNEN NERYEFETIE STRGPKAVDF SKLFETTGFF SYDPGYSSTA GCQSKISYVN 

        70         80         90        100        110        120 
GKKGELYYRG HRIEDLVAKY KYVDVCKLLL TGELPKNQDE SLEFELELRH RSFVHESLLN 

       130        140        150        160        170        180 
MFSAFPSNAH PMAKLSSGVS ILSTLYSTHQ NMHTEEDYQT MARRIVAKIP TLAAICYRNE 

       190        200        210        220        230        240 
VGAPIIYPDI ARSYVENILF MLRGYPYSRL KHTTQGEVEI TPLEVEAFDK ILTLHADHSQ 

       250        260        270        280        290        300 
NASSTTVRNV ASTGVHPYAA ISAGISALWG HLHGGANEKV LLQLEEIGDV KNVDKYIARV 

       310        320        330        340        350        360 
KDKNDNFKLM GFGHRVYKSY DPRAKILKGL KDELHQKGVK MDERLSEIAA KVEEIALKDE 

       370        380        390        400        410        420 
YFIERNLYPN VDFYSGTILR ALKIPVRFFT PVFVIGRTVG WCAQLLEHVK SPQARITRPR 


QVYVGD 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE000511 Genomic DNA. Translation: AAD07097.1.
PIRB64523.
RefSeqNP_206828.1. NC_000915.1.
YP_006933948.1. NC_018939.1.

3D structure databases

ProteinModelPortalP56062.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-3680N.
IntActP56062. 2 interactions.
MINTMINT-170268.
STRING85962.HP0026.

Proteomic databases

PRIDEP56062.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAD07097; AAD07097; HP_0026.
GeneID13869202.
899115.
KEGGheo:C694_00120.
hpy:HP0026.
PATRIC20591249. VBIHelPyl33062_0026.

Phylogenomic databases

eggNOGCOG0372.
KOK01647.
OMANKEDGVR.
OrthoDBEOG6P8TP4.
ProtClustDBPRK05614.

Enzyme and pathway databases

BioCycHPY:HP0026-MONOMER.
UniPathwayUPA00223; UER00717.

Family and domain databases

Gene3D1.10.230.10. 1 hit.
1.10.580.10. 1 hit.
InterProIPR016142. Citrate_synth-like_lrg_a-sub.
IPR016143. Citrate_synth-like_sm_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
IPR024176. Citrate_synthase_bac-typ.
[Graphical view]
PANTHERPTHR11739. PTHR11739. 1 hit.
PfamPF00285. Citrate_synt. 1 hit.
[Graphical view]
PIRSFPIRSF001369. Citrate_synth. 1 hit.
PRINTSPR00143. CITRTSNTHASE.
SUPFAMSSF48256. SSF48256. 1 hit.
PROSITEPS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCISY_HELPY
AccessionPrimary (citable) accession number: P56062
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: December 11, 2013
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Helicobacter pylori

Helicobacter pylori (strain 26695): entries and gene names