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Protein

Microfibril-associated glycoprotein 4

Gene

MFAP4

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Could be involved in calcium-dependent cell adhesion or intercellular interactions. May contribute to the elastic fiber assembly and/or maintenance.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium

Enzyme and pathway databases

ReactomeiR-BTA-2129379. Molecules associated with elastic fibres.

Names & Taxonomyi

Protein namesi
Recommended name:
Microfibril-associated glycoprotein 4
Alternative name(s):
36 kDa microfibril-associated glycoprotein
Short name:
36 kDa MAP
Gene namesi
Name:MFAP4
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 19

Subcellular locationi

GO - Cellular componenti

  • elastic fiber Source: BHF-UCL
  • extracellular exosome Source: Ensembl
  • extracellular matrix Source: UniProtKB
  • microfibril Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000000913321 – 255Microfibril-associated glycoprotein 4Add BLAST235

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi87N-linked (GlcNAc...)Sequence analysis1
Glycosylationi137N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP55918.
PeptideAtlasiP55918.
PRIDEiP55918.

Expressioni

Gene expression databases

BgeeiENSBTAG00000006187.

Interactioni

Subunit structurei

Homodimer. Can also form higher oligomers. Interacts with FBN1, FBN2 and LOX. Interacts with COL1A1 in a Ca (2+)-dependent manner. Interacts with ELN in a Ca (2+)-dependent manner; this interaction promotes ELN self-assembly.By similarity

Protein-protein interaction databases

BioGridi159902. 1 interactor.
STRINGi9913.ENSBTAP00000008130.

Structurei

3D structure databases

ProteinModelPortaliP55918.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini32 – 255Fibrinogen C-terminalPROSITE-ProRule annotationAdd BLAST224

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi26 – 28Cell attachment siteSequence analysis3

Sequence similaritiesi

Contains 1 fibrinogen C-terminal domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2579. Eukaryota.
ENOG410ZYS4. LUCA.
GeneTreeiENSGT00830000128240.
HOGENOMiHOG000037127.
HOVERGENiHBG001644.
InParanoidiP55918.
OMAiGINWAQW.
OrthoDBiEOG091G03M1.
TreeFamiTF336658.

Family and domain databases

CDDicd00087. FReD. 1 hit.
Gene3Di3.90.215.10. 1 hit.
4.10.530.10. 1 hit.
InterProiIPR014716. Fibrinogen_a/b/g_C_1.
IPR014715. Fibrinogen_a/b/g_C_2.
IPR002181. Fibrinogen_a/b/g_C_dom.
[Graphical view]
PfamiPF00147. Fibrinogen_C. 1 hit.
[Graphical view]
SMARTiSM00186. FBG. 1 hit.
[Graphical view]
SUPFAMiSSF56496. SSF56496. 1 hit.
PROSITEiPS51406. FIBRINOGEN_C_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P55918-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEALLVLPLL LLLSAGPCAP QLLGIRGDAL EKSCLQLPLD CDDIYAQGYQ
60 70 80 90 100
ADGVYLIYPS GPSVPVPVFC DMTTEGGKWT VFQKRFNGSV SFFRGWNDYK
110 120 130 140 150
LGFGRADGEY WLGLQNMHLL TLKQKYELRV DLEDFENNTA FAKYADFSIS
160 170 180 190 200
PNAVSAEEDG YTLYVSGFED GGAGDSLTYH SGQKFSTFDR DQDLFVQNCA
210 220 230 240 250
ALSSGAFWFR SCHFANLNGF YLGGSHLSYA NGINWAQWKG FYYSLKRTEM

KIRRA
Length:255
Mass (Da):28,558
Last modified:April 26, 2005 - v2
Checksum:i36E7F81DD3FFBD41
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti34C → E AA sequence (PubMed:8117283).Curated1
Sequence conflicti41C → E AA sequence (PubMed:8117283).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC113263 mRNA. Translation: AAI13264.1.
AY173052 mRNA. Translation: AAN85410.1.
RefSeqiNP_001073686.1. NM_001080217.1.
UniGeneiBt.5155.

Genome annotation databases

EnsembliENSBTAT00000008130; ENSBTAP00000008130; ENSBTAG00000006187.
GeneIDi286766.
KEGGibta:286766.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC113263 mRNA. Translation: AAI13264.1.
AY173052 mRNA. Translation: AAN85410.1.
RefSeqiNP_001073686.1. NM_001080217.1.
UniGeneiBt.5155.

3D structure databases

ProteinModelPortaliP55918.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi159902. 1 interactor.
STRINGi9913.ENSBTAP00000008130.

Proteomic databases

PaxDbiP55918.
PeptideAtlasiP55918.
PRIDEiP55918.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000008130; ENSBTAP00000008130; ENSBTAG00000006187.
GeneIDi286766.
KEGGibta:286766.

Organism-specific databases

CTDi4239.

Phylogenomic databases

eggNOGiKOG2579. Eukaryota.
ENOG410ZYS4. LUCA.
GeneTreeiENSGT00830000128240.
HOGENOMiHOG000037127.
HOVERGENiHBG001644.
InParanoidiP55918.
OMAiGINWAQW.
OrthoDBiEOG091G03M1.
TreeFamiTF336658.

Enzyme and pathway databases

ReactomeiR-BTA-2129379. Molecules associated with elastic fibres.

Gene expression databases

BgeeiENSBTAG00000006187.

Family and domain databases

CDDicd00087. FReD. 1 hit.
Gene3Di3.90.215.10. 1 hit.
4.10.530.10. 1 hit.
InterProiIPR014716. Fibrinogen_a/b/g_C_1.
IPR014715. Fibrinogen_a/b/g_C_2.
IPR002181. Fibrinogen_a/b/g_C_dom.
[Graphical view]
PfamiPF00147. Fibrinogen_C. 1 hit.
[Graphical view]
SMARTiSM00186. FBG. 1 hit.
[Graphical view]
SUPFAMiSSF56496. SSF56496. 1 hit.
PROSITEiPS51406. FIBRINOGEN_C_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMFAP4_BOVIN
AccessioniPrimary (citable) accession number: P55918
Secondary accession number(s): Q29S09, Q8HY48
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: April 26, 2005
Last modified: November 30, 2016
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.