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P55917

- CXA8_SHEEP

UniProt

P55917 - CXA8_SHEEP

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Protein

Gap junction alpha-8 protein

Gene

GJA8

Organism
Ovis aries (Sheep)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.

GO - Biological processi

  1. cell communication Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Gap junction alpha-8 protein
Alternative name(s):
Connexin-49
Short name:
Cx49
Lens fiber protein MP70
MP38
MP64
Gene namesi
Name:GJA8
OrganismiOvis aries (Sheep)
Taxonomic identifieri9940 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeCaprinaeOvis
ProteomesiUP000002356: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 2322CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei24 – 4623HelicalSequence AnalysisAdd
BLAST
Topological domaini47 – 7428ExtracellularSequence AnalysisAdd
BLAST
Transmembranei75 – 9723HelicalSequence AnalysisAdd
BLAST
Topological domaini98 – 15760CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei158 – 18023HelicalSequence AnalysisAdd
BLAST
Topological domaini181 – 20929ExtracellularSequence AnalysisAdd
BLAST
Transmembranei210 – 22920HelicalSequence AnalysisAdd
BLAST
Topological domaini230 – 440211CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. connexon complex Source: InterPro
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Gap junction, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 440439Gap junction alpha-8 proteinPRO_0000057832Add
BLAST

Expressioni

Tissue specificityi

Eye lens.

Interactioni

Subunit structurei

A connexon is composed of a hexamer of connexins.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG009576.
KOiK07617.

Family and domain databases

InterProiIPR000500. Connexin.
IPR002266. Connexin50.
IPR019570. Connexin_CCC.
IPR017990. Connexin_CS.
IPR013092. Connexin_N.
[Graphical view]
PANTHERiPTHR11984. PTHR11984. 1 hit.
PfamiPF00029. Connexin. 1 hit.
PF03509. Connexin50. 1 hit.
PF10582. Connexin_CCC. 1 hit.
[Graphical view]
PRINTSiPR00206. CONNEXIN.
PR01137. CONNEXINA8.
SMARTiSM00037. CNX. 1 hit.
SM01089. Connexin_CCC. 1 hit.
[Graphical view]
PROSITEiPS00407. CONNEXINS_1. 1 hit.
PS00408. CONNEXINS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P55917-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGDWSFLGNI LEEVNEHSTV IGRVWLTVLF IFRILILGTA AEFVWGDEQS
60 70 80 90 100
DFVCNTQQPG CENVCYDEAF PISHIRLWVL QIIFVSTPSL VYVGHAVHHV
110 120 130 140 150
RMEEKRKERE AEELSQQSPG NGGERAPLAA DQGSVKKSSS SSKGTKKFRL
160 170 180 190 200
EGTLLRTYVC HIIFKTLFEV GFIVGHYFLY GFRILPLYRC SRWPCPNVVD
210 220 230 240 250
CFVSRPTEKT IFILFMLSVA SVSLFLNILE MSHLGLKKIR SAFKRPVEQP
260 270 280 290 300
LGEIPEKSLH SIAVSSIQKA KGYQLLEEEK IVSHYFPLTE VGMVEASPLS
310 320 330 340 350
AKPFSQFEEK VGPGPLGDLS RAYQETLPSY AQVGAQEGVE EEQPIEAAAE
360 370 380 390 400
PEVGDKSQEA ERVSTEGEET LAVLEEEKVE PPEVEKEAEK EETPPEKVSK
410 420 430 440
QELTPEKAPS LCAELPGEDT RPLSRLSKAS SRARSDDLTV
Length:440
Mass (Da):49,160
Last modified:January 23, 2007 - v2
Checksum:iBE6E478B98D83891
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti13 – 131E → N AA sequence (PubMed:2830542)Curated
Sequence conflicti15 – 151N → Q AA sequence (PubMed:2830542)Curated
Sequence conflicti42 – 421E → D in AAF01367. 1 PublicationCurated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti9 – 91N → R.
Natural varianti10 – 101I → L.
Natural varianti14 – 141V → A.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF177913 Genomic DNA. Translation: AAF01367.1.
RefSeqiNP_001123510.1. NM_001130038.1.
UniGeneiOar.17419.

Genome annotation databases

GeneIDi100170231.
KEGGioas:100170231.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF177913 Genomic DNA. Translation: AAF01367.1 .
RefSeqi NP_001123510.1. NM_001130038.1.
UniGenei Oar.17419.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100170231.
KEGGi oas:100170231.

Organism-specific databases

CTDi 2703.

Phylogenomic databases

HOVERGENi HBG009576.
KOi K07617.

Family and domain databases

InterProi IPR000500. Connexin.
IPR002266. Connexin50.
IPR019570. Connexin_CCC.
IPR017990. Connexin_CS.
IPR013092. Connexin_N.
[Graphical view ]
PANTHERi PTHR11984. PTHR11984. 1 hit.
Pfami PF00029. Connexin. 1 hit.
PF03509. Connexin50. 1 hit.
PF10582. Connexin_CCC. 1 hit.
[Graphical view ]
PRINTSi PR00206. CONNEXIN.
PR01137. CONNEXINA8.
SMARTi SM00037. CNX. 1 hit.
SM01089. Connexin_CCC. 1 hit.
[Graphical view ]
PROSITEi PS00407. CONNEXINS_1. 1 hit.
PS00408. CONNEXINS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning of sheep connexin49 and its identity with MP70."
    Yang D.-I., Louis C.F.
    Curr. Eye Res. 15:307-314(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Yang D.-I., Louis C.F.
    Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Homologies between gap junction proteins in lens, heart and liver."
    Kistler J., Christie D., Bullivant S.
    Nature 331:721-723(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-21.
    Tissue: Lens.

Entry informationi

Entry nameiCXA8_SHEEP
AccessioniPrimary (citable) accession number: P55917
Secondary accession number(s): Q9MYL3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 23, 2007
Last modified: November 26, 2014
This is version 74 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3