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Protein

Metallothionein-2B

Gene
N/A
Organism
Callinectes sapidus (Blue crab)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Binds six divalent metal ions. Known to bind copper and cadmium.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi5Divalent metal cation; cluster B1
Metal bindingi6Divalent metal cation; cluster B1
Metal bindingi10Divalent metal cation; cluster B1
Metal bindingi12Divalent metal cation; cluster B1
Metal bindingi17Divalent metal cation; cluster B1
Metal bindingi21Divalent metal cation; cluster B1
Metal bindingi23Divalent metal cation; cluster B1
Metal bindingi26Divalent metal cation; cluster B1
Metal bindingi28Divalent metal cation; cluster B1
Metal bindingi31Divalent metal cation; cluster A1
Metal bindingi34Divalent metal cation; cluster A1
Metal bindingi38Divalent metal cation; cluster A1
Metal bindingi40Divalent metal cation; cluster A1
Metal bindingi46Divalent metal cation; cluster A1
Metal bindingi50Divalent metal cation; cluster A1
Metal bindingi54Divalent metal cation; cluster A1
Metal bindingi56Divalent metal cation; cluster A1
Metal bindingi57Divalent metal cation; cluster A1

GO - Molecular functioni

Keywordsi

LigandCadmium, Copper, Metal-binding, Metal-thiolate cluster

Names & Taxonomyi

Protein namesi
Recommended name:
Metallothionein-2B
Short name:
MT-2B
Alternative name(s):
Metallothionein-IIB
Short name:
MT-IIB
Cleaved into the following chain:
Metallothionein-2A
Short name:
MT-2A
Alternative name(s):
Metallothionein-IIA
Short name:
MT-IIA
OrganismiCallinectes sapidus (Blue crab)
Taxonomic identifieri6763 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaCrustaceaMalacostracaEumalacostracaEucaridaDecapodaPleocyemataBrachyuraEubrachyuraPortunoideaPortunidaeCallinectes

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000417561 – 58Metallothionein-2BAdd BLAST58
ChainiPRO_00000417572 – 58Metallothionein-2AAdd BLAST57

Structurei

3D structure databases

ProteinModelPortaliP55950.
SMRiP55950.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 29BetaAdd BLAST29
Regioni30 – 58AlphaAdd BLAST29

Sequence similaritiesi

Family and domain databases

InterProiView protein in InterPro
IPR002045. Metalthion_crustacean.
IPR017854. Metalthion_dom.
PRINTSiPR00858. MTCRUSTACEAN.
SUPFAMiSSF57868. SSF57868. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P55950-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPDPCCNDKC ECKEGECKTG CKCKSCRCPP CDKCSSECKC TSKEECSKTC

SKPCSCCP
Length:58
Mass (Da):6,287
Last modified:November 1, 1997 - v1
Checksum:iEF679CB94975C5F0
GO

Sequence databases

PIRiS59073.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiMT2_CALSI
AccessioniPrimary (citable) accession number: P55950
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: May 10, 2017
This is version 58 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Metallothioneins
    Classification of metallothioneins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families