P55973 (IF3_HELPY) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Translation initiation factor IF-3

Gene names

Name:	infC
Ordered Locus Names:	HP_0124

Organism

Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)

Taxonomic identifier

85962 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter

Protein attributes

Sequence length	203 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins. HAMAP MF_00080
Subunit structure	Monomer By similarity. HAMAP MF_00080
Subcellular location	Cytoplasm HAMAP MF_00080.
Sequence similarities	Belongs to the IF-3 family.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Molecular function	Initiation factor
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	translation initiation factor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 203	203	Translation initiation factor IF-3 HAMAP MF_00080		PRO_0000177525

Sequences

	Sequence		Length	Mass (Da)
	P55973 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: 65B38BFD36CD8003	FASTA	203	23,342
	10 20 30 40 50 60 MSRNEVLLNG DINFKEVRCV GDNGEVYGII SSKEALHIAQ NLGLDLVLIS ASAKPPVCKV 70 80 90 100 110 120 MDYNKFRYQN EKKIKEAKKK QKQIEIKEIK LSTQIAQNDI NYKVKHAREF IESNKHVKFK 130 140 150 160 170 180 VVLKGRESQN SKAGLDVLFR VQTMMQDLAN PEKEPKTEGR FVSWMFVPKA KEAPKNEKKT 190 200 KENNPPFNRI NLMKGENHAK NED

References

[1]

"The complete genome sequence of the gastric pathogen Helicobacter pylori." Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G., Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A., Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N., Loftus B.J., Richardson D.L., Dodson R.J. , Khalak H.G., Glodek A., McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E., Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D., Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S., Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C. Nature 388:539-547(1997) [PubMed: 9252185] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700392 / 26695.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE000511 Genomic DNA. Translation: AAD07193.1.
PIR	D64535.
RefSeq	NP_206924.1. NC_000915.1.
3D structure databases
ProteinModelPortal	P55973.
SMR	P55973. Positions 5-79.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-3195N.
MINT	MINT-171266.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	899823.
GenomeReviews	Gene locus HP_0124 in contig AE000511_GR.
KEGG	hpy:HP0124.
NMPDR	fig|85962.1.peg.122.
PATRIC	20591465. VBIHelPyl33062_0132.
TIGR	HP_0124.
Phylogenomic databases
HOGENOM	HBG744268.
OMA	FDRRAPV.
ProtClustDB	PRK00028.
Family and domain databases
HAMAP	MF_00080. IF-3. [Tree]
InterPro	IPR019813. Translation_initiation_fac3_CS. IPR001288. Translation_initiation_fac_3. IPR019815. Translation_initiation_fac_3_C. IPR019814. Translation_initiation_fac_3_N. [Graphical view]
Gene3D	G3DSA:3.10.20.80. IF3. 1 hit. G3DSA:3.30.110.10. IF3. 1 hit.
KO	K02520.
PANTHER	PTHR10938. IF3. 1 hit.
Pfam	PF00707. IF3_C. 1 hit. PF05198. IF3_N. 1 hit. [Graphical view]
SUPFAM	SSF54364. IF3. 1 hit. SSF55200. IF3. 1 hit.
TIGRFAMs	TIGR00168. InfC. 1 hit.
PROSITE	PS00938. IF3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

IF3_HELPY

Accession

Primary (citable) accession number: P55973

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	January 25, 2012
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program