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P55917

- CXA8_SHEEP

UniProt

P55917 - CXA8_SHEEP

Protein

Gap junction alpha-8 protein

Gene

GJA8

Organism
Ovis aries (Sheep)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 2 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.

    GO - Biological processi

    1. cell communication Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Gap junction alpha-8 protein
    Alternative name(s):
    Connexin-49
    Short name:
    Cx49
    Lens fiber protein MP70
    MP38
    MP64
    Gene namesi
    Name:GJA8
    OrganismiOvis aries (Sheep)
    Taxonomic identifieri9940 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeCaprinaeOvis
    ProteomesiUP000002356: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. connexon complex Source: InterPro
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Gap junction, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 440439Gap junction alpha-8 proteinPRO_0000057832Add
    BLAST

    Expressioni

    Tissue specificityi

    Eye lens.

    Interactioni

    Subunit structurei

    A connexon is composed of a hexamer of connexins.

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini2 – 2322CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini47 – 7428ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini98 – 15760CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini181 – 20929ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini230 – 440211CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei24 – 4623HelicalSequence AnalysisAdd
    BLAST
    Transmembranei75 – 9723HelicalSequence AnalysisAdd
    BLAST
    Transmembranei158 – 18023HelicalSequence AnalysisAdd
    BLAST
    Transmembranei210 – 22920HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOVERGENiHBG009576.

    Family and domain databases

    InterProiIPR000500. Connexin.
    IPR002266. Connexin50.
    IPR019570. Connexin_CCC.
    IPR017990. Connexin_CS.
    IPR013092. Connexin_N.
    [Graphical view]
    PANTHERiPTHR11984. PTHR11984. 1 hit.
    PfamiPF00029. Connexin. 1 hit.
    PF03509. Connexin50. 1 hit.
    PF10582. Connexin_CCC. 1 hit.
    [Graphical view]
    PRINTSiPR00206. CONNEXIN.
    PR01137. CONNEXINA8.
    SMARTiSM00037. CNX. 1 hit.
    SM01089. Connexin_CCC. 1 hit.
    [Graphical view]
    PROSITEiPS00407. CONNEXINS_1. 1 hit.
    PS00408. CONNEXINS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P55917-1 [UniParc]FASTAAdd to Basket

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    MGDWSFLGNI LEEVNEHSTV IGRVWLTVLF IFRILILGTA AEFVWGDEQS    50
    DFVCNTQQPG CENVCYDEAF PISHIRLWVL QIIFVSTPSL VYVGHAVHHV 100
    RMEEKRKERE AEELSQQSPG NGGERAPLAA DQGSVKKSSS SSKGTKKFRL 150
    EGTLLRTYVC HIIFKTLFEV GFIVGHYFLY GFRILPLYRC SRWPCPNVVD 200
    CFVSRPTEKT IFILFMLSVA SVSLFLNILE MSHLGLKKIR SAFKRPVEQP 250
    LGEIPEKSLH SIAVSSIQKA KGYQLLEEEK IVSHYFPLTE VGMVEASPLS 300
    AKPFSQFEEK VGPGPLGDLS RAYQETLPSY AQVGAQEGVE EEQPIEAAAE 350
    PEVGDKSQEA ERVSTEGEET LAVLEEEKVE PPEVEKEAEK EETPPEKVSK 400
    QELTPEKAPS LCAELPGEDT RPLSRLSKAS SRARSDDLTV 440
    Length:440
    Mass (Da):49,160
    Last modified:January 23, 2007 - v2
    Checksum:iBE6E478B98D83891
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti13 – 131E → N AA sequence (PubMed:2830542)Curated
    Sequence conflicti15 – 151N → Q AA sequence (PubMed:2830542)Curated
    Sequence conflicti42 – 421E → D in AAF01367. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti9 – 91N → R.
    Natural varianti10 – 101I → L.
    Natural varianti14 – 141V → A.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF177913 Genomic DNA. Translation: AAF01367.1.
    RefSeqiNP_001123510.1. NM_001130038.1.
    UniGeneiOar.17419.

    Genome annotation databases

    GeneIDi100170231.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF177913 Genomic DNA. Translation: AAF01367.1 .
    RefSeqi NP_001123510.1. NM_001130038.1.
    UniGenei Oar.17419.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100170231.

    Organism-specific databases

    CTDi 2703.

    Phylogenomic databases

    HOVERGENi HBG009576.

    Family and domain databases

    InterProi IPR000500. Connexin.
    IPR002266. Connexin50.
    IPR019570. Connexin_CCC.
    IPR017990. Connexin_CS.
    IPR013092. Connexin_N.
    [Graphical view ]
    PANTHERi PTHR11984. PTHR11984. 1 hit.
    Pfami PF00029. Connexin. 1 hit.
    PF03509. Connexin50. 1 hit.
    PF10582. Connexin_CCC. 1 hit.
    [Graphical view ]
    PRINTSi PR00206. CONNEXIN.
    PR01137. CONNEXINA8.
    SMARTi SM00037. CNX. 1 hit.
    SM01089. Connexin_CCC. 1 hit.
    [Graphical view ]
    PROSITEi PS00407. CONNEXINS_1. 1 hit.
    PS00408. CONNEXINS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of sheep connexin49 and its identity with MP70."
      Yang D.-I., Louis C.F.
      Curr. Eye Res. 15:307-314(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Yang D.-I., Louis C.F.
      Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Homologies between gap junction proteins in lens, heart and liver."
      Kistler J., Christie D., Bullivant S.
      Nature 331:721-723(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-21.
      Tissue: Lens.

    Entry informationi

    Entry nameiCXA8_SHEEP
    AccessioniPrimary (citable) accession number: P55917
    Secondary accession number(s): Q9MYL3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 73 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3