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P55972 (IF2_HELPY) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Translation initiation factor IF-2
Gene names
Name:infB
Ordered Locus Names:HP_1048
OrganismHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) [Reference proteome] [HAMAP]
Taxonomic identifier85962 [NCBI]
Taxonomic lineageBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter

Protein attributes

Sequence length944 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex By similarity. HAMAP-Rule MF_00100_B

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00100_B.

Sequence similarities

Belongs to the IF-2 family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandGTP-binding
Nucleotide-binding
   Molecular functionInitiation factor
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionGTP binding

Inferred from electronic annotation. Source: UniProtKB-KW

GTPase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

translation initiation factor activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 944944Translation initiation factor IF-2 HAMAP-Rule MF_00100_B
PRO_0000137209

Regions

Nucleotide binding452 – 4598GTP By similarity
Nucleotide binding498 – 5025GTP By similarity
Nucleotide binding552 – 5554GTP By similarity
Region446 – 594149G-domain HAMAP-Rule MF_00100_B

Sequences

Sequence LengthMass (Da)Tools
P55972 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: EC90404D9C3B851D

FASTA944105,195
        10         20         30         40         50         60 
MSGMVDLKEF LAELGKTQKE LKNVIEQAKD IGLELKTNSK MTPEQAGKLY KYIVDGIKEQ 

        70         80         90        100        110        120 
IQANQPAKNP EQDNKDDLNT AVASKSLNKK VSKTPKKEET KSQPKPKKTK EKKKEAPTPI 

       130        140        150        160        170        180 
AKKKGGIEIV NTFENQTPPT ENTPKVVSHS QIEKAKQKLQ EIQKSREALN KLTQSNANNA 

       190        200        210        220        230        240 
SNANNAKKEI SEVKKQEQEI KRHENIKRRT GFRVIKRNDE VENESENSVT ESKKPTQSAA 

       250        260        270        280        290        300 
AIFEDIKKEW QEKDKQEAKK AKKPSKPKAT PTAKNNKSHK IDFSDARDFK GNDIYDDETD 

       310        320        330        340        350        360 
EILLFDLHEQ DNFNKEEEEK EIRQNINDRV RVQRKNPWMN ESGIKRQSKK KRAFRNDNSQ 

       370        380        390        400        410        420 
KVIQSTTAIP EEVRVYEFAQ KANLNLADVI KTLFNLGLMV TKNDFLDKDS IEILAEEFHL 

       430        440        450        460        470        480 
EISVQNTLEE FEVEEVLEGV KKERPPVVTI MGHVDHGKTS LLDKIRDKRV AHTEAGGITQ 

       490        500        510        520        530        540 
HIGAYMVEKN DKWVSFIDTP GHEAFSQMRN RGAQVTDIAV IVIAADDGVK QQTIEALEHA 

       550        560        570        580        590        600 
KAANVPVIFA MNKMDKPNVN PDKLKAECAE LGYNPVDWGG EHEFIPVSAK TGDGIDNLLE 

       610        620        630        640        650        660 
TILIQAGIME LKAIEEGSAR AVVLEGSVEK GRGAVATVIV QSGTLSVGDS FFAETAFGKV 

       670        680        690        700        710        720 
RTMTDDQGKS IQNLKPSMVA LITGLSEVPP AGSVLIGVEN DSIARLQAQK RATYLRQKAL 

       730        740        750        760        770        780 
SKSTKVSFDE LSEMVANKEL KNIPVVIKAD TQGSLEAIKN SLLELNNEEV AIQVIHSGVG 

       790        800        810        820        830        840 
GITENDLSLV SSSEHAVILG FNIRPTGNVK NKAKEYNVSI KTYTVIYALI EEMRSLLLGL 

       850        860        870        880        890        900 
MSPIIEEEHT GQAEVRETFN IPKVGTIAGC VVSDGVIARG IKARLIRDGV VIHTGEILSL 

       910        920        930        940 
KRFKDDVKEV SKGYECGIML DNYNEIKVGD VFETYKEIHK KRTL 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE000511 Genomic DNA. Translation: AAD08093.1.
PIRH64650.
RefSeqNP_207839.1. NC_000915.1.
YP_006934964.1. NC_018939.1.

3D structure databases

ProteinModelPortalP55972.
SMRP55972. Positions 846-935.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-3291N.
IntActP55972. 5 interactions.
MINTMINT-163944.
STRING85962.HP1048.

Proteomic databases

PRIDEP55972.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAD08093; AAD08093; HP_1048.
GeneID13870241.
899583.
KEGGheo:C694_05420.
hpy:HP1048.
PATRIC20593433. VBIHelPyl33062_1097.

Phylogenomic databases

eggNOGCOG0532.
KOK02519.
OMAHDERGHE.
OrthoDBEOG67HJSV.
ProtClustDBPRK05306.

Enzyme and pathway databases

BioCycHPY:HP1048-MONOMER.

Family and domain databases

Gene3D3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPMF_00100_B. IF_2_B.
InterProIPR000795. EF_GTP-bd_dom.
IPR006847. IF2_N.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000178. TF_IF2_bacterial-like.
IPR015760. TIF_IF2.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view]
PANTHERPTHR23115:SF41. PTHR23115:SF41. 1 hit.
PfamPF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 2 hits.
PF11987. IF-2. 1 hit.
PF04760. IF2_N. 1 hit.
[Graphical view]
SUPFAMSSF50447. SSF50447. 2 hits.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR00487. IF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEPS01176. IF2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameIF2_HELPY
AccessionPrimary (citable) accession number: P55972
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: April 16, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Translation initiation factors

List of translation initiation factor entries

Helicobacter pylori

Helicobacter pylori (strain 26695): entries and gene names