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P55984

- ISPT_HELPY

UniProt

P55984 - ISPT_HELPY

Protein

Isoprenyl transferase

Gene

uppS

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 1 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.By similarity

    Cofactori

    Binds 2 magnesium ions per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei13 – 131By similarity
    Metal bindingi13 – 131MagnesiumBy similarity
    Binding sitei18 – 181SubstrateBy similarity
    Binding sitei26 – 261Substrate1 Publication
    Binding sitei30 – 301SubstrateBy similarity
    Active sitei61 – 611Proton acceptorBy similarity
    Binding sitei62 – 621SubstrateBy similarity
    Binding sitei64 – 641SubstrateBy similarity
    Binding sitei180 – 1801SubstrateBy similarity
    Metal bindingi199 – 1991MagnesiumBy similarity

    GO - Molecular functioni

    1. magnesium ion binding Source: UniProtKB-HAMAP
    2. prenyltransferase activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Transferase

    Keywords - Ligandi

    Magnesium, Metal-binding

    Enzyme and pathway databases

    BioCyciHPY:HP1221-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isoprenyl transferase (EC:2.5.1.-)
    Gene namesi
    Name:uppS
    Ordered Locus Names:HP_1221
    OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
    Taxonomic identifieri85962 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
    ProteomesiUP000000429: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 234234Isoprenyl transferasePRO_0000123623Add
    BLAST

    Proteomic databases

    PRIDEiP55984.

    Interactioni

    Subunit structurei

    Homodimer.2 Publications

    Protein-protein interaction databases

    IntActiP55984. 2 interactions.
    STRINGi85962.HP1221.

    Structurei

    Secondary structure

    1
    234
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi7 – 115
    Helixi15 – 206
    Turni21 – 233
    Helixi26 – 4520
    Turni46 – 483
    Beta strandi50 – 578
    Helixi69 – 8921
    Beta strandi93 – 986
    Helixi100 – 1023
    Helixi105 – 11814
    Beta strandi125 – 1317
    Helixi134 – 14714
    Helixi153 – 1553
    Helixi160 – 1645
    Turni168 – 1714
    Beta strandi176 – 1805
    Beta strandi189 – 1913
    Turni192 – 1976
    Beta strandi199 – 2024
    Helixi207 – 2093
    Helixi212 – 22514

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2D2RX-ray1.88A/B2-233[»]
    2DTNX-ray2.50A/B2-233[»]
    ProteinModelPortaliP55984.
    SMRiP55984. Positions 3-227.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP55984.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni14 – 174Substrate bindingBy similarity
    Regioni58 – 603Substrate bindingBy similarity
    Regioni186 – 1883Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the UPP synthase family.Curated

    Phylogenomic databases

    eggNOGiCOG0020.
    KOiK00806.
    OMAiISCREER.
    OrthoDBiEOG68H89T.

    Family and domain databases

    Gene3Di3.40.1180.10. 1 hit.
    HAMAPiMF_01139. ISPT.
    InterProiIPR001441. UPP_synth-like.
    IPR018520. UPP_synth-like_CS.
    [Graphical view]
    PANTHERiPTHR10291. PTHR10291. 1 hit.
    PfamiPF01255. Prenyltransf. 1 hit.
    [Graphical view]
    SUPFAMiSSF64005. SSF64005. 1 hit.
    TIGRFAMsiTIGR00055. uppS. 1 hit.
    PROSITEiPS01066. UPP_SYNTHASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P55984-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDNTLKHLAI IMDGNGRWAK LKNKARAYGH KKGVKTLKDI TIWCANHKLE    50
    CLTLYAFSTE NWKRPKSEVD FLMKMLKKYL KDERSTYLNN NIRFRAIGDL 100
    EGFSKELRDT ILQLENDTRH FKDFTQVLAL NYGSKNELSR AFKSLLESPP 150
    SHINLLESLE NEISNRLDTH DLPEVDLLLR TGGEMRLSNF LLWQSSYAEL 200
    FFTPILWPDF TPKDLENIIS DFYKRVRKFG ELKC 234
    Length:234
    Mass (Da):27,455
    Last modified:November 1, 1997 - v1
    Checksum:iF3C84720F9E4EB96
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000511 Genomic DNA. Translation: AAD08263.1.
    PIRiE64672.
    RefSeqiNP_208013.1. NC_000915.1.
    YP_006935139.1. NC_018939.1.

    Genome annotation databases

    EnsemblBacteriaiAAD08263; AAD08263; HP_1221.
    GeneIDi13870426.
    900332.
    KEGGiheo:C694_06305.
    hpy:HP1221.
    PATRICi20593813. VBIHelPyl33062_1277.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000511 Genomic DNA. Translation: AAD08263.1 .
    PIRi E64672.
    RefSeqi NP_208013.1. NC_000915.1.
    YP_006935139.1. NC_018939.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2D2R X-ray 1.88 A/B 2-233 [» ]
    2DTN X-ray 2.50 A/B 2-233 [» ]
    ProteinModelPortali P55984.
    SMRi P55984. Positions 3-227.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P55984. 2 interactions.
    STRINGi 85962.HP1221.

    Proteomic databases

    PRIDEi P55984.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD08263 ; AAD08263 ; HP_1221 .
    GeneIDi 13870426.
    900332.
    KEGGi heo:C694_06305.
    hpy:HP1221.
    PATRICi 20593813. VBIHelPyl33062_1277.

    Phylogenomic databases

    eggNOGi COG0020.
    KOi K00806.
    OMAi ISCREER.
    OrthoDBi EOG68H89T.

    Enzyme and pathway databases

    BioCyci HPY:HP1221-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei P55984.

    Family and domain databases

    Gene3Di 3.40.1180.10. 1 hit.
    HAMAPi MF_01139. ISPT.
    InterProi IPR001441. UPP_synth-like.
    IPR018520. UPP_synth-like_CS.
    [Graphical view ]
    PANTHERi PTHR10291. PTHR10291. 1 hit.
    Pfami PF01255. Prenyltransf. 1 hit.
    [Graphical view ]
    SUPFAMi SSF64005. SSF64005. 1 hit.
    TIGRFAMsi TIGR00055. uppS. 1 hit.
    PROSITEi PS01066. UPP_SYNTHASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700392 / 26695.
    2. "Structure-based inhibitors exhibit differential activities against Helicobacter pylori and Escherichia coli undecaprenyl pyrophosphate synthases."
      Kuo C.J., Guo R.T., Lu I.L., Liu H.G., Wu S.Y., Ko T.P., Wang A.H., Liang P.H.
      J. Biomed. Biotechnol. 2008:841312-841312(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.88 ANGSTROMS) OF 4-233, SUBUNIT.
    3. "Biochemical characterization, crystal structure, and inhibitors of Helicobacter pylori undecaprenyl pyrophosphate synthase."
      Guo R.T., Kuo C.J., Chen C.L., Ko T.P., Liang P.H., Wang A.H.-J.
      Submitted (FEB-2009) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (2.50 ANGSTROMS) IN COMPLEX WITH SUBSTRATE, SUBUNIT.

    Entry informationi

    Entry nameiISPT_HELPY
    AccessioniPrimary (citable) accession number: P55984
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 96 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Helicobacter pylori
      Helicobacter pylori (strain 26695): entries and gene names
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3