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P55986

- Y1459_HELPY

UniProt

P55986 - Y1459_HELPY

Protein

Uncharacterized RNA pseudouridine synthase HP_1459

Gene

HP_1459

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 1 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    RNA uridine = RNA pseudouridine.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei108 – 1081NucleophileBy similarity

    GO - Molecular functioni

    1. pseudouridine synthase activity Source: InterPro
    2. RNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. pseudouridine synthesis Source: InterPro

    Keywords - Molecular functioni

    Isomerase

    Keywords - Ligandi

    RNA-binding

    Enzyme and pathway databases

    BioCyciHPY:HP1459-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Uncharacterized RNA pseudouridine synthase HP_1459 (EC:5.4.99.-)
    Alternative name(s):
    RNA pseudouridylate synthase
    RNA-uridine isomerase
    Gene namesi
    Ordered Locus Names:HP_1459
    OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
    Taxonomic identifieri85962 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
    ProteomesiUP000000429: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 262262Uncharacterized RNA pseudouridine synthase HP_1459PRO_0000100026Add
    BLAST

    Proteomic databases

    PRIDEiP55986.

    Interactioni

    Protein-protein interaction databases

    DIPiDIP-3572N.
    IntActiP55986. 1 interaction.
    MINTiMINT-178262.
    STRINGi85962.HP1459.

    Structurei

    3D structure databases

    ProteinModelPortaliP55986.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini6 – 7065S4 RNA-bindingPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the pseudouridine synthase RsuA family.Curated
    Contains 1 S4 RNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG1187.
    KOiK06178.
    OMAiNDGEFAY.
    OrthoDBiEOG6130DV.

    Family and domain databases

    Gene3Di3.10.290.10. 1 hit.
    InterProiIPR020103. PsdUridine_synth_cat_dom.
    IPR000748. PsdUridine_synth_RsuA/RluB/E/F.
    IPR018496. PsdUridine_synth_RsuA/RluB_CS.
    IPR006145. PsdUridine_synth_RsuA/RluD.
    IPR002942. S4_RNA-bd.
    [Graphical view]
    PfamiPF00849. PseudoU_synth_2. 1 hit.
    PF01479. S4. 1 hit.
    [Graphical view]
    SMARTiSM00363. S4. 1 hit.
    [Graphical view]
    SUPFAMiSSF55120. SSF55120. 1 hit.
    TIGRFAMsiTIGR00093. TIGR00093. 1 hit.
    PROSITEiPS01149. PSI_RSU. 1 hit.
    PS50889. S4. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P55986-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEGFSLRINQ FLAHYTKHSR REAEKLVLEG RVKINHEHAK LASVVKENDR    50
    VFLDKRLIKP LKNKKFSVLV YHKPKGELVS KADPLKRRVI YESLEKKYAH 100
    FAPVGRLDFA SEGVLLLSDS KAVVSALMHA DLEKEYLIKI QGFVTREMEN 150
    AMQEGLKLEN ATKGAHQKTP IKSMEFAPFI GYEIIKNHAK YSKLRVIINE 200
    GKNRELRRFF AFFNAGVLDL RRVRYGFVNL NALPVGKMRF LNRQEYNELH 250
    AFMANAANVK GD 262
    Length:262
    Mass (Da):30,228
    Last modified:November 1, 1997 - v1
    Checksum:i9FDC9FB290F14EA9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000511 Genomic DNA. Translation: AAD08501.1.
    PIRiC64702.
    RefSeqiNP_208250.1. NC_000915.1.

    Genome annotation databases

    EnsemblBacteriaiAAD08501; AAD08501; HP_1459.
    GeneIDi899834.
    KEGGihpy:HP1459.
    PATRICi20594329. VBIHelPyl33062_1533.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000511 Genomic DNA. Translation: AAD08501.1 .
    PIRi C64702.
    RefSeqi NP_208250.1. NC_000915.1.

    3D structure databases

    ProteinModelPortali P55986.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-3572N.
    IntActi P55986. 1 interaction.
    MINTi MINT-178262.
    STRINGi 85962.HP1459.

    Proteomic databases

    PRIDEi P55986.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD08501 ; AAD08501 ; HP_1459 .
    GeneIDi 899834.
    KEGGi hpy:HP1459.
    PATRICi 20594329. VBIHelPyl33062_1533.

    Phylogenomic databases

    eggNOGi COG1187.
    KOi K06178.
    OMAi NDGEFAY.
    OrthoDBi EOG6130DV.

    Enzyme and pathway databases

    BioCyci HPY:HP1459-MONOMER.

    Family and domain databases

    Gene3Di 3.10.290.10. 1 hit.
    InterProi IPR020103. PsdUridine_synth_cat_dom.
    IPR000748. PsdUridine_synth_RsuA/RluB/E/F.
    IPR018496. PsdUridine_synth_RsuA/RluB_CS.
    IPR006145. PsdUridine_synth_RsuA/RluD.
    IPR002942. S4_RNA-bd.
    [Graphical view ]
    Pfami PF00849. PseudoU_synth_2. 1 hit.
    PF01479. S4. 1 hit.
    [Graphical view ]
    SMARTi SM00363. S4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55120. SSF55120. 1 hit.
    TIGRFAMsi TIGR00093. TIGR00093. 1 hit.
    PROSITEi PS01149. PSI_RSU. 1 hit.
    PS50889. S4. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700392 / 26695.

    Entry informationi

    Entry nameiY1459_HELPY
    AccessioniPrimary (citable) accession number: P55986
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Helicobacter pylori
      Helicobacter pylori (strain 26695): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3