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P55899

- FCGRN_HUMAN

UniProt

P55899 - FCGRN_HUMAN

Protein

IgG receptor FcRn large subunit p51

Gene

FCGRT

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 125 (01 Oct 2014)
      Sequence version 1 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Binds to the Fc region of monomeric immunoglobulins gamma. Mediates the uptake of IgG from milk. Possible role in transfer of immunoglobulin G from mother to fetus.

    GO - Molecular functioni

    1. IgG binding Source: UniProtKB

    GO - Biological processi

    1. antigen processing and presentation Source: InterPro
    2. IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor Source: UniProtKB
    3. immune response Source: InterPro

    Keywords - Molecular functioni

    Receptor

    Keywords - Ligandi

    IgG-binding protein

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    IgG receptor FcRn large subunit p51
    Short name:
    FcRn
    Alternative name(s):
    IgG Fc fragment receptor transporter alpha chain
    Neonatal Fc receptor
    Gene namesi
    Name:FCGRT
    Synonyms:FCRN
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:3621. FCGRT.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA28067.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 23231 PublicationAdd
    BLAST
    Chaini24 – 365342IgG receptor FcRn large subunit p51PRO_0000015157Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi119 ↔ 182
    Glycosylationi125 – 1251N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi221 ↔ 275

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiP55899.
    PaxDbiP55899.
    PRIDEiP55899.

    PTM databases

    PhosphoSiteiP55899.

    Expressioni

    Gene expression databases

    ArrayExpressiP55899.
    BgeeiP55899.
    CleanExiHS_FCGRT.
    GenevestigatoriP55899.

    Organism-specific databases

    HPAiHPA012122.
    HPA015130.

    Interactioni

    Subunit structurei

    FcRn complex consist of two subunits: p51, and p14 which is equivalent to beta-2-microglobulin. It forms an MHC class I-like heterodimer By similarity.By similarity

    Protein-protein interaction databases

    BioGridi108511. 2 interactions.
    DIPiDIP-6165N.
    IntActiP55899. 3 interactions.
    MINTiMINT-5002634.
    STRINGi9606.ENSP00000221466.

    Structurei

    Secondary structure

    1
    365
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi29 – 3911
    Beta strandi46 – 538
    Beta strandi56 – 627
    Turni63 – 653
    Helixi72 – 765
    Helixi83 – 10523
    Beta strandi107 – 1093
    Beta strandi112 – 12110
    Beta strandi123 – 1253
    Beta strandi127 – 1359
    Beta strandi138 – 1447
    Turni145 – 1484
    Beta strandi149 – 1513
    Helixi155 – 16612
    Helixi170 – 17910
    Helixi181 – 19212
    Helixi194 – 1974
    Beta strandi204 – 21310
    Beta strandi216 – 22914
    Beta strandi231 – 2377
    Beta strandi240 – 2434
    Beta strandi246 – 2516
    Beta strandi253 – 2553
    Beta strandi257 – 26610
    Helixi270 – 2723
    Beta strandi273 – 2797
    Beta strandi282 – 2843
    Beta strandi286 – 2883

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1EXUX-ray2.70A24-290[»]
    3M17X-ray2.60A/C/E/G24-290[»]
    3M1BX-ray3.10A/C/E/G24-290[»]
    4K71X-ray2.40B/E24-297[»]
    4N0FX-ray3.02A/E/H/K27-297[»]
    4N0UX-ray3.80A27-290[»]
    ProteinModelPortaliP55899.
    SMRiP55899. Positions 28-291.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP55899.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini24 – 297274ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini322 – 36544CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei298 – 32124HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini202 – 28988Ig-like C1-typeAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni24 – 11087Alpha-1Add
    BLAST
    Regioni111 – 20090Alpha-2Add
    BLAST
    Regioni201 – 29090Alpha-3Add
    BLAST
    Regioni291 – 2977Connecting peptide

    Sequence similaritiesi

    Belongs to the immunoglobulin superfamily.Curated

    Keywords - Domaini

    Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG38779.
    HOGENOMiHOG000112560.
    HOVERGENiHBG100415.
    InParanoidiP55899.
    OMAiAPWISLR.
    OrthoDBiEOG7TBC29.
    PhylomeDBiP55899.
    TreeFamiTF336617.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    3.30.500.10. 1 hit.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003006. Ig/MHC_CS.
    IPR003597. Ig_C1-set.
    IPR011161. MHC_I-like_Ag-recog.
    IPR011162. MHC_I/II-like_Ag-recog.
    IPR001039. MHC_I_a_a1/a2.
    [Graphical view]
    PfamiPF07654. C1-set. 1 hit.
    PF00129. MHC_I. 1 hit.
    [Graphical view]
    SMARTiSM00407. IGc1. 1 hit.
    [Graphical view]
    SUPFAMiSSF54452. SSF54452. 1 hit.
    PROSITEiPS50835. IG_LIKE. 1 hit.
    PS00290. IG_MHC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P55899-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGVPRPQPWA LGLLLFLLPG SLGAESHLSL LYHLTAVSSP APGTPAFWVS    50
    GWLGPQQYLS YNSLRGEAEP CGAWVWENQV SWYWEKETTD LRIKEKLFLE 100
    AFKALGGKGP YTLQGLLGCE LGPDNTSVPT AKFALNGEEF MNFDLKQGTW 150
    GGDWPEALAI SQRWQQQDKA ANKELTFLLF SCPHRLREHL ERGRGNLEWK 200
    EPPSMRLKAR PSSPGFSVLT CSAFSFYPPE LQLRFLRNGL AAGTGQGDFG 250
    PNSDGSFHAS SSLTVKSGDE HHYCCIVQHA GLAQPLRVEL ESPAKSSVLV 300
    VGIVIGVLLL TAAAVGGALL WRRMRSGLPA PWISLRGDDT GVLLPTPGEA 350
    QDADLKDVNV IPATA 365
    Length:365
    Mass (Da):39,743
    Last modified:November 1, 1997 - v1
    Checksum:iC886C6A1F66A0D89
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti101 – 1033Missing in AAG31421. (PubMed:10998088)Curated
    Sequence conflicti201 – 2011E → G in AAF72596. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U12255 mRNA. Translation: AAA58958.1.
    AF220542 Genomic DNA. Translation: AAF72596.1.
    AF200220, AF200219 Genomic DNA. Translation: AAG31421.1.
    BX647163 mRNA. Translation: CAI46032.1.
    CH471177 Genomic DNA. Translation: EAW52498.1.
    BC008734 mRNA. Translation: AAH08734.1.
    CCDSiCCDS12770.1.
    PIRiI38720.
    RefSeqiNP_001129491.1. NM_001136019.2.
    NP_004098.1. NM_004107.4.
    UniGeneiHs.111903.

    Genome annotation databases

    EnsembliENST00000221466; ENSP00000221466; ENSG00000104870.
    ENST00000426395; ENSP00000410798; ENSG00000104870.
    GeneIDi2217.
    KEGGihsa:2217.
    UCSCiuc002poe.2. human.

    Polymorphism databases

    DMDMi2497331.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U12255 mRNA. Translation: AAA58958.1 .
    AF220542 Genomic DNA. Translation: AAF72596.1 .
    AF200220 , AF200219 Genomic DNA. Translation: AAG31421.1 .
    BX647163 mRNA. Translation: CAI46032.1 .
    CH471177 Genomic DNA. Translation: EAW52498.1 .
    BC008734 mRNA. Translation: AAH08734.1 .
    CCDSi CCDS12770.1.
    PIRi I38720.
    RefSeqi NP_001129491.1. NM_001136019.2.
    NP_004098.1. NM_004107.4.
    UniGenei Hs.111903.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1EXU X-ray 2.70 A 24-290 [» ]
    3M17 X-ray 2.60 A/C/E/G 24-290 [» ]
    3M1B X-ray 3.10 A/C/E/G 24-290 [» ]
    4K71 X-ray 2.40 B/E 24-297 [» ]
    4N0F X-ray 3.02 A/E/H/K 27-297 [» ]
    4N0U X-ray 3.80 A 27-290 [» ]
    ProteinModelPortali P55899.
    SMRi P55899. Positions 28-291.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 108511. 2 interactions.
    DIPi DIP-6165N.
    IntActi P55899. 3 interactions.
    MINTi MINT-5002634.
    STRINGi 9606.ENSP00000221466.

    Chemistry

    BindingDBi P55899.
    ChEMBLi CHEMBL5966.

    PTM databases

    PhosphoSitei P55899.

    Polymorphism databases

    DMDMi 2497331.

    Proteomic databases

    MaxQBi P55899.
    PaxDbi P55899.
    PRIDEi P55899.

    Protocols and materials databases

    DNASUi 2217.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000221466 ; ENSP00000221466 ; ENSG00000104870 .
    ENST00000426395 ; ENSP00000410798 ; ENSG00000104870 .
    GeneIDi 2217.
    KEGGi hsa:2217.
    UCSCi uc002poe.2. human.

    Organism-specific databases

    CTDi 2217.
    GeneCardsi GC19P050028.
    HGNCi HGNC:3621. FCGRT.
    HPAi HPA012122.
    HPA015130.
    MIMi 601437. gene.
    neXtProti NX_P55899.
    PharmGKBi PA28067.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG38779.
    HOGENOMi HOG000112560.
    HOVERGENi HBG100415.
    InParanoidi P55899.
    OMAi APWISLR.
    OrthoDBi EOG7TBC29.
    PhylomeDBi P55899.
    TreeFami TF336617.

    Miscellaneous databases

    ChiTaRSi FCGRT. human.
    EvolutionaryTracei P55899.
    GeneWikii FCGRT.
    GenomeRNAii 2217.
    NextBioi 8991.
    PROi P55899.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P55899.
    Bgeei P55899.
    CleanExi HS_FCGRT.
    Genevestigatori P55899.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    3.30.500.10. 1 hit.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003006. Ig/MHC_CS.
    IPR003597. Ig_C1-set.
    IPR011161. MHC_I-like_Ag-recog.
    IPR011162. MHC_I/II-like_Ag-recog.
    IPR001039. MHC_I_a_a1/a2.
    [Graphical view ]
    Pfami PF07654. C1-set. 1 hit.
    PF00129. MHC_I. 1 hit.
    [Graphical view ]
    SMARTi SM00407. IGc1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54452. SSF54452. 1 hit.
    PROSITEi PS50835. IG_LIKE. 1 hit.
    PS00290. IG_MHC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A major histocompatibility complex class I-like Fc receptor cloned from human placenta: possible role in transfer of immunoglobulin G from mother to fetus."
      Story C.M., Mikulska J., Simister N.E.
      J. Exp. Med. 180:2377-2381(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Placenta.
    2. "Partial sequence of the human fcgrt gene and its 5' upstream region."
      Tiwari B., Junghans R.P.
      Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Cloning and analysis of the gene encoding the human neonatal Fc receptor."
      Mikulska J.E., Pablo L., Canel J., Simister N.E.
      Eur. J. Immunogenet. 27:231-240(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Rectum tumor.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    7. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
      Zhang Z., Henzel W.J.
      Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 24-38.
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. "Crystal structure and immunoglobulin G binding properties of the human major histocompatibility complex-related Fc receptor."
      West A.P. Jr., Bjorkman P.J.
      Biochemistry 39:9698-9708(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 24-290.

    Entry informationi

    Entry nameiFCGRN_HUMAN
    AccessioniPrimary (citable) accession number: P55899
    Secondary accession number(s): Q5HYM5, Q9HBV7, Q9NZ19
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 125 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3