Reviewed, UniProtKB/Swiss-Prot P55989 (COPA_HELPY)

Names and origin

Protein names

Recommended name:
    Copper-transporting ATPase
    EC=3.6.3.4

Gene names

Name:	copA
Ordered Locus Names:	HP_1072

Organism

Helicobacter pylori (Campylobacter pylori) [Complete proteome] [HAMAP]

Taxonomic identifier

210 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter

Protein attributes

Sequence length	745 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Probably involved in copper export.
Catalytic activity	ATP + H(2)O + Cu(2+)(In) = ADP + phosphate + Cu(2+)(Out).
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the cation transport ATPase (P-type) family. Type IB subfamily. Contains 1 HMA domain.

Ontologies

Keywords
Biological process	Copper transport Ion transport Transport
Cellular component	Cell membrane Membrane
Domain	Transmembrane
Ligand	ATP-binding Copper Magnesium Metal-binding Nucleotide-binding
Molecular function	Hydrolase
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	copper ion transport Inferred from electronic annotation. Source: InterPro metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: InterPro plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: InterPro copper ion binding Inferred from electronic annotation. Source: UniProtKB-KW copper-exporting ATPase activity Inferred from electronic annotation. Source: InterPro magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 745	745	Copper-transporting ATPase		PRO_0000046170
Regions
	Topological domain	1 – 83	83	Cytoplasmic Potential
	Transmembrane	84 – 104	21	Potential
	Topological domain	105 – 124	20	Extracellular Potential
	Transmembrane	125 – 144	20	Potential
	Topological domain	145 – 151	7	Cytoplasmic Potential
	Transmembrane	152 – 172	21	Potential
	Topological domain	173 – 194	22	Extracellular Potential
	Transmembrane	195 – 215	21	Potential
	Topological domain	216 – 343	128	Cytoplasmic Potential
	Transmembrane	344 – 366	23	Potential
	Topological domain	367 – 379	13	Extracellular Potential
	Transmembrane	380 – 397	18	Potential
	Topological domain	398 – 685	288	Cytoplasmic Potential
	Transmembrane	686 – 705	20	Potential
	Topological domain	706 – 716	11	Extracellular Potential
	Transmembrane	717 – 735	19	Potential
	Topological domain	736 – 745	10	Cytoplasmic Potential
	Domain	2 – 68	67	HMA
Sites
	Active site	435	1	4-aspartylphosphate intermediate By similarity
	Metal binding	12	1	Copper Potential
	Metal binding	15	1	Copper Potential
	Metal binding	631	1	Magnesium By similarity
	Metal binding	635	1	Magnesium By similarity

Sequences

	Sequence		Length	Mass (Da)
	P55989-1 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: 855C10A737C072C9	FASTA	745	81,853
	10 20 30 40 50 60 MKESFYIEGM TCTACSSGIE RSLGRKSFVK KIEVSLLNKS ANIEFDENQT NLDEIFKLIE 70 80 90 100 110 120 KLGYSPKKAL TKEKKEFFSP NVKLALAVIF TLFVVYLSMG AMLSPSLLPE SLLAIDNHSN 130 140 150 160 170 180 FLNACLQLIG ALIVMHLGRD FYIQGFKALW HRQPNMSSLI AIGTSAALIS SLWQLYLVYT 190 200 210 220 230 240 NHYTDQWSYG HYYFESVCVI LMFVMVGKRI ENVSKDKALD AMQALMKNAP KTALKMQNNQ 250 260 270 280 290 300 QIEVLVDSIV VGDILKVLPG SAIAVDGEII EGEGELDESM LSGEALPVYK KVGDKVFSGT 310 320 330 340 350 360 FNSHTSFLMK ATQNNKNSTL SQIIEMIYNA QSSKAEISRL ADKVSSVFVP SVIAISILAF 370 380 390 400 410 420 VVWLIIAPKP DFWWNFGIAL EVFVSVLVIS CPCALGLATP MSILVANQKA SSLGLFFKDA 430 440 450 460 470 480 KSLEKARLVN TIVFDKTGTL TNGKPVVKSV HSKIELLELL SLALSIEKSS EHVIAKGIVE 490 500 510 520 530 540 YAKEHNAPLK EMSGVKVKTG FGISAKTDYQ GTKEIIKVGN SEFFNPINTL EIKENGILVF 550 560 570 580 590 600 VGRAISEKED ELLGAFVLED LPKKGVKEHI AQIKNLGINT FLLSGDNREN VQKCAFELGI 610 620 630 640 650 660 DGYISNAKPQ DKLNKIKELK EKGQIVMMVG DGLNDAPSLA MSDVAVVMAK GSDVSVQAAD 670 680 690 700 710 720 IVSFNNDIKS VYSAIKLSQA TIKNIKENLF WAFCYNSVFI PLACGVLYKA NLMLSPAIAG 730 740 LAMSLSSVSV VLNSQRLRNF KIKDH

References

[1]

"The complete genome sequence of the gastric pathogen Helicobacter pylori." Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G., Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A., Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N., Loftus B.J., Richardson D.L., Dodson R.J. , Khalak H.G., Glodek A., McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E., Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D., Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S., Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C. Nature 388:539-547(1997) [PubMed: 9252185] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700392 / 26695.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE000511 Genomic DNA. Translation: AAD08117.1.
PIR	H64653.
RefSeq	NP_207863.1.
3D structure databases
HSSP	HSSP built from PDB template 1CPZ based on UniProtKB Q47840.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP:3096N.
Genome annotation databases
GeneID	899608.
GenomeReviews	Gene locus HP_1072 in contig AE000511_GR.
KEGG	hpy:HP1072.
NMPDR	fig|85962.1.peg.1059.
TIGR	HP_1072.
Phylogenomic databases
HOGENOM	P55989.
Family and domain databases
InterPro	IPR006416. ATPase-IB_hvy. IPR001757. ATPase_P. IPR006403. ATPase_P_cat/Cu. IPR001756. ATPase_P_Cu. IPR005834. Dehalogen-like_hydro. IPR008250. E1-E2_ATPase_reg. IPR006121. HeavyMe_transpt. [Graphical view]
PANTHER	PTHR11939. ATPase_P. 1 hit.
Pfam	PF00122. E1-E2_ATPase. 1 hit. PF00403. HMA. 1 hit. PF00702. Hydrolase. 1 hit. [Graphical view]
PRINTS	PR00119. CATATPASE. PR00943. CUATPASE.
TIGRFAMs	TIGR01511. ATPase-IB1_Cu. 1 hit. TIGR01525. ATPase-IB_hvy. 1 hit. TIGR01494. ATPase_P-type. 2 hits.
PROSITE	PS00154. ATPASE_E1_E2. 1 hit. PS01047. HMA_1. 1 hit. PS50846. HMA_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

COPA_HELPY

Accession

Primary (citable) accession number: P55989

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	November 25, 2008
This is version 66 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)