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Protein

Ribonucleoside-diphosphate reductase subunit beta

Gene

nrdB

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity).By similarity

Catalytic activityi

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.PROSITE-ProRule annotation

Cofactori

Fe cationBy similarityNote: Binds 2 iron ions per subunit.By similarity

Pathway: DNA replication

This protein is involved in the pathway DNA replication, which is part of Genetic information processing.
View all proteins of this organism that are known to be involved in the pathway DNA replication and in Genetic information processing.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi89 – 891Iron 1PROSITE-ProRule annotation
Metal bindingi120 – 1201Iron 1PROSITE-ProRule annotation
Metal bindingi120 – 1201Iron 2By similarity
Metal bindingi123 – 1231Iron 1PROSITE-ProRule annotation
Active sitei127 – 1271PROSITE-ProRule annotation
Metal bindingi185 – 1851Iron 2By similarity
Metal bindingi219 – 2191Iron 2By similarity
Metal bindingi222 – 2221Iron 2By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

DNA replication

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BioCyciHPY:HP0364-MONOMER.
UniPathwayiUPA00326.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonucleoside-diphosphate reductase subunit beta (EC:1.17.4.1)
Alternative name(s):
Ribonucleotide reductase small subunit
Gene namesi
Name:nrdB
Ordered Locus Names:HP_0364
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000429 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 341341Ribonucleoside-diphosphate reductase subunit betaPRO_0000190480Add
BLAST

Proteomic databases

PRIDEiP55983.

Interactioni

Subunit structurei

Tetramer of two alpha and two beta subunits.By similarity

Protein-protein interaction databases

DIPiDIP-3348N.
IntActiP55983. 2 interactions.
MINTiMINT-161059.
STRINGi85962.HP0364.

Structurei

3D structure databases

ProteinModelPortaliP55983.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0208.
KOiK00526.
OMAiCNRRCQQ.
OrthoDBiEOG6J48J7.

Family and domain databases

Gene3Di1.10.620.20. 1 hit.
InterProiIPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR000358. RNR_small.
IPR030475. RNR_small_AS.
[Graphical view]
PANTHERiPTHR23409. PTHR23409. 1 hit.
PfamiPF00268. Ribonuc_red_sm. 1 hit.
[Graphical view]
PIRSFiPIRSF000355. NrdB. 1 hit.
SUPFAMiSSF47240. SSF47240. 1 hit.
PROSITEiPS00368. RIBORED_SMALL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P55983-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEVSRKKIYN PNSTESVNER KIFGGNPTSM FDLNKIKYQW ADHLWKTMLA
60 70 80 90 100
NTWFAEEVSM NDDKRDYLKL SAEEKIGYDR ALAQLIFMDS LQANNLIDNI
110 120 130 140 150
NPFITSPEIN LCLVRQAYEE ALHSHAYAVM VESISANTEE IYDMWRNDMQ
160 170 180 190 200
LKSKNDYIAQ VYMELAKNPT EENILKALFA NQILEGIYFY SGFSYFYTLA
210 220 230 240 250
RSGKMLGSAQ MIRFIQRDEV THLILFQNMI NALRNERADL FTPQLINEVI
260 270 280 290 300
GMFKKAVEIE ALWGDYITQG KILGLTSSLI EQYIQFLADS RLSKVGIAKV
310 320 330 340
YGVQHPIKWV ESFSSFNEQR SNFFEARVSN YAKGSVSFDD F
Length:341
Mass (Da):39,482
Last modified:November 1, 1997 - v1
Checksum:iEB52BA425F14EF6E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD07432.1.
PIRiD64565.
RefSeqiNP_207162.1. NC_000915.1.
WP_000453999.1. NC_018939.1.
YP_006934288.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD07432; AAD07432; HP_0364.
GeneIDi899218.
KEGGiheo:C694_01845.
hpy:HP0364.
PATRICi20591963. VBIHelPyl33062_0376.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD07432.1.
PIRiD64565.
RefSeqiNP_207162.1. NC_000915.1.
WP_000453999.1. NC_018939.1.
YP_006934288.1. NC_018939.1.

3D structure databases

ProteinModelPortaliP55983.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-3348N.
IntActiP55983. 2 interactions.
MINTiMINT-161059.
STRINGi85962.HP0364.

Proteomic databases

PRIDEiP55983.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD07432; AAD07432; HP_0364.
GeneIDi899218.
KEGGiheo:C694_01845.
hpy:HP0364.
PATRICi20591963. VBIHelPyl33062_0376.

Phylogenomic databases

eggNOGiCOG0208.
KOiK00526.
OMAiCNRRCQQ.
OrthoDBiEOG6J48J7.

Enzyme and pathway databases

UniPathwayiUPA00326.
BioCyciHPY:HP0364-MONOMER.

Family and domain databases

Gene3Di1.10.620.20. 1 hit.
InterProiIPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR000358. RNR_small.
IPR030475. RNR_small_AS.
[Graphical view]
PANTHERiPTHR23409. PTHR23409. 1 hit.
PfamiPF00268. Ribonuc_red_sm. 1 hit.
[Graphical view]
PIRSFiPIRSF000355. NrdB. 1 hit.
SUPFAMiSSF47240. SSF47240. 1 hit.
PROSITEiPS00368. RIBORED_SMALL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700392 / 26695.

Entry informationi

Entry nameiRIR2_HELPY
AccessioniPrimary (citable) accession number: P55983
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: May 27, 2015
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.