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Protein

IgG receptor FcRn large subunit p51

Gene

FCGRT

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds to the Fc region of monomeric immunoglobulins gamma (PubMed:7964511, PubMed:10933786). Mediates the selective uptake of IgG from milk and helps newborn animals to acquire passive immunity. IgG in the milk is bound at the apical surface of the intestinal epithelium. The resultant FcRn-IgG complexes are transcytosed across the intestinal epithelium and IgG is released from FcRn into blood or tissue fluids (By similarity). Possible role in transfer of immunoglobulin G from mother to fetus (PubMed:7964511).By similarity2 Publications

GO - Molecular functioni

  • beta-2-microglobulin binding Source: GO_Central
  • IgG binding Source: UniProtKB
  • IgG receptor activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionIgG-binding protein, Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
IgG receptor FcRn large subunit p51
Short name:
FcRn
Alternative name(s):
IgG Fc fragment receptor transporter alpha chain
Neonatal Fc receptor
Gene namesi
Name:FCGRT
Synonyms:FCRN
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000104870.12
HGNCiHGNC:3621 FCGRT
MIMi601437 gene
neXtProtiNX_P55899

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini24 – 297ExtracellularSequence analysisAdd BLAST274
Transmembranei298 – 321HelicalSequence analysisAdd BLAST24
Topological domaini322 – 365CytoplasmicSequence analysisAdd BLAST44

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi2217
OpenTargetsiENSG00000104870
PharmGKBiPA28067

Chemistry databases

ChEMBLiCHEMBL5966
GuidetoPHARMACOLOGYi2985

Polymorphism and mutation databases

BioMutaiFCGRT
DMDMi2497331

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 231 PublicationAdd BLAST23
ChainiPRO_000001515724 – 365IgG receptor FcRn large subunit p511 PublicationAdd BLAST342

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi119 ↔ 182Combined sources1 Publication
Glycosylationi125N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi221 ↔ 275Combined sources1 Publication
Modified residuei334PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiP55899
MaxQBiP55899
PaxDbiP55899
PeptideAtlasiP55899
PRIDEiP55899

PTM databases

iPTMnetiP55899
PhosphoSitePlusiP55899

Expressioni

Tissue specificityi

Expressed in full-term placenta, heart, lung, liver, muscle, kidney, pancreas, and both fetal and adult small intestine.1 Publication

Gene expression databases

BgeeiENSG00000104870
CleanExiHS_FCGRT
ExpressionAtlasiP55899 baseline and differential
GenevisibleiP55899 HS

Organism-specific databases

HPAiHPA012122
HPA015130

Interactioni

Subunit structurei

FcRn complex consist of two subunits: p51, and p14 which is equivalent to beta-2-microglobulin. It forms an MHC class I-like heterodimer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi108511, 64 interactors
DIPiDIP-6165N
IntActiP55899, 5 interactors
MINTiP55899
STRINGi9606.ENSP00000221466

Chemistry databases

BindingDBiP55899

Structurei

Secondary structure

1365
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi29 – 39Combined sources11
Beta strandi46 – 53Combined sources8
Beta strandi56 – 62Combined sources7
Turni63 – 65Combined sources3
Helixi72 – 76Combined sources5
Helixi83 – 105Combined sources23
Beta strandi107 – 109Combined sources3
Beta strandi112 – 121Combined sources10
Beta strandi123 – 125Combined sources3
Beta strandi127 – 135Combined sources9
Beta strandi138 – 144Combined sources7
Turni145 – 148Combined sources4
Beta strandi149 – 151Combined sources3
Helixi155 – 166Combined sources12
Helixi170 – 179Combined sources10
Helixi181 – 192Combined sources12
Helixi194 – 197Combined sources4
Beta strandi204 – 213Combined sources10
Beta strandi216 – 229Combined sources14
Beta strandi231 – 237Combined sources7
Beta strandi240 – 243Combined sources4
Beta strandi246 – 251Combined sources6
Beta strandi253 – 255Combined sources3
Beta strandi257 – 266Combined sources10
Turni267 – 269Combined sources3
Helixi270 – 272Combined sources3
Beta strandi273 – 279Combined sources7
Beta strandi282 – 284Combined sources3
Beta strandi286 – 288Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1EXUX-ray2.70A24-290[»]
3M17X-ray2.60A/C/E/G24-290[»]
3M1BX-ray3.10A/C/E/G24-290[»]
4K71X-ray2.40B/E24-297[»]
4N0FX-ray3.02A/E/H/K27-297[»]
4N0UX-ray3.80A27-290[»]
5BJTX-ray3.20A/C/E/G24-290[»]
5BXFX-ray2.85A/C1-290[»]
5WHKX-ray2.50A1-297[»]
ProteinModelPortaliP55899
SMRiP55899
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP55899

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini202 – 289Ig-like C1-typePROSITE-ProRule annotationAdd BLAST88

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni24 – 110Alpha-1Combined sources1 PublicationAdd BLAST87
Regioni111 – 200Alpha-2Combined sources1 PublicationAdd BLAST90
Regioni201 – 290Alpha-3Combined sources1 PublicationAdd BLAST90
Regioni291 – 297Connecting peptide7

Sequence similaritiesi

Belongs to the immunoglobulin superfamily.Curated

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IPRY Eukaryota
ENOG4111C4R LUCA
GeneTreeiENSGT00740000114936
HOGENOMiHOG000112560
HOVERGENiHBG100415
InParanoidiP55899
OMAiPWISLRG
OrthoDBiEOG091G0KJB
PhylomeDBiP55899
TreeFamiTF336617

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.30.500.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
IPR011161 MHC_I-like_Ag-recog
IPR037055 MHC_I-like_Ag-recog_sf
IPR011162 MHC_I/II-like_Ag-recog
PfamiView protein in Pfam
PF07654 C1-set, 1 hit
PF00129 MHC_I, 1 hit
SMARTiView protein in SMART
SM00407 IGc1, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF54452 SSF54452, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P55899-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGVPRPQPWA LGLLLFLLPG SLGAESHLSL LYHLTAVSSP APGTPAFWVS
60 70 80 90 100
GWLGPQQYLS YNSLRGEAEP CGAWVWENQV SWYWEKETTD LRIKEKLFLE
110 120 130 140 150
AFKALGGKGP YTLQGLLGCE LGPDNTSVPT AKFALNGEEF MNFDLKQGTW
160 170 180 190 200
GGDWPEALAI SQRWQQQDKA ANKELTFLLF SCPHRLREHL ERGRGNLEWK
210 220 230 240 250
EPPSMRLKAR PSSPGFSVLT CSAFSFYPPE LQLRFLRNGL AAGTGQGDFG
260 270 280 290 300
PNSDGSFHAS SSLTVKSGDE HHYCCIVQHA GLAQPLRVEL ESPAKSSVLV
310 320 330 340 350
VGIVIGVLLL TAAAVGGALL WRRMRSGLPA PWISLRGDDT GVLLPTPGEA
360
QDADLKDVNV IPATA
Length:365
Mass (Da):39,743
Last modified:November 1, 1997 - v1
Checksum:iC886C6A1F66A0D89
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti101 – 103Missing in AAG31421 (PubMed:10998088).Curated3
Sequence conflicti201E → G in AAF72596 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U12255 mRNA Translation: AAA58958.1
AF220542 Genomic DNA Translation: AAF72596.1
AF200220, AF200219 Genomic DNA Translation: AAG31421.1
BX647163 mRNA Translation: CAI46032.1
CH471177 Genomic DNA Translation: EAW52498.1
BC008734 mRNA Translation: AAH08734.1
CCDSiCCDS12770.1
PIRiI38720
RefSeqiNP_001129491.1, NM_001136019.2
NP_004098.1, NM_004107.4
UniGeneiHs.111903

Genome annotation databases

EnsembliENST00000221466; ENSP00000221466; ENSG00000104870
ENST00000426395; ENSP00000410798; ENSG00000104870
GeneIDi2217
KEGGihsa:2217
UCSCiuc002poe.3 human

Similar proteinsi

Entry informationi

Entry nameiFCGRN_HUMAN
AccessioniPrimary (citable) accession number: P55899
Secondary accession number(s): Q5HYM5, Q9HBV7, Q9NZ19
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: April 25, 2018
This is version 157 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health