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Reviewed, UniProtKB/Swiss-Prot P55994 (DNAK_HELPY)

Last modified December 15, 2009. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Chaperone protein dnaK
Alternative name(s):
    Heat shock protein 70
    Heat shock 70 kDa protein
    HSP70
Gene names
Name: dnaK
Ordered Locus Names: HP_0109
OrganismHelicobacter pylori (Campylobacter pylori) [Complete proteome] [HAMAP]
Taxonomic identifier210 [NCBI]
Taxonomic lineageBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter

Protein attributes

Sequence length620 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Function

Acts as a chaperone By similarity.

Induction

By stress conditions e.g. heat shock By similarity.

Sequence similarities

Belongs to the heat shock protein 70 family.

Ontologies

Keywords
   Biological processStress response
   LigandATP-binding
Nucleotide-binding
   Molecular functionChaperone
   PTMPhosphoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processprotein folding

Inferred from electronic annotation. Source: InterPro

response to stress

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionATP binding

Inferred from electronic annotation. Source: HAMAP

unfolded protein binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 620619Chaperone protein dnaK HAMAP MF_00332
PRO_0000078470

Amino acid modifications

Modified residue1971Phosphothreonine; by autocatalysis By similarity

Experimental info

Sequence conflict26 – 294IIAN → DLLRI in AAB53800. Ref.2
Sequence conflict1081V → I in AAB53800. Ref.2
Sequence conflict1511K → Q in AAB53800. Ref.2
Sequence conflict1551E → D in AAB53800. Ref.2
Sequence conflict1771A → L in AAB53800. Ref.2
Sequence conflict307 – 3082MK → VE in AAB53800. Ref.2
Sequence conflict3161S → G in AAB53800. Ref.2
Sequence conflict3541D → E in AAB53800. Ref.2
Sequence conflict4171S → SS in AAB53800. Ref.2
Sequence conflict430 – 4356VSIMVL → GVPYGF in AAB53800. Ref.2
Sequence conflict502 – 5076SDSEIE → TIAK in AAB53800. Ref.2
Sequence conflict5221K → R in AAB53800. Ref.2
Sequence conflict570 – 58011VKNDNATKAEL → IKTITLLKRI in AAB53800. Ref.2
Sequence conflict586 – 60015LLAQA…EAMAN → ALKGSKIRRNGE Ref.2

Sequences

Sequence LengthMass (Da)Tools
P55994-1 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: 8C5E42ECC0558481

FASTA62067,052
        10         20         30         40         50         60 
MGKVIGIDLG TTNSAMAVYE GNEAKIIANK EGKNTTPSIV AFTDKGEILV GESAKRQAVT 

        70         80         90        100        110        120 
NPEKTIYSIK RIMGLMFNED KAKEAEKRLP YKIVDRNGAC AIEISGKVYT PQEISAKILM 

       130        140        150        160        170        180 
KLKEDAESYL GESVTEAVIT VPAYFNDSQR KATKEAGTIA GLNVLRIINE PTSAALAYGL 

       190        200        210        220        230        240 
DKKESEKIMV YDLGGGTFDV TVLETGDNVV EVLATGGDAF LGGDDFDNRV IDFLASEFKS 

       250        260        270        280        290        300 
ETGIEIKNDV MALQRLKEAA ENAKKELSSA METEINLPFI TADATGPKHL VKKLTRAKFE 

       310        320        330        340        350        360 
SLTEDLMKET ISKIESVIKD AGLTKNEISE VVMVGGSTRI PKVQERVKAF INKDLNKSVN 

       370        380        390        400        410        420 
PDEVVAVGAS IQGGVLKGDV KDVLLLDVTP LSLGIETLGG VMTKVIDRGT TIPAKKSQVF 

       430        440        450        460        470        480 
STAEDNQPAV SIMVLQGERE LARDNKSLGK FDLQGIAPAP RGVPQIEVTF DIDANGILTV 

       490        500        510        520        530        540 
SAQDKNTGKS QEIKISGSSG LSDSEIEKMV KDAELHKEED AKKKEVIEAR NHADSLAHQT 

       550        560        570        580        590        600 
QKSLDEHKTN LNENDANEIQ NAINALKDCV KNDNATKAEL EDKTKLLAQA AQKLGEAMAN 

       610        620 
KNNAEQPKKK DDDVIDAEVE 

« Hide

References

« Hide 'large scale' references
[1]"The complete genome sequence of the gastric pathogen Helicobacter pylori."
Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G., Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A., Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N., Loftus B.J., Richardson D.L., Dodson R.J. expand/collapse author list , Khalak H.G., Glodek A., McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E., Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D., Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S., Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C.
Nature 388:539-547(1997) [PubMed: 9252185] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 700392 / 26695.
[2]"Characterization of an acidic-pH-inducible stress protein (hsp70), a putative sulfatide binding adhesin, from Helicobacter pylori."
Huesca M., Goodwin A., Bhagwansingh A., Hoffman P., Lingwood C.A.
Infect. Immun. 66:4061-4067(1998) [PubMed: 9712748] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

AE000511 Genomic DNA. Translation: AAD07178.1.
U96271 Genomic DNA. Translation: AAB53800.1.
PIRE64533.
RefSeqNP_206909.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

DIPDIP-3190N.

Genome annotation databases

GeneID900161.
GenomeReviewsGene locus HP_0109 in contig AE000511_GR.
KEGGhpy:HP0109.
NMPDRfig|85962.1.peg.107.
TIGRHP_0109.

Phylogenomic databases

HOGENOMHBG334976.
OMAERIVGRQ.

Family and domain databases

HAMAPMF_00332.
[Tree]
InterProIPR012725. Chaperone_DnaK.
IPR018181. Heat_shock_70_CS.
IPR001023. Hsp70.
IPR013126. Hsp_70.
[Graphical view]
PANTHERPTHR19375. Hsp70. 1 hit.
PfamPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSPR00301. HEATSHOCK70.
PROSITEPS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDNAK_HELPY
AccessionPrimary (citable) accession number: P55994
Secondary accession number(s): O05733
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 23, 2007
Last modified: December 15, 2009
This is version 65 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

Helicobacter pylori

Helicobacter pylori (strain 26695): entries and gene names

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents