P55950 (MT2_CALSI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Metallothionein-2B Short name=MT-2B Alternative name(s): Metallothionein-IIB Short name=MT-IIB Cleaved into the following chain: Metallothionein-2A Short name=MT-2A Alternative name(s): Metallothionein-IIA Short name=MT-IIA
Organism	Callinectes sapidus (Blue crab)
Taxonomic identifier	6763 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Mandibulata › Pancrustacea › Crustacea › Malacostraca › Eumalacostraca › Eucarida › Decapoda › Pleocyemata › Brachyura › Eubrachyura › Heterotremata › Portunoidea › Portunidae › Callinectes

Protein attributes

Sequence length	58 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Binds six divalent metal ions. Known to bind copper and cadmium.
Sequence similarities	Belongs to the metallothionein superfamily. Type 3 family.

Ontologies

Keywords
Ligand	Cadmium Copper Metal-binding Metal-thiolate cluster
Technical term	Direct protein sequencing
Gene Ontology (GO)
Molecular_function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 58	58	Metallothionein-2B		PRO_0000041756
	Chain	2 – 58	57	Metallothionein-2A		PRO_0000041757
Regions
	Region	1 – 29	29	Beta
	Region	30 – 58	29	Alpha
Sites
	Metal binding	5	1	Divalent metal cation; cluster B
	Metal binding	6	1	Divalent metal cation; cluster B
	Metal binding	10	1	Divalent metal cation; cluster B
	Metal binding	12	1	Divalent metal cation; cluster B
	Metal binding	17	1	Divalent metal cation; cluster B
	Metal binding	21	1	Divalent metal cation; cluster B
	Metal binding	23	1	Divalent metal cation; cluster B
	Metal binding	26	1	Divalent metal cation; cluster B
	Metal binding	28	1	Divalent metal cation; cluster B
	Metal binding	31	1	Divalent metal cation; cluster A
	Metal binding	34	1	Divalent metal cation; cluster A
	Metal binding	38	1	Divalent metal cation; cluster A
	Metal binding	40	1	Divalent metal cation; cluster A
	Metal binding	46	1	Divalent metal cation; cluster A
	Metal binding	50	1	Divalent metal cation; cluster A
	Metal binding	54	1	Divalent metal cation; cluster A
	Metal binding	56	1	Divalent metal cation; cluster A
	Metal binding	57	1	Divalent metal cation; cluster A

Sequences

	Sequence		Length	Mass (Da)
	P55950 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: EF679CB94975C5F0	FASTA	58	6,287
	10 20 30 40 50 MPDPCCNDKC ECKEGECKTG CKCKSCRCPP CDKCSSECKC TSKEECSKTC SKPCSCCP

References

[1]	"Primary structure and tissue-specific expression of blue crab (Callinectes sapidus) metallothionein isoforms." Brouwer M., Enghild J., Hoexum-Brouwer T., Thogersen I., Truncali A. Biochem. J. 311:617-622(1995) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE.

Cross-references

Sequence databases
PIR	S59073.
3D structure databases
ProteinModelPortal	P55950.
SMR	P55950. Positions 2-58.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR002045. Metalthion_3_crustacean. IPR017854. Metalthion_dom. IPR003019. Metalthion_sfam_euk. [Graphical view]
Pfam	PF00131. Metallothio. 1 hit. [Graphical view]
PRINTS	PR00858. MTCRUSTACEAN.
SUPFAM	SSF57868. Metallothionein_sfam. 2 hits.
ProtoNet	Search...

Entry information

Entry name

MT2_CALSI

Accession

Primary (citable) accession number: P55950

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	April 3, 2013
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)