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Protein

Succinyl-CoA:3-ketoacid coenzyme A transferase subunit A

Gene

scoA

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Succinyl-CoA + a 3-oxo acid = succinate + a 3-oxoacyl-CoA.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Enzyme and pathway databases

BioCyciHPY:HP0691-MONOMER.
MetaCyc:HP0691-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Succinyl-CoA:3-ketoacid coenzyme A transferase subunit A (EC:2.8.3.5)
Alternative name(s):
Succinyl-CoA:3-oxoacid CoA-transferase
Short name:
OXCT A
Gene namesi
Name:scoA
Ordered Locus Names:HP_0691
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi
  • UP000000429 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001579091 – 232Succinyl-CoA:3-ketoacid coenzyme A transferase subunit AAdd BLAST232

Proteomic databases

PaxDbiP56006.

Interactioni

Subunit structurei

Heterodimer of a subunit A and a subunit B.

Binary interactionsi

WithEntry#Exp.IntActNotes
scoBP560073EBI-7723842,EBI-7724043

Protein-protein interaction databases

DIPiDIP-3481N.
IntActiP56006. 2 interactors.
MINTiMINT-176385.
STRINGi85962.HP0691.

Structurei

Secondary structure

1232
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi4 – 7Combined sources4
Helixi9 – 12Combined sources4
Beta strandi20 – 23Combined sources4
Helixi33 – 42Combined sources10
Beta strandi46 – 50Combined sources5
Beta strandi57 – 59Combined sources3
Helixi60 – 65Combined sources6
Turni66 – 68Combined sources3
Beta strandi70 – 76Combined sources7
Helixi82 – 89Combined sources8
Beta strandi92 – 97Combined sources6
Helixi100 – 112Combined sources13
Beta strandi116 – 120Combined sources5
Turni121 – 124Combined sources4
Helixi126 – 128Combined sources3
Beta strandi133 – 136Combined sources4
Beta strandi139 – 145Combined sources7
Beta strandi149 – 155Combined sources7
Beta strandi157 – 160Combined sources4
Helixi169 – 171Combined sources3
Helixi175 – 180Combined sources6
Beta strandi182 – 193Combined sources12
Turni200 – 202Combined sources3
Helixi207 – 209Combined sources3
Beta strandi211 – 215Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3RRLX-ray2.29A/C1-232[»]
ProteinModelPortaliP56006.
SMRiP56006.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni24 – 30CoA-bindingSequence analysis7

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4107QP7. Bacteria.
COG1788. LUCA.
KOiK01028.
OMAiVKAHRAD.

Family and domain databases

InterProiIPR012792. 3-oxoacid_CoA-transf_A.
IPR004165. CoA_trans_fam_I.
IPR004163. CoA_transf_BS.
[Graphical view]
PANTHERiPTHR13707. PTHR13707. 1 hit.
PfamiPF01144. CoA_trans. 1 hit.
[Graphical view]
SMARTiSM00882. CoA_trans. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02429. pcaI_scoA_fam. 1 hit.
PROSITEiPS01273. COA_TRANSF_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P56006-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKVITDLDK ALSALKDGDT ILVGGFGLCG IPEYAIDYIY KKGIKDLIVV
60 70 80 90 100
SNNCGVDDFG LGILLEKKQI KKIIASYVGE NKIFESQMLN GEIEVVLTPQ
110 120 130 140 150
GTLAENLHAG GAGIPAYYTP TGVGTLIAQG KESREFNGKE YILERAITGD
160 170 180 190 200
YGLIKAYKSD TLGNLVFRKT ARNFNPLCAM AAKICVAEVE EIVPAGELDP
210 220 230
DEIHLPGIYV QHIYKGEKFE KRIEKITTRS TK
Length:232
Mass (Da):25,362
Last modified:November 1, 1997 - v1
Checksum:i83CFEE57C0192F3D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti14A → T no nucleotide entry (PubMed:9325289).Curated1
Sequence conflicti108 – 109HA → RP no nucleotide entry (PubMed:9325289).Curated2
Sequence conflicti116 – 121AYYTPT → LTTPQP no nucleotide entry (PubMed:9325289).Curated6
Sequence conflicti129 – 139QGKESREFNGK → PRQGIQGSLTAR no nucleotide entry (PubMed:9325289).CuratedAdd BLAST11
Sequence conflicti231T → A no nucleotide entry (PubMed:9325289).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD07743.1.
PIRiC64606.
RefSeqiNP_207485.1. NC_000915.1.
WP_001045154.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD07743; AAD07743; HP_0691.
GeneIDi899012.
KEGGiheo:C694_03560.
hpy:HP0691.
PATRICi20592667. VBIHelPyl33062_0722.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD07743.1.
PIRiC64606.
RefSeqiNP_207485.1. NC_000915.1.
WP_001045154.1. NC_018939.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3RRLX-ray2.29A/C1-232[»]
ProteinModelPortaliP56006.
SMRiP56006.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-3481N.
IntActiP56006. 2 interactors.
MINTiMINT-176385.
STRINGi85962.HP0691.

Proteomic databases

PaxDbiP56006.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD07743; AAD07743; HP_0691.
GeneIDi899012.
KEGGiheo:C694_03560.
hpy:HP0691.
PATRICi20592667. VBIHelPyl33062_0722.

Phylogenomic databases

eggNOGiENOG4107QP7. Bacteria.
COG1788. LUCA.
KOiK01028.
OMAiVKAHRAD.

Enzyme and pathway databases

BioCyciHPY:HP0691-MONOMER.
MetaCyc:HP0691-MONOMER.

Family and domain databases

InterProiIPR012792. 3-oxoacid_CoA-transf_A.
IPR004165. CoA_trans_fam_I.
IPR004163. CoA_transf_BS.
[Graphical view]
PANTHERiPTHR13707. PTHR13707. 1 hit.
PfamiPF01144. CoA_trans. 1 hit.
[Graphical view]
SMARTiSM00882. CoA_trans. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02429. pcaI_scoA_fam. 1 hit.
PROSITEiPS01273. COA_TRANSF_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSCOA_HELPY
AccessioniPrimary (citable) accession number: P56006
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 2, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.