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Protein

Translation initiation factor IF-2

Gene

infB

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi452 – 4598GTPBy similarity
Nucleotide bindingi498 – 5025GTPBy similarity
Nucleotide bindingi552 – 5554GTPBy similarity

GO - Molecular functioni

  1. GTPase activity Source: UniProtKB-HAMAP
  2. GTP binding Source: UniProtKB-KW
  3. translation initiation factor activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciHPY:HP1048-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Translation initiation factor IF-2
Gene namesi
Name:infB
Ordered Locus Names:HP_1048
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000429: Chromosome

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 944944Translation initiation factor IF-2PRO_0000137209Add
BLAST

Proteomic databases

PRIDEiP55972.

Interactioni

Protein-protein interaction databases

DIPiDIP-3291N.
IntActiP55972. 5 interactions.
MINTiMINT-163944.
STRINGi85962.HP1048.

Structurei

3D structure databases

ProteinModelPortaliP55972.
SMRiP55972. Positions 846-935.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini443 – 612170tr-type GAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni452 – 4598G1By similarity
Regioni477 – 4815G2By similarity
Regioni498 – 5014G3By similarity
Regioni552 – 5554G4By similarity
Regioni588 – 5903G5By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0532.
KOiK02519.
OMAiANQPAKN.
OrthoDBiEOG67HJSV.

Family and domain databases

Gene3Di3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00100_B. IF_2_B.
InterProiIPR000795. EF_GTP-bd_dom.
IPR006847. IF2_N.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000178. TF_IF2_bacterial-like.
IPR015760. TIF_IF2.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view]
PANTHERiPTHR23115:SF41. PTHR23115:SF41. 1 hit.
PfamiPF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 2 hits.
PF11987. IF-2. 1 hit.
PF04760. IF2_N. 1 hit.
[Graphical view]
SUPFAMiSSF50447. SSF50447. 2 hits.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00487. IF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS51722. G_TR_2. 1 hit.
PS01176. IF2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P55972-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSGMVDLKEF LAELGKTQKE LKNVIEQAKD IGLELKTNSK MTPEQAGKLY
60 70 80 90 100
KYIVDGIKEQ IQANQPAKNP EQDNKDDLNT AVASKSLNKK VSKTPKKEET
110 120 130 140 150
KSQPKPKKTK EKKKEAPTPI AKKKGGIEIV NTFENQTPPT ENTPKVVSHS
160 170 180 190 200
QIEKAKQKLQ EIQKSREALN KLTQSNANNA SNANNAKKEI SEVKKQEQEI
210 220 230 240 250
KRHENIKRRT GFRVIKRNDE VENESENSVT ESKKPTQSAA AIFEDIKKEW
260 270 280 290 300
QEKDKQEAKK AKKPSKPKAT PTAKNNKSHK IDFSDARDFK GNDIYDDETD
310 320 330 340 350
EILLFDLHEQ DNFNKEEEEK EIRQNINDRV RVQRKNPWMN ESGIKRQSKK
360 370 380 390 400
KRAFRNDNSQ KVIQSTTAIP EEVRVYEFAQ KANLNLADVI KTLFNLGLMV
410 420 430 440 450
TKNDFLDKDS IEILAEEFHL EISVQNTLEE FEVEEVLEGV KKERPPVVTI
460 470 480 490 500
MGHVDHGKTS LLDKIRDKRV AHTEAGGITQ HIGAYMVEKN DKWVSFIDTP
510 520 530 540 550
GHEAFSQMRN RGAQVTDIAV IVIAADDGVK QQTIEALEHA KAANVPVIFA
560 570 580 590 600
MNKMDKPNVN PDKLKAECAE LGYNPVDWGG EHEFIPVSAK TGDGIDNLLE
610 620 630 640 650
TILIQAGIME LKAIEEGSAR AVVLEGSVEK GRGAVATVIV QSGTLSVGDS
660 670 680 690 700
FFAETAFGKV RTMTDDQGKS IQNLKPSMVA LITGLSEVPP AGSVLIGVEN
710 720 730 740 750
DSIARLQAQK RATYLRQKAL SKSTKVSFDE LSEMVANKEL KNIPVVIKAD
760 770 780 790 800
TQGSLEAIKN SLLELNNEEV AIQVIHSGVG GITENDLSLV SSSEHAVILG
810 820 830 840 850
FNIRPTGNVK NKAKEYNVSI KTYTVIYALI EEMRSLLLGL MSPIIEEEHT
860 870 880 890 900
GQAEVRETFN IPKVGTIAGC VVSDGVIARG IKARLIRDGV VIHTGEILSL
910 920 930 940
KRFKDDVKEV SKGYECGIML DNYNEIKVGD VFETYKEIHK KRTL
Length:944
Mass (Da):105,195
Last modified:November 1, 1997 - v1
Checksum:iEC90404D9C3B851D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD08093.1.
PIRiH64650.
RefSeqiNP_207839.1. NC_000915.1.
YP_006934964.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD08093; AAD08093; HP_1048.
GeneIDi13870241.
899583.
KEGGiheo:C694_05420.
hpy:HP1048.
PATRICi20593433. VBIHelPyl33062_1097.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD08093.1.
PIRiH64650.
RefSeqiNP_207839.1. NC_000915.1.
YP_006934964.1. NC_018939.1.

3D structure databases

ProteinModelPortaliP55972.
SMRiP55972. Positions 846-935.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-3291N.
IntActiP55972. 5 interactions.
MINTiMINT-163944.
STRINGi85962.HP1048.

Proteomic databases

PRIDEiP55972.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD08093; AAD08093; HP_1048.
GeneIDi13870241.
899583.
KEGGiheo:C694_05420.
hpy:HP1048.
PATRICi20593433. VBIHelPyl33062_1097.

Phylogenomic databases

eggNOGiCOG0532.
KOiK02519.
OMAiANQPAKN.
OrthoDBiEOG67HJSV.

Enzyme and pathway databases

BioCyciHPY:HP1048-MONOMER.

Family and domain databases

Gene3Di3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00100_B. IF_2_B.
InterProiIPR000795. EF_GTP-bd_dom.
IPR006847. IF2_N.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000178. TF_IF2_bacterial-like.
IPR015760. TIF_IF2.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view]
PANTHERiPTHR23115:SF41. PTHR23115:SF41. 1 hit.
PfamiPF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 2 hits.
PF11987. IF-2. 1 hit.
PF04760. IF2_N. 1 hit.
[Graphical view]
SUPFAMiSSF50447. SSF50447. 2 hits.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00487. IF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS51722. G_TR_2. 1 hit.
PS01176. IF2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700392 / 26695.

Entry informationi

Entry nameiIF2_HELPY
AccessioniPrimary (citable) accession number: P55972
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: January 7, 2015
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.