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Protein

Succinyl-CoA:3-ketoacid coenzyme A transferase subunit A

Gene

scoA

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Succinyl-CoA + a 3-oxo acid = succinate + a 3-oxoacyl-CoA.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Enzyme and pathway databases

BioCyciHPY:HP0691-MONOMER.
MetaCyc:HP0691-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Succinyl-CoA:3-ketoacid coenzyme A transferase subunit A (EC:2.8.3.5)
Alternative name(s):
Succinyl-CoA:3-oxoacid CoA-transferase
Short name:
OXCT A
Gene namesi
Name:scoA
Ordered Locus Names:HP_0691
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi
  • UP000000429 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 232232Succinyl-CoA:3-ketoacid coenzyme A transferase subunit APRO_0000157909Add
BLAST

Proteomic databases

PaxDbiP56006.
PRIDEiP56006.

Interactioni

Subunit structurei

Heterodimer of a subunit A and a subunit B.

Binary interactionsi

WithEntry#Exp.IntActNotes
scoBP560073EBI-7723842,EBI-7724043

Protein-protein interaction databases

DIPiDIP-3481N.
IntActiP56006. 2 interactions.
MINTiMINT-176385.
STRINGi85962.HP0691.

Structurei

Secondary structure

1
232
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi4 – 74Combined sources
Helixi9 – 124Combined sources
Beta strandi20 – 234Combined sources
Helixi33 – 4210Combined sources
Beta strandi46 – 505Combined sources
Beta strandi57 – 593Combined sources
Helixi60 – 656Combined sources
Turni66 – 683Combined sources
Beta strandi70 – 767Combined sources
Helixi82 – 898Combined sources
Beta strandi92 – 976Combined sources
Helixi100 – 11213Combined sources
Beta strandi116 – 1205Combined sources
Turni121 – 1244Combined sources
Helixi126 – 1283Combined sources
Beta strandi133 – 1364Combined sources
Beta strandi139 – 1457Combined sources
Beta strandi149 – 1557Combined sources
Beta strandi157 – 1604Combined sources
Helixi169 – 1713Combined sources
Helixi175 – 1806Combined sources
Beta strandi182 – 19312Combined sources
Turni200 – 2023Combined sources
Helixi207 – 2093Combined sources
Beta strandi211 – 2155Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3RRLX-ray2.29A/C1-232[»]
ProteinModelPortaliP56006.
SMRiP56006. Positions 1-229.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni24 – 307CoA-bindingSequence analysis

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4107QP7. Bacteria.
COG1788. LUCA.
KOiK01028.
OMAiVKAHRAD.

Family and domain databases

InterProiIPR012792. 3-oxoacid_CoA-transf_A.
IPR004165. CoA_trans_fam_I.
IPR004163. CoA_transf_BS.
[Graphical view]
PANTHERiPTHR13707. PTHR13707. 1 hit.
PfamiPF01144. CoA_trans. 1 hit.
[Graphical view]
SMARTiSM00882. CoA_trans. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02429. pcaI_scoA_fam. 1 hit.
PROSITEiPS01273. COA_TRANSF_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P56006-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKVITDLDK ALSALKDGDT ILVGGFGLCG IPEYAIDYIY KKGIKDLIVV
60 70 80 90 100
SNNCGVDDFG LGILLEKKQI KKIIASYVGE NKIFESQMLN GEIEVVLTPQ
110 120 130 140 150
GTLAENLHAG GAGIPAYYTP TGVGTLIAQG KESREFNGKE YILERAITGD
160 170 180 190 200
YGLIKAYKSD TLGNLVFRKT ARNFNPLCAM AAKICVAEVE EIVPAGELDP
210 220 230
DEIHLPGIYV QHIYKGEKFE KRIEKITTRS TK
Length:232
Mass (Da):25,362
Last modified:November 1, 1997 - v1
Checksum:i83CFEE57C0192F3D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti14 – 141A → T no nucleotide entry (PubMed:9325289).Curated
Sequence conflicti108 – 1092HA → RP no nucleotide entry (PubMed:9325289).Curated
Sequence conflicti116 – 1216AYYTPT → LTTPQP no nucleotide entry (PubMed:9325289).Curated
Sequence conflicti129 – 13911QGKESREFNGK → PRQGIQGSLTAR no nucleotide entry (PubMed:9325289).CuratedAdd
BLAST
Sequence conflicti231 – 2311T → A no nucleotide entry (PubMed:9325289).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD07743.1.
PIRiC64606.
RefSeqiNP_207485.1. NC_000915.1.
WP_001045154.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD07743; AAD07743; HP_0691.
GeneIDi899012.
KEGGiheo:C694_03560.
hpy:HP0691.
PATRICi20592667. VBIHelPyl33062_0722.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD07743.1.
PIRiC64606.
RefSeqiNP_207485.1. NC_000915.1.
WP_001045154.1. NC_018939.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3RRLX-ray2.29A/C1-232[»]
ProteinModelPortaliP56006.
SMRiP56006. Positions 1-229.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-3481N.
IntActiP56006. 2 interactions.
MINTiMINT-176385.
STRINGi85962.HP0691.

Proteomic databases

PaxDbiP56006.
PRIDEiP56006.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD07743; AAD07743; HP_0691.
GeneIDi899012.
KEGGiheo:C694_03560.
hpy:HP0691.
PATRICi20592667. VBIHelPyl33062_0722.

Phylogenomic databases

eggNOGiENOG4107QP7. Bacteria.
COG1788. LUCA.
KOiK01028.
OMAiVKAHRAD.

Enzyme and pathway databases

BioCyciHPY:HP0691-MONOMER.
MetaCyc:HP0691-MONOMER.

Family and domain databases

InterProiIPR012792. 3-oxoacid_CoA-transf_A.
IPR004165. CoA_trans_fam_I.
IPR004163. CoA_transf_BS.
[Graphical view]
PANTHERiPTHR13707. PTHR13707. 1 hit.
PfamiPF01144. CoA_trans. 1 hit.
[Graphical view]
SMARTiSM00882. CoA_trans. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02429. pcaI_scoA_fam. 1 hit.
PROSITEiPS01273. COA_TRANSF_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSCOA_HELPY
AccessioniPrimary (citable) accession number: P56006
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: September 7, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.