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Protein

Alpha-conotoxin PIVA

Gene
N/A
Organism
Conus purpurascens (Purple cone)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. This toxin has higher affinity for the adult subtype (alpha-1/beta-1/gamma/delta subunits) (IC50=2.3 nM) of the receptor than for the fetal subtype (alpha-1/beta-1/epsilon/delta subunits) (IC50=22 nM).1 Publication

GO - Molecular functioni

Keywordsi

Molecular functionAcetylcholine receptor inhibiting toxin, Ion channel impairing toxin, Neurotoxin, Postsynaptic neurotoxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-conotoxin PIVACurated
Alternative name(s):
Alpha-A-conotoxin PIVA1 Publication
OrganismiConus purpurascens (Purple cone)
Taxonomic identifieri41690 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaHypsogastropodaNeogastropodaConoideaConidaeConusChelyconus

Organism-specific databases

ConoServeri1449 PIVA
1612 PIVA [Hyp7P,Hyp13P]

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Sequence analysisAdd BLAST16
PropeptideiPRO_000044420417 – 411 PublicationAdd BLAST25
PeptideiPRO_000004446642 – 66Alpha-conotoxin PIVA1 PublicationAdd BLAST25

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi43 ↔ 572 Publications
Disulfide bondi44 ↔ 522 Publications
Modified residuei484-hydroxyproline; partial1 Publication1
Modified residuei544-hydroxyproline; partial1 Publication1
Disulfide bondi55 ↔ 642 Publications
Modified residuei614-hydroxyproline1 Publication1
Modified residuei66Glutamine amide1 Publication1

Keywords - PTMi

Amidation, Disulfide bond, Hydroxylation

Expressioni

Tissue specificityi

Expressed by the venom duct.1 Publication

Structurei

Secondary structure

168
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni13 – 15Combined sources3
Helixi21 – 23Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1P1PNMR-A42-66[»]
SMRiP55963
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP55963

Family & Domainsi

Domaini

The cysteine framework is IV (CC-C-C-C-C).Curated

Sequence similaritiesi

Belongs to the conotoxin A superfamily.Curated

Keywords - Domaini

Signal

Family and domain databases

InterProiView protein in InterPro
IPR009958 Conotoxin_a-typ
IPR012498 Toxin_14
PfamiView protein in Pfam
PF07829 Toxin_14, 1 hit
PF07365 Toxin_8, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD045217 Toxin_14, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P55963-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFTVFLLVVL ATTVVSFTSD RASDDRNTND KASRLLSHVV RGCCGSYPNA
60
ACHPCSCKDR PSYCGQGR
Length:68
Mass (Da):7,386
Last modified:May 23, 2018 - v2
Checksum:i618EA3012F2CB90D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GQ981399 mRNA Translation: ADN79118.1
PIRiA58647

Similar proteinsi

Entry informationi

Entry nameiCA4A_CONPU
AccessioniPrimary (citable) accession number: P55963
Secondary accession number(s): E2DEK7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 23, 2018
Last modified: June 20, 2018
This is version 76 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

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