Skip Header

Contribute Send feedback
Read comments (?) or add your own

P55987 (ATPA_HELPY) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
ATP synthase subunit alpha
EC=3.6.3.14
Alternative name(s):
ATP synthase F1 sector subunit alpha
F-ATPase subunit alpha
Gene names
Name:atpA
Ordered Locus Names:HP_1134
OrganismHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifier85962 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter

Protein attributes

Sequence length503 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. HAMAP MF_01346

Catalytic activity

ATP + H2O + H+(In) = ADP + phosphate + H+(Out). HAMAP MF_01346

Subunit structure

F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF1 has five subunits: alpha3, beta3, gamma1, delta1, epsilon1. CF0 has three main subunits: a1, b2 and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF1 is attached to CF0 by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains By similarity.

Subcellular location

Cell inner membrane; Peripheral membrane protein By similarity HAMAP MF_01346.

Sequence similarities

Belongs to the ATPase alpha/beta chains family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 503503ATP synthase subunit alpha HAMAP MF_01346
PRO_0000144330

Regions

Nucleotide binding170 – 1778ATP By similarity

Sites

Site3631Required for activity By similarity

Sequences

Sequence LengthMass (Da)Tools
P55987 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: 2A4F3508860AAA75

FASTA50355,143
        10         20         30         40         50         60 
MSQLKLEEIS SVIEEKIKNF ELDCDMAEVG KVVSYADGVA KVYGLNGVMS YEVLEFETGD 

        70         80         90        100        110        120 
KGVAANLEED SVGVIVFGFG NNIKEGTSVK RTKSLMKVPV GDAVVGRVLN ALGEPIDGKG 

       130        140        150        160        170        180 
EIETNEFSLI EQKAPGIMDR KSVHEPLQTG IKAIDALVPI GRGQRELIIG DKQTGKTTVA 

       190        200        210        220        230        240 
IDAIINQKGQ NVICIYVAIG QKESTVAQVV RKLEEYGAME YSVVINASAS DSAAMQYLAP 

       250        260        270        280        290        300 
YSGVAMGEYF RDHARHALII YDDLSKHAVA YREISLILRR PPGREAFPGD VFYIHSRLLE 

       310        320        330        340        350        360 
RAAKLCDEKG AGSLTALPIV ETQAGDVSAY IPTNIISITD GQIFLETDLF YSGIRPAINV 

       370        380        390        400        410        420 
GLSVSRVGGA AQIKATKQVS GTLRLDLAQY RELQAFTQFA SDLDEASKKQ LERGQRMVEV 

       430        440        450        460        470        480 
LKQAPYSPLP IEKQVVIIYA GAKGFLDSVS VKKVVDFEEQ LHPFLEAKYP QVLEEIHTKK 

       490        500 
ALDKDLEAML RKVLEEFKLT YSE

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE000511 Genomic DNA. Translation: AAD08176.1.
PIRF64661.
RefSeqNP_207925.1. NC_000915.1.

3D structure databases

ProteinModelPortalP55987.
SMRP55987. Positions 28-502.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID899671.
GenomeReviewsGene locus HP_1134 in contig AE000511_GR.
KEGGhpy:HP1134.
NMPDRfig|85962.1.peg.1121.
PATRIC20593613. VBIHelPyl33062_1186.
TIGRHP_1134.

Phylogenomic databases

HOGENOMHBG565875.
OMAFRVGIKA.
ProtClustDBPRK09281.

Family and domain databases

HAMAPMF_01346. ATP_synth_alpha_bact.
[Tree]
InterProIPR020003. ATPase_a/bsu_AS.
IPR005294. ATPase_F1-cplx_asu.
IPR018118. ATPase_F1/A1-cplx_a/bsu_N.
IPR023366. ATPase_F1/A1-cplx_a_su_N.
IPR000793. ATPase_F1/V1/A1-cplx_a/bsu_C.
IPR004100. ATPase_F1/V1/A1-cplx_a/bsu_N.
IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd.
[Graphical view]
Gene3DG3DSA:2.40.30.20. G3DSA:2.40.30.20. 1 hit.
KOK02111.
PANTHERPTHR15184:SF3. ATPase_F1_a. 1 hit.
PfamPF00006. ATP-synt_ab. 1 hit.
PF00306. ATP-synt_ab_C. 1 hit.
PF02874. ATP-synt_ab_N. 1 hit.
[Graphical view]
SUPFAMSSF47917. ATPase_a/b_C. 1 hit.
SSF50615. ATPase_a/b_N. 1 hit.
TIGRFAMsTIGR00962. AtpA. 1 hit.
PROSITEPS00152. ATPASE_ALPHA_BETA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameATPA_HELPY
AccessionPrimary (citable) accession number: P55987
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: January 25, 2012
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Helicobacter pylori

Helicobacter pylori (strain 26695): entries and gene names

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents