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P55945

- MT_PSEAM

UniProt

P55945 - MT_PSEAM

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Protein

Metallothionein

Gene

mt

Organism
Pseudopleuronectes americanus (Winter flounder) (Pleuronectes americanus)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Metallothioneins have a high content of cysteine residues that bind various heavy metals.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi4 – 41Divalent metal cation; cluster BBy similarity
Metal bindingi6 – 61Divalent metal cation; cluster BBy similarity
Metal bindingi12 – 121Divalent metal cation; cluster BBy similarity
Metal bindingi14 – 141Divalent metal cation; cluster BBy similarity
Metal bindingi18 – 181Divalent metal cation; cluster BBy similarity
Metal bindingi20 – 201Divalent metal cation; cluster BBy similarity
Metal bindingi23 – 231Divalent metal cation; cluster BBy similarity
Metal bindingi25 – 251Divalent metal cation; cluster BBy similarity
Metal bindingi28 – 281Divalent metal cation; cluster BBy similarity
Metal bindingi32 – 321Divalent metal cation; cluster ABy similarity
Metal bindingi33 – 331Divalent metal cation; cluster ABy similarity
Metal bindingi35 – 351Divalent metal cation; cluster ABy similarity
Metal bindingi36 – 361Divalent metal cation; cluster ABy similarity
Metal bindingi40 – 401Divalent metal cation; cluster ABy similarity
Metal bindingi43 – 431Divalent metal cation; cluster ABy similarity
Metal bindingi47 – 471Divalent metal cation; cluster ABy similarity
Metal bindingi49 – 491Divalent metal cation; cluster ABy similarity
Metal bindingi54 – 541Divalent metal cation; cluster ABy similarity
Metal bindingi58 – 581Divalent metal cation; cluster ABy similarity
Metal bindingi59 – 591Divalent metal cation; cluster ABy similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Ligandi

Copper, Metal-binding, Metal-thiolate cluster

Names & Taxonomyi

Protein namesi
Recommended name:
Metallothionein
Short name:
MT
Gene namesi
Name:mt
OrganismiPseudopleuronectes americanus (Winter flounder) (Pleuronectes americanus)
Taxonomic identifieri8265 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataCarangariaPleuronectiformesPleuronectoideiPleuronectidaePseudopleuronectes

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 6060MetallothioneinPRO_0000197310Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine

Keywords - PTMi

Acetylation

Structurei

3D structure databases

ProteinModelPortaliP55945.
SMRiP55945. Positions 2-28, 31-60.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 2828BetaAdd
BLAST
Regioni29 – 6032AlphaAdd
BLAST

Domaini

Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.

Sequence similaritiesi

Family and domain databases

Gene3Di4.10.10.10. 1 hit.
InterProiIPR017854. Metalthion_dom.
IPR023587. Metalthion_dom_vert.
IPR003019. Metalthion_sfam_euk.
IPR000006. Metalthion_vert.
IPR018064. Metalthion_vert_metal_BS.
[Graphical view]
PANTHERiPTHR23299. PTHR23299. 1 hit.
PfamiPF00131. Metallothio. 1 hit.
[Graphical view]
PRINTSiPR00860. MTVERTEBRATE.
SUPFAMiSSF57868. SSF57868. 1 hit.
PROSITEiPS00203. METALLOTHIONEIN_VRT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P55945-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDPCECSKTG TCNCGGSCTC KNCSCTTCTK SCCPCCPSGC PKCASGCVCK
60
GKTCDTTCCQ
Length:60
Mass (Da):6,030
Last modified:November 23, 2004 - v2
Checksum:i88FBA6EE5C7C4717
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13594 mRNA. Translation: CAA31930.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13594 mRNA. Translation: CAA31930.1 .

3D structure databases

ProteinModelPortali P55945.
SMRi P55945. Positions 2-28, 31-60.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 4.10.10.10. 1 hit.
InterProi IPR017854. Metalthion_dom.
IPR023587. Metalthion_dom_vert.
IPR003019. Metalthion_sfam_euk.
IPR000006. Metalthion_vert.
IPR018064. Metalthion_vert_metal_BS.
[Graphical view ]
PANTHERi PTHR23299. PTHR23299. 1 hit.
Pfami PF00131. Metallothio. 1 hit.
[Graphical view ]
PRINTSi PR00860. MTVERTEBRATE.
SUPFAMi SSF57868. SSF57868. 1 hit.
PROSITEi PS00203. METALLOTHIONEIN_VRT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning of metallothionein cDNA and analysis of metallothionein gene expression in winter flounder tissues."
    Chan K.-M., Davidson W.S., Hew C.-L., Fletcher G.L.
    Can. J. Zool. 67:2520-2527(1989)
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 1-25.
    Tissue: Liver.

Entry informationi

Entry nameiMT_PSEAM
AccessioniPrimary (citable) accession number: P55945
Secondary accession number(s): Q6LBT7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 23, 2004
Last modified: October 29, 2014
This is version 63 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Metallothioneins
    Classification of metallothioneins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3