P55899 (FCGRN_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
IgG receptor FcRn large subunit p51
Short name=FcRn

Alternative name(s):
IgG Fc fragment receptor transporter alpha chain
Neonatal Fc receptor

Gene names

Name:	FCGRT
Synonyms:	FCRN

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	365 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Binds to the Fc region of monomeric immunoglobulins gamma. Mediates the uptake of IgG from milk. Possible role in transfer of immunoglobulin G from mother to fetus.
Subunit structure	FcRn complex consist of two subunits: p51, and p14 which is equivalent to beta-2-microglobulin. It forms an MHC class I-like heterodimer By similarity.
Subcellular location	Cell membrane; Single-pass type I membrane protein By similarity.
Sequence similarities	Belongs to the immunoglobulin superfamily. Contains 1 Ig-like C1-type (immunoglobulin-like) domain.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Immunoglobulin domain Signal Transmembrane Transmembrane helix
Ligand	IgG-binding protein
Molecular function	Receptor
PTM	Disulfide bond Glycoprotein
Technical term	3D-structure Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor Non-traceable author statement Ref.1. Source: UniProtKB antigen processing and presentation Inferred from electronic annotation. Source: InterPro immune response Inferred from electronic annotation. Source: InterPro
Cellular_component	MHC class I protein complex Inferred from electronic annotation. Source: InterPro integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	IgG binding Inferred from direct assay Ref.1. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 23

23

Ref.7

Chain

24 – 365

342

IgG receptor FcRn large subunit p51

PRO_0000015157

Regions

Topological domain

24 – 297

274

Extracellular Potential

Transmembrane

298 – 321

24

Helical; Potential

Topological domain

322 – 365

44

Cytoplasmic Potential

Domain

202 – 289

88

Ig-like C1-type

Region

24 – 110

87

Alpha-1

Region

111 – 200

90

Alpha-2

Region

201 – 290

90

Alpha-3

Region

291 – 297

7

Connecting peptide

Amino acid modifications

Glycosylation

125

1

N-linked (GlcNAc...) Potential

Disulfide bond

119 ↔ 182

Disulfide bond

221 ↔ 275

Experimental info

Sequence conflict

101 – 103

3

Missing in AAG31421. Ref.3

Sequence conflict

201

1

E → G in AAF72596. Ref.2

Secondary structure

1

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365

Helix Strand Turn

Details...

Beta strand

30 – 39

10

Beta strand

46 – 53

8

Beta strand

56 – 62

7

Turn

63 – 65

3

Helix

72 – 76

5

Helix

83 – 101

19

Helix

102 – 104

3

Beta strand

107 – 109

3

Beta strand

112 – 121

10

Beta strand

123 – 125

3

Beta strand

127 – 135

9

Beta strand

138 – 144

7

Turn

145 – 148

4

Beta strand

149 – 151

3

Helix

155 – 166

12

Helix

170 – 179

10

Helix

181 – 192

12

Helix

194 – 198

5

Beta strand

204 – 211

8

Beta strand

213 – 215

3

Beta strand

216 – 229

14

Beta strand

232 – 237

6

Beta strand

240 – 243

4

Beta strand

248 – 251

4

Beta strand

253 – 255

3

Beta strand

257 – 266

10

Helix

270 – 272

3

Beta strand

273 – 278

6

Beta strand

282 – 284

3

Beta strand

286 – 288

3

Sequences

	Sequence		Length	Mass (Da)
	P55899 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: C886C6A1F66A0D89	FASTA	365	39,743
	10 20 30 40 50 60 MGVPRPQPWA LGLLLFLLPG SLGAESHLSL LYHLTAVSSP APGTPAFWVS GWLGPQQYLS 70 80 90 100 110 120 YNSLRGEAEP CGAWVWENQV SWYWEKETTD LRIKEKLFLE AFKALGGKGP YTLQGLLGCE 130 140 150 160 170 180 LGPDNTSVPT AKFALNGEEF MNFDLKQGTW GGDWPEALAI SQRWQQQDKA ANKELTFLLF 190 200 210 220 230 240 SCPHRLREHL ERGRGNLEWK EPPSMRLKAR PSSPGFSVLT CSAFSFYPPE LQLRFLRNGL 250 260 270 280 290 300 AAGTGQGDFG PNSDGSFHAS SSLTVKSGDE HHYCCIVQHA GLAQPLRVEL ESPAKSSVLV 310 320 330 340 350 360 VGIVIGVLLL TAAAVGGALL WRRMRSGLPA PWISLRGDDT GVLLPTPGEA QDADLKDVNV IPATA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A major histocompatibility complex class I-like Fc receptor cloned from human placenta: possible role in transfer of immunoglobulin G from mother to fetus." Story C.M., Mikulska J., Simister N.E. J. Exp. Med. 180:2377-2381(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Placenta.
[2]	"Partial sequence of the human fcgrt gene and its 5' upstream region." Tiwari B., Junghans R.P. Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Cloning and analysis of the gene encoding the human neonatal Fc receptor." Mikulska J.E., Pablo L., Canel J., Simister N.E. Eur. J. Immunogenet. 27:231-240(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Rectum tumor.
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[7]	"Signal peptide prediction based on analysis of experimentally verified cleavage sites." Zhang Z., Henzel W.J. Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 24-38.
[8]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[9]	"Crystal structure and immunoglobulin G binding properties of the human major histocompatibility complex-related Fc receptor." West A.P. Jr., Bjorkman P.J. Biochemistry 39:9698-9708(2000) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 24-290.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

U12255 mRNA. Translation: AAA58958.1.
AF220542 Genomic DNA. Translation: AAF72596.1.
AF200220, AF200219 Genomic DNA. Translation: AAG31421.1.
BX647163 mRNA. Translation: CAI46032.1.
CH471177 Genomic DNA. Translation: EAW52498.1.
BC008734 mRNA. Translation: AAH08734.1.

IPI

IPI00026646.

PIR

I38720.

RefSeq

NP_001129491.1. NM_001136019.2.
NP_004098.1. NM_004107.4.

UniGene

Hs.111903.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1EXU	X-ray	2.70	A	24-290	[»]
3M17	X-ray	2.60	A/C/E/G	24-290	[»]
3M1B	X-ray	3.10	A/C/E/G	24-290	[»]

ProteinModelPortal

P55899.

ModBase

Search...

Protein-protein interaction databases

DIP

DIP-6165N.

IntAct

P55899. 3 interactions.

MINT

MINT-5002634.

STRING

9606.ENSP00000221466.

PTM databases

PhosphoSite

P55899.

Polymorphism databases

DMDM

2497331.

Proteomic databases

PaxDb

P55899.

PRIDE

P55899.

Protocols and materials databases

DNASU

2217.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000221466; ENSP00000221466; ENSG00000104870.
ENST00000426395; ENSP00000410798; ENSG00000104870.

GeneID

2217.

KEGG

hsa:2217.

UCSC

uc002poe.2. human.

Organism-specific databases

CTD

2217.

GeneCards

GC19P050015.

HGNC

HGNC:3621. FCGRT.

HPA

HPA012122.
HPA015130.

MIM

601437. gene.

neXtProt

NX_P55899.

PharmGKB

PA28067.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG38779.

HOGENOM

HOG000112560.

HOVERGEN

HBG100415.

InParanoid

P55899.

OMA

LPAPWIS.

OrthoDB

EOG4V6ZGW.

PhylomeDB

P55899.

Gene expression databases

ArrayExpress

P55899.

Bgee

P55899.

CleanEx

HS_FCGRT.

Genevestigator

P55899.

GermOnline

ENSG00000104870. Homo sapiens.

Family and domain databases

Gene3D

2.60.40.10. 1 hit.
3.30.500.10. 1 hit.

InterPro

IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR001039. MHC_I_a_a1/a2.
[Graphical view]

Pfam

PF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
[Graphical view]

SMART

SM00407. IGc1. 1 hit.
[Graphical view]

SUPFAM

SSF54452. MHC_I/II-like_Ag-recog. 1 hit.

PROSITE

PS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

BindingDB

P55899.

ChEMBL

CHEMBL5966.

ChiTaRS

FCGRT. human.

EvolutionaryTrace

P55899.

GenomeRNAi

2217.

NextBio

8991.

SOURCE

Search...

Entry information

Entry name

FCGRN_HUMAN

Accession

Primary (citable) accession number: P55899
Secondary accession number(s): Q5HYM5, Q9HBV7, Q9NZ19

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	May 1, 2013
This is version 114 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.