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P55950

- MT2_CALSI

UniProt

P55950 - MT2_CALSI

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Protein
Metallothionein-2B
Gene
N/A
Organism
Callinectes sapidus (Blue crab)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Binds six divalent metal ions. Known to bind copper and cadmium.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi5 – 51Divalent metal cation; cluster B
Metal bindingi6 – 61Divalent metal cation; cluster B
Metal bindingi10 – 101Divalent metal cation; cluster B
Metal bindingi12 – 121Divalent metal cation; cluster B
Metal bindingi17 – 171Divalent metal cation; cluster B
Metal bindingi21 – 211Divalent metal cation; cluster B
Metal bindingi23 – 231Divalent metal cation; cluster B
Metal bindingi26 – 261Divalent metal cation; cluster B
Metal bindingi28 – 281Divalent metal cation; cluster B
Metal bindingi31 – 311Divalent metal cation; cluster A
Metal bindingi34 – 341Divalent metal cation; cluster A
Metal bindingi38 – 381Divalent metal cation; cluster A
Metal bindingi40 – 401Divalent metal cation; cluster A
Metal bindingi46 – 461Divalent metal cation; cluster A
Metal bindingi50 – 501Divalent metal cation; cluster A
Metal bindingi54 – 541Divalent metal cation; cluster A
Metal bindingi56 – 561Divalent metal cation; cluster A
Metal bindingi57 – 571Divalent metal cation; cluster A

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Ligandi

Cadmium, Copper, Metal-binding, Metal-thiolate cluster

Names & Taxonomyi

Protein namesi
Recommended name:
Metallothionein-2B
Short name:
MT-2B
Alternative name(s):
Metallothionein-IIB
Short name:
MT-IIB
Cleaved into the following chain:
Metallothionein-2A
Short name:
MT-2A
Alternative name(s):
Metallothionein-IIA
Short name:
MT-IIA
OrganismiCallinectes sapidus (Blue crab)
Taxonomic identifieri6763 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaCrustaceaMalacostracaEumalacostracaEucaridaDecapodaPleocyemataBrachyuraEubrachyuraPortunoideaPortunidaeCallinectes

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 5858Metallothionein-2B
PRO_0000041756Add
BLAST
Chaini2 – 5857Metallothionein-2A
PRO_0000041757Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP55950.
SMRiP55950. Positions 2-58.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 2929Beta
Add
BLAST
Regioni30 – 5829Alpha
Add
BLAST

Sequence similaritiesi

Family and domain databases

InterProiIPR002045. Metalthion_3_crustacean.
IPR017854. Metalthion_dom.
IPR003019. Metalthion_sfam_euk.
[Graphical view]
PfamiPF00131. Metallothio. 1 hit.
[Graphical view]
PRINTSiPR00858. MTCRUSTACEAN.
SUPFAMiSSF57868. SSF57868. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P55950-1 [UniParc]FASTAAdd to Basket

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MPDPCCNDKC ECKEGECKTG CKCKSCRCPP CDKCSSECKC TSKEECSKTC   50
SKPCSCCP 58
Length:58
Mass (Da):6,287
Last modified:November 1, 1997 - v1
Checksum:iEF679CB94975C5F0
GO

Sequence databases

PIRiS59073.

Cross-referencesi

Sequence databases

PIRi S59073.

3D structure databases

ProteinModelPortali P55950.
SMRi P55950. Positions 2-58.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR002045. Metalthion_3_crustacean.
IPR017854. Metalthion_dom.
IPR003019. Metalthion_sfam_euk.
[Graphical view ]
Pfami PF00131. Metallothio. 1 hit.
[Graphical view ]
PRINTSi PR00858. MTCRUSTACEAN.
SUPFAMi SSF57868. SSF57868. 2 hits.
ProtoNeti Search...

Publicationsi

  1. "Primary structure and tissue-specific expression of blue crab (Callinectes sapidus) metallothionein isoforms."
    Brouwer M., Enghild J., Hoexum-Brouwer T., Thogersen I., Truncali A.
    Biochem. J. 311:617-622(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE.

Entry informationi

Entry nameiMT2_CALSI
AccessioniPrimary (citable) accession number: P55950
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: October 16, 2013
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Metallothioneins
    Classification of metallothioneins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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