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P55920

- CXCR1_PANTR

UniProt

P55920 - CXCR1_PANTR

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Protein

C-X-C chemokine receptor type 1

Gene
CXCR1, IL8RA
Organism
Pan troglodytes (Chimpanzee)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. This receptor binds to IL-8 with a high affinity and to MGSA (GRO) with a low affinity.

GO - Molecular functioni

  1. C-X-C chemokine receptor activity Source: InterPro

GO - Biological processi

  1. chemotaxis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Chemotaxis

Names & Taxonomyi

Protein namesi
Recommended name:
C-X-C chemokine receptor type 1
Short name:
CXC-R1
Short name:
CXCR-1
Alternative name(s):
High affinity interleukin-8 receptor A
Short name:
IL-8R A
IL-8 receptor type 1
CD_antigen: CD181
Gene namesi
Name:CXCR1
Synonyms:IL8RA
OrganismiPan troglodytes (Chimpanzee)
Taxonomic identifieri9598 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
ProteomesiUP000002277: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3939Extracellular Reviewed predictionAdd
BLAST
Transmembranei40 – 6627Helical; Name=1; Reviewed predictionAdd
BLAST
Topological domaini67 – 759Cytoplasmic Reviewed prediction
Transmembranei76 – 9621Helical; Name=2; Reviewed predictionAdd
BLAST
Topological domaini97 – 11115Extracellular Reviewed predictionAdd
BLAST
Transmembranei112 – 13322Helical; Name=3; Reviewed predictionAdd
BLAST
Topological domaini134 – 15421Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei155 – 17420Helical; Name=4; Reviewed predictionAdd
BLAST
Topological domaini175 – 19925Extracellular Reviewed predictionAdd
BLAST
Transmembranei200 – 22021Helical; Name=5; Reviewed predictionAdd
BLAST
Topological domaini221 – 24222Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei243 – 26422Helical; Name=6; Reviewed predictionAdd
BLAST
Topological domaini265 – 28521Extracellular Reviewed predictionAdd
BLAST
Transmembranei286 – 30823Helical; Name=7; Reviewed predictionAdd
BLAST
Topological domaini309 – 35042Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 350350C-X-C chemokine receptor type 1PRO_0000069331Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi3 – 31N-linked (GlcNAc...) Reviewed prediction
Glycosylationi16 – 161N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi110 ↔ 187 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliP55920.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG146068.
HOGENOMiHOG000234122.
HOVERGENiHBG106917.
InParanoidiP55920.
KOiK04175.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR001355. Chemokine_CXCR1.
IPR000174. Chemokine_CXCR_1/2.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24227. PTHR24227. 1 hit.
PTHR24227:SF47. PTHR24227:SF47. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00427. INTRLEUKIN8R.
PR00572. INTRLEUKN8AR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P55920-1 [UniParc]FASTAAdd to Basket

« Hide

MSNITDPQMW DFDDLNFTGM PPTDEGYSPC RLETETLNKY VVIITYALVF    50
LLSLLGNSLV MLVILYSRVG RSVTDVYLLN LALADLLFAL TLPIWAASKV 100
NGWIFGTFLC KVVSLLKEVN FYSGILLLAC ISVDRYLAIV HATRTLTQKR 150
HLVKFVCLGC WGLSMNLSLP FFLFRQAYHP NNSSPVCYEV LGNDTAKWRM 200
VLRILPHTFG FIVPLFVMLF CYGFTLRTLF KAHMGQKHRA MRVIFAVVLI 250
FLLCWLPYNL VLLADTLMRT QVIQESCERR NNIGRALDAT EILGFLHSCL 300
NPIIYAFIGQ NFRHGFLKIL AMHGLVSKEF LARHRVTSYT SSSVNVSSNL 350
Length:350
Mass (Da):39,818
Last modified:November 1, 1997 - v1
Checksum:iA56FD0246EA1D440
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti5 – 51T → I in AAY21510. 1 Publication
Sequence conflicti5 – 51T → I in AAY21511. 1 Publication
Sequence conflicti12 – 121F → Y in AAY21510. 1 Publication
Sequence conflicti12 – 121F → Y in AAY21511. 1 Publication
Sequence conflicti49 – 491V → A in AAY21510. 1 Publication
Sequence conflicti49 – 491V → A in AAY21511. 1 Publication
Sequence conflicti73 – 731V → I in AAY21510. 1 Publication
Sequence conflicti73 – 731V → I in AAY21511. 1 Publication
Sequence conflicti101 – 1011N → T in AAY21510. 1 Publication
Sequence conflicti101 – 1011N → T in AAY21511. 1 Publication
Sequence conflicti108 – 1081F → L in AAY21510. 1 Publication
Sequence conflicti108 – 1081F → L in AAY21511. 1 Publication
Sequence conflicti166 – 1661N → I in AAY21510. 1 Publication
Sequence conflicti166 – 1661N → I in AAY21511. 1 Publication
Sequence conflicti227 – 2271R → H in AAY21510. 1 Publication
Sequence conflicti243 – 2431V → I in AAY21510. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X91109 Genomic DNA. Translation: CAB37850.1.
AY916760 Genomic DNA. Translation: AAY21510.1.
AY916761 Genomic DNA. Translation: AAY21511.1.
RefSeqiNP_001035537.1. NM_001040447.1.
UniGeneiPtr.6172.

Genome annotation databases

GeneIDi470645.
KEGGiptr:470645.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X91109 Genomic DNA. Translation: CAB37850.1 .
AY916760 Genomic DNA. Translation: AAY21510.1 .
AY916761 Genomic DNA. Translation: AAY21511.1 .
RefSeqi NP_001035537.1. NM_001040447.1.
UniGenei Ptr.6172.

3D structure databases

ProteinModelPortali P55920.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

GPCRDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 470645.
KEGGi ptr:470645.

Organism-specific databases

CTDi 3577.

Phylogenomic databases

eggNOGi NOG146068.
HOGENOMi HOG000234122.
HOVERGENi HBG106917.
InParanoidi P55920.
KOi K04175.

Miscellaneous databases

NextBioi 20847771.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR001355. Chemokine_CXCR1.
IPR000174. Chemokine_CXCR_1/2.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
PANTHERi PTHR24227. PTHR24227. 1 hit.
PTHR24227:SF47. PTHR24227:SF47. 1 hit.
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00427. INTRLEUKIN8R.
PR00572. INTRLEUKN8AR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Characterization of interleukin-8 receptors in non-human primates."
    Alvarez V., Coto E., Setien F., Gonzalez S., Gonzalez-Roces S., Lopez-Larrea C.
    Immunogenetics 43:261-267(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Molecular evolution of CXCR1, a G protein-coupled receptor involved in signal transduction of neutrophils."
    Liu Y., Yang S., Lin A.A., Cavalli-Sforza L.L., Su B.
    J. Mol. Evol. 61:691-696(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiCXCR1_PANTR
AccessioniPrimary (citable) accession number: P55920
Secondary accession number(s): Q2YEG9, Q2YEH0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: June 11, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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