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Reviewed, UniProtKB/Swiss-Prot P55931 (ETFD_PIG)

Last modified June 16, 2009. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial
      Short name=ETF-ubiquinone oxidoreductase
      Short name=ETF-QO
    EC=1.5.5.1
Alternative name(s):
    Electron-transferring-flavoprotein dehydrogenase
      Short name=ETF dehydrogenase
Gene names
Name: ETFDH
OrganismSus scrofa (Pig)
Taxonomic identifier9823 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Suina › Suidae › Sus

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Protein attributes

Sequence length607 AA.
Sequence statusFragment.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Accepts electrons from ETF and reduces ubiquinone.

Catalytic activity

Reduced electron-transferring flavoprotein + ubiquinone = electron-transferring flavoprotein + ubiquinol.

Cofactor

Binds 1 4Fe-4S cluster.

FAD.

Subunit structure

Monomer By similarity.

Subcellular location

Mitochondrion inner membrane By similarity.

Sequence similarities

Contains 1 4Fe-4S ferredoxin-type domain.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide‹1 – 23›23Mitochondrion Potential
Chain24 – 607584Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial
PRO_0000008663

Regions

Transmembrane448 – 46821 Potential
Domain567 – 596304Fe-4S ferredoxin-type
Nucleotide binding61 – 7515FAD Potential

Sites

Metal binding5511Iron-sulfur (4Fe-4S) Potential
Metal binding5761Iron-sulfur (4Fe-4S) Potential
Metal binding5791Iron-sulfur (4Fe-4S) Potential
Metal binding5821Iron-sulfur (4Fe-4S) Potential

Amino acid modifications

Modified residue861N6-acetyllysine By similarity
Modified residue1431N6-acetyllysine By similarity
Modified residue2131N6-acetyllysine By similarity
Modified residue3341N6-acetyllysine By similarity

Experimental info

Non-terminal residue11

Secondary structure

1 ................................................................................................................... 607
Helix Strand Turn

Details...

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Sequences

Sequence LengthMass (Da)Tools
P55931-1 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: 243573B0774C6FDE

FASTA60767,590
        10         20         30         40         50         60 
PAYQCFHALK IKKNYLPLCA TRWSSTCKVP RITTHYTIYP RDQDKRWEGV NMERFAEEAD 

        70         80         90        100        110        120 
VVIVGAGPAG LSAATRLKQL AAQHEKDLRV CLVEKAAHIG AHTLSGACLD PRAFEELFPD 

       130        140        150        160        170        180 
WKEKGAPLNT PVTEDRFGIL TEKYRIPVPI LPGLPMNNHG NYVVRLGHLV SWMGEQAEAL 

       190        200        210        220        230        240 
GVEVYPGYAA AEILFHEDGS VKGIATNDVG IQKDGAPKTT FERGLELHAK VTIFAEGCHG 

       250        260        270        280        290        300 
HLAKQLYKKF DLRANCEPQT YGIGLKELWV IDEKKWKPGR VDHTVGWPLD RHTYGGSFLY 

       310        320        330        340        350        360 
HLNEGEPLLA LGFVVGLDYQ NPYLSPFREF QRWKHHPSIK PTLEGGKRIA YGARALNEGG 

       370        380        390        400        410        420 
FQSIPKLTFP GGLLIGCSPG FMNVPKIKGT HTAMKSGTLA AESIFNQLTS ENLQSKTIGL 

       430        440        450        460        470        480 
HVTEYEDNLK NSWVWKELYS VRNIRPSCHG ILGVYGGMIY TGIFYWIFRG MEPWTLKHKG 

       490        500        510        520        530        540 
SDSDQLKPAK DCTPIEYPKP DGQISFDLLS SVALSGTNHE HDQPAHLTLK DDSVPVNRNL 

       550        560        570        580        590        600 
SIYDGPEQRF CPAGVYEFVP LEQGDGFRLQ INAQNCVHCK TCDIKDPSQN INWVVPEGGG 


GPAYNGM

« Hide

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References

[1]"Molecular cloning and expression of a cDNA encoding human electron transfer flavoprotein-ubiquinone oxidoreductase."
Goodman S.I., Axtell K.M., Bindoff L.A., Beard S.E., Gill R.E., Frerman F.E.
Eur. J. Biochem. 219:277-286(1994) [PubMed: 8306995] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE, PARTIAL PROTEIN SEQUENCE.
Tissue: Fetal liver.
+Additional computationally mapped references.

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Cross-references

3D structure databases

EntryMethodResolution (Å)ChainPositionsPDBsum
2GMHX-ray2.50A/B24-607[»]
2GMJX-ray2.60A/B24-607[»]
ModBaseSearch...

Phylogenomic databases

HOVERGENP55931.

Enzyme and pathway databases

BRENDA1.5.5.1. 249.

Family and domain databases

InterProIPR017896. 4Fe4S_Fe-S-bd.
IPR007859. ETFD_OxRdtase.
IPR013027. FAD_pyr_nucl-diS_OxRdtase.
[Graphical view]
PfamPF05187. ETF_QO. 1 hit.
PF07992. Pyr_redox_2. 1 hit.
[Graphical view]
PROSITEPS51379. 4FE4S_FER_2. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameETFD_PIG
AccessionPrimary (citable) accession number: P55931
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: June 16, 2009
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents