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P55944

- MT3_PIG

UniProt

P55944 - MT3_PIG

Protein

Metallothionein-3

Gene

MT3

Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Binds heavy metals. Contains three zinc and three copper atoms per polypeptide chain and only a negligible amount of cadmium. Inhibits survival and neurite formation of cortical neurons in vitro By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi6 – 61Divalent metal cation; cluster BBy similarity
    Metal bindingi8 – 81Divalent metal cation; cluster BBy similarity
    Metal bindingi14 – 141Divalent metal cation; cluster BBy similarity
    Metal bindingi16 – 161Divalent metal cation; cluster BBy similarity
    Metal bindingi20 – 201Divalent metal cation; cluster BBy similarity
    Metal bindingi22 – 221Divalent metal cation; cluster BBy similarity
    Metal bindingi25 – 251Divalent metal cation; cluster BBy similarity
    Metal bindingi27 – 271Divalent metal cation; cluster BBy similarity
    Metal bindingi30 – 301Divalent metal cation; cluster BBy similarity
    Metal bindingi34 – 341Divalent metal cation; cluster ABy similarity
    Metal bindingi35 – 351Divalent metal cation; cluster ABy similarity
    Metal bindingi37 – 371Divalent metal cation; cluster ABy similarity
    Metal bindingi38 – 381Divalent metal cation; cluster ABy similarity
    Metal bindingi42 – 421Divalent metal cation; cluster ABy similarity
    Metal bindingi45 – 451Divalent metal cation; cluster ABy similarity
    Metal bindingi49 – 491Divalent metal cation; cluster ABy similarity
    Metal bindingi51 – 511Divalent metal cation; cluster ABy similarity
    Metal bindingi64 – 641Divalent metal cation; cluster ABy similarity
    Metal bindingi66 – 661Divalent metal cation; cluster ABy similarity
    Metal bindingi67 – 671Divalent metal cation; cluster ABy similarity

    GO - Molecular functioni

    1. cadmium ion binding Source: UniProtKB
    2. copper ion binding Source: UniProtKB
    3. cysteine-type endopeptidase inhibitor activity involved in apoptotic process Source: UniProtKB
    4. drug binding Source: UniProtKB
    5. protein kinase activator activity Source: UniProtKB
    6. zinc ion binding Source: UniProtKB

    GO - Biological processi

    1. activation of protein kinase B activity Source: UniProtKB
    2. astrocyte development Source: UniProtKB
    3. cadmium ion homeostasis Source: UniProtKB
    4. cellular lipid catabolic process Source: UniProtKB
    5. cellular response to cadmium ion Source: UniProtKB
    6. cellular response to drug Source: UniProtKB
    7. cellular response to nitric oxide Source: UniProtKB
    8. cellular response to oxidative stress Source: UniProtKB
    9. cellular zinc ion homeostasis Source: UniProtKB
    10. cholesterol catabolic process Source: UniProtKB
    11. energy reserve metabolic process Source: UniProtKB
    12. ERK1 and ERK2 cascade Source: UniProtKB
    13. histone modification Source: UniProtKB
    14. leptin-mediated signaling pathway Source: UniProtKB
    15. negative regulation of apoptotic process Source: UniProtKB
    16. negative regulation of autophagy Source: UniProtKB
    17. negative regulation of axon extension Source: UniProtKB
    18. negative regulation of cell growth Source: UniProtKB
    19. negative regulation of cysteine-type endopeptidase activity Source: UniProtKB
    20. negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
    21. negative regulation of necrotic cell death Source: UniProtKB
    22. negative regulation of neuron apoptotic process Source: UniProtKB
    23. negative regulation of oxidoreductase activity Source: UniProtKB
    24. negative regulation of reactive oxygen species metabolic process Source: UniProtKB
    25. negative regulation of transcription, DNA-templated Source: UniProtKB
    26. positive regulation of catalytic activity Source: UniProtKB
    27. positive regulation of cell death Source: UniProtKB
    28. positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
    29. positive regulation of gene expression Source: UniProtKB
    30. positive regulation of lysosomal membrane permeability Source: UniProtKB
    31. positive regulation of necrotic cell death Source: UniProtKB
    32. positive regulation of oxygen metabolic process Source: UniProtKB
    33. positive regulation of protein phosphorylation Source: UniProtKB
    34. positive regulation of transcription, DNA-templated Source: UniProtKB
    35. positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress Source: UniProtKB
    36. positive regulation of vascular endothelial growth factor receptor signaling pathway Source: UniProtKB
    37. protein import into nucleus, translocation Source: UniProtKB
    38. protein kinase B signaling Source: UniProtKB
    39. protein stabilization Source: UniProtKB
    40. regulation of protein glycosylation Source: UniProtKB
    41. regulation of response to food Source: UniProtKB
    42. removal of superoxide radicals Source: UniProtKB
    43. response to hypoxia Source: UniProtKB
    44. zinc ion homeostasis Source: UniProtKB
    45. zinc ion transport Source: UniProtKB

    Keywords - Ligandi

    Copper, Metal-binding, Metal-thiolate cluster, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Metallothionein-3
    Short name:
    MT-3
    Alternative name(s):
    Growth inhibitory factor
    Short name:
    GIF
    Metallothionein-III
    Short name:
    MT-III
    Gene namesi
    Name:MT3
    OrganismiSus scrofa (Pig)
    Taxonomic identifieri9823 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
    ProteomesiUP000008227: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. inclusion body Source: UniProtKB
    2. intracellular Source: UniProtKB
    3. nucleus Source: UniProtKB
    4. perinuclear region of cytoplasm Source: UniProtKB
    5. synaptic vesicle Source: UniProtKB

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 6868Metallothionein-3PRO_0000197252Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionineBy similarity

    Keywords - PTMi

    Acetylation

    Expressioni

    Tissue specificityi

    Brain.

    Structurei

    3D structure databases

    ProteinModelPortaliP55944.
    SMRiP55944. Positions 32-68.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 3030BetaAdd
    BLAST
    Regioni31 – 6838AlphaAdd
    BLAST

    Sequence similaritiesi

    Phylogenomic databases

    KOiK14740.

    Family and domain databases

    Gene3Di4.10.10.10. 1 hit.
    InterProiIPR017854. Metalthion_dom.
    IPR023587. Metalthion_dom_vert.
    IPR003019. Metalthion_sfam_euk.
    IPR000006. Metalthion_vert.
    IPR018064. Metalthion_vert_metal_BS.
    [Graphical view]
    PANTHERiPTHR23299. PTHR23299. 1 hit.
    PfamiPF00131. Metallothio. 1 hit.
    [Graphical view]
    PRINTSiPR00860. MTVERTEBRATE.
    SUPFAMiSSF57868. SSF57868. 1 hit.
    PROSITEiPS00203. METALLOTHIONEIN_VRT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P55944-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDPETCPCPT GGSCTCAGSC KCEGCKCTSC KKSCCSCCPA ECEKCAKDCV   50
    CKGGEGAEAE EEKCSCCQ 68
    Length:68
    Mass (Da):6,927
    Last modified:November 1, 1997 - v1
    Checksum:iED801B8331E53300
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U95969 mRNA. Translation: AAC39165.1.
    PIRiJC6521.
    RefSeqiNP_999221.1. NM_214056.1.
    UniGeneiSsc.15694.

    Genome annotation databases

    GeneIDi397123.
    KEGGissc:397123.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U95969 mRNA. Translation: AAC39165.1 .
    PIRi JC6521.
    RefSeqi NP_999221.1. NM_214056.1.
    UniGenei Ssc.15694.

    3D structure databases

    ProteinModelPortali P55944.
    SMRi P55944. Positions 32-68.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 397123.
    KEGGi ssc:397123.

    Organism-specific databases

    CTDi 100855992.

    Phylogenomic databases

    KOi K14740.

    Family and domain databases

    Gene3Di 4.10.10.10. 1 hit.
    InterProi IPR017854. Metalthion_dom.
    IPR023587. Metalthion_dom_vert.
    IPR003019. Metalthion_sfam_euk.
    IPR000006. Metalthion_vert.
    IPR018064. Metalthion_vert_metal_BS.
    [Graphical view ]
    PANTHERi PTHR23299. PTHR23299. 1 hit.
    Pfami PF00131. Metallothio. 1 hit.
    [Graphical view ]
    PRINTSi PR00860. MTVERTEBRATE.
    SUPFAMi SSF57868. SSF57868. 1 hit.
    PROSITEi PS00203. METALLOTHIONEIN_VRT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification and characterization of metallothionein III (growth inhibitory factor) from porcine brain."
      Chen C.-F., Wang S.-H., Lin L.-Y.
      Comp. Biochem. Physiol. 115B:27-32(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.
    2. "Cloning of porcine neuron growth inhibitory factor (metallothionein III) cDNA and expression of the gene in Saccharomyces cerevisiae."
      Wang S.-H., Chang C.-Y., Chen C.-F., Tam M.F., Shih Y.H., Lin L.-Y.
      Gene 203:189-197(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiMT3_PIG
    AccessioniPrimary (citable) accession number: P55944
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Metallothioneins
      Classification of metallothioneins and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3