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Protein

Metallothionein-2B

Gene
N/A
Organism
Callinectes sapidus (Blue crab)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Binds six divalent metal ions. Known to bind copper and cadmium.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi5Divalent metal cation; cluster B1
Metal bindingi6Divalent metal cation; cluster B1
Metal bindingi10Divalent metal cation; cluster B1
Metal bindingi12Divalent metal cation; cluster B1
Metal bindingi17Divalent metal cation; cluster B1
Metal bindingi21Divalent metal cation; cluster B1
Metal bindingi23Divalent metal cation; cluster B1
Metal bindingi26Divalent metal cation; cluster B1
Metal bindingi28Divalent metal cation; cluster B1
Metal bindingi31Divalent metal cation; cluster A1
Metal bindingi34Divalent metal cation; cluster A1
Metal bindingi38Divalent metal cation; cluster A1
Metal bindingi40Divalent metal cation; cluster A1
Metal bindingi46Divalent metal cation; cluster A1
Metal bindingi50Divalent metal cation; cluster A1
Metal bindingi54Divalent metal cation; cluster A1
Metal bindingi56Divalent metal cation; cluster A1
Metal bindingi57Divalent metal cation; cluster A1

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Cadmium, Copper, Metal-binding, Metal-thiolate cluster

Names & Taxonomyi

Protein namesi
Recommended name:
Metallothionein-2B
Short name:
MT-2B
Alternative name(s):
Metallothionein-IIB
Short name:
MT-IIB
Cleaved into the following chain:
Metallothionein-2A
Short name:
MT-2A
Alternative name(s):
Metallothionein-IIA
Short name:
MT-IIA
OrganismiCallinectes sapidus (Blue crab)
Taxonomic identifieri6763 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaCrustaceaMalacostracaEumalacostracaEucaridaDecapodaPleocyemataBrachyuraEubrachyuraPortunoideaPortunidaeCallinectes

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000417561 – 58Metallothionein-2BAdd BLAST58
ChainiPRO_00000417572 – 58Metallothionein-2AAdd BLAST57

Structurei

3D structure databases

ProteinModelPortaliP55950.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 29BetaAdd BLAST29
Regioni30 – 58AlphaAdd BLAST29

Sequence similaritiesi

Family and domain databases

InterProiIPR002045. Metalthion_crustacean.
IPR017854. Metalthion_dom.
[Graphical view]
PRINTSiPR00858. MTCRUSTACEAN.
SUPFAMiSSF57868. SSF57868. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P55950-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPDPCCNDKC ECKEGECKTG CKCKSCRCPP CDKCSSECKC TSKEECSKTC

SKPCSCCP
Length:58
Mass (Da):6,287
Last modified:November 1, 1997 - v1
Checksum:iEF679CB94975C5F0
GO

Sequence databases

PIRiS59073.

Cross-referencesi

Sequence databases

PIRiS59073.

3D structure databases

ProteinModelPortaliP55950.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiIPR002045. Metalthion_crustacean.
IPR017854. Metalthion_dom.
[Graphical view]
PRINTSiPR00858. MTCRUSTACEAN.
SUPFAMiSSF57868. SSF57868. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiMT2_CALSI
AccessioniPrimary (citable) accession number: P55950
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: October 5, 2016
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Metallothioneins
    Classification of metallothioneins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.