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Protein

Copper-transporting ATPase

Gene

copA

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Probably involved in copper export.

Catalytic activityi

ATP + H2O + Cu2+(Side 1) = ADP + phosphate + Cu2+(Side 2).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi12CopperPROSITE-ProRule annotation1
Metal bindingi15CopperPROSITE-ProRule annotation1
Active sitei4354-aspartylphosphate intermediateBy similarity1
Metal bindingi631MagnesiumPROSITE-ProRule annotation1
Metal bindingi635MagnesiumPROSITE-ProRule annotation1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Copper transport, Ion transport, Transport

Keywords - Ligandi

ATP-binding, Copper, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciHPY:HP1072-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Copper-transporting ATPase (EC:3.6.3.4)
Gene namesi
Name:copA
Ordered Locus Names:HP_1072
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi
  • UP000000429 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 83CytoplasmicSequence analysisAdd BLAST83
Transmembranei84 – 104HelicalSequence analysisAdd BLAST21
Topological domaini105 – 124ExtracellularSequence analysisAdd BLAST20
Transmembranei125 – 144HelicalSequence analysisAdd BLAST20
Topological domaini145 – 151CytoplasmicSequence analysis7
Transmembranei152 – 172HelicalSequence analysisAdd BLAST21
Topological domaini173 – 194ExtracellularSequence analysisAdd BLAST22
Transmembranei195 – 215HelicalSequence analysisAdd BLAST21
Topological domaini216 – 343CytoplasmicSequence analysisAdd BLAST128
Transmembranei344 – 366HelicalSequence analysisAdd BLAST23
Topological domaini367 – 379ExtracellularSequence analysisAdd BLAST13
Transmembranei380 – 397HelicalSequence analysisAdd BLAST18
Topological domaini398 – 685CytoplasmicSequence analysisAdd BLAST288
Transmembranei686 – 705HelicalSequence analysisAdd BLAST20
Topological domaini706 – 716ExtracellularSequence analysisAdd BLAST11
Transmembranei717 – 735HelicalSequence analysisAdd BLAST19
Topological domaini736 – 745CytoplasmicSequence analysis10

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000461701 – 745Copper-transporting ATPaseAdd BLAST745

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP55989.

Interactioni

Protein-protein interaction databases

DIPiDIP-3096N.
IntActiP55989. 14 interactors.
MINTiMINT-159462.
STRINGi85962.HP1072.

Structurei

3D structure databases

ProteinModelPortaliP55989.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 68HMAPROSITE-ProRule annotationAdd BLAST67

Sequence similaritiesi

Contains 1 HMA domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105C59. Bacteria.
COG2217. LUCA.
KOiK17686.
OMAiTQANVGI.

Family and domain databases

CDDicd00371. HMA. 1 hit.
Gene3Di2.70.150.10. 1 hit.
3.40.1110.10. 1 hit.
3.40.50.1000. 2 hits.
InterProiIPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR017969. Heavy-metal-associated_CS.
IPR006121. HMA_dom.
IPR027256. P-typ_ATPase_IB.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF00122. E1-E2_ATPase. 1 hit.
PF00403. HMA. 1 hit.
[Graphical view]
SUPFAMiSSF55008. SSF55008. 1 hit.
SSF56784. SSF56784. 2 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01525. ATPase-IB_hvy. 1 hit.
TIGR01494. ATPase_P-type. 1 hit.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
PS01047. HMA_1. 1 hit.
PS50846. HMA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P55989-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKESFYIEGM TCTACSSGIE RSLGRKSFVK KIEVSLLNKS ANIEFDENQT
60 70 80 90 100
NLDEIFKLIE KLGYSPKKAL TKEKKEFFSP NVKLALAVIF TLFVVYLSMG
110 120 130 140 150
AMLSPSLLPE SLLAIDNHSN FLNACLQLIG ALIVMHLGRD FYIQGFKALW
160 170 180 190 200
HRQPNMSSLI AIGTSAALIS SLWQLYLVYT NHYTDQWSYG HYYFESVCVI
210 220 230 240 250
LMFVMVGKRI ENVSKDKALD AMQALMKNAP KTALKMQNNQ QIEVLVDSIV
260 270 280 290 300
VGDILKVLPG SAIAVDGEII EGEGELDESM LSGEALPVYK KVGDKVFSGT
310 320 330 340 350
FNSHTSFLMK ATQNNKNSTL SQIIEMIYNA QSSKAEISRL ADKVSSVFVP
360 370 380 390 400
SVIAISILAF VVWLIIAPKP DFWWNFGIAL EVFVSVLVIS CPCALGLATP
410 420 430 440 450
MSILVANQKA SSLGLFFKDA KSLEKARLVN TIVFDKTGTL TNGKPVVKSV
460 470 480 490 500
HSKIELLELL SLALSIEKSS EHVIAKGIVE YAKEHNAPLK EMSGVKVKTG
510 520 530 540 550
FGISAKTDYQ GTKEIIKVGN SEFFNPINTL EIKENGILVF VGRAISEKED
560 570 580 590 600
ELLGAFVLED LPKKGVKEHI AQIKNLGINT FLLSGDNREN VQKCAFELGI
610 620 630 640 650
DGYISNAKPQ DKLNKIKELK EKGQIVMMVG DGLNDAPSLA MSDVAVVMAK
660 670 680 690 700
GSDVSVQAAD IVSFNNDIKS VYSAIKLSQA TIKNIKENLF WAFCYNSVFI
710 720 730 740
PLACGVLYKA NLMLSPAIAG LAMSLSSVSV VLNSQRLRNF KIKDH
Length:745
Mass (Da):81,853
Last modified:November 1, 1997 - v1
Checksum:i855C10A737C072C9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD08117.1.
PIRiH64653.
RefSeqiNP_207863.1. NC_000915.1.
WP_000664941.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD08117; AAD08117; HP_1072.
GeneIDi899608.
KEGGiheo:C694_05540.
hpy:HP1072.
PATRICi20593483. VBIHelPyl33062_1121.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD08117.1.
PIRiH64653.
RefSeqiNP_207863.1. NC_000915.1.
WP_000664941.1. NC_018939.1.

3D structure databases

ProteinModelPortaliP55989.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-3096N.
IntActiP55989. 14 interactors.
MINTiMINT-159462.
STRINGi85962.HP1072.

Proteomic databases

PaxDbiP55989.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD08117; AAD08117; HP_1072.
GeneIDi899608.
KEGGiheo:C694_05540.
hpy:HP1072.
PATRICi20593483. VBIHelPyl33062_1121.

Phylogenomic databases

eggNOGiENOG4105C59. Bacteria.
COG2217. LUCA.
KOiK17686.
OMAiTQANVGI.

Enzyme and pathway databases

BioCyciHPY:HP1072-MONOMER.

Family and domain databases

CDDicd00371. HMA. 1 hit.
Gene3Di2.70.150.10. 1 hit.
3.40.1110.10. 1 hit.
3.40.50.1000. 2 hits.
InterProiIPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR017969. Heavy-metal-associated_CS.
IPR006121. HMA_dom.
IPR027256. P-typ_ATPase_IB.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF00122. E1-E2_ATPase. 1 hit.
PF00403. HMA. 1 hit.
[Graphical view]
SUPFAMiSSF55008. SSF55008. 1 hit.
SSF56784. SSF56784. 2 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01525. ATPase-IB_hvy. 1 hit.
TIGR01494. ATPase_P-type. 1 hit.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
PS01047. HMA_1. 1 hit.
PS50846. HMA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCOPA_HELPY
AccessioniPrimary (citable) accession number: P55989
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 30, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.