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P56001

- RPOA_HELPY

UniProt

P56001 - RPOA_HELPY

Protein

DNA-directed RNA polymerase subunit alpha

Gene

rpoA

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 1 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.UniRule annotation

    Catalytic activityi

    Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).UniRule annotation

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-HAMAP
    2. DNA-directed RNA polymerase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. transcription, DNA-templated Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Nucleotidyltransferase, Transferase

    Keywords - Biological processi

    Transcription

    Enzyme and pathway databases

    BioCyciHPY:HP1293-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA-directed RNA polymerase subunit alphaUniRule annotation (EC:2.7.7.6UniRule annotation)
    Short name:
    RNAP subunit alphaUniRule annotation
    Alternative name(s):
    RNA polymerase subunit alphaUniRule annotation
    Transcriptase subunit alphaUniRule annotation
    Gene namesi
    Name:rpoAUniRule annotation
    Ordered Locus Names:HP_1293
    OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
    Taxonomic identifieri85962 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
    ProteomesiUP000000429: Chromosome

    Subcellular locationi

    Keywords - Cellular componenti

    DNA-directed RNA polymerase

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 344344DNA-directed RNA polymerase subunit alphaPRO_0000175316Add
    BLAST

    Proteomic databases

    PRIDEiP56001.

    Interactioni

    Subunit structurei

    Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.UniRule annotation

    Protein-protein interaction databases

    DIPiDIP-3396N.
    IntActiP56001. 2 interactions.
    MINTiMINT-172290.
    STRINGi85962.HP1293.

    Structurei

    3D structure databases

    ProteinModelPortaliP56001.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 238238Alpha N-terminal domain (alpha-NTD)UniRule annotationAdd
    BLAST
    Regioni254 – 34491Alpha C-terminal domain (alpha-CTD)UniRule annotationAdd
    BLAST

    Domaini

    The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.UniRule annotation

    Sequence similaritiesi

    Belongs to the RNA polymerase alpha chain family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0202.
    KOiK03040.
    OMAiDDGLEFN.
    OrthoDBiEOG68WR84.

    Family and domain databases

    Gene3Di2.170.120.12. 1 hit.
    HAMAPiMF_00059. RNApol_bact_RpoA.
    InterProiIPR011262. DNA-dir_RNA_pol_insert.
    IPR011263. DNA-dir_RNA_pol_RpoA/D/Rpb3.
    IPR011773. DNA-dir_RpoA.
    IPR009025. RBP11-like_dimer.
    IPR011260. RNAP_asu_C.
    [Graphical view]
    PfamiPF01000. RNA_pol_A_bac. 1 hit.
    PF03118. RNA_pol_A_CTD. 1 hit.
    PF01193. RNA_pol_L. 1 hit.
    [Graphical view]
    ProDomiPD001179. RNAP_asu_C. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SMARTiSM00662. RPOLD. 1 hit.
    [Graphical view]
    SUPFAMiSSF55257. SSF55257. 2 hits.
    SSF56553. SSF56553. 1 hit.
    TIGRFAMsiTIGR02027. rpoA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P56001-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKVIKTAPLI PSEIKVLEKE GNRVKISLAP FEFGYAVTLA HPIRRLLLLS    50
    SVGYAPVGLK IEGVHHEFDS LRGVTEDVSL FIMNLKNIRF IAKALVGQDS 100
    SLENQSVVVD YSFKGPMELR ARDLNSEQIE IVNPEMPLAT INEDAQLNFS 150
    LIIYKGMGYV PSENTRELMP EGYMPLDGSF TPIKKVVYEI ENVLVEGDPN 200
    YEKIIFDIET DGQIDPYKAF LSAVKVMSKQ LGVFGERPIA NTEYSGDYAQ 250
    RDDAKDLSAK IESMNLSARC FNCLDKIGIK YVGELVLMSE EELKGVKNMG 300
    KKSYDEIAEK LNDLGYPVGT ELSPEQRESL KKRLEKLEDK GGND 344
    Length:344
    Mass (Da):38,499
    Last modified:November 1, 1997 - v1
    Checksum:i0F812B0020DF7414
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000511 Genomic DNA. Translation: AAD08336.1.
    PIRiE64681.
    RefSeqiNP_208085.1. NC_000915.1.
    YP_006935214.1. NC_018939.1.

    Genome annotation databases

    EnsemblBacteriaiAAD08336; AAD08336; HP_1293.
    GeneIDi13870501.
    898788.
    KEGGiheo:C694_06680.
    hpy:HP1293.
    PATRICi20593967. VBIHelPyl33062_1354.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000511 Genomic DNA. Translation: AAD08336.1 .
    PIRi E64681.
    RefSeqi NP_208085.1. NC_000915.1.
    YP_006935214.1. NC_018939.1.

    3D structure databases

    ProteinModelPortali P56001.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-3396N.
    IntActi P56001. 2 interactions.
    MINTi MINT-172290.
    STRINGi 85962.HP1293.

    Proteomic databases

    PRIDEi P56001.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD08336 ; AAD08336 ; HP_1293 .
    GeneIDi 13870501.
    898788.
    KEGGi heo:C694_06680.
    hpy:HP1293.
    PATRICi 20593967. VBIHelPyl33062_1354.

    Phylogenomic databases

    eggNOGi COG0202.
    KOi K03040.
    OMAi DDGLEFN.
    OrthoDBi EOG68WR84.

    Enzyme and pathway databases

    BioCyci HPY:HP1293-MONOMER.

    Family and domain databases

    Gene3Di 2.170.120.12. 1 hit.
    HAMAPi MF_00059. RNApol_bact_RpoA.
    InterProi IPR011262. DNA-dir_RNA_pol_insert.
    IPR011263. DNA-dir_RNA_pol_RpoA/D/Rpb3.
    IPR011773. DNA-dir_RpoA.
    IPR009025. RBP11-like_dimer.
    IPR011260. RNAP_asu_C.
    [Graphical view ]
    Pfami PF01000. RNA_pol_A_bac. 1 hit.
    PF03118. RNA_pol_A_CTD. 1 hit.
    PF01193. RNA_pol_L. 1 hit.
    [Graphical view ]
    ProDomi PD001179. RNAP_asu_C. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SMARTi SM00662. RPOLD. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55257. SSF55257. 2 hits.
    SSF56553. SSF56553. 1 hit.
    TIGRFAMsi TIGR02027. rpoA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700392 / 26695.

    Entry informationi

    Entry nameiRPOA_HELPY
    AccessioniPrimary (citable) accession number: P56001
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Helicobacter pylori
      Helicobacter pylori (strain 26695): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3