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Protein

C-X-C chemokine receptor type 1

Gene

CXCR1

Organism
Pan troglodytes (Chimpanzee)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. This receptor binds to IL-8 with a high affinity and to MGSA (GRO) with a low affinity.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processChemotaxis

Names & Taxonomyi

Protein namesi
Recommended name:
C-X-C chemokine receptor type 1
Short name:
CXC-R1
Short name:
CXCR-1
Alternative name(s):
High affinity interleukin-8 receptor A
Short name:
IL-8R A
IL-8 receptor type 1
CD_antigen: CD181
Gene namesi
Name:CXCR1
Synonyms:IL8RA
OrganismiPan troglodytes (Chimpanzee)
Taxonomic identifieri9598 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
Proteomesi
  • UP000002277 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 39ExtracellularSequence analysisAdd BLAST39
Transmembranei40 – 66Helical; Name=1Sequence analysisAdd BLAST27
Topological domaini67 – 75CytoplasmicSequence analysis9
Transmembranei76 – 96Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini97 – 111ExtracellularSequence analysisAdd BLAST15
Transmembranei112 – 133Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini134 – 154CytoplasmicSequence analysisAdd BLAST21
Transmembranei155 – 174Helical; Name=4Sequence analysisAdd BLAST20
Topological domaini175 – 199ExtracellularSequence analysisAdd BLAST25
Transmembranei200 – 220Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini221 – 242CytoplasmicSequence analysisAdd BLAST22
Transmembranei243 – 264Helical; Name=6Sequence analysisAdd BLAST22
Topological domaini265 – 285ExtracellularSequence analysisAdd BLAST21
Transmembranei286 – 308Helical; Name=7Sequence analysisAdd BLAST23
Topological domaini309 – 350CytoplasmicSequence analysisAdd BLAST42

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000693311 – 350C-X-C chemokine receptor type 1Add BLAST350

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi3N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi16N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi110 ↔ 187PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP55920.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000022066.

Structurei

3D structure databases

ProteinModelPortaliP55920.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEHI. Eukaryota.
ENOG410Y9Y6. LUCA.
HOGENOMiHOG000234122.
HOVERGENiHBG106917.
InParanoidiP55920.
KOiK04175.

Family and domain databases

CDDicd15178. 7tmA_CXCR1_2. 1 hit.
InterProiView protein in InterPro
IPR001355. Chemokine_CXCR1.
IPR000174. Chemokine_CXCR_1/2.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
PfamiView protein in Pfam
PF00001. 7tm_1. 1 hit.
PRINTSiPR00237. GPCRRHODOPSN.
PR00427. INTRLEUKIN8R.
PR00572. INTRLEUKN8AR.
PROSITEiView protein in PROSITE
PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P55920-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNITDPQMW DFDDLNFTGM PPTDEGYSPC RLETETLNKY VVIITYALVF
60 70 80 90 100
LLSLLGNSLV MLVILYSRVG RSVTDVYLLN LALADLLFAL TLPIWAASKV
110 120 130 140 150
NGWIFGTFLC KVVSLLKEVN FYSGILLLAC ISVDRYLAIV HATRTLTQKR
160 170 180 190 200
HLVKFVCLGC WGLSMNLSLP FFLFRQAYHP NNSSPVCYEV LGNDTAKWRM
210 220 230 240 250
VLRILPHTFG FIVPLFVMLF CYGFTLRTLF KAHMGQKHRA MRVIFAVVLI
260 270 280 290 300
FLLCWLPYNL VLLADTLMRT QVIQESCERR NNIGRALDAT EILGFLHSCL
310 320 330 340 350
NPIIYAFIGQ NFRHGFLKIL AMHGLVSKEF LARHRVTSYT SSSVNVSSNL
Length:350
Mass (Da):39,818
Last modified:November 1, 1997 - v1
Checksum:iA56FD0246EA1D440
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti5T → I in AAY21510 (PubMed:16205979).Curated1
Sequence conflicti5T → I in AAY21511 (PubMed:16205979).Curated1
Sequence conflicti12F → Y in AAY21510 (PubMed:16205979).Curated1
Sequence conflicti12F → Y in AAY21511 (PubMed:16205979).Curated1
Sequence conflicti49V → A in AAY21510 (PubMed:16205979).Curated1
Sequence conflicti49V → A in AAY21511 (PubMed:16205979).Curated1
Sequence conflicti73V → I in AAY21510 (PubMed:16205979).Curated1
Sequence conflicti73V → I in AAY21511 (PubMed:16205979).Curated1
Sequence conflicti101N → T in AAY21510 (PubMed:16205979).Curated1
Sequence conflicti101N → T in AAY21511 (PubMed:16205979).Curated1
Sequence conflicti108F → L in AAY21510 (PubMed:16205979).Curated1
Sequence conflicti108F → L in AAY21511 (PubMed:16205979).Curated1
Sequence conflicti166N → I in AAY21510 (PubMed:16205979).Curated1
Sequence conflicti166N → I in AAY21511 (PubMed:16205979).Curated1
Sequence conflicti227R → H in AAY21510 (PubMed:16205979).Curated1
Sequence conflicti243V → I in AAY21510 (PubMed:16205979).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X91109 Genomic DNA. Translation: CAB37850.1.
AY916760 Genomic DNA. Translation: AAY21510.1.
AY916761 Genomic DNA. Translation: AAY21511.1.
RefSeqiNP_001035537.1. NM_001040447.1.
UniGeneiPtr.6172.

Genome annotation databases

GeneIDi470645.
KEGGiptr:470645.

Similar proteinsi

Entry informationi

Entry nameiCXCR1_PANTR
AccessioniPrimary (citable) accession number: P55920
Secondary accession number(s): Q2YEG9, Q2YEH0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: August 30, 2017
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families