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Protein

40S ribosomal protein S9

Gene

RpS9

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • rRNA binding Source: GO_Central
  • structural constituent of ribosome Source: FlyBase

GO - Biological processi

  • cytoplasmic translation Source: FlyBase
  • positive regulation of translational fidelity Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Keywords - Ligandi

RNA-binding, rRNA-binding

Enzyme and pathway databases

ReactomeiR-DME-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-DME-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-DME-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.
R-DME-72649. Translation initiation complex formation.
R-DME-72689. Formation of a pool of free 40S subunits.
R-DME-72695. Formation of the ternary complex, and subsequently, the 43S complex.
R-DME-72702. Ribosomal scanning and start codon recognition.
R-DME-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-DME-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-DME-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S9
Gene namesi
Name:RpS9Imported
ORF Names:CG3395Imported
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0010408. RpS9.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: FlyBase
  • cytosol Source: FlyBase
  • cytosolic ribosome Source: FlyBase
  • cytosolic small ribosomal subunit Source: GO_Central
  • nuclear chromosome Source: FlyBase
  • nucleolus Source: FlyBase
  • ribosome Source: FlyBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001326951 – 19540S ribosomal protein S9Add BLAST195

Proteomic databases

PaxDbiP55935.
PRIDEiP55935.

Expressioni

Developmental stagei

Expressed both maternally and zygotically throughout development.1 Publication

Gene expression databases

BgeeiFBgn0010408.
GenevisibleiP55935. DM.

Interactioni

Protein-protein interaction databases

BioGridi64500. 15 interactors.
IntActiP55935. 4 interactors.
STRINGi7227.FBpp0076152.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4V6Welectron microscopy6.00AJ1-195[»]
ProteinModelPortaliP55935.
SMRiP55935.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini109 – 183S4 RNA-bindingPROSITE-ProRule annotationAdd BLAST75

Sequence similaritiesi

Belongs to the ribosomal protein S4P family.Curated
Contains 1 S4 RNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3301. Eukaryota.
COG0522. LUCA.
GeneTreeiENSGT00550000074829.
InParanoidiP55935.
KOiK02997.
OMAiTIVYRKG.
OrthoDBiEOG091G0S57.
PhylomeDBiP55935.

Family and domain databases

Gene3Di3.10.290.10. 1 hit.
InterProiIPR022801. Ribosomal_S4/S9.
IPR005710. Ribosomal_S4/S9_euk/arc.
IPR001912. Ribosomal_S4/S9_N.
IPR018079. Ribosomal_S4_CS.
IPR002942. S4_RNA-bd.
[Graphical view]
PANTHERiPTHR11831. PTHR11831. 1 hit.
PfamiPF00163. Ribosomal_S4. 1 hit.
PF01479. S4. 1 hit.
[Graphical view]
SMARTiSM01390. Ribosomal_S4. 1 hit.
SM00363. S4. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01018. uS4_arch. 1 hit.
PROSITEiPS00632. RIBOSOMAL_S4. 1 hit.
PS50889. S4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P55935-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVNGRIPSVF SKTYVTPRRP YEKARLDQEL KIIGEYGLRN KREVWRVKYA
60 70 80 90 100
LAKIRKAARE LLTLDEKDEK RLFQGNALLR RLVRIGVLDE SRMKLDYVLG
110 120 130 140 150
LKIEDFLERR LQTQVFKLGL AKSIHHARVL IRQRHIRVRK QVVNIPSFVV
160 170 180 190
RLDSQKHIDF SLKSPFGGGR PGRVKRKNLK KNQGGGGGAA EEEED
Length:195
Mass (Da):22,623
Last modified:March 1, 2005 - v2
Checksum:i7619DFAEF8B4157F
GO

Sequence cautioni

The sequence CAB41492 differs from that shown. Reason: Frameshift at positions 39, 47, 90, 91, 119, 135, 145, 151, 157, 159, 165 and 180.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti57A → V in CAB41492 (PubMed:8400363).Curated1
Sequence conflicti69E → A in CAB41492 (PubMed:8400363).Curated1
Sequence conflicti76 – 79NALL → KSLV in CAB41492 (PubMed:8400363).Curated4
Sequence conflicti104E → Q in CAB41492 (PubMed:8400363).Curated1
Sequence conflicti138V → A in CAB41492 (PubMed:8400363).Curated1
Sequence conflicti164S → M in CAB41492 (PubMed:8400363).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69677 mRNA. Translation: CAB41492.1. Frameshift.
AE014296 Genomic DNA. Translation: AAF50249.1.
AE014296 Genomic DNA. Translation: AAN11946.1.
RefSeqiNP_001287008.1. NM_001300079.1.
NP_524004.2. NM_079280.4.
NP_729506.1. NM_168350.2.
UniGeneiDm.6943.

Genome annotation databases

EnsemblMetazoaiFBtr0076423; FBpp0076152; FBgn0010408.
FBtr0076425; FBpp0076154; FBgn0010408.
FBtr0342577; FBpp0309532; FBgn0010408.
GeneIDi39108.
KEGGidme:Dmel_CG3395.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69677 mRNA. Translation: CAB41492.1. Frameshift.
AE014296 Genomic DNA. Translation: AAF50249.1.
AE014296 Genomic DNA. Translation: AAN11946.1.
RefSeqiNP_001287008.1. NM_001300079.1.
NP_524004.2. NM_079280.4.
NP_729506.1. NM_168350.2.
UniGeneiDm.6943.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4V6Welectron microscopy6.00AJ1-195[»]
ProteinModelPortaliP55935.
SMRiP55935.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi64500. 15 interactors.
IntActiP55935. 4 interactors.
STRINGi7227.FBpp0076152.

Proteomic databases

PaxDbiP55935.
PRIDEiP55935.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0076423; FBpp0076152; FBgn0010408.
FBtr0076425; FBpp0076154; FBgn0010408.
FBtr0342577; FBpp0309532; FBgn0010408.
GeneIDi39108.
KEGGidme:Dmel_CG3395.

Organism-specific databases

CTDi6203.
FlyBaseiFBgn0010408. RpS9.

Phylogenomic databases

eggNOGiKOG3301. Eukaryota.
COG0522. LUCA.
GeneTreeiENSGT00550000074829.
InParanoidiP55935.
KOiK02997.
OMAiTIVYRKG.
OrthoDBiEOG091G0S57.
PhylomeDBiP55935.

Enzyme and pathway databases

ReactomeiR-DME-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-DME-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-DME-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.
R-DME-72649. Translation initiation complex formation.
R-DME-72689. Formation of a pool of free 40S subunits.
R-DME-72695. Formation of the ternary complex, and subsequently, the 43S complex.
R-DME-72702. Ribosomal scanning and start codon recognition.
R-DME-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-DME-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-DME-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Miscellaneous databases

ChiTaRSiRpS9. fly.
GenomeRNAii39108.
PROiP55935.

Gene expression databases

BgeeiFBgn0010408.
GenevisibleiP55935. DM.

Family and domain databases

Gene3Di3.10.290.10. 1 hit.
InterProiIPR022801. Ribosomal_S4/S9.
IPR005710. Ribosomal_S4/S9_euk/arc.
IPR001912. Ribosomal_S4/S9_N.
IPR018079. Ribosomal_S4_CS.
IPR002942. S4_RNA-bd.
[Graphical view]
PANTHERiPTHR11831. PTHR11831. 1 hit.
PfamiPF00163. Ribosomal_S4. 1 hit.
PF01479. S4. 1 hit.
[Graphical view]
SMARTiSM01390. Ribosomal_S4. 1 hit.
SM00363. S4. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01018. uS4_arch. 1 hit.
PROSITEiPS00632. RIBOSOMAL_S4. 1 hit.
PS50889. S4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRS9_DROME
AccessioniPrimary (citable) accession number: P55935
Secondary accession number(s): A4V1R4
, Q6XIN2, Q9VT06, Q9VT07, Q9XZU5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: March 1, 2005
Last modified: November 2, 2016
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Ribosomal proteins
    Ribosomal proteins families and list of entries
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.