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P55984

- ISPT_HELPY

UniProt

P55984 - ISPT_HELPY

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Protein

Isoprenyl transferase

Gene
uppS, HP_1221
Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids By similarity.UniRule annotation

Cofactori

Binds 2 magnesium ions per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei13 – 131 By similarity
Metal bindingi13 – 131Magnesium By similarity
Binding sitei18 – 181Substrate By similarity
Binding sitei26 – 261Substrate
Binding sitei30 – 301Substrate By similarity
Active sitei61 – 611Proton acceptor By similarity
Binding sitei62 – 621Substrate By similarity
Binding sitei64 – 641Substrate By similarity
Binding sitei180 – 1801Substrate By similarity
Metal bindingi199 – 1991Magnesium By similarity

GO - Molecular functioni

  1. magnesium ion binding Source: UniProtKB-HAMAP
  2. prenyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciHPY:HP1221-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isoprenyl transferase (EC:2.5.1.-)
Gene namesi
Name:uppS
Ordered Locus Names:HP_1221
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000429: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 234234Isoprenyl transferaseUniRule annotationPRO_0000123623Add
BLAST

Proteomic databases

PRIDEiP55984.

Interactioni

Subunit structurei

Homodimer.2 Publications

Protein-protein interaction databases

IntActiP55984. 2 interactions.
STRINGi85962.HP1221.

Structurei

Secondary structure

1
234
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi7 – 115
Helixi15 – 206
Turni21 – 233
Helixi26 – 4520
Turni46 – 483
Beta strandi50 – 578
Helixi69 – 8921
Beta strandi93 – 986
Helixi100 – 1023
Helixi105 – 11814
Beta strandi125 – 1317
Helixi134 – 14714
Helixi153 – 1553
Helixi160 – 1645
Turni168 – 1714
Beta strandi176 – 1805
Beta strandi189 – 1913
Turni192 – 1976
Beta strandi199 – 2024
Helixi207 – 2093
Helixi212 – 22514

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2D2RX-ray1.88A/B2-233[»]
2DTNX-ray2.50A/B2-233[»]
ProteinModelPortaliP55984.
SMRiP55984. Positions 3-227.

Miscellaneous databases

EvolutionaryTraceiP55984.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni14 – 174Substrate binding By similarity
Regioni58 – 603Substrate binding By similarity
Regioni186 – 1883Substrate binding By similarity

Sequence similaritiesi

Belongs to the UPP synthase family.

Phylogenomic databases

eggNOGiCOG0020.
KOiK00806.
OMAiISCREER.
OrthoDBiEOG68H89T.

Family and domain databases

Gene3Di3.40.1180.10. 1 hit.
HAMAPiMF_01139. ISPT.
InterProiIPR001441. UPP_synth-like.
IPR018520. UPP_synth-like_CS.
[Graphical view]
PANTHERiPTHR10291. PTHR10291. 1 hit.
PfamiPF01255. Prenyltransf. 1 hit.
[Graphical view]
SUPFAMiSSF64005. SSF64005. 1 hit.
TIGRFAMsiTIGR00055. uppS. 1 hit.
PROSITEiPS01066. UPP_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P55984-1 [UniParc]FASTAAdd to Basket

« Hide

MDNTLKHLAI IMDGNGRWAK LKNKARAYGH KKGVKTLKDI TIWCANHKLE    50
CLTLYAFSTE NWKRPKSEVD FLMKMLKKYL KDERSTYLNN NIRFRAIGDL 100
EGFSKELRDT ILQLENDTRH FKDFTQVLAL NYGSKNELSR AFKSLLESPP 150
SHINLLESLE NEISNRLDTH DLPEVDLLLR TGGEMRLSNF LLWQSSYAEL 200
FFTPILWPDF TPKDLENIIS DFYKRVRKFG ELKC 234
Length:234
Mass (Da):27,455
Last modified:November 1, 1997 - v1
Checksum:iF3C84720F9E4EB96
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000511 Genomic DNA. Translation: AAD08263.1.
PIRiE64672.
RefSeqiNP_208013.1. NC_000915.1.
YP_006935139.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD08263; AAD08263; HP_1221.
GeneIDi13870426.
900332.
KEGGiheo:C694_06305.
hpy:HP1221.
PATRICi20593813. VBIHelPyl33062_1277.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000511 Genomic DNA. Translation: AAD08263.1 .
PIRi E64672.
RefSeqi NP_208013.1. NC_000915.1.
YP_006935139.1. NC_018939.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2D2R X-ray 1.88 A/B 2-233 [» ]
2DTN X-ray 2.50 A/B 2-233 [» ]
ProteinModelPortali P55984.
SMRi P55984. Positions 3-227.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P55984. 2 interactions.
STRINGi 85962.HP1221.

Proteomic databases

PRIDEi P55984.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD08263 ; AAD08263 ; HP_1221 .
GeneIDi 13870426.
900332.
KEGGi heo:C694_06305.
hpy:HP1221.
PATRICi 20593813. VBIHelPyl33062_1277.

Phylogenomic databases

eggNOGi COG0020.
KOi K00806.
OMAi ISCREER.
OrthoDBi EOG68H89T.

Enzyme and pathway databases

BioCyci HPY:HP1221-MONOMER.

Miscellaneous databases

EvolutionaryTracei P55984.

Family and domain databases

Gene3Di 3.40.1180.10. 1 hit.
HAMAPi MF_01139. ISPT.
InterProi IPR001441. UPP_synth-like.
IPR018520. UPP_synth-like_CS.
[Graphical view ]
PANTHERi PTHR10291. PTHR10291. 1 hit.
Pfami PF01255. Prenyltransf. 1 hit.
[Graphical view ]
SUPFAMi SSF64005. SSF64005. 1 hit.
TIGRFAMsi TIGR00055. uppS. 1 hit.
PROSITEi PS01066. UPP_SYNTHASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700392 / 26695.
  2. "Structure-based inhibitors exhibit differential activities against Helicobacter pylori and Escherichia coli undecaprenyl pyrophosphate synthases."
    Kuo C.J., Guo R.T., Lu I.L., Liu H.G., Wu S.Y., Ko T.P., Wang A.H., Liang P.H.
    J. Biomed. Biotechnol. 2008:841312-841312(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.88 ANGSTROMS) OF 4-233, SUBUNIT.
  3. "Biochemical characterization, crystal structure, and inhibitors of Helicobacter pylori undecaprenyl pyrophosphate synthase."
    Guo R.T., Kuo C.J., Chen C.L., Ko T.P., Liang P.H., Wang A.H.-J.
    Submitted (FEB-2009) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.50 ANGSTROMS) IN COMPLEX WITH SUBSTRATE, SUBUNIT.

Entry informationi

Entry nameiISPT_HELPY
AccessioniPrimary (citable) accession number: P55984
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: September 3, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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