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Protein

Metallothionein-2B

Gene
N/A
Organism
Callinectes sapidus (Blue crab)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Binds six divalent metal ions. Known to bind copper and cadmium.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi5 – 51Divalent metal cation; cluster B
Metal bindingi6 – 61Divalent metal cation; cluster B
Metal bindingi10 – 101Divalent metal cation; cluster B
Metal bindingi12 – 121Divalent metal cation; cluster B
Metal bindingi17 – 171Divalent metal cation; cluster B
Metal bindingi21 – 211Divalent metal cation; cluster B
Metal bindingi23 – 231Divalent metal cation; cluster B
Metal bindingi26 – 261Divalent metal cation; cluster B
Metal bindingi28 – 281Divalent metal cation; cluster B
Metal bindingi31 – 311Divalent metal cation; cluster A
Metal bindingi34 – 341Divalent metal cation; cluster A
Metal bindingi38 – 381Divalent metal cation; cluster A
Metal bindingi40 – 401Divalent metal cation; cluster A
Metal bindingi46 – 461Divalent metal cation; cluster A
Metal bindingi50 – 501Divalent metal cation; cluster A
Metal bindingi54 – 541Divalent metal cation; cluster A
Metal bindingi56 – 561Divalent metal cation; cluster A
Metal bindingi57 – 571Divalent metal cation; cluster A

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Cadmium, Copper, Metal-binding, Metal-thiolate cluster

Names & Taxonomyi

Protein namesi
Recommended name:
Metallothionein-2B
Short name:
MT-2B
Alternative name(s):
Metallothionein-IIB
Short name:
MT-IIB
Cleaved into the following chain:
Metallothionein-2A
Short name:
MT-2A
Alternative name(s):
Metallothionein-IIA
Short name:
MT-IIA
OrganismiCallinectes sapidus (Blue crab)
Taxonomic identifieri6763 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaCrustaceaMalacostracaEumalacostracaEucaridaDecapodaPleocyemataBrachyuraEubrachyuraPortunoideaPortunidaeCallinectes

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 5858Metallothionein-2BPRO_0000041756Add
BLAST
Chaini2 – 5857Metallothionein-2APRO_0000041757Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP55950.
SMRiP55950. Positions 2-58.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 2929BetaAdd
BLAST
Regioni30 – 5829AlphaAdd
BLAST

Sequence similaritiesi

Family and domain databases

InterProiIPR002045. Metalthion_crustacean.
IPR017854. Metalthion_dom.
[Graphical view]
PRINTSiPR00858. MTCRUSTACEAN.
SUPFAMiSSF57868. SSF57868. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P55950-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPDPCCNDKC ECKEGECKTG CKCKSCRCPP CDKCSSECKC TSKEECSKTC

SKPCSCCP
Length:58
Mass (Da):6,287
Last modified:November 1, 1997 - v1
Checksum:iEF679CB94975C5F0
GO

Sequence databases

PIRiS59073.

Cross-referencesi

Sequence databases

PIRiS59073.

3D structure databases

ProteinModelPortaliP55950.
SMRiP55950. Positions 2-58.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiIPR002045. Metalthion_crustacean.
IPR017854. Metalthion_dom.
[Graphical view]
PRINTSiPR00858. MTCRUSTACEAN.
SUPFAMiSSF57868. SSF57868. 2 hits.
ProtoNetiSearch...

Publicationsi

  1. "Primary structure and tissue-specific expression of blue crab (Callinectes sapidus) metallothionein isoforms."
    Brouwer M., Enghild J., Hoexum-Brouwer T., Thogersen I., Truncali A.
    Biochem. J. 311:617-622(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE.

Entry informationi

Entry nameiMT2_CALSI
AccessioniPrimary (citable) accession number: P55950
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: December 9, 2015
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Metallothioneins
    Classification of metallothioneins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.