SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P55899

- FCGRN_HUMAN

UniProt

P55899 - FCGRN_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

IgG receptor FcRn large subunit p51

Gene
FCGRT, FCRN
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Binds to the Fc region of monomeric immunoglobulins gamma. Mediates the uptake of IgG from milk. Possible role in transfer of immunoglobulin G from mother to fetus.

GO - Molecular functioni

  1. antigen binding Source: RefGenome
  2. beta-2-microglobulin binding Source: RefGenome
  3. IgG binding Source: UniProtKB
  4. IgG receptor activity Source: RefGenome

GO - Biological processi

  1. antigen processing and presentation Source: RefGenome
  2. Fc-gamma receptor signaling pathway Source: GOC
  3. IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor Source: UniProtKB
  4. immune response Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Ligandi

IgG-binding protein

Names & Taxonomyi

Protein namesi
Recommended name:
IgG receptor FcRn large subunit p51
Short name:
FcRn
Alternative name(s):
IgG Fc fragment receptor transporter alpha chain
Neonatal Fc receptor
Gene namesi
Name:FCGRT
Synonyms:FCRN
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:3621. FCGRT.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini24 – 297274Extracellular Reviewed predictionAdd
BLAST
Transmembranei298 – 32124Helical; Reviewed predictionAdd
BLAST
Topological domaini322 – 36544Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28067.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 23231 PublicationAdd
BLAST
Chaini24 – 365342IgG receptor FcRn large subunit p51PRO_0000015157Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi119 ↔ 182
Glycosylationi125 – 1251N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi221 ↔ 275

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP55899.
PaxDbiP55899.
PRIDEiP55899.

PTM databases

PhosphoSiteiP55899.

Expressioni

Gene expression databases

ArrayExpressiP55899.
BgeeiP55899.
CleanExiHS_FCGRT.
GenevestigatoriP55899.

Organism-specific databases

HPAiHPA012122.
HPA015130.

Interactioni

Subunit structurei

FcRn complex consist of two subunits: p51, and p14 which is equivalent to beta-2-microglobulin. It forms an MHC class I-like heterodimer By similarity.

Protein-protein interaction databases

BioGridi108511. 2 interactions.
DIPiDIP-6165N.
IntActiP55899. 3 interactions.
MINTiMINT-5002634.
STRINGi9606.ENSP00000221466.

Structurei

Secondary structure

1
365
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi29 – 3911
Beta strandi46 – 538
Beta strandi56 – 627
Turni63 – 653
Helixi72 – 765
Helixi83 – 10523
Beta strandi107 – 1093
Beta strandi112 – 12110
Beta strandi123 – 1253
Beta strandi127 – 1359
Beta strandi138 – 1447
Turni145 – 1484
Beta strandi149 – 1513
Helixi155 – 16612
Helixi170 – 17910
Helixi181 – 19212
Helixi194 – 1974
Beta strandi204 – 21310
Beta strandi216 – 22914
Beta strandi231 – 2377
Beta strandi240 – 2434
Beta strandi246 – 2516
Beta strandi253 – 2553
Beta strandi257 – 26610
Helixi270 – 2723
Beta strandi273 – 2797
Beta strandi282 – 2843
Beta strandi286 – 2883

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1EXUX-ray2.70A24-290[»]
3M17X-ray2.60A/C/E/G24-290[»]
3M1BX-ray3.10A/C/E/G24-290[»]
4K71X-ray2.40B/E24-297[»]
4N0FX-ray3.02A/E/H/K27-297[»]
4N0UX-ray3.80A27-290[»]
ProteinModelPortaliP55899.
SMRiP55899. Positions 28-291.

Miscellaneous databases

EvolutionaryTraceiP55899.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini202 – 28988Ig-like C1-typeAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni24 – 11087Alpha-1Add
BLAST
Regioni111 – 20090Alpha-2Add
BLAST
Regioni201 – 29090Alpha-3Add
BLAST
Regioni291 – 2977Connecting peptide

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG38779.
HOGENOMiHOG000112560.
HOVERGENiHBG100415.
InParanoidiP55899.
OMAiAPWISLR.
OrthoDBiEOG7TBC29.
PhylomeDBiP55899.
TreeFamiTF336617.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR001039. MHC_I_a_a1/a2.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
[Graphical view]
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P55899-1 [UniParc]FASTAAdd to Basket

« Hide

MGVPRPQPWA LGLLLFLLPG SLGAESHLSL LYHLTAVSSP APGTPAFWVS    50
GWLGPQQYLS YNSLRGEAEP CGAWVWENQV SWYWEKETTD LRIKEKLFLE 100
AFKALGGKGP YTLQGLLGCE LGPDNTSVPT AKFALNGEEF MNFDLKQGTW 150
GGDWPEALAI SQRWQQQDKA ANKELTFLLF SCPHRLREHL ERGRGNLEWK 200
EPPSMRLKAR PSSPGFSVLT CSAFSFYPPE LQLRFLRNGL AAGTGQGDFG 250
PNSDGSFHAS SSLTVKSGDE HHYCCIVQHA GLAQPLRVEL ESPAKSSVLV 300
VGIVIGVLLL TAAAVGGALL WRRMRSGLPA PWISLRGDDT GVLLPTPGEA 350
QDADLKDVNV IPATA 365
Length:365
Mass (Da):39,743
Last modified:November 1, 1997 - v1
Checksum:iC886C6A1F66A0D89
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti101 – 1033Missing in AAG31421. 1 Publication
Sequence conflicti201 – 2011E → G in AAF72596. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U12255 mRNA. Translation: AAA58958.1.
AF220542 Genomic DNA. Translation: AAF72596.1.
AF200220, AF200219 Genomic DNA. Translation: AAG31421.1.
BX647163 mRNA. Translation: CAI46032.1.
CH471177 Genomic DNA. Translation: EAW52498.1.
BC008734 mRNA. Translation: AAH08734.1.
CCDSiCCDS12770.1.
PIRiI38720.
RefSeqiNP_001129491.1. NM_001136019.2.
NP_004098.1. NM_004107.4.
UniGeneiHs.111903.

Genome annotation databases

EnsembliENST00000221466; ENSP00000221466; ENSG00000104870.
ENST00000426395; ENSP00000410798; ENSG00000104870.
GeneIDi2217.
KEGGihsa:2217.
UCSCiuc002poe.2. human.

Polymorphism databases

DMDMi2497331.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U12255 mRNA. Translation: AAA58958.1 .
AF220542 Genomic DNA. Translation: AAF72596.1 .
AF200220 , AF200219 Genomic DNA. Translation: AAG31421.1 .
BX647163 mRNA. Translation: CAI46032.1 .
CH471177 Genomic DNA. Translation: EAW52498.1 .
BC008734 mRNA. Translation: AAH08734.1 .
CCDSi CCDS12770.1.
PIRi I38720.
RefSeqi NP_001129491.1. NM_001136019.2.
NP_004098.1. NM_004107.4.
UniGenei Hs.111903.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1EXU X-ray 2.70 A 24-290 [» ]
3M17 X-ray 2.60 A/C/E/G 24-290 [» ]
3M1B X-ray 3.10 A/C/E/G 24-290 [» ]
4K71 X-ray 2.40 B/E 24-297 [» ]
4N0F X-ray 3.02 A/E/H/K 27-297 [» ]
4N0U X-ray 3.80 A 27-290 [» ]
ProteinModelPortali P55899.
SMRi P55899. Positions 28-291.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 108511. 2 interactions.
DIPi DIP-6165N.
IntActi P55899. 3 interactions.
MINTi MINT-5002634.
STRINGi 9606.ENSP00000221466.

Chemistry

BindingDBi P55899.
ChEMBLi CHEMBL5966.

PTM databases

PhosphoSitei P55899.

Polymorphism databases

DMDMi 2497331.

Proteomic databases

MaxQBi P55899.
PaxDbi P55899.
PRIDEi P55899.

Protocols and materials databases

DNASUi 2217.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000221466 ; ENSP00000221466 ; ENSG00000104870 .
ENST00000426395 ; ENSP00000410798 ; ENSG00000104870 .
GeneIDi 2217.
KEGGi hsa:2217.
UCSCi uc002poe.2. human.

Organism-specific databases

CTDi 2217.
GeneCardsi GC19P050028.
HGNCi HGNC:3621. FCGRT.
HPAi HPA012122.
HPA015130.
MIMi 601437. gene.
neXtProti NX_P55899.
PharmGKBi PA28067.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG38779.
HOGENOMi HOG000112560.
HOVERGENi HBG100415.
InParanoidi P55899.
OMAi APWISLR.
OrthoDBi EOG7TBC29.
PhylomeDBi P55899.
TreeFami TF336617.

Miscellaneous databases

ChiTaRSi FCGRT. human.
EvolutionaryTracei P55899.
GeneWikii FCGRT.
GenomeRNAii 2217.
NextBioi 8991.
PROi P55899.
SOURCEi Search...

Gene expression databases

ArrayExpressi P55899.
Bgeei P55899.
CleanExi HS_FCGRT.
Genevestigatori P55899.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR001039. MHC_I_a_a1/a2.
[Graphical view ]
Pfami PF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
[Graphical view ]
SMARTi SM00407. IGc1. 1 hit.
[Graphical view ]
SUPFAMi SSF54452. SSF54452. 1 hit.
PROSITEi PS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A major histocompatibility complex class I-like Fc receptor cloned from human placenta: possible role in transfer of immunoglobulin G from mother to fetus."
    Story C.M., Mikulska J., Simister N.E.
    J. Exp. Med. 180:2377-2381(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Placenta.
  2. "Partial sequence of the human fcgrt gene and its 5' upstream region."
    Tiwari B., Junghans R.P.
    Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Cloning and analysis of the gene encoding the human neonatal Fc receptor."
    Mikulska J.E., Pablo L., Canel J., Simister N.E.
    Eur. J. Immunogenet. 27:231-240(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Rectum tumor.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  7. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
    Zhang Z., Henzel W.J.
    Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 24-38.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "Crystal structure and immunoglobulin G binding properties of the human major histocompatibility complex-related Fc receptor."
    West A.P. Jr., Bjorkman P.J.
    Biochemistry 39:9698-9708(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 24-290.

Entry informationi

Entry nameiFCGRN_HUMAN
AccessioniPrimary (citable) accession number: P55899
Secondary accession number(s): Q5HYM5, Q9HBV7, Q9NZ19
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: July 9, 2014
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi