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P55950 (MT2_CALSI) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Metallothionein-2B

Short name=MT-2B
Alternative name(s):
Metallothionein-IIB
Short name=MT-IIB

Cleaved into the following chain:

  1. Metallothionein-2A
    Short name=MT-2A
    Alternative name(s):
    Metallothionein-IIA
    Short name=MT-IIA
OrganismCallinectes sapidus (Blue crab)
Taxonomic identifier6763 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaCrustaceaMalacostracaEumalacostracaEucaridaDecapodaPleocyemataBrachyuraEubrachyuraPortunoideaPortunidaeCallinectes

Protein attributes

Sequence length58 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Binds six divalent metal ions. Known to bind copper and cadmium.

Sequence similarities

Belongs to the metallothionein superfamily. Type 3 family.

Ontologies

Keywords
   LigandCadmium
Copper
Metal-binding
Metal-thiolate cluster
   Technical termDirect protein sequencing
Gene Ontology (GO)
   Molecular_functionmetal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 5858Metallothionein-2B
PRO_0000041756
Chain2 – 5857Metallothionein-2A
PRO_0000041757

Regions

Region1 – 2929Beta
Region30 – 5829Alpha

Sites

Metal binding51Divalent metal cation; cluster B
Metal binding61Divalent metal cation; cluster B
Metal binding101Divalent metal cation; cluster B
Metal binding121Divalent metal cation; cluster B
Metal binding171Divalent metal cation; cluster B
Metal binding211Divalent metal cation; cluster B
Metal binding231Divalent metal cation; cluster B
Metal binding261Divalent metal cation; cluster B
Metal binding281Divalent metal cation; cluster B
Metal binding311Divalent metal cation; cluster A
Metal binding341Divalent metal cation; cluster A
Metal binding381Divalent metal cation; cluster A
Metal binding401Divalent metal cation; cluster A
Metal binding461Divalent metal cation; cluster A
Metal binding501Divalent metal cation; cluster A
Metal binding541Divalent metal cation; cluster A
Metal binding561Divalent metal cation; cluster A
Metal binding571Divalent metal cation; cluster A

Sequences

Sequence LengthMass (Da)Tools
P55950 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: EF679CB94975C5F0

FASTA586,287
        10         20         30         40         50 
MPDPCCNDKC ECKEGECKTG CKCKSCRCPP CDKCSSECKC TSKEECSKTC SKPCSCCP 

« Hide

References

[1]"Primary structure and tissue-specific expression of blue crab (Callinectes sapidus) metallothionein isoforms."
Brouwer M., Enghild J., Hoexum-Brouwer T., Thogersen I., Truncali A.
Biochem. J. 311:617-622(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE.

Cross-references

Sequence databases

PIRS59073.

3D structure databases

ProteinModelPortalP55950.
SMRP55950. Positions 2-58.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR002045. Metalthion_3_crustacean.
IPR017854. Metalthion_dom.
IPR003019. Metalthion_sfam_euk.
[Graphical view]
PfamPF00131. Metallothio. 1 hit.
[Graphical view]
PRINTSPR00858. MTCRUSTACEAN.
SUPFAMSSF57868. SSF57868. 2 hits.
ProtoNetSearch...

Entry information

Entry nameMT2_CALSI
AccessionPrimary (citable) accession number: P55950
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: October 16, 2013
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Metallothioneins

Classification of metallothioneins and list of entries