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P55920 (CXCR1_PANTR) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
C-X-C chemokine receptor type 1

Short name=CXC-R1
Short name=CXCR-1
Alternative name(s):
High affinity interleukin-8 receptor A
Short name=IL-8R A
IL-8 receptor type 1
CD_antigen=CD181
Gene names
Name:CXCR1
Synonyms:IL8RA
OrganismPan troglodytes (Chimpanzee) [Reference proteome]
Taxonomic identifier9598 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan

Protein attributes

Sequence length350 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. This receptor binds to IL-8 with a high affinity and to MGSA (GRO) with a low affinity.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
   Biological processChemotaxis
   Cellular componentCell membrane
Membrane
   DomainTransmembrane
Transmembrane helix
   Molecular functionG-protein coupled receptor
Receptor
Transducer
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processchemotaxis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionC-X-C chemokine receptor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 350350C-X-C chemokine receptor type 1
PRO_0000069331

Regions

Topological domain1 – 3939Extracellular Potential
Transmembrane40 – 6627Helical; Name=1; Potential
Topological domain67 – 759Cytoplasmic Potential
Transmembrane76 – 9621Helical; Name=2; Potential
Topological domain97 – 11115Extracellular Potential
Transmembrane112 – 13322Helical; Name=3; Potential
Topological domain134 – 15421Cytoplasmic Potential
Transmembrane155 – 17420Helical; Name=4; Potential
Topological domain175 – 19925Extracellular Potential
Transmembrane200 – 22021Helical; Name=5; Potential
Topological domain221 – 24222Cytoplasmic Potential
Transmembrane243 – 26422Helical; Name=6; Potential
Topological domain265 – 28521Extracellular Potential
Transmembrane286 – 30823Helical; Name=7; Potential
Topological domain309 – 35042Cytoplasmic Potential

Amino acid modifications

Glycosylation31N-linked (GlcNAc...) Potential
Glycosylation161N-linked (GlcNAc...) Potential
Disulfide bond110 ↔ 187 By similarity

Experimental info

Sequence conflict51T → I in AAY21510. Ref.2
Sequence conflict51T → I in AAY21511. Ref.2
Sequence conflict121F → Y in AAY21510. Ref.2
Sequence conflict121F → Y in AAY21511. Ref.2
Sequence conflict491V → A in AAY21510. Ref.2
Sequence conflict491V → A in AAY21511. Ref.2
Sequence conflict731V → I in AAY21510. Ref.2
Sequence conflict731V → I in AAY21511. Ref.2
Sequence conflict1011N → T in AAY21510. Ref.2
Sequence conflict1011N → T in AAY21511. Ref.2
Sequence conflict1081F → L in AAY21510. Ref.2
Sequence conflict1081F → L in AAY21511. Ref.2
Sequence conflict1661N → I in AAY21510. Ref.2
Sequence conflict1661N → I in AAY21511. Ref.2
Sequence conflict2271R → H in AAY21510. Ref.2
Sequence conflict2431V → I in AAY21510. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P55920 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: A56FD0246EA1D440

FASTA35039,818
        10         20         30         40         50         60 
MSNITDPQMW DFDDLNFTGM PPTDEGYSPC RLETETLNKY VVIITYALVF LLSLLGNSLV 

        70         80         90        100        110        120 
MLVILYSRVG RSVTDVYLLN LALADLLFAL TLPIWAASKV NGWIFGTFLC KVVSLLKEVN 

       130        140        150        160        170        180 
FYSGILLLAC ISVDRYLAIV HATRTLTQKR HLVKFVCLGC WGLSMNLSLP FFLFRQAYHP 

       190        200        210        220        230        240 
NNSSPVCYEV LGNDTAKWRM VLRILPHTFG FIVPLFVMLF CYGFTLRTLF KAHMGQKHRA 

       250        260        270        280        290        300 
MRVIFAVVLI FLLCWLPYNL VLLADTLMRT QVIQESCERR NNIGRALDAT EILGFLHSCL 

       310        320        330        340        350 
NPIIYAFIGQ NFRHGFLKIL AMHGLVSKEF LARHRVTSYT SSSVNVSSNL 

« Hide

References

[1]"Characterization of interleukin-8 receptors in non-human primates."
Alvarez V., Coto E., Setien F., Gonzalez S., Gonzalez-Roces S., Lopez-Larrea C.
Immunogenetics 43:261-267(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Molecular evolution of CXCR1, a G protein-coupled receptor involved in signal transduction of neutrophils."
Liu Y., Yang S., Lin A.A., Cavalli-Sforza L.L., Su B.
J. Mol. Evol. 61:691-696(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X91109 Genomic DNA. Translation: CAB37850.1.
AY916760 Genomic DNA. Translation: AAY21510.1.
AY916761 Genomic DNA. Translation: AAY21511.1.
RefSeqNP_001035537.1. NM_001040447.1.
UniGenePtr.6172.

3D structure databases

ProteinModelPortalP55920.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

GPCRDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID470645.
KEGGptr:470645.

Organism-specific databases

CTD3577.

Phylogenomic databases

eggNOGNOG146068.
HOGENOMHOG000234122.
HOVERGENHBG106917.
InParanoidP55920.
KOK04175.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR001355. Chemokine_CXCR1.
IPR000174. Chemokine_CXCR_1/2.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERPTHR24227. PTHR24227. 1 hit.
PTHR24227:SF47. PTHR24227:SF47. 1 hit.
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00427. INTRLEUKIN8R.
PR00572. INTRLEUKN8AR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20847771.

Entry information

Entry nameCXCR1_PANTR
AccessionPrimary (citable) accession number: P55920
Secondary accession number(s): Q2YEG9, Q2YEH0
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: June 11, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries