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Protein

Isoprenyl transferase

Gene

uppS

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.By similarity

Cofactori

Mg2+By similarityNote: Binds 2 magnesium ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei13By similarity1
Metal bindingi13MagnesiumBy similarity1
Binding sitei18SubstrateBy similarity1
Binding sitei26Substrate1 Publication1
Binding sitei30SubstrateBy similarity1
Active sitei61Proton acceptorBy similarity1
Binding sitei62SubstrateBy similarity1
Binding sitei64SubstrateBy similarity1
Binding sitei180SubstrateBy similarity1
Metal bindingi199MagnesiumBy similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciHPY:HP1221-MONOMER.
BRENDAi2.5.1.31. 2604.

Names & Taxonomyi

Protein namesi
Recommended name:
Isoprenyl transferase (EC:2.5.1.-)
Gene namesi
Name:uppS
Ordered Locus Names:HP_1221
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi
  • UP000000429 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001236231 – 234Isoprenyl transferaseAdd BLAST234

Proteomic databases

PaxDbiP55984.

Interactioni

Subunit structurei

Homodimer.2 Publications

Protein-protein interaction databases

IntActiP55984. 2 interactors.
STRINGi85962.HP1221.

Structurei

Secondary structure

1234
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi7 – 11Combined sources5
Helixi15 – 20Combined sources6
Turni21 – 23Combined sources3
Helixi26 – 45Combined sources20
Turni46 – 48Combined sources3
Beta strandi50 – 57Combined sources8
Helixi69 – 89Combined sources21
Beta strandi93 – 98Combined sources6
Helixi100 – 102Combined sources3
Helixi105 – 118Combined sources14
Beta strandi125 – 131Combined sources7
Helixi134 – 147Combined sources14
Helixi153 – 155Combined sources3
Helixi160 – 164Combined sources5
Turni168 – 171Combined sources4
Beta strandi176 – 180Combined sources5
Beta strandi189 – 191Combined sources3
Turni192 – 197Combined sources6
Beta strandi199 – 202Combined sources4
Helixi207 – 209Combined sources3
Helixi212 – 225Combined sources14

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2D2RX-ray1.88A/B2-233[»]
2DTNX-ray2.50A/B2-233[»]
ProteinModelPortaliP55984.
SMRiP55984.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP55984.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni14 – 17Substrate bindingBy similarity4
Regioni58 – 60Substrate bindingBy similarity3
Regioni186 – 188Substrate bindingBy similarity3

Sequence similaritiesi

Belongs to the UPP synthase family.Curated

Phylogenomic databases

eggNOGiENOG4105CR3. Bacteria.
COG0020. LUCA.
KOiK00806.
OMAiWAKLKNK.

Family and domain databases

CDDicd00475. Cis_IPPS. 1 hit.
Gene3Di3.40.1180.10. 1 hit.
HAMAPiMF_01139. ISPT. 1 hit.
InterProiIPR001441. UPP_synth-like.
IPR018520. UPP_synth-like_CS.
[Graphical view]
PANTHERiPTHR10291. PTHR10291. 1 hit.
PfamiPF01255. Prenyltransf. 1 hit.
[Graphical view]
SUPFAMiSSF64005. SSF64005. 1 hit.
TIGRFAMsiTIGR00055. uppS. 1 hit.
PROSITEiPS01066. UPP_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P55984-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDNTLKHLAI IMDGNGRWAK LKNKARAYGH KKGVKTLKDI TIWCANHKLE
60 70 80 90 100
CLTLYAFSTE NWKRPKSEVD FLMKMLKKYL KDERSTYLNN NIRFRAIGDL
110 120 130 140 150
EGFSKELRDT ILQLENDTRH FKDFTQVLAL NYGSKNELSR AFKSLLESPP
160 170 180 190 200
SHINLLESLE NEISNRLDTH DLPEVDLLLR TGGEMRLSNF LLWQSSYAEL
210 220 230
FFTPILWPDF TPKDLENIIS DFYKRVRKFG ELKC
Length:234
Mass (Da):27,455
Last modified:November 1, 1997 - v1
Checksum:iF3C84720F9E4EB96
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD08263.1.
PIRiE64672.
RefSeqiNP_208013.1. NC_000915.1.
WP_000370674.1. NC_000915.1.

Genome annotation databases

EnsemblBacteriaiAAD08263; AAD08263; HP_1221.
GeneIDi900332.
KEGGiheo:C694_06305.
hpy:HP1221.
PATRICi20593813. VBIHelPyl33062_1277.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD08263.1.
PIRiE64672.
RefSeqiNP_208013.1. NC_000915.1.
WP_000370674.1. NC_000915.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2D2RX-ray1.88A/B2-233[»]
2DTNX-ray2.50A/B2-233[»]
ProteinModelPortaliP55984.
SMRiP55984.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP55984. 2 interactors.
STRINGi85962.HP1221.

Proteomic databases

PaxDbiP55984.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD08263; AAD08263; HP_1221.
GeneIDi900332.
KEGGiheo:C694_06305.
hpy:HP1221.
PATRICi20593813. VBIHelPyl33062_1277.

Phylogenomic databases

eggNOGiENOG4105CR3. Bacteria.
COG0020. LUCA.
KOiK00806.
OMAiWAKLKNK.

Enzyme and pathway databases

BioCyciHPY:HP1221-MONOMER.
BRENDAi2.5.1.31. 2604.

Miscellaneous databases

EvolutionaryTraceiP55984.

Family and domain databases

CDDicd00475. Cis_IPPS. 1 hit.
Gene3Di3.40.1180.10. 1 hit.
HAMAPiMF_01139. ISPT. 1 hit.
InterProiIPR001441. UPP_synth-like.
IPR018520. UPP_synth-like_CS.
[Graphical view]
PANTHERiPTHR10291. PTHR10291. 1 hit.
PfamiPF01255. Prenyltransf. 1 hit.
[Graphical view]
SUPFAMiSSF64005. SSF64005. 1 hit.
TIGRFAMsiTIGR00055. uppS. 1 hit.
PROSITEiPS01066. UPP_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiISPT_HELPY
AccessioniPrimary (citable) accession number: P55984
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 2, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.