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Protein

Uncharacterized RNA pseudouridine synthase HP_1459

Gene

HP_1459

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

RNA uridine = RNA pseudouridine.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei108NucleophileBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase, RNA-binding

Enzyme and pathway databases

BioCyciHPY:HP1459-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized RNA pseudouridine synthase HP_1459 (EC:5.4.99.-)
Alternative name(s):
RNA pseudouridylate synthase
RNA-uridine isomerase
Gene namesi
Ordered Locus Names:HP_1459
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi
  • UP000000429 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001000261 – 262Uncharacterized RNA pseudouridine synthase HP_1459Add BLAST262

Proteomic databases

PaxDbiP55986.
PRIDEiP55986.

Interactioni

Protein-protein interaction databases

DIPiDIP-3572N.
IntActiP55986. 1 interactor.
MINTiMINT-178262.
STRINGi85962.HP1459.

Structurei

3D structure databases

ProteinModelPortaliP55986.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 70S4 RNA-bindingPROSITE-ProRule annotationAdd BLAST65

Sequence similaritiesi

Belongs to the pseudouridine synthase RsuA family.Curated

Phylogenomic databases

eggNOGiENOG4105FE9. Bacteria.
COG1187. LUCA.
KOiK06178.
OMAiSMEFAPF.

Family and domain databases

CDDicd00165. S4. 1 hit.
Gene3Di3.10.290.10. 1 hit.
InterProiView protein in InterPro
IPR020103. PsdUridine_synth_cat_dom.
IPR000748. PsdUridine_synth_RsuA/RluB/E/F.
IPR018496. PsdUridine_synth_RsuA/RluB_CS.
IPR006145. PsdUridine_synth_RsuA/RluD.
IPR002942. S4_RNA-bd.
IPR036986. S4_RNA-bd_sf.
PANTHERiPTHR21600. PTHR21600. 1 hit.
PfamiView protein in Pfam
PF00849. PseudoU_synth_2. 1 hit.
PF01479. S4. 1 hit.
SMARTiView protein in SMART
SM00363. S4. 1 hit.
SUPFAMiSSF55120. SSF55120. 1 hit.
TIGRFAMsiTIGR00093. TIGR00093. 1 hit.
PROSITEiView protein in PROSITE
PS01149. PSI_RSU. 1 hit.
PS50889. S4. 1 hit.

Sequencei

Sequence statusi: Complete.

P55986-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGFSLRINQ FLAHYTKHSR REAEKLVLEG RVKINHEHAK LASVVKENDR
60 70 80 90 100
VFLDKRLIKP LKNKKFSVLV YHKPKGELVS KADPLKRRVI YESLEKKYAH
110 120 130 140 150
FAPVGRLDFA SEGVLLLSDS KAVVSALMHA DLEKEYLIKI QGFVTREMEN
160 170 180 190 200
AMQEGLKLEN ATKGAHQKTP IKSMEFAPFI GYEIIKNHAK YSKLRVIINE
210 220 230 240 250
GKNRELRRFF AFFNAGVLDL RRVRYGFVNL NALPVGKMRF LNRQEYNELH
260
AFMANAANVK GD
Length:262
Mass (Da):30,228
Last modified:November 1, 1997 - v1
Checksum:i9FDC9FB290F14EA9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD08501.1.
PIRiC64702.
RefSeqiNP_208250.1. NC_000915.1.
WP_000398405.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD08501; AAD08501; HP_1459.
GeneIDi899834.
KEGGihpy:HP1459.
PATRICifig|85962.8.peg.1533.

Similar proteinsi

Entry informationi

Entry nameiY1459_HELPY
AccessioniPrimary (citable) accession number: P55986
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: October 25, 2017
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families