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P55990 (DHE4_HELPY) Reviewed, UniProtKB/Swiss-Prot

Last modified December 11, 2013. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NADP-specific glutamate dehydrogenase

Short name=NADP-GDH
EC=1.4.1.4
Gene names
Name:gdhA
Ordered Locus Names:HP_0380
OrganismHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) [Reference proteome] [HAMAP]
Taxonomic identifier85962 [NCBI]
Taxonomic lineageBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter

Protein attributes

Sequence length448 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the reversible oxidative deamination of glutamate to alpha-ketoglutarate and ammonia By similarity.

Catalytic activity

L-glutamate + H2O + NADP+ = 2-oxoglutarate + NH3 + NADPH.

Subunit structure

Homohexamer By similarity.

Sequence similarities

Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

Ontologies

Keywords
   LigandNADP
   Molecular functionOxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processglutamate biosynthetic process

Inferred from sequence or structural similarity. Source: UniProtKB

   Cellular_componentcytoplasm

Inferred from sequence or structural similarity. Source: UniProtKB

   Molecular_functionglutamate dehydrogenase (NADP+) activity

Inferred from sequence or structural similarity. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 448448NADP-specific glutamate dehydrogenase
PRO_0000182771

Sites

Active site1241Proton donor By similarity
Binding site881Substrate By similarity
Binding site1091Substrate By similarity
Binding site1121Substrate By similarity
Binding site1631Substrate; via carbonyl oxygen By similarity
Binding site2071NADP By similarity
Binding site2381NADP By similarity
Binding site3811Substrate By similarity
Site1641Important for catalysis By similarity

Sequences

Sequence LengthMass (Da)Tools
P55990 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: 1044636E2F696A43

FASTA44849,379
        10         20         30         40         50         60 
MYVEKILQSL QKKYPYQKEF HQAVYEAITS LKPLLDSDKS YEKHAILERL IEPEREIFFR 

        70         80         90        100        110        120 
VCWLDDNNQI QVNRGCRVEF NSAIGPYKGG LRFHPSVNES VIKFLGFEQV LKNSLTTLAM 

       130        140        150        160        170        180 
GGAKGGSDFD PKGKSEHEIM RFCQAFMNEL YRHIGATTDV PAGDIGVGER EIGYLFGQYK 

       190        200        210        220        230        240 
KLVNRFEGVL TGKGLTYGGS LCRKEATGYG CVYFAEEMLQ ERNSSLEGKV CSVSGSGNVA 

       250        260        270        280        290        300 
IYTIEKLLQI GAKPVTASDS NGMIYDKDGI DLELLKEIKE VRRGRIKEYA LEKKSAEYTP 

       310        320        330        340        350        360 
TENYPKGGNA VWHVPCFAAF PSATENELSV LDAKTLLSNG CKCVAEGANM PSSNEAIGLF 

       370        380        390        400        410        420 
LQAKISYGIG KAANAGGVSV SGLEMAQNAS MHPWSFEVVD AKLHHIMKEI YKNVSQTAKE 

       430        440 
FKDPTNFVLG ANIAGFRKVA SAMIAQGV 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE000511 Genomic DNA. Translation: AAD07448.1.
PIRD64567.
RefSeqNP_207178.1. NC_000915.1.
YP_006934304.1. NC_018939.1.

3D structure databases

ProteinModelPortalP55990.
SMRP55990. Positions 2-448.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING85962.HP0380.

Proteomic databases

PRIDEP55990.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAD07448; AAD07448; HP_0380.
GeneID13869566.
898871.
KEGGheo:C694_01930.
hpy:HP0380.
PATRIC20591997. VBIHelPyl33062_0392.

Phylogenomic databases

eggNOGCOG0334.
KOK00262.
OMAVAIYTIE.
OrthoDBEOG65XN4D.
ProtClustDBPRK09414.

Enzyme and pathway databases

BioCycHPY:HP0380-MONOMER.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
InterProIPR006095. Glu/Leu/Phe/Val_DH.
IPR006096. Glu/Leu/Phe/Val_DH_C.
IPR006097. Glu/Leu/Phe/Val_DH_dimer_dom.
IPR014362. Glu_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamPF00208. ELFV_dehydrog. 1 hit.
PF02812. ELFV_dehydrog_N. 1 hit.
[Graphical view]
PIRSFPIRSF000185. Glu_DH. 1 hit.
PRINTSPR00082. GLFDHDRGNASE.
SMARTSM00839. ELFV_dehydrog. 1 hit.
[Graphical view]
PROSITEPS00074. GLFV_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDHE4_HELPY
AccessionPrimary (citable) accession number: P55990
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: December 11, 2013
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Helicobacter pylori

Helicobacter pylori (strain 26695): entries and gene names