Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P55983

- RIR2_HELPY

UniProt

P55983 - RIR2_HELPY

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Ribonucleoside-diphosphate reductase subunit beta

Gene

nrdB

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides By similarity.By similarity

Catalytic activityi

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.PROSITE-ProRule annotation

Cofactori

Binds 2 iron ions per subunit.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi89 – 891Iron 1PROSITE-ProRule annotation
Metal bindingi120 – 1201Iron 1PROSITE-ProRule annotation
Metal bindingi120 – 1201Iron 2By similarity
Metal bindingi123 – 1231Iron 1PROSITE-ProRule annotation
Active sitei127 – 1271PROSITE-ProRule annotation
Metal bindingi185 – 1851Iron 2By similarity
Metal bindingi219 – 2191Iron 2By similarity
Metal bindingi222 – 2221Iron 2By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Source: UniProtKB-EC

GO - Biological processi

  1. deoxyribonucleoside diphosphate metabolic process Source: InterPro
  2. deoxyribonucleotide biosynthetic process Source: InterPro
  3. DNA replication Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

DNA replication

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BioCyciHPY:HP0364-MONOMER.
UniPathwayiUPA00326.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonucleoside-diphosphate reductase subunit beta (EC:1.17.4.1)
Alternative name(s):
Ribonucleotide reductase small subunit
Gene namesi
Name:nrdB
Ordered Locus Names:HP_0364
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000429: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. ribonucleoside-diphosphate reductase complex Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 341341Ribonucleoside-diphosphate reductase subunit betaPRO_0000190480Add
BLAST

Proteomic databases

PRIDEiP55983.

Interactioni

Subunit structurei

Tetramer of two alpha and two beta subunits.By similarity

Protein-protein interaction databases

DIPiDIP-3348N.
IntActiP55983. 2 interactions.
MINTiMINT-161059.
STRINGi85962.HP0364.

Structurei

3D structure databases

ProteinModelPortaliP55983.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0208.
KOiK00526.
OMAiSEIFNAY.
OrthoDBiEOG6J48J7.

Family and domain databases

Gene3Di1.10.620.20. 1 hit.
InterProiIPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR026023. RNR_bsu_prok.
IPR000358. RNR_small.
[Graphical view]
PANTHERiPTHR23409. PTHR23409. 1 hit.
PfamiPF00268. Ribonuc_red_sm. 1 hit.
[Graphical view]
PIRSFiPIRSF000355. NrdB. 1 hit.
SUPFAMiSSF47240. SSF47240. 1 hit.
PROSITEiPS00368. RIBORED_SMALL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P55983-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEVSRKKIYN PNSTESVNER KIFGGNPTSM FDLNKIKYQW ADHLWKTMLA
60 70 80 90 100
NTWFAEEVSM NDDKRDYLKL SAEEKIGYDR ALAQLIFMDS LQANNLIDNI
110 120 130 140 150
NPFITSPEIN LCLVRQAYEE ALHSHAYAVM VESISANTEE IYDMWRNDMQ
160 170 180 190 200
LKSKNDYIAQ VYMELAKNPT EENILKALFA NQILEGIYFY SGFSYFYTLA
210 220 230 240 250
RSGKMLGSAQ MIRFIQRDEV THLILFQNMI NALRNERADL FTPQLINEVI
260 270 280 290 300
GMFKKAVEIE ALWGDYITQG KILGLTSSLI EQYIQFLADS RLSKVGIAKV
310 320 330 340
YGVQHPIKWV ESFSSFNEQR SNFFEARVSN YAKGSVSFDD F
Length:341
Mass (Da):39,482
Last modified:November 1, 1997 - v1
Checksum:iEB52BA425F14EF6E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000511 Genomic DNA. Translation: AAD07432.1.
PIRiD64565.
RefSeqiNP_207162.1. NC_000915.1.
YP_006934288.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD07432; AAD07432; HP_0364.
GeneIDi13869549.
899218.
KEGGiheo:C694_01845.
hpy:HP0364.
PATRICi20591963. VBIHelPyl33062_0376.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000511 Genomic DNA. Translation: AAD07432.1 .
PIRi D64565.
RefSeqi NP_207162.1. NC_000915.1.
YP_006934288.1. NC_018939.1.

3D structure databases

ProteinModelPortali P55983.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-3348N.
IntActi P55983. 2 interactions.
MINTi MINT-161059.
STRINGi 85962.HP0364.

Proteomic databases

PRIDEi P55983.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD07432 ; AAD07432 ; HP_0364 .
GeneIDi 13869549.
899218.
KEGGi heo:C694_01845.
hpy:HP0364.
PATRICi 20591963. VBIHelPyl33062_0376.

Phylogenomic databases

eggNOGi COG0208.
KOi K00526.
OMAi SEIFNAY.
OrthoDBi EOG6J48J7.

Enzyme and pathway databases

UniPathwayi UPA00326 .
BioCyci HPY:HP0364-MONOMER.

Family and domain databases

Gene3Di 1.10.620.20. 1 hit.
InterProi IPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR026023. RNR_bsu_prok.
IPR000358. RNR_small.
[Graphical view ]
PANTHERi PTHR23409. PTHR23409. 1 hit.
Pfami PF00268. Ribonuc_red_sm. 1 hit.
[Graphical view ]
PIRSFi PIRSF000355. NrdB. 1 hit.
SUPFAMi SSF47240. SSF47240. 1 hit.
PROSITEi PS00368. RIBORED_SMALL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700392 / 26695.

Entry informationi

Entry nameiRIR2_HELPY
AccessioniPrimary (citable) accession number: P55983
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: October 1, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3