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P55944

- MT3_PIG

UniProt

P55944 - MT3_PIG

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Protein

Metallothionein-3

Gene

MT3

Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Binds heavy metals. Contains three zinc and three copper atoms per polypeptide chain and only a negligible amount of cadmium. Inhibits survival and neurite formation of cortical neurons in vitro (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi6 – 61Divalent metal cation; cluster BBy similarity
Metal bindingi8 – 81Divalent metal cation; cluster BBy similarity
Metal bindingi14 – 141Divalent metal cation; cluster BBy similarity
Metal bindingi16 – 161Divalent metal cation; cluster BBy similarity
Metal bindingi20 – 201Divalent metal cation; cluster BBy similarity
Metal bindingi22 – 221Divalent metal cation; cluster BBy similarity
Metal bindingi25 – 251Divalent metal cation; cluster BBy similarity
Metal bindingi27 – 271Divalent metal cation; cluster BBy similarity
Metal bindingi30 – 301Divalent metal cation; cluster BBy similarity
Metal bindingi34 – 341Divalent metal cation; cluster ABy similarity
Metal bindingi35 – 351Divalent metal cation; cluster ABy similarity
Metal bindingi37 – 371Divalent metal cation; cluster ABy similarity
Metal bindingi38 – 381Divalent metal cation; cluster ABy similarity
Metal bindingi42 – 421Divalent metal cation; cluster ABy similarity
Metal bindingi45 – 451Divalent metal cation; cluster ABy similarity
Metal bindingi49 – 491Divalent metal cation; cluster ABy similarity
Metal bindingi51 – 511Divalent metal cation; cluster ABy similarity
Metal bindingi64 – 641Divalent metal cation; cluster ABy similarity
Metal bindingi66 – 661Divalent metal cation; cluster ABy similarity
Metal bindingi67 – 671Divalent metal cation; cluster ABy similarity

GO - Molecular functioni

  1. cadmium ion binding Source: UniProtKB
  2. copper ion binding Source: UniProtKB
  3. cysteine-type endopeptidase inhibitor activity involved in apoptotic process Source: UniProtKB
  4. drug binding Source: UniProtKB
  5. protein kinase activator activity Source: UniProtKB
  6. zinc ion binding Source: UniProtKB

GO - Biological processi

  1. activation of protein kinase B activity Source: UniProtKB
  2. astrocyte development Source: UniProtKB
  3. cadmium ion homeostasis Source: UniProtKB
  4. cellular lipid catabolic process Source: UniProtKB
  5. cellular response to cadmium ion Source: UniProtKB
  6. cellular response to drug Source: UniProtKB
  7. cellular response to nitric oxide Source: UniProtKB
  8. cellular response to oxidative stress Source: UniProtKB
  9. cellular zinc ion homeostasis Source: UniProtKB
  10. cholesterol catabolic process Source: UniProtKB
  11. energy reserve metabolic process Source: UniProtKB
  12. ERK1 and ERK2 cascade Source: UniProtKB
  13. histone modification Source: UniProtKB
  14. leptin-mediated signaling pathway Source: UniProtKB
  15. negative regulation of apoptotic process Source: UniProtKB
  16. negative regulation of autophagy Source: UniProtKB
  17. negative regulation of axon extension Source: UniProtKB
  18. negative regulation of cell growth Source: UniProtKB
  19. negative regulation of cysteine-type endopeptidase activity Source: UniProtKB
  20. negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
  21. negative regulation of necrotic cell death Source: UniProtKB
  22. negative regulation of neuron apoptotic process Source: UniProtKB
  23. negative regulation of oxidoreductase activity Source: UniProtKB
  24. negative regulation of reactive oxygen species metabolic process Source: UniProtKB
  25. negative regulation of transcription, DNA-templated Source: UniProtKB
  26. positive regulation of catalytic activity Source: UniProtKB
  27. positive regulation of cell death Source: UniProtKB
  28. positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
  29. positive regulation of gene expression Source: UniProtKB
  30. positive regulation of lysosomal membrane permeability Source: UniProtKB
  31. positive regulation of necrotic cell death Source: UniProtKB
  32. positive regulation of oxygen metabolic process Source: UniProtKB
  33. positive regulation of protein phosphorylation Source: UniProtKB
  34. positive regulation of transcription, DNA-templated Source: UniProtKB
  35. positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress Source: UniProtKB
  36. positive regulation of vascular endothelial growth factor receptor signaling pathway Source: UniProtKB
  37. protein import into nucleus, translocation Source: UniProtKB
  38. protein kinase B signaling Source: UniProtKB
  39. protein stabilization Source: UniProtKB
  40. regulation of protein glycosylation Source: UniProtKB
  41. regulation of response to food Source: UniProtKB
  42. removal of superoxide radicals Source: UniProtKB
  43. response to hypoxia Source: UniProtKB
  44. zinc ion homeostasis Source: UniProtKB
  45. zinc ion transport Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

Copper, Metal-binding, Metal-thiolate cluster, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Metallothionein-3
Short name:
MT-3
Alternative name(s):
Growth inhibitory factor
Short name:
GIF
Metallothionein-III
Short name:
MT-III
Gene namesi
Name:MT3
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
ProteomesiUP000008227: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. inclusion body Source: UniProtKB
  2. intracellular Source: UniProtKB
  3. nucleus Source: UniProtKB
  4. perinuclear region of cytoplasm Source: UniProtKB
  5. synaptic vesicle Source: UniProtKB
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 6868Metallothionein-3PRO_0000197252Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity

Keywords - PTMi

Acetylation

Expressioni

Tissue specificityi

Brain.

Structurei

3D structure databases

ProteinModelPortaliP55944.
SMRiP55944. Positions 32-68.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 3030BetaAdd
BLAST
Regioni31 – 6838AlphaAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

InParanoidiP55944.
KOiK14740.

Family and domain databases

Gene3Di4.10.10.10. 1 hit.
InterProiIPR017854. Metalthion_dom.
IPR023587. Metalthion_dom_vert.
IPR003019. Metalthion_sfam_euk.
IPR000006. Metalthion_vert.
IPR018064. Metalthion_vert_metal_BS.
[Graphical view]
PANTHERiPTHR23299. PTHR23299. 1 hit.
PfamiPF00131. Metallothio. 1 hit.
[Graphical view]
PRINTSiPR00860. MTVERTEBRATE.
SUPFAMiSSF57868. SSF57868. 1 hit.
PROSITEiPS00203. METALLOTHIONEIN_VRT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P55944-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDPETCPCPT GGSCTCAGSC KCEGCKCTSC KKSCCSCCPA ECEKCAKDCV
60
CKGGEGAEAE EEKCSCCQ
Length:68
Mass (Da):6,927
Last modified:November 1, 1997 - v1
Checksum:iED801B8331E53300
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U95969 mRNA. Translation: AAC39165.1.
PIRiJC6521.
RefSeqiNP_999221.1. NM_214056.1.
UniGeneiSsc.15694.

Genome annotation databases

GeneIDi397123.
KEGGissc:397123.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U95969 mRNA. Translation: AAC39165.1 .
PIRi JC6521.
RefSeqi NP_999221.1. NM_214056.1.
UniGenei Ssc.15694.

3D structure databases

ProteinModelPortali P55944.
SMRi P55944. Positions 32-68.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 397123.
KEGGi ssc:397123.

Organism-specific databases

CTDi 100855992.

Phylogenomic databases

InParanoidi P55944.
KOi K14740.

Family and domain databases

Gene3Di 4.10.10.10. 1 hit.
InterProi IPR017854. Metalthion_dom.
IPR023587. Metalthion_dom_vert.
IPR003019. Metalthion_sfam_euk.
IPR000006. Metalthion_vert.
IPR018064. Metalthion_vert_metal_BS.
[Graphical view ]
PANTHERi PTHR23299. PTHR23299. 1 hit.
Pfami PF00131. Metallothio. 1 hit.
[Graphical view ]
PRINTSi PR00860. MTVERTEBRATE.
SUPFAMi SSF57868. SSF57868. 1 hit.
PROSITEi PS00203. METALLOTHIONEIN_VRT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Identification and characterization of metallothionein III (growth inhibitory factor) from porcine brain."
    Chen C.-F., Wang S.-H., Lin L.-Y.
    Comp. Biochem. Physiol. 115B:27-32(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "Cloning of porcine neuron growth inhibitory factor (metallothionein III) cDNA and expression of the gene in Saccharomyces cerevisiae."
    Wang S.-H., Chang C.-Y., Chen C.-F., Tam M.F., Shih Y.H., Lin L.-Y.
    Gene 203:189-197(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiMT3_PIG
AccessioniPrimary (citable) accession number: P55944
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: October 29, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Metallothioneins
    Classification of metallothioneins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3