P55899 (FCGRN_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
IgG receptor FcRn large subunit p51
Short name=FcRn

Alternative name(s):
IgG Fc fragment receptor transporter alpha chain
Neonatal Fc receptor

Gene names

Name:	FCGRT
Synonyms:	FCRN

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	365 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Binds to the Fc region of monomeric immunoglobulins gamma. Mediates the uptake of IgG from milk. Possible role in transfer of immunoglobulin G from mother to fetus.
Subunit structure	FcRn complex consist of two subunits: p51, and p14 which is equivalent to beta-2-microglobulin. It forms an MHC class I-like heterodimer By similarity.
Subcellular location	Cell membrane; Single-pass type I membrane protein By similarity.
Sequence similarities	Belongs to the immunoglobulin superfamily.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Immunoglobulin domain Signal Transmembrane Transmembrane helix
Ligand	IgG-binding protein
Molecular function	Receptor
PTM	Disulfide bond Glycoprotein
Technical term	3D-structure Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological process	antigen processing and presentation Inferred from electronic annotation. Source: InterPro female pregnancy Traceable author statement. Source: ProtInc immune response Traceable author statement. Source: ProtInc
Cellular component	MHC class I protein complex Inferred from electronic annotation. Source: InterPro integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	IgG binding Inferred from electronic annotation. Source: UniProtKB-KW receptor activity Traceable author statement. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 23

23

Ref.7

Chain

24 – 365

342

IgG receptor FcRn large subunit p51

PRO_0000015157

Regions

Topological domain

24 – 297

274

Extracellular Potential

Transmembrane

298 – 321

24

Helical; Potential

Topological domain

322 – 365

44

Cytoplasmic Potential

Region

24 – 110

87

Alpha-1

Region

111 – 200

90

Alpha-2

Region

201 – 290

90

Alpha-3

Region

291 – 297

7

Connecting peptide

Amino acid modifications

Glycosylation

125

1

N-linked (GlcNAc...) Potential

Disulfide bond

119 ↔ 182

Disulfide bond

221 ↔ 275

Experimental info

Sequence conflict

101 – 103

3

Missing in AAG31421. Ref.3

Sequence conflict

201

1

E → G in AAF72596. Ref.2

Secondary structure

1

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365

Helix Strand Turn

Details...

Beta strand

29 – 39

11

Beta strand

46 – 53

8

Beta strand

56 – 62

7

Turn

63 – 65

3

Helix

85 – 103

19

Beta strand

112 – 121

10

Beta strand

127 – 135

9

Beta strand

138 – 144

7

Turn

145 – 148

4

Beta strand

149 – 151

3

Helix

155 – 165

11

Helix

170 – 179

10

Helix

181 – 191

11

Helix

194 – 197

4

Beta strand

204 – 211

8

Beta strand

216 – 229

14

Beta strand

231 – 237

7

Beta strand

249 – 251

3

Beta strand

257 – 266

10

Helix

270 – 272

3

Beta strand

273 – 279

7

Beta strand

282 – 284

3

Beta strand

286 – 289

4

Sequences

	Sequence		Length	Mass (Da)
	P55899 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: C886C6A1F66A0D89	FASTA	365	39,743
	10 20 30 40 50 60 MGVPRPQPWA LGLLLFLLPG SLGAESHLSL LYHLTAVSSP APGTPAFWVS GWLGPQQYLS 70 80 90 100 110 120 YNSLRGEAEP CGAWVWENQV SWYWEKETTD LRIKEKLFLE AFKALGGKGP YTLQGLLGCE 130 140 150 160 170 180 LGPDNTSVPT AKFALNGEEF MNFDLKQGTW GGDWPEALAI SQRWQQQDKA ANKELTFLLF 190 200 210 220 230 240 SCPHRLREHL ERGRGNLEWK EPPSMRLKAR PSSPGFSVLT CSAFSFYPPE LQLRFLRNGL 250 260 270 280 290 300 AAGTGQGDFG PNSDGSFHAS SSLTVKSGDE HHYCCIVQHA GLAQPLRVEL ESPAKSSVLV 310 320 330 340 350 360 VGIVIGVLLL TAAAVGGALL WRRMRSGLPA PWISLRGDDT GVLLPTPGEA QDADLKDVNV IPATA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A major histocompatibility complex class I-like Fc receptor cloned from human placenta: possible role in transfer of immunoglobulin G from mother to fetus." Story C.M., Mikulska J., Simister N.E. J. Exp. Med. 180:2377-2381(1994) [PubMed: 7964511] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Placenta.
[2]	"Partial sequence of the human fcgrt gene and its 5' upstream region." Tiwari B., Junghans R.P. Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Cloning and analysis of the gene encoding the human neonatal Fc receptor." Mikulska J.E., Pablo L., Canel J., Simister N.E. Eur. J. Immunogenet. 27:231-240(2000) [PubMed: 10998088] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Rectum tumor.
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[7]	"Signal peptide prediction based on analysis of experimentally verified cleavage sites." Zhang Z., Henzel W.J. Protein Sci. 13:2819-2824(2004) [PubMed: 15340161] [Abstract] Cited for: PROTEIN SEQUENCE OF 24-38.
[8]	"Crystal structure and immunoglobulin G binding properties of the human major histocompatibility complex-related Fc receptor." West A.P. Jr., Bjorkman P.J. Biochemistry 39:9698-9708(2000) [PubMed: 10933786] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 24-290.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

U12255 mRNA. Translation: AAA58958.1.
AF220542 Genomic DNA. Translation: AAF72596.1.
AF200220, AF200219 Genomic DNA. Translation: AAG31421.1.
BX647163 mRNA. Translation: CAI46032.1.
CH471177 Genomic DNA. Translation: EAW52498.1.
BC008734 mRNA. Translation: AAH08734.1.

IPI

IPI00026646.

PIR

I38720.

RefSeq

NP_001129491.1. NM_001136019.2.
NP_004098.1. NM_004107.4.

UniGene

Hs.111903.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1EXU	X-ray	2.70	A	24-290	[»]
3M17	X-ray	2.60	A/C/E/G	24-290	[»]
3M1B	X-ray	3.10	A/C/E/G	24-290	[»]

ProteinModelPortal

P55899.

SMR

P55899. Positions 28-290.

ModBase

Search...

Protein-protein interaction databases

DIP

DIP-6165N.

IntAct

P55899. 3 interactions.

MINT

MINT-5002634.

STRING

P55899.

PTM databases

PhosphoSite

P55899.

Polymorphism databases

DMDM

2497331.

Proteomic databases

PRIDE

P55899.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000221466; ENSP00000221466; ENSG00000104870.
ENST00000426395; ENSP00000410798; ENSG00000104870.

GeneID

2217.

KEGG

hsa:2217.

UCSC

uc002poe.1. human.

Organism-specific databases

CTD

2217.

GeneCards

GC19P050015.

H-InvDB

HIX0015331.

HGNC

HGNC:3621. FCGRT.

HPA

HPA012122.
HPA015130.

MIM

601437. gene.

neXtProt

NX_P55899.

PharmGKB

PA28067.

GenAtlas

Search...

Phylogenomic databases

eggNOG

prNOG14963.

HOGENOM

HBG126911.

HOVERGEN

HBG100415.

InParanoid

P55899.

OMA

APWISLR.

OrthoDB

EOG4V6ZGW.

PhylomeDB

P55899.

Gene expression databases

ArrayExpress

P55899.

Bgee

P55899.

CleanEx

HS_FCGRT.

Genevestigator

P55899.

GermOnline

ENSG00000104870. Homo sapiens.

Family and domain databases

InterPro

IPR007110. Ig-like.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR001039. MHC_I_a_a1/a2.
[Graphical view]

Gene3D

G3DSA:2.60.40.10. Ig-like_fold. 1 hit.
G3DSA:3.30.500.10. MHC_I-like_Ag-recog. 1 hit.

Pfam

PF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
[Graphical view]

SMART

SM00407. IGc1. 1 hit.
[Graphical view]

SUPFAM

SSF54452. MHC_I/II-like_Ag-recog. 1 hit.

PROSITE

PS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

NextBio

8991.

SOURCE

Search...

Entry information

Entry name

FCGRN_HUMAN

Accession

Primary (citable) accession number: P55899
Secondary accession number(s): Q5HYM5, Q9HBV7, Q9NZ19

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	January 25, 2012
This is version 101 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.