Reviewed, UniProtKB/Swiss-Prot P55999 (RF2_HELPY)

Names and origin

Protein names

Recommended name:
    Peptide chain release factor 2
      Short name=RF-2

Gene names

Name:	prfB
Ordered Locus Names:	HP_0171

Organism

Helicobacter pylori (Campylobacter pylori) [Complete proteome] [HAMAP]

Taxonomic identifier

210 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter

Protein attributes

Sequence length	363 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA By similarity.
Subcellular location	Cytoplasm.
Sequence similarities	Belongs to the prokaryotic/mitochondrial release factor family.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	translational termination Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	translation release factor activity, codon specific Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 363	363	Peptide chain release factor 2 HAMAP MF_00094		PRO_0000166821

Sequences

	Sequence		Length	Mass (Da)
	P55999-1 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: 7DE21BC84D69DA9E	FASTA	363	41,317
	10 20 30 40 50 60 MDNYTYSELL KSLQNKCDNI ALIIKPEKIK QELERIEKEQ EDPNFWQDVL KARDTNKEKV 70 80 90 100 110 120 RLNRLLETYQ KTKNSLDESV ELFELAQNDN DEVTLSLLYE EAPILENSVQ KVEIEIMLSG 130 140 150 160 170 180 ENDASNAIIT IQPGAGGTES QDWASILYRM YLRWAERRGF KSEILDYQDG EEAGIKGVAF 190 200 210 220 230 240 IIKGENAYGY LKNENGVHRL VRISPFDANA KRHTSFASVQ ISPELDDDID IEIDEKDVRY 250 260 270 280 290 300 DYYRSSGAGG QHVNKTESAV RITHFPTGIV VQCQNDRSQH KNKASALKML KSKLYELELE 310 320 330 340 350 360 KQQSSAKNEE KSEIGWGHQI RSYVLAPYQQ VKDARSNTAY SNVEAILDGD IDAILEGVLI AKA

References

[1]

"The complete genome sequence of the gastric pathogen Helicobacter pylori." Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G., Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A., Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N., Loftus B.J., Richardson D.L., Dodson R.J. , Khalak H.G., Glodek A., McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E., Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D., Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S., Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C. Nature 388:539-547(1997) [PubMed: 9252185] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700392 / 26695.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE000511 Genomic DNA. Translation: AAD07236.1.
PIR	C64541.
RefSeq	NP_206970.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	899148.
GenomeReviews	Gene locus HP_0171 in contig AE000511_GR.
KEGG	hpy:HP0171.
NMPDR	fig|85962.1.peg.168.
TIGR	HP_0171.
Phylogenomic databases
HOGENOM	P55999.
OMA	TEMLLRM
Family and domain databases
HAMAP	MF_00094. [Tree]
InterPro	IPR005139. PCRF. IPR000352. Pep_rel_factor_I. IPR020853. Peptide_chain_release_fac2_bac. IPR004374. PrfB. [Graphical view]
PANTHER	PTHR11075:SF6. PrfB. 1 hit.
Pfam	PF03462. PCRF. 1 hit. PF00472. RF-1. 1 hit. [Graphical view]
TIGRFAMs	TIGR00020. prfB. 1 hit.
PROSITE	PS00745. RF_PROK_I. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

RF2_HELPY

Accession

Primary (citable) accession number: P55999

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	November 24, 2009
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)