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Protein

Golgin subfamily A member 3

Gene

Golga3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays an important role in spermatogenesis and/or testis development. Probably identical with the serologically detectable male antigen (SDM). Probably involved in maintaining Golgi structure.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Spermatogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Golgin subfamily A member 3
Alternative name(s):
Golgin-160
Male-enhanced antigen 2
Short name:
MEA-2
Gene namesi
Name:Golga3
Synonyms:Mea2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:96958. Golga3.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001900581 – 1487Golgin subfamily A member 3Add BLAST1487

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei18PhosphoserineBy similarity1
Modified residuei60PhosphoserineCombined sources1
Modified residuei270PhosphoserineBy similarity1
Modified residuei381PhosphoserineBy similarity1
Modified residuei385PhosphoserineBy similarity1
Modified residuei461PhosphoserineBy similarity1
Modified residuei979PhosphoserineCombined sources1
Modified residuei1387PhosphoserineBy similarity1
Modified residuei1479PhosphoserineCombined sources1

Post-translational modificationi

Cleaved by caspases in apoptotic cells.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP55937.
PeptideAtlasiP55937.
PRIDEiP55937.

PTM databases

iPTMnetiP55937.
PhosphoSitePlusiP55937.

Expressioni

Tissue specificityi

Highly expressed in testis. Transcripts can be found in spermatids during spermatogenesis. No expression in Leydig cells, spermatogonia or spermatocytes. Detected at low levels in all tissues.

Gene expression databases

BgeeiENSMUSG00000029502.
CleanExiMM_GOLGA3.

Interactioni

Subunit structurei

Homodimer. Interacts with GOLGA7. Interacts with GOPC (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi234694. 2 interactors.
IntActiP55937. 1 interactor.
MINTiMINT-4655626.
STRINGi10090.ENSMUSP00000108131.

Structurei

3D structure databases

ProteinModelPortaliP55937.
SMRiP55937.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni121 – 141Interaction with GOPCBy similarityAdd BLAST21
Regioni172 – 257Golgi-targeting domainBy similarityAdd BLAST86

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili358 – 1454Sequence analysisAdd BLAST1097

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi238 – 321Ser-richAdd BLAST84
Compositional biasi363 – 366Poly-Ala4
Compositional biasi534 – 734Gln-richAdd BLAST201
Compositional biasi1228 – 1366Gln-richAdd BLAST139

Domaini

Extended rod-like protein with coiled-coil domains.

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IFW4. Eukaryota.
ENOG410YGSW. LUCA.
HOGENOMiHOG000112752.
HOVERGENiHBG051753.
InParanoidiP55937.
PhylomeDBiP55937.

Family and domain databases

InterProiView protein in InterPro
IPR033288. Golga3.
PANTHERiPTHR18902:SF33. PTHR18902:SF33. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 2 (identifier: P55937-2) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDGASAKQDG LWESKSSSDV SSCPEASLET VGSLARLPDQ QDTAQDASVE
60 70 80 90 100
VNRGFKEEGS PDRSSQVAIC QNGQIPDLQL SLDPTTSPVG PDASTGVDGF
110 120 130 140 150
HDNLRNSQGT SAEGSVRKEA LQSLRLSLPM QETQLCSTAS SLPLEKEEQV
160 170 180 190 200
RLQARKRLEE QLMQYRVKRH RERSSQPATK MKLFSTLDPE LMLNPENLPR
210 220 230 240 250
ASTVAVTKEY SFLRTSVPRG PKVGSLGLLA HSKEKKNSKS SKIRSLADYR
260 270 280 290 300
TEDPSDSGGL GSTADAVGSS LKQSRSSTSV VSEVSPSSET DNRVESASMT
310 320 330 340 350
GDSVSEADGN ESDSSSHSSL SARGACGVLG NVGMPGTAYM VDGQEISAEA
360 370 380 390 400
LGQFPSIKDV LQAAAAQHQD QNQEANGEVR SRRDSICSSV SMESSLAEPQ
410 420 430 440 450
DELLQILKDK RRLEGQVEAL SLEASQALQE KAELQAQLAA LSTRLQAQVE
460 470 480 490 500
HSHSSQQKQD SLSSEVDTLK QSCWDLGRAM TDLQSMLEAK NASLASSNND
510 520 530 540 550
LQVAEEQYQR LMAKVEDMQR NILSKDNTVH DLRQQMTALQ SQLQQVQLER
560 570 580 590 600
TTLTSKLQAS QAEITSLQHA RQWYQQQLTL AQEARVRLQG EMAHIQVGQM
610 620 630 640 650
TQAGLLEHLK LENVSLSHQL TETQHRSIKE KERIAVQLQS IEADMLDQEA
660 670 680 690 700
AFVQIREAKT MVEEDLQRRL EEFEGEREQL QKVADAAASL EQQLEQVKLT
710 720 730 740 750
LFQRDQQLAA LQQEHLDVIK QLTSTQEALQ AKGQSLDDLH TRYDELQARL
760 770 780 790 800
EELQREADSR EDAIHFLQNE KIVLEVALQS AKSDKEELDR GARRLEEDTE
810 820 830 840 850
ETSGLLEQLR QDLAVKSNQV EHLQQETATL RKQMQKVKEQ FVQQKVMVEA
860 870 880 890 900
YRRDATSKDQ LINELKATKK RLDSEMKELR QELIKLQGEK KTVEVEHSRL
910 920 930 940 950
QKDMSLVHQQ MAELEGHLQS VQKERDEMEI HLQSLKFDKE QMIALTEANE
960 970 980 990 1000
TLKKQIEELQ QEAKKAITEQ KQKMKRLGSD LTSAQKEMKT KHKAYENAVS
1010 1020 1030 1040 1050
ILSRRLQEAL ASKEATDAEL NQLRAQSTGG SSDPVLHEKI RALEVELQNV
1060 1070 1080 1090 1100
GQSKILLEKE LQEVITMTSQ ELEESREKVL ELEDELQESR GFRRKIKRLE
1110 1120 1130 1140 1150
ESNKKLALEL EHERGKLTGL GQSNAALREH NSILETALAK READLVQLNL
1160 1170 1180 1190 1200
QVQAVLQRKE EEDRQMKQLV QALQVSLEKE KMEVNSLKEQ MAAARIEAGH
1210 1220 1230 1240 1250
NRRHFKAATL ELSEVKKELQ AKEHLVQTLQ AEVDELQIQD GKHSQEIAQF
1260 1270 1280 1290 1300
QTELAEARTQ LQLLQKKLDE QMSQQPTGSQ EMEDLKWELD QKEREIQSLK
1310 1320 1330 1340 1350
QQLDLTEQQG KKELEGTQQT LQTIKSELEM VQEDLSETQK DKFMLQAKVS
1360 1370 1380 1390 1400
ELKNNMKTLL QQNQQLKLDL RRGAAKKKEP KGESNSSSPA TPIKIPDCPV
1410 1420 1430 1440 1450
PASLLEELLR PPPAVSKEPL KNLNNCLQQL KQEMDSLQRQ MEEHTITVHE
1460 1470 1480
SLSSWAQVEA APAEHAHPRG DTKLHNQNSV PRDGLGQ
Note: No experimental confirmation available.
Length:1,487
Mass (Da):167,220
Last modified:November 8, 2005 - v3
Checksum:i831303DC90754F0B
GO
Isoform 1 (identifier: P55937-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     97-136: Missing.

Show »
Length:1,447
Mass (Da):162,821
Checksum:i8BB68F2D142F8A9B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti30T → I in AAH53002 (PubMed:15489334).Curated1
Sequence conflicti477G → E in AAH53002 (PubMed:15489334).Curated1
Sequence conflicti592M → T in BAA86889 (PubMed:11835574).Curated1
Sequence conflicti592M → T in BAA86890 (PubMed:11835574).Curated1
Sequence conflicti843Q → L in BAA86889 (PubMed:11835574).Curated1
Sequence conflicti843Q → L in BAA86890 (PubMed:11835574).Curated1
Sequence conflicti982T → S in AAH53002 (PubMed:15489334).Curated1
Sequence conflicti1015A → S in AAH43452 (PubMed:15489334).Curated1
Sequence conflicti1466A → P in BAC27949 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01607197 – 136Missing in isoform 1. 2 PublicationsAdd BLAST40

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D78270 mRNA. Translation: BAA19612.2.
AB029537 Genomic DNA. Translation: BAA86889.2.
AB029537 Genomic DNA. Translation: BAA86890.2.
BC043452 mRNA. Translation: AAH43452.1.
BC053002 mRNA. Translation: AAH53002.1.
AK032610 mRNA. Translation: BAC27949.1.
CCDSiCCDS39209.1. [P55937-1]
CCDS84928.1. [P55937-2]
PIRiT42722.
RefSeqiNP_032172.3. NM_008146.3.
UniGeneiMm.393008.
Mm.9392.

Genome annotation databases

GeneIDi269682.

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiGOGA3_MOUSE
AccessioniPrimary (citable) accession number: P55937
Secondary accession number(s): Q80VF5
, Q8CCK4, Q9QYT2, Q9QYT3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 8, 2005
Last modified: May 10, 2017
This is version 128 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot