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P55990

- DHE4_HELPY

UniProt

P55990 - DHE4_HELPY

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Protein

NADP-specific glutamate dehydrogenase

Gene
gdhA, HP_0380
Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidative deamination of glutamate to alpha-ketoglutarate and ammonia By similarity.

Catalytic activityi

L-glutamate + H2O + NADP+ = 2-oxoglutarate + NH3 + NADPH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei88 – 881Substrate By similarity
Binding sitei109 – 1091Substrate By similarity
Binding sitei112 – 1121Substrate By similarity
Active sitei124 – 1241Proton donor By similarity
Binding sitei163 – 1631Substrate; via carbonyl oxygen By similarity
Sitei164 – 1641Important for catalysis By similarity
Binding sitei207 – 2071NADP By similarity
Binding sitei238 – 2381NADP By similarity
Binding sitei381 – 3811Substrate By similarity

GO - Molecular functioni

  1. glutamate dehydrogenase (NADP+) activity Source: UniProtKB

GO - Biological processi

  1. glutamate biosynthetic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NADP

Enzyme and pathway databases

BioCyciHPY:HP0380-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NADP-specific glutamate dehydrogenase (EC:1.4.1.4)
Short name:
NADP-GDH
Gene namesi
Name:gdhA
Ordered Locus Names:HP_0380
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000429: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 448448NADP-specific glutamate dehydrogenasePRO_0000182771Add
BLAST

Proteomic databases

PRIDEiP55990.

Interactioni

Subunit structurei

Homohexamer By similarity.

Protein-protein interaction databases

STRINGi85962.HP0380.

Structurei

3D structure databases

ProteinModelPortaliP55990.
SMRiP55990. Positions 2-448.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0334.
KOiK00262.
OMAiRNTNECT.
OrthoDBiEOG65XN4D.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR006095. Glu/Leu/Phe/Val_DH.
IPR006096. Glu/Leu/Phe/Val_DH_C.
IPR006097. Glu/Leu/Phe/Val_DH_dimer_dom.
IPR014362. Glu_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00208. ELFV_dehydrog. 1 hit.
PF02812. ELFV_dehydrog_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000185. Glu_DH. 1 hit.
PRINTSiPR00082. GLFDHDRGNASE.
SMARTiSM00839. ELFV_dehydrog. 1 hit.
[Graphical view]
PROSITEiPS00074. GLFV_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P55990-1 [UniParc]FASTAAdd to Basket

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MYVEKILQSL QKKYPYQKEF HQAVYEAITS LKPLLDSDKS YEKHAILERL    50
IEPEREIFFR VCWLDDNNQI QVNRGCRVEF NSAIGPYKGG LRFHPSVNES 100
VIKFLGFEQV LKNSLTTLAM GGAKGGSDFD PKGKSEHEIM RFCQAFMNEL 150
YRHIGATTDV PAGDIGVGER EIGYLFGQYK KLVNRFEGVL TGKGLTYGGS 200
LCRKEATGYG CVYFAEEMLQ ERNSSLEGKV CSVSGSGNVA IYTIEKLLQI 250
GAKPVTASDS NGMIYDKDGI DLELLKEIKE VRRGRIKEYA LEKKSAEYTP 300
TENYPKGGNA VWHVPCFAAF PSATENELSV LDAKTLLSNG CKCVAEGANM 350
PSSNEAIGLF LQAKISYGIG KAANAGGVSV SGLEMAQNAS MHPWSFEVVD 400
AKLHHIMKEI YKNVSQTAKE FKDPTNFVLG ANIAGFRKVA SAMIAQGV 448
Length:448
Mass (Da):49,379
Last modified:November 1, 1997 - v1
Checksum:i1044636E2F696A43
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000511 Genomic DNA. Translation: AAD07448.1.
PIRiD64567.
RefSeqiNP_207178.1. NC_000915.1.
YP_006934304.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD07448; AAD07448; HP_0380.
GeneIDi13869566.
898871.
KEGGiheo:C694_01930.
hpy:HP0380.
PATRICi20591997. VBIHelPyl33062_0392.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000511 Genomic DNA. Translation: AAD07448.1 .
PIRi D64567.
RefSeqi NP_207178.1. NC_000915.1.
YP_006934304.1. NC_018939.1.

3D structure databases

ProteinModelPortali P55990.
SMRi P55990. Positions 2-448.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 85962.HP0380.

Proteomic databases

PRIDEi P55990.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD07448 ; AAD07448 ; HP_0380 .
GeneIDi 13869566.
898871.
KEGGi heo:C694_01930.
hpy:HP0380.
PATRICi 20591997. VBIHelPyl33062_0392.

Phylogenomic databases

eggNOGi COG0334.
KOi K00262.
OMAi RNTNECT.
OrthoDBi EOG65XN4D.

Enzyme and pathway databases

BioCyci HPY:HP0380-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
InterProi IPR006095. Glu/Leu/Phe/Val_DH.
IPR006096. Glu/Leu/Phe/Val_DH_C.
IPR006097. Glu/Leu/Phe/Val_DH_dimer_dom.
IPR014362. Glu_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
Pfami PF00208. ELFV_dehydrog. 1 hit.
PF02812. ELFV_dehydrog_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000185. Glu_DH. 1 hit.
PRINTSi PR00082. GLFDHDRGNASE.
SMARTi SM00839. ELFV_dehydrog. 1 hit.
[Graphical view ]
PROSITEi PS00074. GLFV_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700392 / 26695.

Entry informationi

Entry nameiDHE4_HELPY
AccessioniPrimary (citable) accession number: P55990
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: September 3, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi