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Protein

Uncharacterized RNA pseudouridine synthase HP_1459

Gene

HP_1459

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

RNA uridine = RNA pseudouridine.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei108 – 1081NucleophileBy similarity

GO - Molecular functioni

  1. pseudouridine synthase activity Source: InterPro
  2. RNA binding Source: UniProtKB-KW

GO - Biological processi

  1. pseudouridine synthesis Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

BioCyciHPY:HP1459-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized RNA pseudouridine synthase HP_1459 (EC:5.4.99.-)
Alternative name(s):
RNA pseudouridylate synthase
RNA-uridine isomerase
Gene namesi
Ordered Locus Names:HP_1459
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000429: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 262262Uncharacterized RNA pseudouridine synthase HP_1459PRO_0000100026Add
BLAST

Proteomic databases

PRIDEiP55986.

Interactioni

Protein-protein interaction databases

DIPiDIP-3572N.
IntActiP55986. 1 interaction.
MINTiMINT-178262.
STRINGi85962.HP1459.

Structurei

3D structure databases

ProteinModelPortaliP55986.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 7065S4 RNA-bindingPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the pseudouridine synthase RsuA family.Curated
Contains 1 S4 RNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG1187.
KOiK06178.
OMAiHAFMANA.
OrthoDBiEOG6130DV.

Family and domain databases

Gene3Di3.10.290.10. 1 hit.
InterProiIPR020103. PsdUridine_synth_cat_dom.
IPR000748. PsdUridine_synth_RsuA/RluB/E/F.
IPR018496. PsdUridine_synth_RsuA/RluB_CS.
IPR006145. PsdUridine_synth_RsuA/RluD.
IPR002942. S4_RNA-bd.
[Graphical view]
PfamiPF00849. PseudoU_synth_2. 1 hit.
PF01479. S4. 1 hit.
[Graphical view]
SMARTiSM00363. S4. 1 hit.
[Graphical view]
SUPFAMiSSF55120. SSF55120. 1 hit.
TIGRFAMsiTIGR00093. TIGR00093. 1 hit.
PROSITEiPS01149. PSI_RSU. 1 hit.
PS50889. S4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P55986-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEGFSLRINQ FLAHYTKHSR REAEKLVLEG RVKINHEHAK LASVVKENDR
60 70 80 90 100
VFLDKRLIKP LKNKKFSVLV YHKPKGELVS KADPLKRRVI YESLEKKYAH
110 120 130 140 150
FAPVGRLDFA SEGVLLLSDS KAVVSALMHA DLEKEYLIKI QGFVTREMEN
160 170 180 190 200
AMQEGLKLEN ATKGAHQKTP IKSMEFAPFI GYEIIKNHAK YSKLRVIINE
210 220 230 240 250
GKNRELRRFF AFFNAGVLDL RRVRYGFVNL NALPVGKMRF LNRQEYNELH
260
AFMANAANVK GD
Length:262
Mass (Da):30,228
Last modified:November 1, 1997 - v1
Checksum:i9FDC9FB290F14EA9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD08501.1.
PIRiC64702.
RefSeqiNP_208250.1. NC_000915.1.

Genome annotation databases

EnsemblBacteriaiAAD08501; AAD08501; HP_1459.
GeneIDi899834.
KEGGihpy:HP1459.
PATRICi20594329. VBIHelPyl33062_1533.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD08501.1.
PIRiC64702.
RefSeqiNP_208250.1. NC_000915.1.

3D structure databases

ProteinModelPortaliP55986.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-3572N.
IntActiP55986. 1 interaction.
MINTiMINT-178262.
STRINGi85962.HP1459.

Proteomic databases

PRIDEiP55986.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD08501; AAD08501; HP_1459.
GeneIDi899834.
KEGGihpy:HP1459.
PATRICi20594329. VBIHelPyl33062_1533.

Phylogenomic databases

eggNOGiCOG1187.
KOiK06178.
OMAiHAFMANA.
OrthoDBiEOG6130DV.

Enzyme and pathway databases

BioCyciHPY:HP1459-MONOMER.

Family and domain databases

Gene3Di3.10.290.10. 1 hit.
InterProiIPR020103. PsdUridine_synth_cat_dom.
IPR000748. PsdUridine_synth_RsuA/RluB/E/F.
IPR018496. PsdUridine_synth_RsuA/RluB_CS.
IPR006145. PsdUridine_synth_RsuA/RluD.
IPR002942. S4_RNA-bd.
[Graphical view]
PfamiPF00849. PseudoU_synth_2. 1 hit.
PF01479. S4. 1 hit.
[Graphical view]
SMARTiSM00363. S4. 1 hit.
[Graphical view]
SUPFAMiSSF55120. SSF55120. 1 hit.
TIGRFAMsiTIGR00093. TIGR00093. 1 hit.
PROSITEiPS01149. PSI_RSU. 1 hit.
PS50889. S4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700392 / 26695.

Entry informationi

Entry nameiY1459_HELPY
AccessioniPrimary (citable) accession number: P55986
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: January 7, 2015
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.