P55911 (AROF_STRLI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Phospho-2-dehydro-3-deoxyheptonate aldolase EC=2.5.1.54 Alternative name(s): 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase DAHP synthase Phospho-2-keto-3-deoxyheptonate aldolase
Organism	Streptomyces lividans
Taxonomic identifier	1916 [NCBI]
Taxonomic lineage	Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Streptomycineae › Streptomycetaceae › Streptomyces

Protein attributes

Sequence length	146 AA.
Sequence status	Fragment.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Phosphoenolpyruvate + D-erythrose 4-phosphate + H2O = 3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate + phosphate.
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 1/7.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the class-II DAHP synthase family.
Sequence caution	The sequence L13767 differs from that shown. Reason: Frameshift at positions 37 and 71.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Molecular function	Transferase
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	3-deoxy-7-phosphoheptulonate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – 146	›146	Phospho-2-dehydro-3-deoxyheptonate aldolase		PRO_0000140856
Experimental info
	Non-terminal residue	1	1

Sequences

	Sequence		Length	Mass (Da)
	P55911 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: 1A837D3371EDC546	FASTA	146	16,589
	10 20 30 40 50 60 LQYIERLDPE REPGRLTFIV RMGADKIRDK LPELVERSPP PATVAWITDP MHGNTYEAAP 70 80 90 100 110 120 VHKTRRFDDV LDEVKGFFEV HKSLGTHPGG IHVELTGDDV TECVGGGDEI FVDDLHQRYE 130 140 TACDPRLNRS QSLDLAFLVA EMYRDQ

References

[1]	Liaw L.L., Su M.H., Lee Y.H.W. Submitted (MAY-1993) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: TK64.
[2]	"Evidence for a novel class of microbial 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase in Streptomyces coelicolor A3(2), Streptomyces rimosus and Neurospora crassa." Walker G.E., Dunbar B., Hunter I.S., Nimmo H.G., Coggins J.R. Microbiology 142:1973-1982(1996) [PubMed: 8760910] [Abstract] Cited for: IDENTIFICATION, CONCEPTUAL TRANSLATION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L13767 Genomic DNA. No translation available.
3D structure databases
ProteinModelPortal	P55911.
SMR	P55911. Positions 1-145.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR002480. DAHP_synth_2. [Graphical view]
PANTHER	PTHR21337. DAHP_synth_2. 1 hit.
Pfam	PF01474. DAHP_synth_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROF_STRLI

Accession

Primary (citable) accession number: P55911

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	May 31, 2011
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program