Reviewed, UniProtKB/Swiss-Prot P55998 (RF1_HELPY)

Names and origin

Protein names

Recommended name:
    Peptide chain release factor 1
      Short name=RF-1

Gene names

Name:	prfA
Ordered Locus Names:	HP_0077

Organism

Helicobacter pylori (Campylobacter pylori) [Complete proteome] [HAMAP]

Taxonomic identifier

210 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter

Protein attributes

Sequence length	352 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA By similarity.
Subcellular location	Cytoplasm.
Sequence similarities	Belongs to the prokaryotic/mitochondrial release factor family.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	translational termination Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	translation release factor activity, codon specific Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 352	352	Peptide chain release factor 1 HAMAP MF_00093		PRO_0000177681

Sequences

	Sequence		Length	Mass (Da)
	P55998-1 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: 4643B5DDC6E6F2E3	FASTA	352	39,587
	10 20 30 40 50 60 MSILAEKLSS ILKRYDELTA LLSSAEVVSD IKKLTELSKE QSSIEEISIA SKEYLSVLEN 70 80 90 100 110 120 IKENKELLED KELSELAKEE LKILEIQKSD LETAIKQLLI PKDPNDDKNI YLELRAGTGG 130 140 150 160 170 180 DEAGIFVGDL FKAYCRYADL KKWKVEIVSS SENSVGGYKE IIALIKGKGV YSRLKFEAGT 190 200 210 220 230 240 HRVQRVPETE SQGRIHTSAI TVAIMPEVDD VEVSINPSDL KIEVFRAGGH GGQCVNTTDS 250 260 270 280 290 300 AVRITHLPTN ISVSMQDEKS QHKNKDKALK ILKARLYEKQ IEEQQLANAK DRKEQVGSGD 310 320 330 340 350 RSERIRTYNY PQNRLSEHRI NLTLYSLEEI MLSGNLDEVI NPLIAHAQSQ FE

References

[1]

"The complete genome sequence of the gastric pathogen Helicobacter pylori." Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G., Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A., Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N., Loftus B.J., Richardson D.L., Dodson R.J. , Khalak H.G., Glodek A., McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E., Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D., Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S., Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C. Nature 388:539-547(1997) [PubMed: 9252185] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700392 / 26695.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE000511 Genomic DNA. Translation: AAD07148.1.
PIR	E64529.
RefSeq	NP_206877.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	899973.
GenomeReviews	Gene locus HP_0077 in contig AE000511_GR.
KEGG	hpy:HP0077.
NMPDR	fig|85962.1.peg.75.
TIGR	HP_0077.
Phylogenomic databases
HOGENOM	P55998.
OMA	MSILAEK
Family and domain databases
HAMAP	MF_00093. [Tree]
InterPro	IPR005139. PCRF. IPR000352. Pep_rel_factor_I. IPR004373. PrfA. [Graphical view]
Pfam	PF03462. PCRF. 1 hit. PF00472. RF-1. 1 hit. [Graphical view]
TIGRFAMs	TIGR00019. prfA. 1 hit.
PROSITE	PS00745. RF_PROK_I. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

RF1_HELPY

Accession

Primary (citable) accession number: P55998

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	November 24, 2009
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)