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Protein

NADP-specific glutamate dehydrogenase

Gene

gdhA

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidative deamination of glutamate to alpha-ketoglutarate and ammonia.By similarity

Catalytic activityi

L-glutamate + H2O + NADP+ = 2-oxoglutarate + NH3 + NADPH.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei88SubstrateBy similarity1
Binding sitei109SubstrateBy similarity1
Binding sitei112SubstrateBy similarity1
Active sitei124Proton donorPROSITE-ProRule annotation1
Binding sitei163Substrate; via carbonyl oxygenBy similarity1
Sitei164Important for catalysisBy similarity1
Binding sitei207NADPBy similarity1
Binding sitei238NADPBy similarity1
Binding sitei381SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NADP

Enzyme and pathway databases

BioCyciHPY:HP0380-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NADP-specific glutamate dehydrogenase (EC:1.4.1.4)
Short name:
NADP-GDH
Gene namesi
Name:gdhA
Ordered Locus Names:HP_0380
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi
  • UP000000429 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001827711 – 448NADP-specific glutamate dehydrogenaseAdd BLAST448

Proteomic databases

PaxDbiP55990.
PRIDEiP55990.

Interactioni

Subunit structurei

Homohexamer.By similarity

Protein-protein interaction databases

STRINGi85962.HP0380.

Structurei

3D structure databases

ProteinModelPortaliP55990.
SMRiP55990.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105D82. Bacteria.
COG0334. LUCA.
KOiK00262.
OMAiVPWVDDA.

Family and domain databases

CDDicd05313. NAD_bind_2_Glu_DH. 1 hit.
Gene3Di3.40.50.720. 1 hit.
InterProiIPR006095. Glu/Leu/Phe/Val_DH.
IPR033524. Glu/Leu/Phe/Val_DH_AS.
IPR006096. Glu/Leu/Phe/Val_DH_C.
IPR006097. Glu/Leu/Phe/Val_DH_dimer_dom.
IPR014362. Glu_DH.
IPR016040. NAD(P)-bd_dom.
IPR033922. NAD_bind_Glu_DH.
[Graphical view]
PfamiPF00208. ELFV_dehydrog. 1 hit.
PF02812. ELFV_dehydrog_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000185. Glu_DH. 1 hit.
PRINTSiPR00082. GLFDHDRGNASE.
SMARTiSM00839. ELFV_dehydrog. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00074. GLFV_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P55990-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYVEKILQSL QKKYPYQKEF HQAVYEAITS LKPLLDSDKS YEKHAILERL
60 70 80 90 100
IEPEREIFFR VCWLDDNNQI QVNRGCRVEF NSAIGPYKGG LRFHPSVNES
110 120 130 140 150
VIKFLGFEQV LKNSLTTLAM GGAKGGSDFD PKGKSEHEIM RFCQAFMNEL
160 170 180 190 200
YRHIGATTDV PAGDIGVGER EIGYLFGQYK KLVNRFEGVL TGKGLTYGGS
210 220 230 240 250
LCRKEATGYG CVYFAEEMLQ ERNSSLEGKV CSVSGSGNVA IYTIEKLLQI
260 270 280 290 300
GAKPVTASDS NGMIYDKDGI DLELLKEIKE VRRGRIKEYA LEKKSAEYTP
310 320 330 340 350
TENYPKGGNA VWHVPCFAAF PSATENELSV LDAKTLLSNG CKCVAEGANM
360 370 380 390 400
PSSNEAIGLF LQAKISYGIG KAANAGGVSV SGLEMAQNAS MHPWSFEVVD
410 420 430 440
AKLHHIMKEI YKNVSQTAKE FKDPTNFVLG ANIAGFRKVA SAMIAQGV
Length:448
Mass (Da):49,379
Last modified:November 1, 1997 - v1
Checksum:i1044636E2F696A43
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD07448.1.
PIRiD64567.
RefSeqiNP_207178.1. NC_000915.1.
WP_000289187.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD07448; AAD07448; HP_0380.
GeneIDi898871.
KEGGiheo:C694_01930.
hpy:HP0380.
PATRICi20591997. VBIHelPyl33062_0392.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD07448.1.
PIRiD64567.
RefSeqiNP_207178.1. NC_000915.1.
WP_000289187.1. NC_018939.1.

3D structure databases

ProteinModelPortaliP55990.
SMRiP55990.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi85962.HP0380.

Proteomic databases

PaxDbiP55990.
PRIDEiP55990.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD07448; AAD07448; HP_0380.
GeneIDi898871.
KEGGiheo:C694_01930.
hpy:HP0380.
PATRICi20591997. VBIHelPyl33062_0392.

Phylogenomic databases

eggNOGiENOG4105D82. Bacteria.
COG0334. LUCA.
KOiK00262.
OMAiVPWVDDA.

Enzyme and pathway databases

BioCyciHPY:HP0380-MONOMER.

Family and domain databases

CDDicd05313. NAD_bind_2_Glu_DH. 1 hit.
Gene3Di3.40.50.720. 1 hit.
InterProiIPR006095. Glu/Leu/Phe/Val_DH.
IPR033524. Glu/Leu/Phe/Val_DH_AS.
IPR006096. Glu/Leu/Phe/Val_DH_C.
IPR006097. Glu/Leu/Phe/Val_DH_dimer_dom.
IPR014362. Glu_DH.
IPR016040. NAD(P)-bd_dom.
IPR033922. NAD_bind_Glu_DH.
[Graphical view]
PfamiPF00208. ELFV_dehydrog. 1 hit.
PF02812. ELFV_dehydrog_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000185. Glu_DH. 1 hit.
PRINTSiPR00082. GLFDHDRGNASE.
SMARTiSM00839. ELFV_dehydrog. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00074. GLFV_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDHE4_HELPY
AccessioniPrimary (citable) accession number: P55990
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 30, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.