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Protein

Zinc-containing ferredoxin-1

Gene

zfx1

Organism
Sulfolobus tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

Cofactori

Protein has several cofactor binding sites:

Redox potential

E0 is -280 mV for the 3Fe-4S and -530 mV for the 4Fe-4S clusters.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi17 – 171Zinc
Metal bindingi20 – 201Zinc
Metal bindingi35 – 351Zinc
Metal bindingi46 – 461Iron-sulfur 1 (3Fe-4S)
Metal bindingi52 – 521Iron-sulfur 1 (3Fe-4S)
Metal bindingi56 – 561Iron-sulfur 2 (4Fe-4S)
Metal bindingi77 – 771Zinc
Metal bindingi84 – 841Iron-sulfur 2 (4Fe-4S)
Metal bindingi87 – 871Iron-sulfur 2 (4Fe-4S)
Metal bindingi90 – 901Iron-sulfur 2 (4Fe-4S)
Metal bindingi94 – 941Iron-sulfur 1 (3Fe-4S)

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Electron transport, Transport

Keywords - Ligandi

3Fe-4S, 4Fe-4S, Iron, Iron-sulfur, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciSTOK273063:GJC7-181-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc-containing ferredoxin-1
Gene namesi
Name:zfx1
Synonyms:zfx
Ordered Locus Names:STK_01630
OrganismiSulfolobus tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)
Taxonomic identifieri273063 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
Proteomesi
  • UP000001015 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved1 Publication
Chaini2 – 104103Zinc-containing ferredoxin-1PRO_0000159180Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei30 – 301N6-methyllysine1 Publication

Keywords - PTMi

Methylation

Interactioni

Protein-protein interaction databases

STRINGi273063.ST0163.

Structurei

Secondary structure

1
104
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi7 – 104Combined sources
Beta strandi13 – 175Combined sources
Beta strandi20 – 245Combined sources
Turni28 – 303Combined sources
Beta strandi37 – 426Combined sources
Turni43 – 453Combined sources
Helixi51 – 555Combined sources
Beta strandi62 – 654Combined sources
Beta strandi73 – 775Combined sources
Helixi81 – 833Combined sources
Helixi89 – 935Combined sources
Beta strandi99 – 1013Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1XERX-ray2.00A2-104[»]
ProteinModelPortaliP55907.
SMRiP55907. Positions 2-104.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP55907.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini38 – 66294Fe-4S ferredoxin-type 1PROSITE-ProRule annotationAdd
BLAST
Domaini75 – 104304Fe-4S ferredoxin-type 2PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni2 – 3736N-terminal extensionAdd
BLAST

Sequence similaritiesi

Contains 2 4Fe-4S ferredoxin-type domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiarCOG04548. Archaea.
COG1146. LUCA.
HOGENOMiHOG000044616.
OMAiEWVDTPG.

Family and domain databases

InterProiIPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR009157. Fd_Zn-bd.
[Graphical view]
PfamiPF13187. Fer4_9. 1 hit.
[Graphical view]
PIRSFiPIRSF000068. Zn_Fdx_Sulfol. 1 hit.
PROSITEiPS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P55907-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGIDPNYRTN RQVVGEHSGH KVYGPVEPPK VLGIHGTIVG VDFDLCIADG
60 70 80 90 100
SCINACPVNV FQWYDTPGHP ASEKKADPVN EQACIFCMAC VNVCPVAAID

VKPP
Length:104
Mass (Da):11,134
Last modified:January 23, 2007 - v3
Checksum:i04A9E52F5EDA4F4A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti26 – 261V → L AA sequence (PubMed:7826373).Curated
Sequence conflicti54 – 541N → T in BAA22587 (PubMed:8753789).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D78179 Genomic DNA. Translation: BAA22587.1.
BA000023 Genomic DNA. Translation: BAB65120.1.
PIRiJC4907.
RefSeqiWP_010978102.1. NC_003106.2.

Genome annotation databases

EnsemblBacteriaiBAB65120; BAB65120; STK_01630.
GeneIDi1458046.
KEGGisto:STK_01630.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D78179 Genomic DNA. Translation: BAA22587.1.
BA000023 Genomic DNA. Translation: BAB65120.1.
PIRiJC4907.
RefSeqiWP_010978102.1. NC_003106.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1XERX-ray2.00A2-104[»]
ProteinModelPortaliP55907.
SMRiP55907. Positions 2-104.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi273063.ST0163.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB65120; BAB65120; STK_01630.
GeneIDi1458046.
KEGGisto:STK_01630.

Phylogenomic databases

eggNOGiarCOG04548. Archaea.
COG1146. LUCA.
HOGENOMiHOG000044616.
OMAiEWVDTPG.

Enzyme and pathway databases

BioCyciSTOK273063:GJC7-181-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP55907.

Family and domain databases

InterProiIPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR009157. Fd_Zn-bd.
[Graphical view]
PfamiPF13187. Fer4_9. 1 hit.
[Graphical view]
PIRSFiPIRSF000068. Zn_Fdx_Sulfol. 1 hit.
PROSITEiPS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning, sequencing, and heterologous expression of a novel zinc-containing ferredoxin gene from a thermoacidophilic Archaeon Sulfolobus sp. strain 7."
    Wakagi T., Fujii T., Oshima T.
    Biochem. Biophys. Res. Commun. 225:489-493(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: DSM 16993 / JCM 10545 / NBRC 100140 / 7.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 16993 / JCM 10545 / NBRC 100140 / 7.
  3. "Alternative form of the dicluster ferredoxin from the thermoacidophilic archaeon, Sulfolobus sp. strain 7."
    Iwasaki T., Fujii T., Wakagi T., Oshima T.
    Biochem. Biophys. Res. Commun. 206:563-569(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-31, METHYLATION AT LYS-30.
    Strain: DSM 16993 / JCM 10545 / NBRC 100140 / 7.
  4. "Functional and evolutionary implications of a [3Fe-4S] cluster of the dicluster-type ferredoxin from the thermoacidophilic archaeon, Sulfolobus sp. strain 7."
    Iwasaki T., Wakagi T., Isogai Y., Tanaka K., Iizuka T., Oshima T.
    J. Biol. Chem. 269:29444-29450(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
    Strain: DSM 16993 / JCM 10545 / NBRC 100140 / 7.
  5. "The crystal structure of zinc-containing ferredoxin from the thermoacidophilic archaeon Sulfolobus sp. strain 7."
    Fujii T., Hata Y., Oozeki M., Moriyama H., Wakagi T., Tanaka N., Oshima T.
    Biochemistry 36:1505-1513(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS).
    Strain: DSM 16993 / JCM 10545 / NBRC 100140 / 7.

Entry informationi

Entry nameiFER1_SULTO
AccessioniPrimary (citable) accession number: P55907
Secondary accession number(s): O32423
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 23, 2007
Last modified: December 9, 2015
This is version 121 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.