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P55986

- Y1459_HELPY

UniProt

P55986 - Y1459_HELPY

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Protein

Uncharacterized RNA pseudouridine synthase HP_1459

Gene

HP_1459

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

RNA uridine = RNA pseudouridine.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei108 – 1081NucleophileBy similarity

GO - Molecular functioni

  1. pseudouridine synthase activity Source: InterPro
  2. RNA binding Source: UniProtKB-KW

GO - Biological processi

  1. pseudouridine synthesis Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

BioCyciHPY:HP1459-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized RNA pseudouridine synthase HP_1459 (EC:5.4.99.-)
Alternative name(s):
RNA pseudouridylate synthase
RNA-uridine isomerase
Gene namesi
Ordered Locus Names:HP_1459
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000429: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 262262Uncharacterized RNA pseudouridine synthase HP_1459PRO_0000100026Add
BLAST

Proteomic databases

PRIDEiP55986.

Interactioni

Protein-protein interaction databases

DIPiDIP-3572N.
IntActiP55986. 1 interaction.
MINTiMINT-178262.
STRINGi85962.HP1459.

Structurei

3D structure databases

ProteinModelPortaliP55986.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 7065S4 RNA-bindingPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the pseudouridine synthase RsuA family.Curated
Contains 1 S4 RNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG1187.
KOiK06178.
OMAiNDGEFAY.
OrthoDBiEOG6130DV.

Family and domain databases

Gene3Di3.10.290.10. 1 hit.
InterProiIPR020103. PsdUridine_synth_cat_dom.
IPR000748. PsdUridine_synth_RsuA/RluB/E/F.
IPR018496. PsdUridine_synth_RsuA/RluB_CS.
IPR006145. PsdUridine_synth_RsuA/RluD.
IPR002942. S4_RNA-bd.
[Graphical view]
PfamiPF00849. PseudoU_synth_2. 1 hit.
PF01479. S4. 1 hit.
[Graphical view]
SMARTiSM00363. S4. 1 hit.
[Graphical view]
SUPFAMiSSF55120. SSF55120. 1 hit.
TIGRFAMsiTIGR00093. TIGR00093. 1 hit.
PROSITEiPS01149. PSI_RSU. 1 hit.
PS50889. S4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P55986-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEGFSLRINQ FLAHYTKHSR REAEKLVLEG RVKINHEHAK LASVVKENDR
60 70 80 90 100
VFLDKRLIKP LKNKKFSVLV YHKPKGELVS KADPLKRRVI YESLEKKYAH
110 120 130 140 150
FAPVGRLDFA SEGVLLLSDS KAVVSALMHA DLEKEYLIKI QGFVTREMEN
160 170 180 190 200
AMQEGLKLEN ATKGAHQKTP IKSMEFAPFI GYEIIKNHAK YSKLRVIINE
210 220 230 240 250
GKNRELRRFF AFFNAGVLDL RRVRYGFVNL NALPVGKMRF LNRQEYNELH
260
AFMANAANVK GD
Length:262
Mass (Da):30,228
Last modified:November 1, 1997 - v1
Checksum:i9FDC9FB290F14EA9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000511 Genomic DNA. Translation: AAD08501.1.
PIRiC64702.
RefSeqiNP_208250.1. NC_000915.1.

Genome annotation databases

EnsemblBacteriaiAAD08501; AAD08501; HP_1459.
GeneIDi899834.
KEGGihpy:HP1459.
PATRICi20594329. VBIHelPyl33062_1533.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000511 Genomic DNA. Translation: AAD08501.1 .
PIRi C64702.
RefSeqi NP_208250.1. NC_000915.1.

3D structure databases

ProteinModelPortali P55986.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-3572N.
IntActi P55986. 1 interaction.
MINTi MINT-178262.
STRINGi 85962.HP1459.

Proteomic databases

PRIDEi P55986.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD08501 ; AAD08501 ; HP_1459 .
GeneIDi 899834.
KEGGi hpy:HP1459.
PATRICi 20594329. VBIHelPyl33062_1533.

Phylogenomic databases

eggNOGi COG1187.
KOi K06178.
OMAi NDGEFAY.
OrthoDBi EOG6130DV.

Enzyme and pathway databases

BioCyci HPY:HP1459-MONOMER.

Family and domain databases

Gene3Di 3.10.290.10. 1 hit.
InterProi IPR020103. PsdUridine_synth_cat_dom.
IPR000748. PsdUridine_synth_RsuA/RluB/E/F.
IPR018496. PsdUridine_synth_RsuA/RluB_CS.
IPR006145. PsdUridine_synth_RsuA/RluD.
IPR002942. S4_RNA-bd.
[Graphical view ]
Pfami PF00849. PseudoU_synth_2. 1 hit.
PF01479. S4. 1 hit.
[Graphical view ]
SMARTi SM00363. S4. 1 hit.
[Graphical view ]
SUPFAMi SSF55120. SSF55120. 1 hit.
TIGRFAMsi TIGR00093. TIGR00093. 1 hit.
PROSITEi PS01149. PSI_RSU. 1 hit.
PS50889. S4. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700392 / 26695.

Entry informationi

Entry nameiY1459_HELPY
AccessioniPrimary (citable) accession number: P55986
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: October 1, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3