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Protein

Cytochrome c oxidase subunit 5A, mitochondrial

Gene

cco-2

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

This is the heme A-containing chain of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

GO - Molecular functioni

GO - Biological processi

  • mitochondrial electron transport, cytochrome c to oxygen Source: WormBase

Keywordsi

LigandHeme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 5A, mitochondrial
Alternative name(s):
Cytochrome c oxidase polypeptide Va
Gene namesi
Name:cco-2
ORF Names:Y37D8A.14
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiY37D8A.14; CE20218; WBGene00012553; cco-2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 29Mitochondrion1 PublicationAdd BLAST29
ChainiPRO_000000610330 – 174Cytochrome c oxidase subunit 5A, mitochondrialAdd BLAST145

Proteomic databases

EPDiP55954.
PaxDbiP55954.
PeptideAtlasiP55954.
PRIDEiP55954.

Expressioni

Gene expression databases

BgeeiWBGene00012553.

Interactioni

Protein-protein interaction databases

BioGridi41880. 1 interactor.
DIPiDIP-27022N.
MINTiMINT-1090908.
STRINGi6239.Y37D8A.14.2.

Structurei

3D structure databases

ProteinModelPortaliP55954.
SMRiP55954.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG4077. Eukaryota.
ENOG4111MPD. LUCA.
GeneTreeiENSGT00390000001424.
HOGENOMiHOG000160656.
InParanoidiP55954.
KOiK02264.
OMAiMEKWPAD.
OrthoDBiEOG091G0FVR.
PhylomeDBiP55954.

Family and domain databases

CDDicd00923. Cyt_c_Oxidase_Va. 1 hit.
Gene3Di1.25.40.40. 1 hit.
InterProiView protein in InterPro
IPR003204. Cyt_c_oxidase_su5A/6.
IPR036545. Cyt_c_oxidase_su5A/6_sf.
PANTHERiPTHR14200. PTHR14200. 1 hit.
PfamiView protein in Pfam
PF02284. COX5A. 1 hit.
SUPFAMiSSF48479. SSF48479. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P55954-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASLTRAVTR LAIAGRQAVR TIATTTPVSG HGDDIMEKWP ADKFDNHFIN
60 70 80 90 100
YLNRPEIDGW EVRKALSELH DYDVIPDPKV VEAALRACRR VNDFALAVRF
110 120 130 140 150
LEAIKIKCGA QKNRDTVYAY IVKQVEPVLK ELGIDTPEQL GYGEPEFFVP
160 170
EPEYWWEKKW YKDYGYDKHP NIQI
Length:174
Mass (Da):20,111
Last modified:December 7, 2004 - v2
Checksum:iDAB897567143BF1C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti30G → H AA sequence (PubMed:9150941).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL032626 Genomic DNA. Translation: CAA21532.1.
PIRiT26631.
RefSeqiNP_499681.1. NM_067280.5.
UniGeneiCel.8875.

Genome annotation databases

EnsemblMetazoaiY37D8A.14; Y37D8A.14; WBGene00012553.
GeneIDi176707.
KEGGicel:CELE_Y37D8A.14.
UCSCiY37D8A.14.1. c. elegans.

Similar proteinsi

Entry informationi

Entry nameiCOX5A_CAEEL
AccessioniPrimary (citable) accession number: P55954
Secondary accession number(s): Q9XWV8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: December 7, 2004
Last modified: October 25, 2017
This is version 106 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families