Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P55920

- CXCR1_PANTR

UniProt

P55920 - CXCR1_PANTR

Protein

C-X-C chemokine receptor type 1

Gene

CXCR1

Organism
Pan troglodytes (Chimpanzee)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 1 (01 Nov 1997)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. This receptor binds to IL-8 with a high affinity and to MGSA (GRO) with a low affinity.

    GO - Molecular functioni

    1. C-X-C chemokine receptor activity Source: InterPro

    GO - Biological processi

    1. chemotaxis Source: UniProtKB-KW

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Chemotaxis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-X-C chemokine receptor type 1
    Short name:
    CXC-R1
    Short name:
    CXCR-1
    Alternative name(s):
    High affinity interleukin-8 receptor A
    Short name:
    IL-8R A
    IL-8 receptor type 1
    CD_antigen: CD181
    Gene namesi
    Name:CXCR1
    Synonyms:IL8RA
    OrganismiPan troglodytes (Chimpanzee)
    Taxonomic identifieri9598 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
    ProteomesiUP000002277: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 350350C-X-C chemokine receptor type 1PRO_0000069331Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi3 – 31N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi16 – 161N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi110 ↔ 187PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Structurei

    3D structure databases

    ProteinModelPortaliP55920.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3939ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini67 – 759CytoplasmicSequence Analysis
    Topological domaini97 – 11115ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini134 – 15421CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini175 – 19925ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini221 – 24222CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini265 – 28521ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini309 – 35042CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei40 – 6627Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei76 – 9621Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei112 – 13322Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei155 – 17420Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei200 – 22021Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei243 – 26422Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei286 – 30823Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG146068.
    HOGENOMiHOG000234122.
    HOVERGENiHBG106917.
    InParanoidiP55920.
    KOiK04175.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR001355. Chemokine_CXCR1.
    IPR000174. Chemokine_CXCR_1/2.
    IPR000355. Chemokine_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PANTHERiPTHR24227. PTHR24227. 1 hit.
    PTHR24227:SF47. PTHR24227:SF47. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00427. INTRLEUKIN8R.
    PR00572. INTRLEUKN8AR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P55920-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSNITDPQMW DFDDLNFTGM PPTDEGYSPC RLETETLNKY VVIITYALVF    50
    LLSLLGNSLV MLVILYSRVG RSVTDVYLLN LALADLLFAL TLPIWAASKV 100
    NGWIFGTFLC KVVSLLKEVN FYSGILLLAC ISVDRYLAIV HATRTLTQKR 150
    HLVKFVCLGC WGLSMNLSLP FFLFRQAYHP NNSSPVCYEV LGNDTAKWRM 200
    VLRILPHTFG FIVPLFVMLF CYGFTLRTLF KAHMGQKHRA MRVIFAVVLI 250
    FLLCWLPYNL VLLADTLMRT QVIQESCERR NNIGRALDAT EILGFLHSCL 300
    NPIIYAFIGQ NFRHGFLKIL AMHGLVSKEF LARHRVTSYT SSSVNVSSNL 350
    Length:350
    Mass (Da):39,818
    Last modified:November 1, 1997 - v1
    Checksum:iA56FD0246EA1D440
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti5 – 51T → I in AAY21510. (PubMed:16205979)Curated
    Sequence conflicti5 – 51T → I in AAY21511. (PubMed:16205979)Curated
    Sequence conflicti12 – 121F → Y in AAY21510. (PubMed:16205979)Curated
    Sequence conflicti12 – 121F → Y in AAY21511. (PubMed:16205979)Curated
    Sequence conflicti49 – 491V → A in AAY21510. (PubMed:16205979)Curated
    Sequence conflicti49 – 491V → A in AAY21511. (PubMed:16205979)Curated
    Sequence conflicti73 – 731V → I in AAY21510. (PubMed:16205979)Curated
    Sequence conflicti73 – 731V → I in AAY21511. (PubMed:16205979)Curated
    Sequence conflicti101 – 1011N → T in AAY21510. (PubMed:16205979)Curated
    Sequence conflicti101 – 1011N → T in AAY21511. (PubMed:16205979)Curated
    Sequence conflicti108 – 1081F → L in AAY21510. (PubMed:16205979)Curated
    Sequence conflicti108 – 1081F → L in AAY21511. (PubMed:16205979)Curated
    Sequence conflicti166 – 1661N → I in AAY21510. (PubMed:16205979)Curated
    Sequence conflicti166 – 1661N → I in AAY21511. (PubMed:16205979)Curated
    Sequence conflicti227 – 2271R → H in AAY21510. (PubMed:16205979)Curated
    Sequence conflicti243 – 2431V → I in AAY21510. (PubMed:16205979)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X91109 Genomic DNA. Translation: CAB37850.1.
    AY916760 Genomic DNA. Translation: AAY21510.1.
    AY916761 Genomic DNA. Translation: AAY21511.1.
    RefSeqiNP_001035537.1. NM_001040447.1.
    UniGeneiPtr.6172.

    Genome annotation databases

    GeneIDi470645.
    KEGGiptr:470645.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X91109 Genomic DNA. Translation: CAB37850.1 .
    AY916760 Genomic DNA. Translation: AAY21510.1 .
    AY916761 Genomic DNA. Translation: AAY21511.1 .
    RefSeqi NP_001035537.1. NM_001040447.1.
    UniGenei Ptr.6172.

    3D structure databases

    ProteinModelPortali P55920.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    GPCRDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 470645.
    KEGGi ptr:470645.

    Organism-specific databases

    CTDi 3577.

    Phylogenomic databases

    eggNOGi NOG146068.
    HOGENOMi HOG000234122.
    HOVERGENi HBG106917.
    InParanoidi P55920.
    KOi K04175.

    Miscellaneous databases

    NextBioi 20847771.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR001355. Chemokine_CXCR1.
    IPR000174. Chemokine_CXCR_1/2.
    IPR000355. Chemokine_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    PANTHERi PTHR24227. PTHR24227. 1 hit.
    PTHR24227:SF47. PTHR24227:SF47. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00427. INTRLEUKIN8R.
    PR00572. INTRLEUKN8AR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of interleukin-8 receptors in non-human primates."
      Alvarez V., Coto E., Setien F., Gonzalez S., Gonzalez-Roces S., Lopez-Larrea C.
      Immunogenetics 43:261-267(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Molecular evolution of CXCR1, a G protein-coupled receptor involved in signal transduction of neutrophils."
      Liu Y., Yang S., Lin A.A., Cavalli-Sforza L.L., Su B.
      J. Mol. Evol. 61:691-696(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiCXCR1_PANTR
    AccessioniPrimary (citable) accession number: P55920
    Secondary accession number(s): Q2YEG9, Q2YEH0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 95 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3