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P55928 (KAX72_PANIM) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Potassium channel toxin alpha-KTx 7.2
Alternative name(s):
Pandinotoxin-beta
Potassium channel-blocking toxin 3
Short name=Pi-3
Short name=Pi3
Toxin PiTX-K-beta
OrganismPandinus imperator (Emperor scorpion)
Taxonomic identifier55084 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesIuridaScorpionoideaScorpionidaeScorpioninaePandinus

Protein attributes

Sequence length35 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Potent inhibitor of the A-type voltage-gated potassium channels. Most potent inhibitor of Kv1.2/KCNA2 channels. Reversibly block the Shaker B potassium-channels (Kv1.1 sub-family), but with a lower affinity than PiTX-K alpha. Ref.2

Subcellular location

Secreted.

Tissue specificity

Expressed by the venom gland.

Domain

Has the structural arrangement of an alpha-helix connected to a beta-sheet by disulfide bonds (CSalpha/beta).

Sequence similarities

Belongs to the short scorpion toxin superfamily. Potassium channel inhibitor family. Alpha-KTx 7 subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Peptide1 – 3535Potassium channel toxin alpha-KTx 7.2
PRO_0000044911

Sites

Site241Basic residue of the functional dyad By similarity
Site331Aromatic residue of the functional dyad By similarity

Amino acid modifications

Disulfide bond4 ↔ 25 Ref.3
Disulfide bond10 ↔ 30 Ref.3
Disulfide bond14 ↔ 32 Ref.3

Secondary structure

........ 35
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P55928 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: DFCC26880D4C792A

FASTA354,072
        10         20         30 
TISCTNEKQC YPHCKKETGY PNAKCMNRKC KCFGR 

« Hide

References

[1]"Three new toxins from the scorpion Pandinus imperator selectively block certain voltage-gated K+ channels."
Rogowski R.S., Collins J.H., O'Neill T.J., Gustafson T.A., Werkman T.R., Rogawski M.A., Tenenholz T.C., Weber D.J., Blaustein M.P.
Mol. Pharmacol. 50:1167-1177(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE.
Tissue: Venom.
[2]"Two novel toxins from the venom of the scorpion Pandinus imperator show that the N-terminal amino acid sequence is important for their affinities towards Shaker B K+ channels."
Gomez-Lagunas F., Olamendi-Portugal T., Zamudio F.Z., Possani L.D.
J. Membr. Biol. 152:49-56(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE, FUNCTION.
Tissue: Venom.
[3]"Structural and functional differences of two toxins from the scorpion Pandinus imperator."
Klenk K.C., Tenenholz T.C., Matteson D.R., Rogowski R.S., Blaustein M.P., Weber D.J.
Proteins 38:441-449(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: STRUCTURE BY NMR, DISULFIDE BONDS.

Cross-references

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1C49NMR-A1-35[»]
ProteinModelPortalP55928.
SMRP55928. Positions 1-35.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.30.30.10. 1 hit.
InterProIPR003614. Scorpion_toxin-like.
IPR001947. Scorpion_toxinS_K_inh.
[Graphical view]
PfamPF00451. Toxin_2. 1 hit.
[Graphical view]
PRINTSPR00286. CHARYBDTOXIN.
ProDomPD003586. Scorpion_toxinS. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMSSF57095. SSF57095. 1 hit.
PROSITEPS01138. SCORP_SHORT_TOXIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP55928.

Entry information

Entry nameKAX72_PANIM
AccessionPrimary (citable) accession number: P55928
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: June 11, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Scorpion potassium channel toxins

Nomenclature of scorpion potassium channel toxins and list of entries

PDB cross-references

Index of Protein Data Bank (PDB) cross-references