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Protein

Zinc-containing ferredoxin-1

Gene

zfx1

Organism
Sulfolobus tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

Cofactori

Protein has several cofactor binding sites:

Redox potential

E0 is -280 mV for the 3Fe-4S and -530 mV for the 4Fe-4S clusters.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi17Zinc1
Metal bindingi20Zinc1
Metal bindingi35Zinc1
Metal bindingi46Iron-sulfur 1 (3Fe-4S)1
Metal bindingi52Iron-sulfur 1 (3Fe-4S)1
Metal bindingi56Iron-sulfur 2 (4Fe-4S)1
Metal bindingi77Zinc1
Metal bindingi84Iron-sulfur 2 (4Fe-4S)1
Metal bindingi87Iron-sulfur 2 (4Fe-4S)1
Metal bindingi90Iron-sulfur 2 (4Fe-4S)1
Metal bindingi94Iron-sulfur 1 (3Fe-4S)1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Electron transport, Transport

Keywords - Ligandi

3Fe-4S, 4Fe-4S, Iron, Iron-sulfur, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc-containing ferredoxin-1
Gene namesi
Name:zfx1
Synonyms:zfx
Ordered Locus Names:STK_01630
OrganismiSulfolobus tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)
Taxonomic identifieri273063 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
Proteomesi
  • UP000001015 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001591802 – 104Zinc-containing ferredoxin-1Add BLAST103

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei30N6-methyllysine1 Publication1

Keywords - PTMi

Methylation

Interactioni

Protein-protein interaction databases

STRINGi273063.ST0163.

Structurei

Secondary structure

1104
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi7 – 10Combined sources4
Beta strandi13 – 17Combined sources5
Beta strandi20 – 24Combined sources5
Turni28 – 30Combined sources3
Beta strandi37 – 42Combined sources6
Turni43 – 45Combined sources3
Helixi51 – 55Combined sources5
Beta strandi62 – 65Combined sources4
Beta strandi73 – 77Combined sources5
Helixi81 – 83Combined sources3
Helixi89 – 93Combined sources5
Beta strandi99 – 101Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1XERX-ray2.00A2-104[»]
ProteinModelPortaliP55907.
SMRiP55907.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP55907.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini38 – 664Fe-4S ferredoxin-type 1PROSITE-ProRule annotationAdd BLAST29
Domaini75 – 1044Fe-4S ferredoxin-type 2PROSITE-ProRule annotationAdd BLAST30

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 37N-terminal extensionAdd BLAST36

Sequence similaritiesi

Contains 2 4Fe-4S ferredoxin-type domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiarCOG04548. Archaea.
COG1146. LUCA.
HOGENOMiHOG000044616.
OMAiEWVDTPG.

Family and domain databases

InterProiIPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR009157. Fd_Zn-bd.
[Graphical view]
PfamiPF13187. Fer4_9. 1 hit.
[Graphical view]
PIRSFiPIRSF000068. Zn_Fdx_Sulfol. 1 hit.
PROSITEiPS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P55907-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGIDPNYRTN RQVVGEHSGH KVYGPVEPPK VLGIHGTIVG VDFDLCIADG
60 70 80 90 100
SCINACPVNV FQWYDTPGHP ASEKKADPVN EQACIFCMAC VNVCPVAAID

VKPP
Length:104
Mass (Da):11,134
Last modified:January 23, 2007 - v3
Checksum:i04A9E52F5EDA4F4A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti26V → L AA sequence (PubMed:7826373).Curated1
Sequence conflicti54N → T in BAA22587 (PubMed:8753789).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D78179 Genomic DNA. Translation: BAA22587.1.
BA000023 Genomic DNA. Translation: BAB65120.1.
PIRiJC4907.
RefSeqiWP_010978102.1. NC_003106.2.

Genome annotation databases

EnsemblBacteriaiBAB65120; BAB65120; STK_01630.
GeneIDi1458046.
KEGGisto:STK_01630.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D78179 Genomic DNA. Translation: BAA22587.1.
BA000023 Genomic DNA. Translation: BAB65120.1.
PIRiJC4907.
RefSeqiWP_010978102.1. NC_003106.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1XERX-ray2.00A2-104[»]
ProteinModelPortaliP55907.
SMRiP55907.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi273063.ST0163.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB65120; BAB65120; STK_01630.
GeneIDi1458046.
KEGGisto:STK_01630.

Phylogenomic databases

eggNOGiarCOG04548. Archaea.
COG1146. LUCA.
HOGENOMiHOG000044616.
OMAiEWVDTPG.

Miscellaneous databases

EvolutionaryTraceiP55907.

Family and domain databases

InterProiIPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR009157. Fd_Zn-bd.
[Graphical view]
PfamiPF13187. Fer4_9. 1 hit.
[Graphical view]
PIRSFiPIRSF000068. Zn_Fdx_Sulfol. 1 hit.
PROSITEiPS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFER1_SULTO
AccessioniPrimary (citable) accession number: P55907
Secondary accession number(s): O32423
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 123 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.