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Protein

Aspartic protease 3

Gene

asp-3

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei87 – 871PROSITE-ProRule annotation
Active sitei279 – 2791PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

  • necrotic cell death Source: WormBase
Complete GO annotation...

Keywords - Molecular functioni

Aspartyl protease, Hydrolase, Protease

Protein family/group databases

MEROPSiA01.A69.

Names & Taxonomyi

Protein namesi
Recommended name:
Aspartic protease 3 (EC:3.4.23.-)
Gene namesi
Name:asp-3
ORF Names:H22K11.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiH22K11.1; CE47856; WBGene00000216; asp-3.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: WormBase
  • extracellular region Source: UniProtKB-SubCell
  • lysosome Source: WormBase
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence analysisAdd
BLAST
Propeptidei18 – 5538Removed in mature form1 PublicationPRO_0000025937Add
BLAST
Chaini56 – 398343Aspartic protease 3PRO_0000025938Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi100 ↔ 107By similarity
Disulfide bondi313 ↔ 351By similarity
Glycosylationi321 – 3211N-linked (GlcNAc...)1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

EPDiP55956.
PaxDbiP55956.
PRIDEiP55956.

Interactioni

Protein-protein interaction databases

BioGridi45876. 3 interactions.
DIPiDIP-26574N.
IntActiP55956. 3 interactions.
MINTiMINT-1064632.
STRINGi6239.H22K11.1.

Structurei

3D structure databases

ProteinModelPortaliP55956.
SMRiP55956. Positions 58-394.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini69 – 392324Peptidase A1PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase A1 family.Curated
Contains 1 peptidase A1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1339. Eukaryota.
ENOG410XNV7. LUCA.
GeneTreeiENSGT00760000118929.
HOGENOMiHOG000197681.
InParanoidiP55956.
KOiK01379.
OMAiCATSEPG.
OrthoDBiEOG7HQN88.

Family and domain databases

Gene3Di2.40.70.10. 2 hits.
InterProiIPR001461. Aspartic_peptidase_A1.
IPR001969. Aspartic_peptidase_AS.
IPR033121. PEPTIDASE_A1.
IPR021109. Peptidase_aspartic_dom.
[Graphical view]
PANTHERiPTHR13683. PTHR13683. 1 hit.
PfamiPF00026. Asp. 1 hit.
[Graphical view]
PRINTSiPR00792. PEPSIN.
SUPFAMiSSF50630. SSF50630. 1 hit.
PROSITEiPS00141. ASP_PROTEASE. 1 hit.
PS51767. PEPTIDASE_A1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P55956-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGRVFLLLA LVALASAIQR IKLEKRTYTR EQYKFGSIQE HLKAKYVPGY
60 70 80 90 100
IPNKDAFNEG LSDYSNAQYY GPVTIGTPPQ NFQVLFDTGS SNLWVPCANC
110 120 130 140 150
PFGDIACRMH NRFDCKKSSS CTATGASFEI QYGTGSMKGT VDNDVVCFGH
160 170 180 190 200
DTTYCTDKNQ GLACATSEPG ITFVAAKFDG IFGMGWDTIS VNKISQPMDQ
210 220 230 240 250
IFANSAICKN QLFAFWLSRD ANDITNGGEI TLCDTDPNHY VGNIAWEPLV
260 270 280 290 300
SEDYWRIKLA SVVIDGTTYT SGPIDSIVDT GTSLLTGPTD VIKKIQHKIG
310 320 330 340 350
GIPLFNGEYE VECSKIPSLP NITFNLGGQN FDLQGKDYIL QMSNGNGGST
360 370 380 390
CLSGFMGMDI PAPAGPLWIL GDVFIGRFYS VFDHGNKRVG FATSRTGK
Length:398
Mass (Da):43,399
Last modified:September 18, 2013 - v3
Checksum:i5F03244C695E1F2F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081559 Genomic DNA. Translation: CCD72415.2.
PIRiT33383.
RefSeqiNP_509142.2. NM_076741.6.

Genome annotation databases

EnsemblMetazoaiH22K11.1; H22K11.1; WBGene00000216.
GeneIDi180947.
KEGGicel:CELE_H22K11.1.
UCSCiH22K11.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081559 Genomic DNA. Translation: CCD72415.2.
PIRiT33383.
RefSeqiNP_509142.2. NM_076741.6.

3D structure databases

ProteinModelPortaliP55956.
SMRiP55956. Positions 58-394.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi45876. 3 interactions.
DIPiDIP-26574N.
IntActiP55956. 3 interactions.
MINTiMINT-1064632.
STRINGi6239.H22K11.1.

Protein family/group databases

MEROPSiA01.A69.

Proteomic databases

EPDiP55956.
PaxDbiP55956.
PRIDEiP55956.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiH22K11.1; H22K11.1; WBGene00000216.
GeneIDi180947.
KEGGicel:CELE_H22K11.1.
UCSCiH22K11.1. c. elegans.

Organism-specific databases

CTDi180947.
WormBaseiH22K11.1; CE47856; WBGene00000216; asp-3.

Phylogenomic databases

eggNOGiKOG1339. Eukaryota.
ENOG410XNV7. LUCA.
GeneTreeiENSGT00760000118929.
HOGENOMiHOG000197681.
InParanoidiP55956.
KOiK01379.
OMAiCATSEPG.
OrthoDBiEOG7HQN88.

Miscellaneous databases

NextBioi911692.
PROiP55956.

Family and domain databases

Gene3Di2.40.70.10. 2 hits.
InterProiIPR001461. Aspartic_peptidase_A1.
IPR001969. Aspartic_peptidase_AS.
IPR033121. PEPTIDASE_A1.
IPR021109. Peptidase_aspartic_dom.
[Graphical view]
PANTHERiPTHR13683. PTHR13683. 1 hit.
PfamiPF00026. Asp. 1 hit.
[Graphical view]
PRINTSiPR00792. PEPSIN.
SUPFAMiSSF50630. SSF50630. 1 hit.
PROSITEiPS00141. ASP_PROTEASE. 1 hit.
PS51767. PEPTIDASE_A1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  2. "Two-dimensional gel electrophoresis of Caenorhabditis elegans homogenates and identification of protein spots by microsequencing."
    Bini L., Heid H., Liberatori S., Geier G., Pallini V., Zwilling R.
    Electrophoresis 18:557-562(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 56-65.
    Strain: Bristol N2.
  3. "Proteomics reveals N-linked glycoprotein diversity in Caenorhabditis elegans and suggests an atypical translocation mechanism for integral membrane proteins."
    Kaji H., Kamiie J., Kawakami H., Kido K., Yamauchi Y., Shinkawa T., Taoka M., Takahashi N., Isobe T.
    Mol. Cell. Proteomics 6:2100-2109(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-321, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: Bristol N2.

Entry informationi

Entry nameiASP3_CAEEL
AccessioniPrimary (citable) accession number: P55956
Secondary accession number(s): Q9TXI5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: September 18, 2013
Last modified: May 11, 2016
This is version 120 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.