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P55950

- MT2_CALSI

UniProt

P55950 - MT2_CALSI

Protein

Metallothionein-2B

Gene
N/A
Organism
Callinectes sapidus (Blue crab)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Binds six divalent metal ions. Known to bind copper and cadmium.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi5 – 51Divalent metal cation; cluster B
    Metal bindingi6 – 61Divalent metal cation; cluster B
    Metal bindingi10 – 101Divalent metal cation; cluster B
    Metal bindingi12 – 121Divalent metal cation; cluster B
    Metal bindingi17 – 171Divalent metal cation; cluster B
    Metal bindingi21 – 211Divalent metal cation; cluster B
    Metal bindingi23 – 231Divalent metal cation; cluster B
    Metal bindingi26 – 261Divalent metal cation; cluster B
    Metal bindingi28 – 281Divalent metal cation; cluster B
    Metal bindingi31 – 311Divalent metal cation; cluster A
    Metal bindingi34 – 341Divalent metal cation; cluster A
    Metal bindingi38 – 381Divalent metal cation; cluster A
    Metal bindingi40 – 401Divalent metal cation; cluster A
    Metal bindingi46 – 461Divalent metal cation; cluster A
    Metal bindingi50 – 501Divalent metal cation; cluster A
    Metal bindingi54 – 541Divalent metal cation; cluster A
    Metal bindingi56 – 561Divalent metal cation; cluster A
    Metal bindingi57 – 571Divalent metal cation; cluster A

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW

    Keywords - Ligandi

    Cadmium, Copper, Metal-binding, Metal-thiolate cluster

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Metallothionein-2B
    Short name:
    MT-2B
    Alternative name(s):
    Metallothionein-IIB
    Short name:
    MT-IIB
    Cleaved into the following chain:
    Metallothionein-2A
    Short name:
    MT-2A
    Alternative name(s):
    Metallothionein-IIA
    Short name:
    MT-IIA
    OrganismiCallinectes sapidus (Blue crab)
    Taxonomic identifieri6763 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaCrustaceaMalacostracaEumalacostracaEucaridaDecapodaPleocyemataBrachyuraEubrachyuraPortunoideaPortunidaeCallinectes

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 5858Metallothionein-2BPRO_0000041756Add
    BLAST
    Chaini2 – 5857Metallothionein-2APRO_0000041757Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP55950.
    SMRiP55950. Positions 2-58.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 2929BetaAdd
    BLAST
    Regioni30 – 5829AlphaAdd
    BLAST

    Sequence similaritiesi

    Family and domain databases

    InterProiIPR002045. Metalthion_3_crustacean.
    IPR017854. Metalthion_dom.
    IPR003019. Metalthion_sfam_euk.
    [Graphical view]
    PfamiPF00131. Metallothio. 1 hit.
    [Graphical view]
    PRINTSiPR00858. MTCRUSTACEAN.
    SUPFAMiSSF57868. SSF57868. 2 hits.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P55950-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPDPCCNDKC ECKEGECKTG CKCKSCRCPP CDKCSSECKC TSKEECSKTC   50
    SKPCSCCP 58
    Length:58
    Mass (Da):6,287
    Last modified:November 1, 1997 - v1
    Checksum:iEF679CB94975C5F0
    GO

    Sequence databases

    PIRiS59073.

    Cross-referencesi

    Sequence databases

    PIRi S59073.

    3D structure databases

    ProteinModelPortali P55950.
    SMRi P55950. Positions 2-58.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR002045. Metalthion_3_crustacean.
    IPR017854. Metalthion_dom.
    IPR003019. Metalthion_sfam_euk.
    [Graphical view ]
    Pfami PF00131. Metallothio. 1 hit.
    [Graphical view ]
    PRINTSi PR00858. MTCRUSTACEAN.
    SUPFAMi SSF57868. SSF57868. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. "Primary structure and tissue-specific expression of blue crab (Callinectes sapidus) metallothionein isoforms."
      Brouwer M., Enghild J., Hoexum-Brouwer T., Thogersen I., Truncali A.
      Biochem. J. 311:617-622(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE.

    Entry informationi

    Entry nameiMT2_CALSI
    AccessioniPrimary (citable) accession number: P55950
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 52 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. Metallothioneins
      Classification of metallothioneins and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3