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P55986 (Y1459_HELPY) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Uncharacterized RNA pseudouridine synthase HP_1459

EC=5.4.99.-
Alternative name(s):
RNA pseudouridylate synthase
RNA-uridine isomerase
Gene names
Ordered Locus Names:HP_1459
OrganismHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) [Reference proteome] [HAMAP]
Taxonomic identifier85962 [NCBI]
Taxonomic lineageBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter

Protein attributes

Sequence length262 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

RNA uridine = RNA pseudouridine.

Sequence similarities

Belongs to the pseudouridine synthase RsuA family.

Contains 1 S4 RNA-binding domain.

Ontologies

Keywords
   LigandRNA-binding
   Molecular functionIsomerase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processpseudouridine synthesis

Inferred from electronic annotation. Source: InterPro

   Molecular_functionRNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

pseudouridine synthase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 262262Uncharacterized RNA pseudouridine synthase HP_1459
PRO_0000100026

Regions

Domain6 – 7065S4 RNA-binding

Sites

Active site1081Nucleophile By similarity

Sequences

Sequence LengthMass (Da)Tools
P55986 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: 9FDC9FB290F14EA9

FASTA26230,228
        10         20         30         40         50         60 
MEGFSLRINQ FLAHYTKHSR REAEKLVLEG RVKINHEHAK LASVVKENDR VFLDKRLIKP 

        70         80         90        100        110        120 
LKNKKFSVLV YHKPKGELVS KADPLKRRVI YESLEKKYAH FAPVGRLDFA SEGVLLLSDS 

       130        140        150        160        170        180 
KAVVSALMHA DLEKEYLIKI QGFVTREMEN AMQEGLKLEN ATKGAHQKTP IKSMEFAPFI 

       190        200        210        220        230        240 
GYEIIKNHAK YSKLRVIINE GKNRELRRFF AFFNAGVLDL RRVRYGFVNL NALPVGKMRF 

       250        260 
LNRQEYNELH AFMANAANVK GD 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE000511 Genomic DNA. Translation: AAD08501.1.
PIRC64702.
RefSeqNP_208250.1. NC_000915.1.

3D structure databases

ProteinModelPortalP55986.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-3572N.
IntActP55986. 1 interaction.
MINTMINT-178262.
STRING85962.HP1459.

Proteomic databases

PRIDEP55986.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAD08501; AAD08501; HP_1459.
GeneID899834.
KEGGhpy:HP1459.
PATRIC20594329. VBIHelPyl33062_1533.

Phylogenomic databases

eggNOGCOG1187.
KOK06178.
OMANDGEFAY.
OrthoDBEOG6130DV.

Enzyme and pathway databases

BioCycHPY:HP1459-MONOMER.

Family and domain databases

Gene3D3.10.290.10. 1 hit.
InterProIPR020103. PsdUridine_synth_cat_dom.
IPR000748. PsdUridine_synth_RsuA/RluB/E/F.
IPR018496. PsdUridine_synth_RsuA/RluB_CS.
IPR006145. PsdUridine_synth_RsuA/RluD.
IPR002942. S4_RNA-bd.
[Graphical view]
PfamPF00849. PseudoU_synth_2. 1 hit.
PF01479. S4. 1 hit.
[Graphical view]
SMARTSM00363. S4. 1 hit.
[Graphical view]
SUPFAMSSF55120. SSF55120. 1 hit.
TIGRFAMsTIGR00093. TIGR00093. 1 hit.
PROSITEPS01149. PSI_RSU. 1 hit.
PS50889. S4. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameY1459_HELPY
AccessionPrimary (citable) accession number: P55986
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: May 14, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Helicobacter pylori

Helicobacter pylori (strain 26695): entries and gene names