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Protein

Lon protease

Gene

lon

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.UniRule annotation

Catalytic activityi

Hydrolysis of proteins in presence of ATP.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei741UniRule annotation1
Active sitei784UniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi367 – 374ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Serine protease
Biological processStress response
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciHPY:HP1379-MONOMER

Protein family/group databases

MEROPSiS16.001

Names & Taxonomyi

Protein namesi
Recommended name:
Lon proteaseUniRule annotation (EC:3.4.21.53UniRule annotation)
Alternative name(s):
ATP-dependent protease LaUniRule annotation
Gene namesi
Name:lonUniRule annotation
Ordered Locus Names:HP_1379
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi
  • UP000000429 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000761371 – 835Lon proteaseAdd BLAST835

Proteomic databases

PaxDbiP55995
PRIDEiP55995

Expressioni

Inductioni

By heat shock.UniRule annotation

Interactioni

Subunit structurei

Homohexamer. Organized in a ring with a central cavity.UniRule annotation

Protein-protein interaction databases

DIPiDIP-3184N
IntActiP55995, 7 interactors
MINTiP55995
STRINGi85962.HP1379

Structurei

3D structure databases

ProteinModelPortaliP55995
SMRiP55995
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini9 – 200Lon N-terminalPROSITE-ProRule annotationAdd BLAST192
Domaini636 – 835Lon proteolyticPROSITE-ProRule annotationAdd BLAST200

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi712 – 716Poly-Lys5

Sequence similaritiesi

Belongs to the peptidase S16 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C6P Bacteria
COG0466 LUCA
KOiK01338
OMAiGTILCFY

Family and domain databases

Gene3Di3.30.230.10, 1 hit
HAMAPiMF_01973 lon_bact, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR003959 ATPase_AAA_core
IPR027543 Lon_bac
IPR004815 Lon_bac/euk-typ
IPR008269 Lon_proteolytic
IPR027065 Lon_Prtase
IPR003111 Lon_substr-bd
IPR027417 P-loop_NTPase
IPR008268 Peptidase_S16_AS
IPR015947 PUA-like_sf
IPR020568 Ribosomal_S5_D2-typ_fold
IPR014721 Ribosomal_S5_D2-typ_fold_subgr
PANTHERiPTHR10046 PTHR10046, 1 hit
PfamiView protein in Pfam
PF00004 AAA, 1 hit
PF05362 Lon_C, 1 hit
PF02190 LON_substr_bdg, 1 hit
PIRSFiPIRSF001174 Lon_proteas, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SM00464 LON, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
SSF54211 SSF54211, 1 hit
SSF88697 SSF88697, 1 hit
TIGRFAMsiTIGR00763 lon, 1 hit
PROSITEiView protein in PROSITE
PS51787 LON_N, 1 hit
PS51786 LON_PROTEOLYTIC, 1 hit
PS01046 LON_SER, 1 hit

Sequencei

Sequence statusi: Complete.

P55995-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTEDFPKILP LLVEEDTFLY PFMIAPIFLQ NNASIKAVAY AKNNKSLVFI
60 70 80 90 100
ACQKDKLNDN EAPYYDVGVI GSVMREANMP NGRVKLLFNG IAKGRILEPA
110 120 130 140 150
KENEQGFLEA QISPIEYLEY DKENIQAIVE VLKEKVITLA NVSSLFPPDL
160 170 180 190 200
IKALEDNDDP NRIADLIAAA LHLKKDQAYS LFANNNTEQR LLDLIDIVIE
210 220 230 240 250
ETKTQKLQKE IKSKVHQKME QTNKEYFLKE QLKQIQKELG TDKQRDEDLN
260 270 280 290 300
QYYQKLESIK PFLKEEAFKE IKKQIDRLSR THADSSDSAT LQNYIETMLD
310 320 330 340 350
VPFGQYGKKA LDIKHVREQL DKDHYSLKRP KERIVEYFAT MQLLEMRRKK
360 370 380 390 400
KPEKKDKTKG TILCFYGPPG VGKTSLANSI AKAIERPLVR IALGGLEDVN
410 420 430 440 450
ELRGHRRTYI GSMPGRIVQG LIEAKKMNPV MVLDEIDKVD RSVRGDPASA
460 470 480 490 500
LLEILDPEQN TAFRDHYANF SIDLSQVIFI ATANNIDRIP APLRDRMEFI
510 520 530 540 550
SVSSYTPNEK EEIAKNYLIP QELEKHALKP SEVEISHECL KLIIEKYTRE
560 570 580 590 600
AGVRDLRRQI ATIMRKVALK YLEDNPHQKG RTKKGKNEKS EDQKSEDQKS
610 620 630 640 650
ENQKSENKDF CVSITPNNLK EYLERMVFEI DPIDEENKIG IVNGLAWTPV
660 670 680 690 700
GGDVLKIEVL KIRGKGELKL TGSLGDVMKE SAIIAFSVVK VLLDNETLKV
710 720 730 740 750
PKIPSETDAE GKKKKKVLKV YNAYDLHLHV PEGATPKDGP SAGIAMASVM
760 770 780 790 800
ASILCDRATR SEVAMTGELT LSGEVLPIGG LKEKLIAAFK AGIKTALIPV
810 820 830
KNYERDLDEI PAEVRENLNI VAVKNIAEVL EKTLL
Length:835
Mass (Da):94,419
Last modified:November 1, 1997 - v1
Checksum:i4BDA52814191C727
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA Translation: AAD08421.1
PIRiC64692
RefSeqiNP_208170.1, NC_000915.1
WP_000133787.1, NC_018939.1

Genome annotation databases

EnsemblBacteriaiAAD08421; AAD08421; HP_1379
GeneIDi900303
KEGGiheo:C694_07120
hpy:HP1379
PATRICifig|85962.47.peg.1477

Similar proteinsi

Entry informationi

Entry nameiLON_HELPY
AccessioniPrimary (citable) accession number: P55995
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: May 23, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health