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P55902

- SIX1_BUTOC

UniProt

P55902 - SIX1_BUTOC

Protein

Alpha-insect toxin BotIT1

Gene
N/A
Organism
Buthus occitanus tunetanus (Common European scorpion)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Alpha toxins bind voltage-independently at site-3 of sodium channels (Nav) and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission. This contractive toxin is highly toxic to insects and barely toxic to mammals.

    GO - Molecular functioni

    1. ATP-activated nucleotide receptor activity Source: BHF-UCL
    2. ion channel inhibitor activity Source: InterPro

    GO - Biological processi

    1. adenosine receptor signaling pathway Source: GOC
    2. defense response Source: InterPro

    Keywords - Molecular functioni

    Ion channel impairing toxin, Neurotoxin, Toxin, Voltage-gated sodium channel impairing toxin

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alpha-insect toxin BotIT1
    OrganismiButhus occitanus tunetanus (Common European scorpion)
    Taxonomic identifieri6871 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesButhidaButhoideaButhidaeButhus

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Toxic dosei

    LD50 is 50 µg/kg in mouse by intracerebroventricular injection and 600 ng/g in Blattella germanica.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 6565Alpha-insect toxin BotIT1PRO_0000066713Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi12 ↔ 63By similarity
    Disulfide bondi16 ↔ 36By similarity
    Disulfide bondi22 ↔ 46By similarity
    Disulfide bondi26 ↔ 48By similarity

    Keywords - PTMi

    Disulfide bond

    Expressioni

    Tissue specificityi

    Expressed by the venom gland.

    Structurei

    3D structure databases

    ProteinModelPortaliP55902.
    SMRiP55902. Positions 1-64.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Family and domain databases

    Gene3Di3.30.30.10. 1 hit.
    InterProiIPR003614. Scorpion_toxin-like.
    IPR018218. Scorpion_toxinL.
    IPR002061. Scorpion_toxinL/defensin.
    [Graphical view]
    PfamiPF00537. Toxin_3. 1 hit.
    [Graphical view]
    PRINTSiPR00285. SCORPNTOXIN.
    SMARTiSM00505. Knot1. 1 hit.
    [Graphical view]
    SUPFAMiSSF57095. SSF57095. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P55902-1 [UniParc]FASTAAdd to Basket

    « Hide

    VRDAYIAQNY NCVYFCMKDD YCNDLCTKNG ASSGYCQWAG KYGNACWCYA   50
    LPDNVPIRIP GKCHS 65
    Length:65
    Mass (Da):7,343
    Last modified:November 1, 1997 - v1
    Checksum:i93A1371D877D7123
    GO

    Mass spectrometryi

    Molecular mass is 7334.93±0.23 Da from positions 1 - 65. Determined by ESI. 1 Publication

    Cross-referencesi

    3D structure databases

    ProteinModelPortali P55902.
    SMRi P55902. Positions 1-64.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.30.30.10. 1 hit.
    InterProi IPR003614. Scorpion_toxin-like.
    IPR018218. Scorpion_toxinL.
    IPR002061. Scorpion_toxinL/defensin.
    [Graphical view ]
    Pfami PF00537. Toxin_3. 1 hit.
    [Graphical view ]
    PRINTSi PR00285. SCORPNTOXIN.
    SMARTi SM00505. Knot1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57095. SSF57095. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Purification, structure and activity of three insect toxins from Buthus occitanus tunetanus venom."
      Borchani L., Stankiewicz M., Kopeyan C., Mansuelle P., Kharrat R., Cestele S., Karoui H., Rochat H., Pelhate M., el Ayeb M.
      Toxicon 35:365-382(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE, LETHAL DOSE, MASS SPECTROMETRY.
      Tissue: Venom.

    Entry informationi

    Entry nameiSIX1_BUTOC
    AccessioniPrimary (citable) accession number: P55902
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 70 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programAnimal Toxin Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3