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P55920

- CXCR1_PANTR

UniProt

P55920 - CXCR1_PANTR

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Protein

C-X-C chemokine receptor type 1

Gene

CXCR1

Organism
Pan troglodytes (Chimpanzee)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. This receptor binds to IL-8 with a high affinity and to MGSA (GRO) with a low affinity.

GO - Molecular functioni

  1. C-X-C chemokine receptor activity Source: InterPro

GO - Biological processi

  1. chemotaxis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Chemotaxis

Names & Taxonomyi

Protein namesi
Recommended name:
C-X-C chemokine receptor type 1
Short name:
CXC-R1
Short name:
CXCR-1
Alternative name(s):
High affinity interleukin-8 receptor A
Short name:
IL-8R A
IL-8 receptor type 1
CD_antigen: CD181
Gene namesi
Name:CXCR1
Synonyms:IL8RA
OrganismiPan troglodytes (Chimpanzee)
Taxonomic identifieri9598 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
ProteomesiUP000002277: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3939ExtracellularSequence AnalysisAdd
BLAST
Transmembranei40 – 6627Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini67 – 759CytoplasmicSequence Analysis
Transmembranei76 – 9621Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini97 – 11115ExtracellularSequence AnalysisAdd
BLAST
Transmembranei112 – 13322Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini134 – 15421CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei155 – 17420Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini175 – 19925ExtracellularSequence AnalysisAdd
BLAST
Transmembranei200 – 22021Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini221 – 24222CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei243 – 26422Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini265 – 28521ExtracellularSequence AnalysisAdd
BLAST
Transmembranei286 – 30823Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini309 – 35042CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 350350C-X-C chemokine receptor type 1PRO_0000069331Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi3 – 31N-linked (GlcNAc...)Sequence Analysis
Glycosylationi16 – 161N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi110 ↔ 187PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliP55920.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG146068.
HOGENOMiHOG000234122.
HOVERGENiHBG106917.
InParanoidiP55920.
KOiK04175.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR001355. Chemokine_CXCR1.
IPR000174. Chemokine_CXCR_1/2.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24227. PTHR24227. 1 hit.
PTHR24227:SF47. PTHR24227:SF47. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00427. INTRLEUKIN8R.
PR00572. INTRLEUKN8AR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P55920-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSNITDPQMW DFDDLNFTGM PPTDEGYSPC RLETETLNKY VVIITYALVF
60 70 80 90 100
LLSLLGNSLV MLVILYSRVG RSVTDVYLLN LALADLLFAL TLPIWAASKV
110 120 130 140 150
NGWIFGTFLC KVVSLLKEVN FYSGILLLAC ISVDRYLAIV HATRTLTQKR
160 170 180 190 200
HLVKFVCLGC WGLSMNLSLP FFLFRQAYHP NNSSPVCYEV LGNDTAKWRM
210 220 230 240 250
VLRILPHTFG FIVPLFVMLF CYGFTLRTLF KAHMGQKHRA MRVIFAVVLI
260 270 280 290 300
FLLCWLPYNL VLLADTLMRT QVIQESCERR NNIGRALDAT EILGFLHSCL
310 320 330 340 350
NPIIYAFIGQ NFRHGFLKIL AMHGLVSKEF LARHRVTSYT SSSVNVSSNL
Length:350
Mass (Da):39,818
Last modified:November 1, 1997 - v1
Checksum:iA56FD0246EA1D440
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti5 – 51T → I in AAY21510. (PubMed:16205979)Curated
Sequence conflicti5 – 51T → I in AAY21511. (PubMed:16205979)Curated
Sequence conflicti12 – 121F → Y in AAY21510. (PubMed:16205979)Curated
Sequence conflicti12 – 121F → Y in AAY21511. (PubMed:16205979)Curated
Sequence conflicti49 – 491V → A in AAY21510. (PubMed:16205979)Curated
Sequence conflicti49 – 491V → A in AAY21511. (PubMed:16205979)Curated
Sequence conflicti73 – 731V → I in AAY21510. (PubMed:16205979)Curated
Sequence conflicti73 – 731V → I in AAY21511. (PubMed:16205979)Curated
Sequence conflicti101 – 1011N → T in AAY21510. (PubMed:16205979)Curated
Sequence conflicti101 – 1011N → T in AAY21511. (PubMed:16205979)Curated
Sequence conflicti108 – 1081F → L in AAY21510. (PubMed:16205979)Curated
Sequence conflicti108 – 1081F → L in AAY21511. (PubMed:16205979)Curated
Sequence conflicti166 – 1661N → I in AAY21510. (PubMed:16205979)Curated
Sequence conflicti166 – 1661N → I in AAY21511. (PubMed:16205979)Curated
Sequence conflicti227 – 2271R → H in AAY21510. (PubMed:16205979)Curated
Sequence conflicti243 – 2431V → I in AAY21510. (PubMed:16205979)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X91109 Genomic DNA. Translation: CAB37850.1.
AY916760 Genomic DNA. Translation: AAY21510.1.
AY916761 Genomic DNA. Translation: AAY21511.1.
RefSeqiNP_001035537.1. NM_001040447.1.
UniGeneiPtr.6172.

Genome annotation databases

GeneIDi470645.
KEGGiptr:470645.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X91109 Genomic DNA. Translation: CAB37850.1 .
AY916760 Genomic DNA. Translation: AAY21510.1 .
AY916761 Genomic DNA. Translation: AAY21511.1 .
RefSeqi NP_001035537.1. NM_001040447.1.
UniGenei Ptr.6172.

3D structure databases

ProteinModelPortali P55920.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

GPCRDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 470645.
KEGGi ptr:470645.

Organism-specific databases

CTDi 3577.

Phylogenomic databases

eggNOGi NOG146068.
HOGENOMi HOG000234122.
HOVERGENi HBG106917.
InParanoidi P55920.
KOi K04175.

Miscellaneous databases

NextBioi 20847771.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR001355. Chemokine_CXCR1.
IPR000174. Chemokine_CXCR_1/2.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
PANTHERi PTHR24227. PTHR24227. 1 hit.
PTHR24227:SF47. PTHR24227:SF47. 1 hit.
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00427. INTRLEUKIN8R.
PR00572. INTRLEUKN8AR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Characterization of interleukin-8 receptors in non-human primates."
    Alvarez V., Coto E., Setien F., Gonzalez S., Gonzalez-Roces S., Lopez-Larrea C.
    Immunogenetics 43:261-267(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Molecular evolution of CXCR1, a G protein-coupled receptor involved in signal transduction of neutrophils."
    Liu Y., Yang S., Lin A.A., Cavalli-Sforza L.L., Su B.
    J. Mol. Evol. 61:691-696(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiCXCR1_PANTR
AccessioniPrimary (citable) accession number: P55920
Secondary accession number(s): Q2YEG9, Q2YEH0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: October 29, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3