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P55983

- RIR2_HELPY

UniProt

P55983 - RIR2_HELPY

Protein

Ribonucleoside-diphosphate reductase subunit beta

Gene

nrdB

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 1 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides By similarity.By similarity

    Catalytic activityi

    2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.PROSITE-ProRule annotation

    Cofactori

    Binds 2 iron ions per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi89 – 891Iron 1PROSITE-ProRule annotation
    Metal bindingi120 – 1201Iron 1PROSITE-ProRule annotation
    Metal bindingi120 – 1201Iron 2By similarity
    Metal bindingi123 – 1231Iron 1PROSITE-ProRule annotation
    Active sitei127 – 1271PROSITE-ProRule annotation
    Metal bindingi185 – 1851Iron 2By similarity
    Metal bindingi219 – 2191Iron 2By similarity
    Metal bindingi222 – 2221Iron 2By similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Source: UniProtKB-EC

    GO - Biological processi

    1. deoxyribonucleoside diphosphate metabolic process Source: InterPro
    2. deoxyribonucleotide biosynthetic process Source: InterPro
    3. DNA replication Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    DNA replication

    Keywords - Ligandi

    Iron, Metal-binding

    Enzyme and pathway databases

    BioCyciHPY:HP0364-MONOMER.
    UniPathwayiUPA00326.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribonucleoside-diphosphate reductase subunit beta (EC:1.17.4.1)
    Alternative name(s):
    Ribonucleotide reductase small subunit
    Gene namesi
    Name:nrdB
    Ordered Locus Names:HP_0364
    OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
    Taxonomic identifieri85962 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
    ProteomesiUP000000429: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. ribonucleoside-diphosphate reductase complex Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 341341Ribonucleoside-diphosphate reductase subunit betaPRO_0000190480Add
    BLAST

    Proteomic databases

    PRIDEiP55983.

    Interactioni

    Subunit structurei

    Tetramer of two alpha and two beta subunits.By similarity

    Protein-protein interaction databases

    DIPiDIP-3348N.
    IntActiP55983. 2 interactions.
    MINTiMINT-161059.
    STRINGi85962.HP0364.

    Structurei

    3D structure databases

    ProteinModelPortaliP55983.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0208.
    KOiK00526.
    OMAiSEIFNAY.
    OrthoDBiEOG6J48J7.

    Family and domain databases

    Gene3Di1.10.620.20. 1 hit.
    InterProiIPR009078. Ferritin-like_SF.
    IPR012348. RNR-rel.
    IPR026023. RNR_bsu_prok.
    IPR000358. RNR_small.
    [Graphical view]
    PANTHERiPTHR23409. PTHR23409. 1 hit.
    PfamiPF00268. Ribonuc_red_sm. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000355. NrdB. 1 hit.
    SUPFAMiSSF47240. SSF47240. 1 hit.
    PROSITEiPS00368. RIBORED_SMALL. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P55983-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEVSRKKIYN PNSTESVNER KIFGGNPTSM FDLNKIKYQW ADHLWKTMLA    50
    NTWFAEEVSM NDDKRDYLKL SAEEKIGYDR ALAQLIFMDS LQANNLIDNI 100
    NPFITSPEIN LCLVRQAYEE ALHSHAYAVM VESISANTEE IYDMWRNDMQ 150
    LKSKNDYIAQ VYMELAKNPT EENILKALFA NQILEGIYFY SGFSYFYTLA 200
    RSGKMLGSAQ MIRFIQRDEV THLILFQNMI NALRNERADL FTPQLINEVI 250
    GMFKKAVEIE ALWGDYITQG KILGLTSSLI EQYIQFLADS RLSKVGIAKV 300
    YGVQHPIKWV ESFSSFNEQR SNFFEARVSN YAKGSVSFDD F 341
    Length:341
    Mass (Da):39,482
    Last modified:November 1, 1997 - v1
    Checksum:iEB52BA425F14EF6E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000511 Genomic DNA. Translation: AAD07432.1.
    PIRiD64565.
    RefSeqiNP_207162.1. NC_000915.1.
    YP_006934288.1. NC_018939.1.

    Genome annotation databases

    EnsemblBacteriaiAAD07432; AAD07432; HP_0364.
    GeneIDi13869549.
    899218.
    KEGGiheo:C694_01845.
    hpy:HP0364.
    PATRICi20591963. VBIHelPyl33062_0376.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000511 Genomic DNA. Translation: AAD07432.1 .
    PIRi D64565.
    RefSeqi NP_207162.1. NC_000915.1.
    YP_006934288.1. NC_018939.1.

    3D structure databases

    ProteinModelPortali P55983.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-3348N.
    IntActi P55983. 2 interactions.
    MINTi MINT-161059.
    STRINGi 85962.HP0364.

    Proteomic databases

    PRIDEi P55983.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD07432 ; AAD07432 ; HP_0364 .
    GeneIDi 13869549.
    899218.
    KEGGi heo:C694_01845.
    hpy:HP0364.
    PATRICi 20591963. VBIHelPyl33062_0376.

    Phylogenomic databases

    eggNOGi COG0208.
    KOi K00526.
    OMAi SEIFNAY.
    OrthoDBi EOG6J48J7.

    Enzyme and pathway databases

    UniPathwayi UPA00326 .
    BioCyci HPY:HP0364-MONOMER.

    Family and domain databases

    Gene3Di 1.10.620.20. 1 hit.
    InterProi IPR009078. Ferritin-like_SF.
    IPR012348. RNR-rel.
    IPR026023. RNR_bsu_prok.
    IPR000358. RNR_small.
    [Graphical view ]
    PANTHERi PTHR23409. PTHR23409. 1 hit.
    Pfami PF00268. Ribonuc_red_sm. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000355. NrdB. 1 hit.
    SUPFAMi SSF47240. SSF47240. 1 hit.
    PROSITEi PS00368. RIBORED_SMALL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700392 / 26695.

    Entry informationi

    Entry nameiRIR2_HELPY
    AccessioniPrimary (citable) accession number: P55983
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Helicobacter pylori
      Helicobacter pylori (strain 26695): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3