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P55984 (ISPT_HELPY) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Isoprenyl transferase

EC=2.5.1.-
Gene names
Name:uppS
Ordered Locus Names:HP_1221
OrganismHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) [Reference proteome] [HAMAP]
Taxonomic identifier85962 [NCBI]
Taxonomic lineageBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter

Protein attributes

Sequence length234 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids By similarity. HAMAP-Rule MF_01139

Cofactor

Binds 2 magnesium ions per subunit By similarity. HAMAP-Rule MF_01139

Subunit structure

Homodimer. Ref.2 Ref.3

Sequence similarities

Belongs to the UPP synthase family.

Ontologies

Keywords
   LigandMagnesium
Metal-binding
   Molecular functionTransferase
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Molecular_functionmagnesium ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

prenyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 234234Isoprenyl transferase HAMAP-Rule MF_01139
PRO_0000123623

Regions

Region14 – 174Substrate binding By similarity
Region58 – 603Substrate binding By similarity
Region186 – 1883Substrate binding By similarity

Sites

Active site131 By similarity
Active site611Proton acceptor By similarity
Metal binding131Magnesium By similarity
Metal binding1991Magnesium By similarity
Binding site181Substrate By similarity
Binding site261Substrate
Binding site301Substrate By similarity
Binding site621Substrate By similarity
Binding site641Substrate By similarity
Binding site1801Substrate By similarity

Secondary structure

........................................ 234
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P55984 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: F3C84720F9E4EB96

FASTA23427,455
        10         20         30         40         50         60 
MDNTLKHLAI IMDGNGRWAK LKNKARAYGH KKGVKTLKDI TIWCANHKLE CLTLYAFSTE 

        70         80         90        100        110        120 
NWKRPKSEVD FLMKMLKKYL KDERSTYLNN NIRFRAIGDL EGFSKELRDT ILQLENDTRH 

       130        140        150        160        170        180 
FKDFTQVLAL NYGSKNELSR AFKSLLESPP SHINLLESLE NEISNRLDTH DLPEVDLLLR 

       190        200        210        220        230 
TGGEMRLSNF LLWQSSYAEL FFTPILWPDF TPKDLENIIS DFYKRVRKFG ELKC 

« Hide

References

« Hide 'large scale' references
[1]"The complete genome sequence of the gastric pathogen Helicobacter pylori."
Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G., Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A., Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N., Loftus B.J., Richardson D.L., Dodson R.J. expand/collapse author list , Khalak H.G., Glodek A., McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E., Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D., Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S., Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C.
Nature 388:539-547(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 700392 / 26695.
[2]"Structure-based inhibitors exhibit differential activities against Helicobacter pylori and Escherichia coli undecaprenyl pyrophosphate synthases."
Kuo C.J., Guo R.T., Lu I.L., Liu H.G., Wu S.Y., Ko T.P., Wang A.H., Liang P.H.
J. Biomed. Biotechnol. 2008:841312-841312(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.88 ANGSTROMS) OF 4-233, SUBUNIT.
[3]"Biochemical characterization, crystal structure, and inhibitors of Helicobacter pylori undecaprenyl pyrophosphate synthase."
Guo R.T., Kuo C.J., Chen C.L., Ko T.P., Liang P.H., Wang A.H.-J.
Submitted (FEB-2009) to the PDB data bank
Cited for: X-RAY CRYSTALLOGRAPHY (2.50 ANGSTROMS) IN COMPLEX WITH SUBSTRATE, SUBUNIT.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE000511 Genomic DNA. Translation: AAD08263.1.
PIRE64672.
RefSeqNP_208013.1. NC_000915.1.
YP_006935139.1. NC_018939.1.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2D2RX-ray1.88A/B2-233[»]
2DTNX-ray2.50A/B2-233[»]
ProteinModelPortalP55984.
SMRP55984. Positions 3-227.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP55984. 2 interactions.
STRING85962.HP1221.

Proteomic databases

PRIDEP55984.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAD08263; AAD08263; HP_1221.
GeneID900332.
KEGGheo:C694_06305.
hpy:HP1221.
PATRIC20593813. VBIHelPyl33062_1277.

Phylogenomic databases

eggNOGCOG0020.
KOK00806.
OMAISCREER.
OrthoDBEOG68H89T.

Enzyme and pathway databases

BioCycHPY:HP1221-MONOMER.

Family and domain databases

Gene3D3.40.1180.10. 1 hit.
HAMAPMF_01139. ISPT.
InterProIPR001441. UPP_synth-like.
IPR018520. UPP_synth-like_CS.
[Graphical view]
PANTHERPTHR10291. PTHR10291. 1 hit.
PfamPF01255. Prenyltransf. 1 hit.
[Graphical view]
SUPFAMSSF64005. SSF64005. 1 hit.
TIGRFAMsTIGR00055. uppS. 1 hit.
PROSITEPS01066. UPP_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP55984.

Entry information

Entry nameISPT_HELPY
AccessionPrimary (citable) accession number: P55984
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: July 9, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

Helicobacter pylori

Helicobacter pylori (strain 26695): entries and gene names