SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P55983

- RIR2_HELPY

UniProt

P55983 - RIR2_HELPY

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Ribonucleoside-diphosphate reductase subunit beta
Gene
nrdB, HP_0364
Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides By similarity.

Catalytic activityi

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.

Cofactori

Binds 2 iron ions per subunit By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi89 – 891Iron 1 By similarity
Metal bindingi120 – 1201Iron 1 By similarity
Metal bindingi120 – 1201Iron 2 By similarity
Metal bindingi123 – 1231Iron 1 By similarity
Active sitei127 – 1271 By similarity
Metal bindingi185 – 1851Iron 2 By similarity
Metal bindingi219 – 2191Iron 2 By similarity
Metal bindingi222 – 2221Iron 2 By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. DNA replication Source: UniProtKB-UniPathway
  2. deoxyribonucleoside diphosphate metabolic process Source: InterPro
  3. deoxyribonucleotide biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

DNA replication

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BioCyciHPY:HP0364-MONOMER.
UniPathwayiUPA00326.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonucleoside-diphosphate reductase subunit beta (EC:1.17.4.1)
Alternative name(s):
Ribonucleotide reductase small subunit
Gene namesi
Name:nrdB
Ordered Locus Names:HP_0364
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000429: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. ribonucleoside-diphosphate reductase complex Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 341341Ribonucleoside-diphosphate reductase subunit beta
PRO_0000190480Add
BLAST

Proteomic databases

PRIDEiP55983.

Interactioni

Subunit structurei

Tetramer of two alpha and two beta subunits By similarity.

Protein-protein interaction databases

DIPiDIP-3348N.
IntActiP55983. 2 interactions.
MINTiMINT-161059.
STRINGi85962.HP0364.

Structurei

3D structure databases

ProteinModelPortaliP55983.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0208.
KOiK00526.
OMAiSEIFNAY.
OrthoDBiEOG6J48J7.

Family and domain databases

Gene3Di1.10.620.20. 1 hit.
InterProiIPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR026023. RNR_bsu_prok.
IPR000358. RNR_small.
[Graphical view]
PANTHERiPTHR23409. PTHR23409. 1 hit.
PfamiPF00268. Ribonuc_red_sm. 1 hit.
[Graphical view]
PIRSFiPIRSF000355. NrdB. 1 hit.
SUPFAMiSSF47240. SSF47240. 1 hit.
PROSITEiPS00368. RIBORED_SMALL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P55983-1 [UniParc]FASTAAdd to Basket

« Hide

MEVSRKKIYN PNSTESVNER KIFGGNPTSM FDLNKIKYQW ADHLWKTMLA    50
NTWFAEEVSM NDDKRDYLKL SAEEKIGYDR ALAQLIFMDS LQANNLIDNI 100
NPFITSPEIN LCLVRQAYEE ALHSHAYAVM VESISANTEE IYDMWRNDMQ 150
LKSKNDYIAQ VYMELAKNPT EENILKALFA NQILEGIYFY SGFSYFYTLA 200
RSGKMLGSAQ MIRFIQRDEV THLILFQNMI NALRNERADL FTPQLINEVI 250
GMFKKAVEIE ALWGDYITQG KILGLTSSLI EQYIQFLADS RLSKVGIAKV 300
YGVQHPIKWV ESFSSFNEQR SNFFEARVSN YAKGSVSFDD F 341
Length:341
Mass (Da):39,482
Last modified:November 1, 1997 - v1
Checksum:iEB52BA425F14EF6E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000511 Genomic DNA. Translation: AAD07432.1.
PIRiD64565.
RefSeqiNP_207162.1. NC_000915.1.
YP_006934288.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD07432; AAD07432; HP_0364.
GeneIDi13869549.
899218.
KEGGiheo:C694_01845.
hpy:HP0364.
PATRICi20591963. VBIHelPyl33062_0376.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000511 Genomic DNA. Translation: AAD07432.1 .
PIRi D64565.
RefSeqi NP_207162.1. NC_000915.1.
YP_006934288.1. NC_018939.1.

3D structure databases

ProteinModelPortali P55983.
ModBasei Search...

Protein-protein interaction databases

DIPi DIP-3348N.
IntActi P55983. 2 interactions.
MINTi MINT-161059.
STRINGi 85962.HP0364.

Proteomic databases

PRIDEi P55983.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD07432 ; AAD07432 ; HP_0364 .
GeneIDi 13869549.
899218.
KEGGi heo:C694_01845.
hpy:HP0364.
PATRICi 20591963. VBIHelPyl33062_0376.

Phylogenomic databases

eggNOGi COG0208.
KOi K00526.
OMAi SEIFNAY.
OrthoDBi EOG6J48J7.

Enzyme and pathway databases

UniPathwayi UPA00326 .
BioCyci HPY:HP0364-MONOMER.

Family and domain databases

Gene3Di 1.10.620.20. 1 hit.
InterProi IPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR026023. RNR_bsu_prok.
IPR000358. RNR_small.
[Graphical view ]
PANTHERi PTHR23409. PTHR23409. 1 hit.
Pfami PF00268. Ribonuc_red_sm. 1 hit.
[Graphical view ]
PIRSFi PIRSF000355. NrdB. 1 hit.
SUPFAMi SSF47240. SSF47240. 1 hit.
PROSITEi PS00368. RIBORED_SMALL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700392 / 26695.

Entry informationi

Entry nameiRIR2_HELPY
AccessioniPrimary (citable) accession number: P55983
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: September 3, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi