Chaperone protein DnaK - Helicobacter pylori (strain ATCC 700392 / 26695)

Preferred order of sections

Names and origin

Protein names

Recommended name:
Chaperone protein DnaK

Alternative name(s):
HSP70
Heat shock 70 kDa protein
Heat shock protein 70

Gene names

Name:	dnaK
Ordered Locus Names:	HP_0109

Organism

Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)

Taxonomic identifier

85962 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter

Protein attributes

Sequence length	620 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Acts as a chaperone By similarity. HAMAP MF_00332
Induction	By stress conditions e.g. heat shock By similarity. HAMAP MF_00332
Sequence similarities	Belongs to the heat shock protein 70 family.

Ontologies

Keywords
Biological process	Stress response
Ligand	ATP-binding Nucleotide-binding
Molecular function	Chaperone
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	protein folding Inferred from electronic annotation. Source: InterPro response to stress Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW unfolded protein binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Initiator methionine

1

Removed By similarity

Chain

2 – 620

619

Chaperone protein DnaK HAMAP MF_00332

PRO_0000078470

Amino acid modifications

Modified residue

197

1

Phosphothreonine; by autocatalysis By similarity

Experimental info

Sequence conflict

26 – 29

4

IIAN → DLLRI in AAB53800. Ref.2

Sequence conflict

108

1

V → I in AAB53800. Ref.2

Sequence conflict

151

1

K → Q in AAB53800. Ref.2

Sequence conflict

155

1

E → D in AAB53800. Ref.2

Sequence conflict

177

1

A → L in AAB53800. Ref.2

Sequence conflict

307 – 308

2

MK → VE in AAB53800. Ref.2

Sequence conflict

316

1

S → G in AAB53800. Ref.2

Sequence conflict

354

1

D → E in AAB53800. Ref.2

Sequence conflict

417

1

S → SS in AAB53800. Ref.2

Sequence conflict

430 – 435

6

VSIMVL → GVPYGF in AAB53800. Ref.2

Sequence conflict

502 – 507

6

SDSEIE → TIAK in AAB53800. Ref.2

Sequence conflict

522

1

K → R in AAB53800. Ref.2

Sequence conflict

570 – 580

11

VKNDNATKAEL → IKTITLLKRI in AAB53800. Ref.2

Sequence conflict

586 – 600

15

LLAQA…EAMAN → ALKGSKIRRNGE Ref.2

Sequences

Sequence

Length

Mass (Da)

Tools

P55994 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: 8C5E42ECC0558481
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FASTA

620

67,052

        10         20         30         40         50         60 
MGKVIGIDLG TTNSAMAVYE GNEAKIIANK EGKNTTPSIV AFTDKGEILV GESAKRQAVT 

        70         80         90        100        110        120 
NPEKTIYSIK RIMGLMFNED KAKEAEKRLP YKIVDRNGAC AIEISGKVYT PQEISAKILM 

       130        140        150        160        170        180 
KLKEDAESYL GESVTEAVIT VPAYFNDSQR KATKEAGTIA GLNVLRIINE PTSAALAYGL 

       190        200        210        220        230        240 
DKKESEKIMV YDLGGGTFDV TVLETGDNVV EVLATGGDAF LGGDDFDNRV IDFLASEFKS 

       250        260        270        280        290        300 
ETGIEIKNDV MALQRLKEAA ENAKKELSSA METEINLPFI TADATGPKHL VKKLTRAKFE 

       310        320        330        340        350        360 
SLTEDLMKET ISKIESVIKD AGLTKNEISE VVMVGGSTRI PKVQERVKAF INKDLNKSVN 

       370        380        390        400        410        420 
PDEVVAVGAS IQGGVLKGDV KDVLLLDVTP LSLGIETLGG VMTKVIDRGT TIPAKKSQVF 

       430        440        450        460        470        480 
STAEDNQPAV SIMVLQGERE LARDNKSLGK FDLQGIAPAP RGVPQIEVTF DIDANGILTV 

       490        500        510        520        530        540 
SAQDKNTGKS QEIKISGSSG LSDSEIEKMV KDAELHKEED AKKKEVIEAR NHADSLAHQT 

       550        560        570        580        590        600 
QKSLDEHKTN LNENDANEIQ NAINALKDCV KNDNATKAEL EDKTKLLAQA AQKLGEAMAN 

       610        620 
KNNAEQPKKK DDDVIDAEVE

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The complete genome sequence of the gastric pathogen Helicobacter pylori." Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G., Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A., Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N., Loftus B.J., Richardson D.L., Dodson R.J. Venter J.C. Nature 388:539-547(1997) [PubMed: 9252185] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700392 / 26695.
[2]	"Characterization of an acidic-pH-inducible stress protein (hsp70), a putative sulfatide binding adhesin, from Helicobacter pylori." Huesca M., Goodwin A., Bhagwansingh A., Hoffman P., Lingwood C.A. Infect. Immun. 66:4061-4067(1998) [PubMed: 9712748] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE000511 Genomic DNA. Translation: AAD07178.1. U96271 Genomic DNA. Translation: AAB53800.1.
PIR	E64533.
RefSeq	NP_206909.1. NC_000915.1.
3D structure databases
ProteinModelPortal	P55994.
SMR	P55994. Positions 1-596.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-3190N.
MINT	MINT-161980.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	900161.
GenomeReviews	Gene locus HP_0109 in contig AE000511_GR.
KEGG	hpy:HP0109.
NMPDR	fig\|85962.1.peg.107.
PATRIC	20591433. VBIHelPyl33062_0116.
TIGR	HP_0109.
Phylogenomic databases
HOGENOM	HBG334976.
OMA	VEDDQER.
ProtClustDB	PRK00290.
Family and domain databases
HAMAP	MF_00332. DnaK. [Tree]
InterPro	IPR012725. Chaperone_DnaK. IPR018181. Heat_shock_70_CS. IPR001023. Hsp70. IPR013126. Hsp_70. [Graphical view]
KO	K04043.
PANTHER	PTHR19375. Hsp70. 1 hit.
Pfam	PF00012. HSP70. 1 hit. [Graphical view]
PRINTS	PR00301. HEATSHOCK70.
TIGRFAMs	TIGR02350. Prok_dnaK. 1 hit.
PROSITE	PS00297. HSP70_1. 1 hit. PS00329. HSP70_2. 1 hit. PS01036. HSP70_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DNAK_HELPY

Accession

Primary (citable) accession number: P55994
Secondary accession number(s): O05733

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	January 23, 2007
Last modified:	January 25, 2012
This is version 78 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program

Relevant documents

Helicobacter pylori

Helicobacter pylori (strain 26695): entries and gene names

SIMILARITY comments

Index of protein domains and families

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Amino acid modifications

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Family and domain databases

Entry information

Relevant documents