P56030 (RL2_HELPY) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
50S ribosomal protein L2

Gene names

Name:	rplB
Ordered Locus Names:	HP_1316

Organism

Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) [Reference proteome] [HAMAP]

Taxonomic identifier

85962 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › delta/epsilon subdivisions › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter › Helicobacter pylori

Protein attributes

Sequence length	276 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome By similarity. HAMAP-Rule MF_01320
Subunit structure	Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome By similarity.
Sequence similarities	Belongs to the ribosomal protein L2P family.

Ontologies

Keywords
Ligand	RNA-binding rRNA-binding
Molecular function	Ribonucleoprotein Ribosomal protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	translation Inferred from electronic annotation. Source: HAMAP
Cellular_component	large ribosomal subunit Inferred from electronic annotation. Source: InterPro
Molecular_function	rRNA binding Inferred from electronic annotation. Source: HAMAP structural constituent of ribosome Inferred from electronic annotation. Source: InterPro transferase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 276	276	50S ribosomal protein L2 HAMAP-Rule MF_01320		PRO_0000129569

Sequences

	Sequence		Length	Mass (Da)
	P56030 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: 5DCA6F36726C9A35	FASTA	276	30,271
	10 20 30 40 50 60 MAIKTYKPYT PSRRFMSVLD SKDITAKSSV KGLLTKLKAT AGRNNNGRIT SRHKERGAKK 70 80 90 100 110 120 LYRIIDFKRN KYNIEGKVAA IEYDPYRNAR IALVVYPDGD KRYILQPSGL KVGDSVIAAE 130 140 150 160 170 180 GGLDIKVGFA MKLKNIPIGT VVHNIEMHPG AGGQLARSAG MSAQIMGREN KYTIIRMPSS 190 200 210 220 230 240 EMRYILSECM ASVGVVGNED FINVSIGKAG RNRHRGIRPQ TRGSAMNPVD HPHGGGEGKT 250 260 270 GTSGHPVSPW GTPAKGYKTR KKKASDKLII SRKKHK

References

[1]

"The complete genome sequence of the gastric pathogen Helicobacter pylori." Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G., Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A., Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N., Loftus B.J., Richardson D.L., Dodson R.J. , Khalak H.G., Glodek A., McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E., Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D., Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S., Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C. Nature 388:539-547(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700392 / 26695.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE000511 Genomic DNA. Translation: AAD08355.1.
PIR	D64684.
RefSeq	NP_208108.1. NC_000915.1. YP_006935237.1. NC_018939.1.
3D structure databases
ProteinModelPortal	P56030.
SMR	P56030. Positions 62-196.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-3298N.
MINT	MINT-162822.
STRING	85962.HP1316.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAD08355; AAD08355; HP_1316.
GeneID	13870524. 900326.
KEGG	heo:C694_06795. hpy:HP1316.
PATRIC	20594013. VBIHelPyl33062_1377.
Phylogenomic databases
eggNOG	COG0090.
KO	K02886.
OMA	STIHCIE.
ProtClustDB	PRK09374.
Family and domain databases
Gene3D	2.30.30.30. 1 hit. 2.40.50.140. 1 hit. 4.10.950.10. 1 hit.
HAMAP	MF_01320_B. Ribosomal_L2_B.
InterPro	IPR012340. NA-bd_OB-fold. IPR022666. Rbsml_prot_L2_RNA-bd_dom. IPR014722. Rib_L2_dom2. IPR002171. Ribosomal_L2. IPR005880. Ribosomal_L2_bac/org-type. IPR022669. Ribosomal_L2_C. IPR022671. Ribosomal_L2_CS. IPR014726. Ribosomal_L2_dom3. IPR008991. Translation_prot_SH3-like. [Graphical view]
PANTHER	PTHR13691. PTHR13691. 1 hit. PTHR13691:SF5. PTHR13691:SF5. 1 hit.
Pfam	PF00181. Ribosomal_L2. 1 hit. PF03947. Ribosomal_L2_C. 1 hit. [Graphical view]
PIRSF	PIRSF002158. Ribosomal_L2. 1 hit.
SUPFAM	SSF50249. Nucleic_acid_OB. 1 hit. SSF50104. Transl_SH3_like. 1 hit.
TIGRFAMs	TIGR01171. rplB_bact. 1 hit.
PROSITE	PS00467. RIBOSOMAL_L2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

RL2_HELPY

Accession

Primary (citable) accession number: P56030

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	May 1, 2013
This is version 78 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program