Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P55990

- DHE4_HELPY

UniProt

P55990 - DHE4_HELPY

Protein

NADP-specific glutamate dehydrogenase

Gene

gdhA

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 1 (01 Nov 1997)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalyzes the reversible oxidative deamination of glutamate to alpha-ketoglutarate and ammonia.By similarity

    Catalytic activityi

    L-glutamate + H2O + NADP+ = 2-oxoglutarate + NH3 + NADPH.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei88 – 881SubstrateBy similarity
    Binding sitei109 – 1091SubstrateBy similarity
    Binding sitei112 – 1121SubstrateBy similarity
    Active sitei124 – 1241Proton donorPROSITE-ProRule annotation
    Binding sitei163 – 1631Substrate; via carbonyl oxygenBy similarity
    Sitei164 – 1641Important for catalysisBy similarity
    Binding sitei207 – 2071NADPBy similarity
    Binding sitei238 – 2381NADPBy similarity
    Binding sitei381 – 3811SubstrateBy similarity

    GO - Molecular functioni

    1. glutamate dehydrogenase (NADP+) activity Source: UniProtKB

    GO - Biological processi

    1. glutamate biosynthetic process Source: UniProtKB

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    BioCyciHPY:HP0380-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NADP-specific glutamate dehydrogenase (EC:1.4.1.4)
    Short name:
    NADP-GDH
    Gene namesi
    Name:gdhA
    Ordered Locus Names:HP_0380
    OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
    Taxonomic identifieri85962 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
    ProteomesiUP000000429: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 448448NADP-specific glutamate dehydrogenasePRO_0000182771Add
    BLAST

    Proteomic databases

    PRIDEiP55990.

    Interactioni

    Subunit structurei

    Homohexamer.By similarity

    Protein-protein interaction databases

    STRINGi85962.HP0380.

    Structurei

    3D structure databases

    ProteinModelPortaliP55990.
    SMRiP55990. Positions 2-448.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0334.
    KOiK00262.
    OMAiRNTNECT.
    OrthoDBiEOG65XN4D.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    InterProiIPR006095. Glu/Leu/Phe/Val_DH.
    IPR006096. Glu/Leu/Phe/Val_DH_C.
    IPR006097. Glu/Leu/Phe/Val_DH_dimer_dom.
    IPR014362. Glu_DH.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PfamiPF00208. ELFV_dehydrog. 1 hit.
    PF02812. ELFV_dehydrog_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000185. Glu_DH. 1 hit.
    PRINTSiPR00082. GLFDHDRGNASE.
    SMARTiSM00839. ELFV_dehydrog. 1 hit.
    [Graphical view]
    PROSITEiPS00074. GLFV_DEHYDROGENASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P55990-1 [UniParc]FASTAAdd to Basket

    « Hide

    MYVEKILQSL QKKYPYQKEF HQAVYEAITS LKPLLDSDKS YEKHAILERL    50
    IEPEREIFFR VCWLDDNNQI QVNRGCRVEF NSAIGPYKGG LRFHPSVNES 100
    VIKFLGFEQV LKNSLTTLAM GGAKGGSDFD PKGKSEHEIM RFCQAFMNEL 150
    YRHIGATTDV PAGDIGVGER EIGYLFGQYK KLVNRFEGVL TGKGLTYGGS 200
    LCRKEATGYG CVYFAEEMLQ ERNSSLEGKV CSVSGSGNVA IYTIEKLLQI 250
    GAKPVTASDS NGMIYDKDGI DLELLKEIKE VRRGRIKEYA LEKKSAEYTP 300
    TENYPKGGNA VWHVPCFAAF PSATENELSV LDAKTLLSNG CKCVAEGANM 350
    PSSNEAIGLF LQAKISYGIG KAANAGGVSV SGLEMAQNAS MHPWSFEVVD 400
    AKLHHIMKEI YKNVSQTAKE FKDPTNFVLG ANIAGFRKVA SAMIAQGV 448
    Length:448
    Mass (Da):49,379
    Last modified:November 1, 1997 - v1
    Checksum:i1044636E2F696A43
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000511 Genomic DNA. Translation: AAD07448.1.
    PIRiD64567.
    RefSeqiNP_207178.1. NC_000915.1.
    YP_006934304.1. NC_018939.1.

    Genome annotation databases

    EnsemblBacteriaiAAD07448; AAD07448; HP_0380.
    GeneIDi13869566.
    898871.
    KEGGiheo:C694_01930.
    hpy:HP0380.
    PATRICi20591997. VBIHelPyl33062_0392.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000511 Genomic DNA. Translation: AAD07448.1 .
    PIRi D64567.
    RefSeqi NP_207178.1. NC_000915.1.
    YP_006934304.1. NC_018939.1.

    3D structure databases

    ProteinModelPortali P55990.
    SMRi P55990. Positions 2-448.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 85962.HP0380.

    Proteomic databases

    PRIDEi P55990.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD07448 ; AAD07448 ; HP_0380 .
    GeneIDi 13869566.
    898871.
    KEGGi heo:C694_01930.
    hpy:HP0380.
    PATRICi 20591997. VBIHelPyl33062_0392.

    Phylogenomic databases

    eggNOGi COG0334.
    KOi K00262.
    OMAi RNTNECT.
    OrthoDBi EOG65XN4D.

    Enzyme and pathway databases

    BioCyci HPY:HP0380-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    InterProi IPR006095. Glu/Leu/Phe/Val_DH.
    IPR006096. Glu/Leu/Phe/Val_DH_C.
    IPR006097. Glu/Leu/Phe/Val_DH_dimer_dom.
    IPR014362. Glu_DH.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    Pfami PF00208. ELFV_dehydrog. 1 hit.
    PF02812. ELFV_dehydrog_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000185. Glu_DH. 1 hit.
    PRINTSi PR00082. GLFDHDRGNASE.
    SMARTi SM00839. ELFV_dehydrog. 1 hit.
    [Graphical view ]
    PROSITEi PS00074. GLFV_DEHYDROGENASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700392 / 26695.

    Entry informationi

    Entry nameiDHE4_HELPY
    AccessioniPrimary (citable) accession number: P55990
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Helicobacter pylori
      Helicobacter pylori (strain 26695): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3