P55969 (HPAA_HELPY) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Neuraminyllactose-binding hemagglutinin

Alternative name(s):
Flagellar sheath adhesin
N-acetylneuraminyllactose-binding fibrillar hemagglutinin receptor-binding subunit
Short name=NLBH

Gene names

Name:	hpaA
Ordered Locus Names:	HP_0797

Organism

Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) [Reference proteome] [HAMAP]

Taxonomic identifier

85962 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › delta/epsilon subdivisions › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter › Helicobacter pylori

Protein attributes

Sequence length	260 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Subcellular location

Cell outer membrane; Lipid-anchor Probable.

Ontologies

Keywords
Cellular component	Cell membrane Cell outer membrane Membrane
Domain	Signal
PTM	Lipoprotein Palmitate
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	cell outer membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 27	27	By similarity
	Chain	28 – 260	233	Neuraminyllactose-binding hemagglutinin		PRO_0000018100
Amino acid modifications
	Lipidation	28	1	N-palmitoyl cysteine Probable
	Lipidation	28	1	S-diacylglycerol cysteine Probable

Sequences

	Sequence		Length	Mass (Da)
	P55969 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: D9F86C8B0556D071	FASTA	260	29,040
	10 20 30 40 50 60 MKANNHFKDF AWKKCLLGAS VVALLVGCSP HIIETNEVAL KLNYHPASEK VQALDEKILL 70 80 90 100 110 120 LRPAFQYSDN IAKEYENKFK NQTALKVEQI LQNQGYKVIS VDSSDKDDLS FSQKKEGYLA 130 140 150 160 170 180 VAMNGEIVLR PDPKRTIQKK SEPGLLFSTG LDKMEGVLIP AGFVKVTILE PMSGESLDSF 190 200 210 220 230 240 TMDLSELDIQ EKFLKTTHSS HSGGLVSTMV KGTDNSNDAI KSALNKIFAN IMQEIDKKLT 250 260 QKNLESYQKD AKELKGKRNR

References

[1]

"The complete genome sequence of the gastric pathogen Helicobacter pylori." Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G., Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A., Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N., Loftus B.J., Richardson D.L., Dodson R.J. , Khalak H.G., Glodek A., McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E., Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D., Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S., Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C. Nature 388:539-547(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700392 / 26695.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE000511 Genomic DNA. Translation: AAD07844.1.
PIR	E64619.
RefSeq	NP_207590.1. NC_000915.1. YP_006934711.1. NC_018939.1.
3D structure databases
ProteinModelPortal	P55969.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-3518N.
MINT	MINT-168283.
STRING	85962.HP0797.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAD07844; AAD07844; HP_0797.
GeneID	13869980. 898975.
KEGG	heo:C694_04085. hpy:HP0797.
PATRIC	20592881. VBIHelPyl33062_0829.
Phylogenomic databases
KO	K15846.
OMA	PAFQYSD.
ProtClustDB	CLSK2748728.
Family and domain databases
InterPro	IPR007876. NeuraminylLac-bd_hemagglutn. [Graphical view]
Pfam	PF05211. NLBH. 1 hit. [Graphical view]
PIRSF	PIRSF019714. Neuraminyllac-bd_haemagglutn. 1 hit.
PROSITE	PS51257. PROKAR_LIPOPROTEIN. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HPAA_HELPY

Accession

Primary (citable) accession number: P55969

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	May 1, 2013
This is version 75 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program