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Protein

Gap junction alpha-8 protein

Gene

GJA8

Organism
Ovis aries (Sheep)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Gap junction alpha-8 protein
Alternative name(s):
Connexin-49
Short name:
Cx49
Lens fiber protein MP70
MP38
MP64
Gene namesi
Name:GJA8
OrganismiOvis aries (Sheep)
Taxonomic identifieri9940 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeCaprinaeOvis
Proteomesi
  • UP000002356 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 23CytoplasmicSequence analysisAdd BLAST22
Transmembranei24 – 46HelicalSequence analysisAdd BLAST23
Topological domaini47 – 74ExtracellularSequence analysisAdd BLAST28
Transmembranei75 – 97HelicalSequence analysisAdd BLAST23
Topological domaini98 – 157CytoplasmicSequence analysisAdd BLAST60
Transmembranei158 – 180HelicalSequence analysisAdd BLAST23
Topological domaini181 – 209ExtracellularSequence analysisAdd BLAST29
Transmembranei210 – 229HelicalSequence analysisAdd BLAST20
Topological domaini230 – 440CytoplasmicSequence analysisAdd BLAST211

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Gap junction, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000578322 – 440Gap junction alpha-8 proteinAdd BLAST439

Expressioni

Tissue specificityi

Eye lens.

Interactioni

Subunit structurei

A connexon is composed of a hexamer of connexins.

Structurei

3D structure databases

ProteinModelPortaliP55917.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG009576.
KOiK07617.

Family and domain databases

InterProiIPR000500. Connexin.
IPR002266. Connexin50.
IPR019570. Connexin_CCC.
IPR017990. Connexin_CS.
IPR013092. Connexin_N.
[Graphical view]
PANTHERiPTHR11984. PTHR11984. 2 hits.
PTHR11984:SF19. PTHR11984:SF19. 2 hits.
PfamiPF00029. Connexin. 1 hit.
PF03509. Connexin50. 1 hit.
[Graphical view]
PRINTSiPR00206. CONNEXIN.
PR01137. CONNEXINA8.
SMARTiSM00037. CNX. 1 hit.
SM01089. Connexin_CCC. 1 hit.
[Graphical view]
PROSITEiPS00407. CONNEXINS_1. 1 hit.
PS00408. CONNEXINS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P55917-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDWSFLGNI LEEVNEHSTV IGRVWLTVLF IFRILILGTA AEFVWGDEQS
60 70 80 90 100
DFVCNTQQPG CENVCYDEAF PISHIRLWVL QIIFVSTPSL VYVGHAVHHV
110 120 130 140 150
RMEEKRKERE AEELSQQSPG NGGERAPLAA DQGSVKKSSS SSKGTKKFRL
160 170 180 190 200
EGTLLRTYVC HIIFKTLFEV GFIVGHYFLY GFRILPLYRC SRWPCPNVVD
210 220 230 240 250
CFVSRPTEKT IFILFMLSVA SVSLFLNILE MSHLGLKKIR SAFKRPVEQP
260 270 280 290 300
LGEIPEKSLH SIAVSSIQKA KGYQLLEEEK IVSHYFPLTE VGMVEASPLS
310 320 330 340 350
AKPFSQFEEK VGPGPLGDLS RAYQETLPSY AQVGAQEGVE EEQPIEAAAE
360 370 380 390 400
PEVGDKSQEA ERVSTEGEET LAVLEEEKVE PPEVEKEAEK EETPPEKVSK
410 420 430 440
QELTPEKAPS LCAELPGEDT RPLSRLSKAS SRARSDDLTV
Length:440
Mass (Da):49,160
Last modified:January 23, 2007 - v2
Checksum:iBE6E478B98D83891
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti13E → N AA sequence (PubMed:2830542).Curated1
Sequence conflicti15N → Q AA sequence (PubMed:2830542).Curated1
Sequence conflicti42E → D in AAF01367 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti9N → R.1
Natural varianti10I → L.1
Natural varianti14V → A.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF177913 Genomic DNA. Translation: AAF01367.1.
RefSeqiNP_001123510.1. NM_001130038.1.
UniGeneiOar.17419.

Genome annotation databases

GeneIDi100170231.
KEGGioas:100170231.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF177913 Genomic DNA. Translation: AAF01367.1.
RefSeqiNP_001123510.1. NM_001130038.1.
UniGeneiOar.17419.

3D structure databases

ProteinModelPortaliP55917.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100170231.
KEGGioas:100170231.

Organism-specific databases

CTDi2703.

Phylogenomic databases

HOVERGENiHBG009576.
KOiK07617.

Family and domain databases

InterProiIPR000500. Connexin.
IPR002266. Connexin50.
IPR019570. Connexin_CCC.
IPR017990. Connexin_CS.
IPR013092. Connexin_N.
[Graphical view]
PANTHERiPTHR11984. PTHR11984. 2 hits.
PTHR11984:SF19. PTHR11984:SF19. 2 hits.
PfamiPF00029. Connexin. 1 hit.
PF03509. Connexin50. 1 hit.
[Graphical view]
PRINTSiPR00206. CONNEXIN.
PR01137. CONNEXINA8.
SMARTiSM00037. CNX. 1 hit.
SM01089. Connexin_CCC. 1 hit.
[Graphical view]
PROSITEiPS00407. CONNEXINS_1. 1 hit.
PS00408. CONNEXINS_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCXA8_SHEEP
AccessioniPrimary (citable) accession number: P55917
Secondary accession number(s): Q9MYL3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 79 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.