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P56001

- RPOA_HELPY

UniProt

P56001 - RPOA_HELPY

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Protein

DNA-directed RNA polymerase subunit alpha

Gene

rpoA

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.UniRule annotation

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).UniRule annotation

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-HAMAP
  2. DNA-directed RNA polymerase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. transcription, DNA-templated Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Biological processi

Transcription

Enzyme and pathway databases

BioCyciHPY:HP1293-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-directed RNA polymerase subunit alphaUniRule annotation (EC:2.7.7.6UniRule annotation)
Short name:
RNAP subunit alphaUniRule annotation
Alternative name(s):
RNA polymerase subunit alphaUniRule annotation
Transcriptase subunit alphaUniRule annotation
Gene namesi
Name:rpoAUniRule annotation
Ordered Locus Names:HP_1293
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000429: Chromosome

Subcellular locationi

Keywords - Cellular componenti

DNA-directed RNA polymerase

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 344344DNA-directed RNA polymerase subunit alphaPRO_0000175316Add
BLAST

Proteomic databases

PRIDEiP56001.

Interactioni

Subunit structurei

Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.UniRule annotation

Protein-protein interaction databases

DIPiDIP-3396N.
IntActiP56001. 2 interactions.
MINTiMINT-172290.
STRINGi85962.HP1293.

Structurei

3D structure databases

ProteinModelPortaliP56001.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 238238Alpha N-terminal domain (alpha-NTD)UniRule annotationAdd
BLAST
Regioni254 – 34491Alpha C-terminal domain (alpha-CTD)UniRule annotationAdd
BLAST

Domaini

The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.UniRule annotation

Sequence similaritiesi

Belongs to the RNA polymerase alpha chain family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0202.
KOiK03040.
OMAiDDGLEFN.
OrthoDBiEOG68WR84.

Family and domain databases

Gene3Di2.170.120.12. 1 hit.
HAMAPiMF_00059. RNApol_bact_RpoA.
InterProiIPR011262. DNA-dir_RNA_pol_insert.
IPR011263. DNA-dir_RNA_pol_RpoA/D/Rpb3.
IPR011773. DNA-dir_RpoA.
IPR009025. RBP11-like_dimer.
IPR011260. RNAP_asu_C.
[Graphical view]
PfamiPF01000. RNA_pol_A_bac. 1 hit.
PF03118. RNA_pol_A_CTD. 1 hit.
PF01193. RNA_pol_L. 1 hit.
[Graphical view]
ProDomiPD001179. RNAP_asu_C. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00662. RPOLD. 1 hit.
[Graphical view]
SUPFAMiSSF55257. SSF55257. 2 hits.
SSF56553. SSF56553. 1 hit.
TIGRFAMsiTIGR02027. rpoA. 1 hit.

Sequencei

Sequence statusi: Complete.

P56001 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKVIKTAPLI PSEIKVLEKE GNRVKISLAP FEFGYAVTLA HPIRRLLLLS
60 70 80 90 100
SVGYAPVGLK IEGVHHEFDS LRGVTEDVSL FIMNLKNIRF IAKALVGQDS
110 120 130 140 150
SLENQSVVVD YSFKGPMELR ARDLNSEQIE IVNPEMPLAT INEDAQLNFS
160 170 180 190 200
LIIYKGMGYV PSENTRELMP EGYMPLDGSF TPIKKVVYEI ENVLVEGDPN
210 220 230 240 250
YEKIIFDIET DGQIDPYKAF LSAVKVMSKQ LGVFGERPIA NTEYSGDYAQ
260 270 280 290 300
RDDAKDLSAK IESMNLSARC FNCLDKIGIK YVGELVLMSE EELKGVKNMG
310 320 330 340
KKSYDEIAEK LNDLGYPVGT ELSPEQRESL KKRLEKLEDK GGND
Length:344
Mass (Da):38,499
Last modified:November 1, 1997 - v1
Checksum:i0F812B0020DF7414
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000511 Genomic DNA. Translation: AAD08336.1.
PIRiE64681.
RefSeqiNP_208085.1. NC_000915.1.
YP_006935214.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD08336; AAD08336; HP_1293.
GeneIDi13870501.
898788.
KEGGiheo:C694_06680.
hpy:HP1293.
PATRICi20593967. VBIHelPyl33062_1354.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000511 Genomic DNA. Translation: AAD08336.1 .
PIRi E64681.
RefSeqi NP_208085.1. NC_000915.1.
YP_006935214.1. NC_018939.1.

3D structure databases

ProteinModelPortali P56001.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-3396N.
IntActi P56001. 2 interactions.
MINTi MINT-172290.
STRINGi 85962.HP1293.

Proteomic databases

PRIDEi P56001.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD08336 ; AAD08336 ; HP_1293 .
GeneIDi 13870501.
898788.
KEGGi heo:C694_06680.
hpy:HP1293.
PATRICi 20593967. VBIHelPyl33062_1354.

Phylogenomic databases

eggNOGi COG0202.
KOi K03040.
OMAi DDGLEFN.
OrthoDBi EOG68WR84.

Enzyme and pathway databases

BioCyci HPY:HP1293-MONOMER.

Family and domain databases

Gene3Di 2.170.120.12. 1 hit.
HAMAPi MF_00059. RNApol_bact_RpoA.
InterProi IPR011262. DNA-dir_RNA_pol_insert.
IPR011263. DNA-dir_RNA_pol_RpoA/D/Rpb3.
IPR011773. DNA-dir_RpoA.
IPR009025. RBP11-like_dimer.
IPR011260. RNAP_asu_C.
[Graphical view ]
Pfami PF01000. RNA_pol_A_bac. 1 hit.
PF03118. RNA_pol_A_CTD. 1 hit.
PF01193. RNA_pol_L. 1 hit.
[Graphical view ]
ProDomi PD001179. RNAP_asu_C. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SMARTi SM00662. RPOLD. 1 hit.
[Graphical view ]
SUPFAMi SSF55257. SSF55257. 2 hits.
SSF56553. SSF56553. 1 hit.
TIGRFAMsi TIGR02027. rpoA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700392 / 26695.

Entry informationi

Entry nameiRPOA_HELPY
AccessioniPrimary (citable) accession number: P56001
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: October 1, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3