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Protein

Aspartic protease 3

Gene

asp-3

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei87PROSITE-ProRule annotation1
Active sitei279PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

  • necrotic cell death Source: WormBase
  • protein catabolic process Source: GO_Central
  • proteolysis Source: GO_Central

Keywordsi

Molecular functionAspartyl protease, Hydrolase, Protease

Enzyme and pathway databases

ReactomeiR-CEL-1442490 Collagen degradation
R-CEL-2132295 MHC class II antigen presentation
R-CEL-6798695 Neutrophil degranulation

Protein family/group databases

MEROPSiA01.A69

Names & Taxonomyi

Protein namesi
Recommended name:
Aspartic protease 3 (EC:3.4.23.-)
Gene namesi
Name:asp-3
ORF Names:H22K11.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiH22K11.1 ; CE47856 ; WBGene00000216 ; asp-3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
PropeptideiPRO_000002593718 – 55Removed in mature form1 PublicationAdd BLAST38
ChainiPRO_000002593856 – 398Aspartic protease 3Add BLAST343

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi100 ↔ 107By similarity
Disulfide bondi313 ↔ 351By similarity
Glycosylationi321N-linked (GlcNAc...) asparagine1 Publication1

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

EPDiP55956
PaxDbiP55956
PeptideAtlasiP55956
PRIDEiP55956

PTM databases

iPTMnetiP55956

Expressioni

Gene expression databases

BgeeiWBGene00000216

Interactioni

Protein-protein interaction databases

BioGridi45876, 3 interactors
DIPiDIP-26574N
IntActiP55956, 5 interactors
STRINGi6239.H22K11.1

Structurei

3D structure databases

ProteinModelPortaliP55956
SMRiP55956
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini69 – 392Peptidase A1PROSITE-ProRule annotationAdd BLAST324

Sequence similaritiesi

Belongs to the peptidase A1 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1339 Eukaryota
ENOG410XNV7 LUCA
GeneTreeiENSGT00760000118929
HOGENOMiHOG000197681
InParanoidiP55956
KOiK01379
OMAiFYSVFDH
OrthoDBiEOG091G0JP7

Family and domain databases

Gene3Di2.40.70.10, 2 hits
InterProiView protein in InterPro
IPR001461 Aspartic_peptidase_A1
IPR001969 Aspartic_peptidase_AS
IPR033121 PEPTIDASE_A1
IPR021109 Peptidase_aspartic_dom_sf
PANTHERiPTHR13683 PTHR13683, 1 hit
PfamiView protein in Pfam
PF00026 Asp, 1 hit
PRINTSiPR00792 PEPSIN
SUPFAMiSSF50630 SSF50630, 1 hit
PROSITEiView protein in PROSITE
PS00141 ASP_PROTEASE, 1 hit
PS51767 PEPTIDASE_A1, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P55956-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGRVFLLLA LVALASAIQR IKLEKRTYTR EQYKFGSIQE HLKAKYVPGY
60 70 80 90 100
IPNKDAFNEG LSDYSNAQYY GPVTIGTPPQ NFQVLFDTGS SNLWVPCANC
110 120 130 140 150
PFGDIACRMH NRFDCKKSSS CTATGASFEI QYGTGSMKGT VDNDVVCFGH
160 170 180 190 200
DTTYCTDKNQ GLACATSEPG ITFVAAKFDG IFGMGWDTIS VNKISQPMDQ
210 220 230 240 250
IFANSAICKN QLFAFWLSRD ANDITNGGEI TLCDTDPNHY VGNIAWEPLV
260 270 280 290 300
SEDYWRIKLA SVVIDGTTYT SGPIDSIVDT GTSLLTGPTD VIKKIQHKIG
310 320 330 340 350
GIPLFNGEYE VECSKIPSLP NITFNLGGQN FDLQGKDYIL QMSNGNGGST
360 370 380 390
CLSGFMGMDI PAPAGPLWIL GDVFIGRFYS VFDHGNKRVG FATSRTGK
Length:398
Mass (Da):43,399
Last modified:September 18, 2013 - v3
Checksum:i5F03244C695E1F2F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081559 Genomic DNA Translation: CCD72415.2
PIRiT33383
RefSeqiNP_509142.2, NM_076741.6

Genome annotation databases

EnsemblMetazoaiH22K11.1; H22K11.1; WBGene00000216
GeneIDi180947
KEGGicel:CELE_H22K11.1
UCSCiH22K11.1 c. elegans

Similar proteinsi

Entry informationi

Entry nameiASP3_CAEEL
AccessioniPrimary (citable) accession number: P55956
Secondary accession number(s): Q9TXI5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: September 18, 2013
Last modified: March 28, 2018
This is version 134 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health