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P55917

- CXA8_SHEEP

UniProt

P55917 - CXA8_SHEEP

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Protein
Gap junction alpha-8 protein
Gene
GJA8
Organism
Ovis aries (Sheep)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.

GO - Biological processi

  1. cell communication Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Gap junction alpha-8 protein
Alternative name(s):
Connexin-49
Short name:
Cx49
Lens fiber protein MP70
MP38
MP64
Gene namesi
Name:GJA8
OrganismiOvis aries (Sheep)
Taxonomic identifieri9940 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeCaprinaeOvis
ProteomesiUP000002356: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 2322Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei24 – 4623Helical; Reviewed prediction
Add
BLAST
Topological domaini47 – 7428Extracellular Reviewed prediction
Add
BLAST
Transmembranei75 – 9723Helical; Reviewed prediction
Add
BLAST
Topological domaini98 – 15760Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei158 – 18023Helical; Reviewed prediction
Add
BLAST
Topological domaini181 – 20929Extracellular Reviewed prediction
Add
BLAST
Transmembranei210 – 22920Helical; Reviewed prediction
Add
BLAST
Topological domaini230 – 440211Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. connexon complex Source: InterPro
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Gap junction, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 440439Gap junction alpha-8 protein
PRO_0000057832Add
BLAST

Expressioni

Tissue specificityi

Eye lens.

Interactioni

Subunit structurei

A connexon is composed of a hexamer of connexins.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG009576.

Family and domain databases

InterProiIPR000500. Connexin.
IPR002266. Connexin50.
IPR019570. Connexin_CCC.
IPR017990. Connexin_CS.
IPR013092. Connexin_N.
[Graphical view]
PANTHERiPTHR11984. PTHR11984. 1 hit.
PfamiPF00029. Connexin. 1 hit.
PF03509. Connexin50. 1 hit.
PF10582. Connexin_CCC. 1 hit.
[Graphical view]
PRINTSiPR00206. CONNEXIN.
PR01137. CONNEXINA8.
SMARTiSM00037. CNX. 1 hit.
SM01089. Connexin_CCC. 1 hit.
[Graphical view]
PROSITEiPS00407. CONNEXINS_1. 1 hit.
PS00408. CONNEXINS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P55917-1 [UniParc]FASTAAdd to Basket

« Hide

MGDWSFLGNI LEEVNEHSTV IGRVWLTVLF IFRILILGTA AEFVWGDEQS    50
DFVCNTQQPG CENVCYDEAF PISHIRLWVL QIIFVSTPSL VYVGHAVHHV 100
RMEEKRKERE AEELSQQSPG NGGERAPLAA DQGSVKKSSS SSKGTKKFRL 150
EGTLLRTYVC HIIFKTLFEV GFIVGHYFLY GFRILPLYRC SRWPCPNVVD 200
CFVSRPTEKT IFILFMLSVA SVSLFLNILE MSHLGLKKIR SAFKRPVEQP 250
LGEIPEKSLH SIAVSSIQKA KGYQLLEEEK IVSHYFPLTE VGMVEASPLS 300
AKPFSQFEEK VGPGPLGDLS RAYQETLPSY AQVGAQEGVE EEQPIEAAAE 350
PEVGDKSQEA ERVSTEGEET LAVLEEEKVE PPEVEKEAEK EETPPEKVSK 400
QELTPEKAPS LCAELPGEDT RPLSRLSKAS SRARSDDLTV 440
Length:440
Mass (Da):49,160
Last modified:January 23, 2007 - v2
Checksum:iBE6E478B98D83891
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti9 – 91N → R.
Natural varianti10 – 101I → L.
Natural varianti14 – 141V → A.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti13 – 131E → N AA sequence 1 Publication
Sequence conflicti15 – 151N → Q AA sequence 1 Publication
Sequence conflicti42 – 421E → D in AAF01367. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF177913 Genomic DNA. Translation: AAF01367.1.
RefSeqiNP_001123510.1. NM_001130038.1.
UniGeneiOar.17419.

Genome annotation databases

GeneIDi100170231.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF177913 Genomic DNA. Translation: AAF01367.1 .
RefSeqi NP_001123510.1. NM_001130038.1.
UniGenei Oar.17419.

3D structure databases

ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100170231.

Organism-specific databases

CTDi 2703.

Phylogenomic databases

HOVERGENi HBG009576.

Family and domain databases

InterProi IPR000500. Connexin.
IPR002266. Connexin50.
IPR019570. Connexin_CCC.
IPR017990. Connexin_CS.
IPR013092. Connexin_N.
[Graphical view ]
PANTHERi PTHR11984. PTHR11984. 1 hit.
Pfami PF00029. Connexin. 1 hit.
PF03509. Connexin50. 1 hit.
PF10582. Connexin_CCC. 1 hit.
[Graphical view ]
PRINTSi PR00206. CONNEXIN.
PR01137. CONNEXINA8.
SMARTi SM00037. CNX. 1 hit.
SM01089. Connexin_CCC. 1 hit.
[Graphical view ]
PROSITEi PS00407. CONNEXINS_1. 1 hit.
PS00408. CONNEXINS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning of sheep connexin49 and its identity with MP70."
    Yang D.-I., Louis C.F.
    Curr. Eye Res. 15:307-314(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Yang D.-I., Louis C.F.
    Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Homologies between gap junction proteins in lens, heart and liver."
    Kistler J., Christie D., Bullivant S.
    Nature 331:721-723(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-21.
    Tissue: Lens.

Entry informationi

Entry nameiCXA8_SHEEP
AccessioniPrimary (citable) accession number: P55917
Secondary accession number(s): Q9MYL3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 23, 2007
Last modified: July 9, 2014
This is version 72 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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