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P55972

- IF2_HELPY

UniProt

P55972 - IF2_HELPY

Protein

Translation initiation factor IF-2

Gene

infB

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 1 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi452 – 4598GTPBy similarity
    Nucleotide bindingi498 – 5025GTPBy similarity
    Nucleotide bindingi552 – 5554GTPBy similarity

    GO - Molecular functioni

    1. GTPase activity Source: UniProtKB-HAMAP
    2. GTP binding Source: UniProtKB-KW
    3. translation initiation factor activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Initiation factor

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciHPY:HP1048-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Translation initiation factor IF-2
    Gene namesi
    Name:infB
    Ordered Locus Names:HP_1048
    OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
    Taxonomic identifieri85962 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
    ProteomesiUP000000429: Chromosome

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 944944Translation initiation factor IF-2PRO_0000137209Add
    BLAST

    Proteomic databases

    PRIDEiP55972.

    Interactioni

    Protein-protein interaction databases

    DIPiDIP-3291N.
    IntActiP55972. 5 interactions.
    MINTiMINT-163944.
    STRINGi85962.HP1048.

    Structurei

    3D structure databases

    ProteinModelPortaliP55972.
    SMRiP55972. Positions 846-935.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini443 – 612170tr-type GAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni452 – 4598G1By similarity
    Regioni477 – 4815G2By similarity
    Regioni498 – 5014G3By similarity
    Regioni552 – 5554G4By similarity
    Regioni588 – 5903G5By similarity

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0532.
    KOiK02519.
    OMAiEHEFIPV.
    OrthoDBiEOG67HJSV.

    Family and domain databases

    Gene3Di3.40.50.10050. 1 hit.
    3.40.50.300. 1 hit.
    HAMAPiMF_00100_B. IF_2_B.
    InterProiIPR000795. EF_GTP-bd_dom.
    IPR006847. IF2_N.
    IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR000178. TF_IF2_bacterial-like.
    IPR015760. TIF_IF2.
    IPR023115. TIF_IF2_dom3.
    IPR009000. Transl_B-barrel.
    IPR004161. Transl_elong_EFTu/EF1A_2.
    [Graphical view]
    PANTHERiPTHR23115:SF41. PTHR23115:SF41. 1 hit.
    PfamiPF00009. GTP_EFTU. 1 hit.
    PF03144. GTP_EFTU_D2. 2 hits.
    PF11987. IF-2. 1 hit.
    PF04760. IF2_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF50447. SSF50447. 2 hits.
    SSF52156. SSF52156. 1 hit.
    SSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00487. IF-2. 1 hit.
    TIGR00231. small_GTP. 1 hit.
    PROSITEiPS51722. G_TR_2. 1 hit.
    PS01176. IF2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P55972-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSGMVDLKEF LAELGKTQKE LKNVIEQAKD IGLELKTNSK MTPEQAGKLY    50
    KYIVDGIKEQ IQANQPAKNP EQDNKDDLNT AVASKSLNKK VSKTPKKEET 100
    KSQPKPKKTK EKKKEAPTPI AKKKGGIEIV NTFENQTPPT ENTPKVVSHS 150
    QIEKAKQKLQ EIQKSREALN KLTQSNANNA SNANNAKKEI SEVKKQEQEI 200
    KRHENIKRRT GFRVIKRNDE VENESENSVT ESKKPTQSAA AIFEDIKKEW 250
    QEKDKQEAKK AKKPSKPKAT PTAKNNKSHK IDFSDARDFK GNDIYDDETD 300
    EILLFDLHEQ DNFNKEEEEK EIRQNINDRV RVQRKNPWMN ESGIKRQSKK 350
    KRAFRNDNSQ KVIQSTTAIP EEVRVYEFAQ KANLNLADVI KTLFNLGLMV 400
    TKNDFLDKDS IEILAEEFHL EISVQNTLEE FEVEEVLEGV KKERPPVVTI 450
    MGHVDHGKTS LLDKIRDKRV AHTEAGGITQ HIGAYMVEKN DKWVSFIDTP 500
    GHEAFSQMRN RGAQVTDIAV IVIAADDGVK QQTIEALEHA KAANVPVIFA 550
    MNKMDKPNVN PDKLKAECAE LGYNPVDWGG EHEFIPVSAK TGDGIDNLLE 600
    TILIQAGIME LKAIEEGSAR AVVLEGSVEK GRGAVATVIV QSGTLSVGDS 650
    FFAETAFGKV RTMTDDQGKS IQNLKPSMVA LITGLSEVPP AGSVLIGVEN 700
    DSIARLQAQK RATYLRQKAL SKSTKVSFDE LSEMVANKEL KNIPVVIKAD 750
    TQGSLEAIKN SLLELNNEEV AIQVIHSGVG GITENDLSLV SSSEHAVILG 800
    FNIRPTGNVK NKAKEYNVSI KTYTVIYALI EEMRSLLLGL MSPIIEEEHT 850
    GQAEVRETFN IPKVGTIAGC VVSDGVIARG IKARLIRDGV VIHTGEILSL 900
    KRFKDDVKEV SKGYECGIML DNYNEIKVGD VFETYKEIHK KRTL 944
    Length:944
    Mass (Da):105,195
    Last modified:November 1, 1997 - v1
    Checksum:iEC90404D9C3B851D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000511 Genomic DNA. Translation: AAD08093.1.
    PIRiH64650.
    RefSeqiNP_207839.1. NC_000915.1.
    YP_006934964.1. NC_018939.1.

    Genome annotation databases

    EnsemblBacteriaiAAD08093; AAD08093; HP_1048.
    GeneIDi13870241.
    899583.
    KEGGiheo:C694_05420.
    hpy:HP1048.
    PATRICi20593433. VBIHelPyl33062_1097.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000511 Genomic DNA. Translation: AAD08093.1 .
    PIRi H64650.
    RefSeqi NP_207839.1. NC_000915.1.
    YP_006934964.1. NC_018939.1.

    3D structure databases

    ProteinModelPortali P55972.
    SMRi P55972. Positions 846-935.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-3291N.
    IntActi P55972. 5 interactions.
    MINTi MINT-163944.
    STRINGi 85962.HP1048.

    Proteomic databases

    PRIDEi P55972.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAD08093 ; AAD08093 ; HP_1048 .
    GeneIDi 13870241.
    899583.
    KEGGi heo:C694_05420.
    hpy:HP1048.
    PATRICi 20593433. VBIHelPyl33062_1097.

    Phylogenomic databases

    eggNOGi COG0532.
    KOi K02519.
    OMAi EHEFIPV.
    OrthoDBi EOG67HJSV.

    Enzyme and pathway databases

    BioCyci HPY:HP1048-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.10050. 1 hit.
    3.40.50.300. 1 hit.
    HAMAPi MF_00100_B. IF_2_B.
    InterProi IPR000795. EF_GTP-bd_dom.
    IPR006847. IF2_N.
    IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR000178. TF_IF2_bacterial-like.
    IPR015760. TIF_IF2.
    IPR023115. TIF_IF2_dom3.
    IPR009000. Transl_B-barrel.
    IPR004161. Transl_elong_EFTu/EF1A_2.
    [Graphical view ]
    PANTHERi PTHR23115:SF41. PTHR23115:SF41. 1 hit.
    Pfami PF00009. GTP_EFTU. 1 hit.
    PF03144. GTP_EFTU_D2. 2 hits.
    PF11987. IF-2. 1 hit.
    PF04760. IF2_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50447. SSF50447. 2 hits.
    SSF52156. SSF52156. 1 hit.
    SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00487. IF-2. 1 hit.
    TIGR00231. small_GTP. 1 hit.
    PROSITEi PS51722. G_TR_2. 1 hit.
    PS01176. IF2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700392 / 26695.

    Entry informationi

    Entry nameiIF2_HELPY
    AccessioniPrimary (citable) accession number: P55972
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Helicobacter pylori
      Helicobacter pylori (strain 26695): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3