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Protein

Isoprenyl transferase

Gene

uppS

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.By similarity

Cofactori

Mg2+By similarityNote: Binds 2 magnesium ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei13 – 131By similarity
Metal bindingi13 – 131MagnesiumBy similarity
Binding sitei18 – 181SubstrateBy similarity
Binding sitei26 – 261Substrate1 Publication
Binding sitei30 – 301SubstrateBy similarity
Active sitei61 – 611Proton acceptorBy similarity
Binding sitei62 – 621SubstrateBy similarity
Binding sitei64 – 641SubstrateBy similarity
Binding sitei180 – 1801SubstrateBy similarity
Metal bindingi199 – 1991MagnesiumBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciHPY:HP1221-MONOMER.
BRENDAi2.5.1.31. 2604.

Names & Taxonomyi

Protein namesi
Recommended name:
Isoprenyl transferase (EC:2.5.1.-)
Gene namesi
Name:uppS
Ordered Locus Names:HP_1221
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000429 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 234234Isoprenyl transferasePRO_0000123623Add
BLAST

Proteomic databases

PRIDEiP55984.

Interactioni

Subunit structurei

Homodimer.2 Publications

Protein-protein interaction databases

IntActiP55984. 2 interactions.
STRINGi85962.HP1221.

Structurei

Secondary structure

1
234
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi7 – 115Combined sources
Helixi15 – 206Combined sources
Turni21 – 233Combined sources
Helixi26 – 4520Combined sources
Turni46 – 483Combined sources
Beta strandi50 – 578Combined sources
Helixi69 – 8921Combined sources
Beta strandi93 – 986Combined sources
Helixi100 – 1023Combined sources
Helixi105 – 11814Combined sources
Beta strandi125 – 1317Combined sources
Helixi134 – 14714Combined sources
Helixi153 – 1553Combined sources
Helixi160 – 1645Combined sources
Turni168 – 1714Combined sources
Beta strandi176 – 1805Combined sources
Beta strandi189 – 1913Combined sources
Turni192 – 1976Combined sources
Beta strandi199 – 2024Combined sources
Helixi207 – 2093Combined sources
Helixi212 – 22514Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2D2RX-ray1.88A/B2-233[»]
2DTNX-ray2.50A/B2-233[»]
ProteinModelPortaliP55984.
SMRiP55984. Positions 3-227.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP55984.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni14 – 174Substrate bindingBy similarity
Regioni58 – 603Substrate bindingBy similarity
Regioni186 – 1883Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the UPP synthase family.Curated

Phylogenomic databases

eggNOGiCOG0020.
KOiK00806.
OMAiYQNRERR.
OrthoDBiEOG68H89T.

Family and domain databases

Gene3Di3.40.1180.10. 1 hit.
HAMAPiMF_01139. ISPT.
InterProiIPR001441. UPP_synth-like.
IPR018520. UPP_synth-like_CS.
[Graphical view]
PANTHERiPTHR10291. PTHR10291. 1 hit.
PfamiPF01255. Prenyltransf. 1 hit.
[Graphical view]
SUPFAMiSSF64005. SSF64005. 1 hit.
TIGRFAMsiTIGR00055. uppS. 1 hit.
PROSITEiPS01066. UPP_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P55984-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDNTLKHLAI IMDGNGRWAK LKNKARAYGH KKGVKTLKDI TIWCANHKLE
60 70 80 90 100
CLTLYAFSTE NWKRPKSEVD FLMKMLKKYL KDERSTYLNN NIRFRAIGDL
110 120 130 140 150
EGFSKELRDT ILQLENDTRH FKDFTQVLAL NYGSKNELSR AFKSLLESPP
160 170 180 190 200
SHINLLESLE NEISNRLDTH DLPEVDLLLR TGGEMRLSNF LLWQSSYAEL
210 220 230
FFTPILWPDF TPKDLENIIS DFYKRVRKFG ELKC
Length:234
Mass (Da):27,455
Last modified:November 1, 1997 - v1
Checksum:iF3C84720F9E4EB96
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD08263.1.
PIRiE64672.
RefSeqiNP_208013.1. NC_000915.1.
WP_000370674.1. NC_018939.1.
YP_006935139.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD08263; AAD08263; HP_1221.
GeneIDi900332.
KEGGiheo:C694_06305.
hpy:HP1221.
PATRICi20593813. VBIHelPyl33062_1277.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD08263.1.
PIRiE64672.
RefSeqiNP_208013.1. NC_000915.1.
WP_000370674.1. NC_018939.1.
YP_006935139.1. NC_018939.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2D2RX-ray1.88A/B2-233[»]
2DTNX-ray2.50A/B2-233[»]
ProteinModelPortaliP55984.
SMRiP55984. Positions 3-227.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP55984. 2 interactions.
STRINGi85962.HP1221.

Proteomic databases

PRIDEiP55984.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD08263; AAD08263; HP_1221.
GeneIDi900332.
KEGGiheo:C694_06305.
hpy:HP1221.
PATRICi20593813. VBIHelPyl33062_1277.

Phylogenomic databases

eggNOGiCOG0020.
KOiK00806.
OMAiYQNRERR.
OrthoDBiEOG68H89T.

Enzyme and pathway databases

BioCyciHPY:HP1221-MONOMER.
BRENDAi2.5.1.31. 2604.

Miscellaneous databases

EvolutionaryTraceiP55984.

Family and domain databases

Gene3Di3.40.1180.10. 1 hit.
HAMAPiMF_01139. ISPT.
InterProiIPR001441. UPP_synth-like.
IPR018520. UPP_synth-like_CS.
[Graphical view]
PANTHERiPTHR10291. PTHR10291. 1 hit.
PfamiPF01255. Prenyltransf. 1 hit.
[Graphical view]
SUPFAMiSSF64005. SSF64005. 1 hit.
TIGRFAMsiTIGR00055. uppS. 1 hit.
PROSITEiPS01066. UPP_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700392 / 26695.
  2. "Structure-based inhibitors exhibit differential activities against Helicobacter pylori and Escherichia coli undecaprenyl pyrophosphate synthases."
    Kuo C.J., Guo R.T., Lu I.L., Liu H.G., Wu S.Y., Ko T.P., Wang A.H., Liang P.H.
    J. Biomed. Biotechnol. 2008:841312-841312(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.88 ANGSTROMS) OF 4-233, SUBUNIT.
  3. "Biochemical characterization, crystal structure, and inhibitors of Helicobacter pylori undecaprenyl pyrophosphate synthase."
    Guo R.T., Kuo C.J., Chen C.L., Ko T.P., Liang P.H., Wang A.H.-J.
    Submitted (FEB-2009) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.50 ANGSTROMS) IN COMPLEX WITH SUBSTRATE, SUBUNIT.

Entry informationi

Entry nameiISPT_HELPY
AccessioniPrimary (citable) accession number: P55984
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: May 27, 2015
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.