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Protein

Lon protease

Gene

lon

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.UniRule annotation

Catalytic activityi

Hydrolysis of proteins in presence of ATP.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei741 – 7411UniRule annotation
Active sitei784 – 7841UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi367 – 3748ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Keywords - Biological processi

Stress response

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciHPY:HP1379-MONOMER.

Protein family/group databases

MEROPSiS16.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Lon proteaseUniRule annotation (EC:3.4.21.53UniRule annotation)
Alternative name(s):
ATP-dependent protease LaUniRule annotation
Gene namesi
Name:lonUniRule annotation
Ordered Locus Names:HP_1379
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi
  • UP000000429 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 835835Lon proteasePRO_0000076137Add
BLAST

Proteomic databases

PaxDbiP55995.
PRIDEiP55995.

Expressioni

Inductioni

By heat shock.UniRule annotation

Interactioni

Subunit structurei

Homohexamer. Organized in a ring with a central cavity.UniRule annotation

Protein-protein interaction databases

DIPiDIP-3184N.
IntActiP55995. 7 interactions.
MINTiMINT-186118.
STRINGi85962.HP1379.

Structurei

3D structure databases

ProteinModelPortaliP55995.
SMRiP55995. Positions 638-834.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini9 – 200192Lon N-terminalPROSITE-ProRule annotationAdd
BLAST
Domaini636 – 835200Lon proteolyticPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi712 – 7165Poly-Lys

Sequence similaritiesi

Belongs to the peptidase S16 family.UniRule annotation
Contains 1 Lon N-terminal domain.PROSITE-ProRule annotation
Contains 1 Lon proteolytic domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4105C6P. Bacteria.
COG0466. LUCA.
KOiK01338.
OMAiDNPHKKG.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_01973. lon_bact. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR027543. Lon_bac.
IPR004815. Lon_bac/euk-typ.
IPR027065. Lon_Prtase.
IPR003111. LON_substr-bd_dom.
IPR027417. P-loop_NTPase.
IPR008269. Pept_S16_C.
IPR008268. Peptidase_S16_AS.
IPR015947. PUA-like_domain.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
PANTHERiPTHR10046. PTHR10046. 1 hit.
PfamiPF00004. AAA. 1 hit.
PF05362. Lon_C. 1 hit.
PF02190. LON_substr_bdg. 1 hit.
[Graphical view]
PIRSFiPIRSF001174. Lon_proteas. 1 hit.
SMARTiSM00382. AAA. 1 hit.
SM00464. LON. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF54211. SSF54211. 1 hit.
SSF88697. SSF88697. 1 hit.
TIGRFAMsiTIGR00763. lon. 1 hit.
PROSITEiPS51787. LON_N. 1 hit.
PS51786. LON_PROTEOLYTIC. 1 hit.
PS01046. LON_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P55995-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTEDFPKILP LLVEEDTFLY PFMIAPIFLQ NNASIKAVAY AKNNKSLVFI
60 70 80 90 100
ACQKDKLNDN EAPYYDVGVI GSVMREANMP NGRVKLLFNG IAKGRILEPA
110 120 130 140 150
KENEQGFLEA QISPIEYLEY DKENIQAIVE VLKEKVITLA NVSSLFPPDL
160 170 180 190 200
IKALEDNDDP NRIADLIAAA LHLKKDQAYS LFANNNTEQR LLDLIDIVIE
210 220 230 240 250
ETKTQKLQKE IKSKVHQKME QTNKEYFLKE QLKQIQKELG TDKQRDEDLN
260 270 280 290 300
QYYQKLESIK PFLKEEAFKE IKKQIDRLSR THADSSDSAT LQNYIETMLD
310 320 330 340 350
VPFGQYGKKA LDIKHVREQL DKDHYSLKRP KERIVEYFAT MQLLEMRRKK
360 370 380 390 400
KPEKKDKTKG TILCFYGPPG VGKTSLANSI AKAIERPLVR IALGGLEDVN
410 420 430 440 450
ELRGHRRTYI GSMPGRIVQG LIEAKKMNPV MVLDEIDKVD RSVRGDPASA
460 470 480 490 500
LLEILDPEQN TAFRDHYANF SIDLSQVIFI ATANNIDRIP APLRDRMEFI
510 520 530 540 550
SVSSYTPNEK EEIAKNYLIP QELEKHALKP SEVEISHECL KLIIEKYTRE
560 570 580 590 600
AGVRDLRRQI ATIMRKVALK YLEDNPHQKG RTKKGKNEKS EDQKSEDQKS
610 620 630 640 650
ENQKSENKDF CVSITPNNLK EYLERMVFEI DPIDEENKIG IVNGLAWTPV
660 670 680 690 700
GGDVLKIEVL KIRGKGELKL TGSLGDVMKE SAIIAFSVVK VLLDNETLKV
710 720 730 740 750
PKIPSETDAE GKKKKKVLKV YNAYDLHLHV PEGATPKDGP SAGIAMASVM
760 770 780 790 800
ASILCDRATR SEVAMTGELT LSGEVLPIGG LKEKLIAAFK AGIKTALIPV
810 820 830
KNYERDLDEI PAEVRENLNI VAVKNIAEVL EKTLL
Length:835
Mass (Da):94,419
Last modified:November 1, 1997 - v1
Checksum:i4BDA52814191C727
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD08421.1.
PIRiC64692.
RefSeqiNP_208170.1. NC_000915.1.
WP_000133787.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD08421; AAD08421; HP_1379.
GeneIDi900303.
KEGGiheo:C694_07120.
hpy:HP1379.
PATRICi20594147. VBIHelPyl33062_1444.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD08421.1.
PIRiC64692.
RefSeqiNP_208170.1. NC_000915.1.
WP_000133787.1. NC_018939.1.

3D structure databases

ProteinModelPortaliP55995.
SMRiP55995. Positions 638-834.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-3184N.
IntActiP55995. 7 interactions.
MINTiMINT-186118.
STRINGi85962.HP1379.

Protein family/group databases

MEROPSiS16.001.

Proteomic databases

PaxDbiP55995.
PRIDEiP55995.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD08421; AAD08421; HP_1379.
GeneIDi900303.
KEGGiheo:C694_07120.
hpy:HP1379.
PATRICi20594147. VBIHelPyl33062_1444.

Phylogenomic databases

eggNOGiENOG4105C6P. Bacteria.
COG0466. LUCA.
KOiK01338.
OMAiDNPHKKG.

Enzyme and pathway databases

BioCyciHPY:HP1379-MONOMER.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_01973. lon_bact. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR027543. Lon_bac.
IPR004815. Lon_bac/euk-typ.
IPR027065. Lon_Prtase.
IPR003111. LON_substr-bd_dom.
IPR027417. P-loop_NTPase.
IPR008269. Pept_S16_C.
IPR008268. Peptidase_S16_AS.
IPR015947. PUA-like_domain.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
PANTHERiPTHR10046. PTHR10046. 1 hit.
PfamiPF00004. AAA. 1 hit.
PF05362. Lon_C. 1 hit.
PF02190. LON_substr_bdg. 1 hit.
[Graphical view]
PIRSFiPIRSF001174. Lon_proteas. 1 hit.
SMARTiSM00382. AAA. 1 hit.
SM00464. LON. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF54211. SSF54211. 1 hit.
SSF88697. SSF88697. 1 hit.
TIGRFAMsiTIGR00763. lon. 1 hit.
PROSITEiPS51787. LON_N. 1 hit.
PS51786. LON_PROTEOLYTIC. 1 hit.
PS01046. LON_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLON_HELPY
AccessioniPrimary (citable) accession number: P55995
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: September 7, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.