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P55899 (FCGRN_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 122. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
IgG receptor FcRn large subunit p51

Short name=FcRn
Alternative name(s):
IgG Fc fragment receptor transporter alpha chain
Neonatal Fc receptor
Gene names
Name:FCGRT
Synonyms:FCRN
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length365 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Binds to the Fc region of monomeric immunoglobulins gamma. Mediates the uptake of IgG from milk. Possible role in transfer of immunoglobulin G from mother to fetus.

Subunit structure

FcRn complex consist of two subunits: p51, and p14 which is equivalent to beta-2-microglobulin. It forms an MHC class I-like heterodimer By similarity.

Subcellular location

Cell membrane; Single-pass type I membrane protein By similarity.

Sequence similarities

Belongs to the immunoglobulin superfamily.

Contains 1 Ig-like C1-type (immunoglobulin-like) domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Ref.7
Chain24 – 365342IgG receptor FcRn large subunit p51
PRO_0000015157

Regions

Topological domain24 – 297274Extracellular Potential
Transmembrane298 – 32124Helical; Potential
Topological domain322 – 36544Cytoplasmic Potential
Domain202 – 28988Ig-like C1-type
Region24 – 11087Alpha-1
Region111 – 20090Alpha-2
Region201 – 29090Alpha-3
Region291 – 2977Connecting peptide

Amino acid modifications

Glycosylation1251N-linked (GlcNAc...) Potential
Disulfide bond119 ↔ 182
Disulfide bond221 ↔ 275

Experimental info

Sequence conflict101 – 1033Missing in AAG31421. Ref.3
Sequence conflict2011E → G in AAF72596. Ref.2

Secondary structure

..................................................... 365
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P55899 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: C886C6A1F66A0D89

FASTA36539,743
        10         20         30         40         50         60 
MGVPRPQPWA LGLLLFLLPG SLGAESHLSL LYHLTAVSSP APGTPAFWVS GWLGPQQYLS 

        70         80         90        100        110        120 
YNSLRGEAEP CGAWVWENQV SWYWEKETTD LRIKEKLFLE AFKALGGKGP YTLQGLLGCE 

       130        140        150        160        170        180 
LGPDNTSVPT AKFALNGEEF MNFDLKQGTW GGDWPEALAI SQRWQQQDKA ANKELTFLLF 

       190        200        210        220        230        240 
SCPHRLREHL ERGRGNLEWK EPPSMRLKAR PSSPGFSVLT CSAFSFYPPE LQLRFLRNGL 

       250        260        270        280        290        300 
AAGTGQGDFG PNSDGSFHAS SSLTVKSGDE HHYCCIVQHA GLAQPLRVEL ESPAKSSVLV 

       310        320        330        340        350        360 
VGIVIGVLLL TAAAVGGALL WRRMRSGLPA PWISLRGDDT GVLLPTPGEA QDADLKDVNV 


IPATA 

« Hide

References

« Hide 'large scale' references
[1]"A major histocompatibility complex class I-like Fc receptor cloned from human placenta: possible role in transfer of immunoglobulin G from mother to fetus."
Story C.M., Mikulska J., Simister N.E.
J. Exp. Med. 180:2377-2381(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Placenta.
[2]"Partial sequence of the human fcgrt gene and its 5' upstream region."
Tiwari B., Junghans R.P.
Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Cloning and analysis of the gene encoding the human neonatal Fc receptor."
Mikulska J.E., Pablo L., Canel J., Simister N.E.
Eur. J. Immunogenet. 27:231-240(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Rectum tumor.
[5]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[7]"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Zhang Z., Henzel W.J.
Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 24-38.
[8]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[9]"Crystal structure and immunoglobulin G binding properties of the human major histocompatibility complex-related Fc receptor."
West A.P. Jr., Bjorkman P.J.
Biochemistry 39:9698-9708(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 24-290.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U12255 mRNA. Translation: AAA58958.1.
AF220542 Genomic DNA. Translation: AAF72596.1.
AF200220, AF200219 Genomic DNA. Translation: AAG31421.1.
BX647163 mRNA. Translation: CAI46032.1.
CH471177 Genomic DNA. Translation: EAW52498.1.
BC008734 mRNA. Translation: AAH08734.1.
PIRI38720.
RefSeqNP_001129491.1. NM_001136019.2.
NP_004098.1. NM_004107.4.
UniGeneHs.111903.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1EXUX-ray2.70A24-290[»]
3M17X-ray2.60A/C/E/G24-290[»]
3M1BX-ray3.10A/C/E/G24-290[»]
4K71X-ray2.40B/E24-297[»]
4N0FX-ray3.02A/E/H/K27-297[»]
4N0UX-ray3.80A27-290[»]
ProteinModelPortalP55899.
SMRP55899. Positions 28-291.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid108511. 2 interactions.
DIPDIP-6165N.
IntActP55899. 3 interactions.
MINTMINT-5002634.
STRING9606.ENSP00000221466.

Chemistry

BindingDBP55899.
ChEMBLCHEMBL5966.

PTM databases

PhosphoSiteP55899.

Polymorphism databases

DMDM2497331.

Proteomic databases

PaxDbP55899.
PRIDEP55899.

Protocols and materials databases

DNASU2217.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000221466; ENSP00000221466; ENSG00000104870.
ENST00000426395; ENSP00000410798; ENSG00000104870.
GeneID2217.
KEGGhsa:2217.
UCSCuc002poe.2. human.

Organism-specific databases

CTD2217.
GeneCardsGC19P050028.
HGNCHGNC:3621. FCGRT.
HPAHPA012122.
HPA015130.
MIM601437. gene.
neXtProtNX_P55899.
PharmGKBPA28067.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG38779.
HOGENOMHOG000112560.
HOVERGENHBG100415.
InParanoidP55899.
OMAAPWISLR.
OrthoDBEOG7TBC29.
PhylomeDBP55899.
TreeFamTF336617.

Gene expression databases

ArrayExpressP55899.
BgeeP55899.
CleanExHS_FCGRT.
GenevestigatorP55899.

Family and domain databases

Gene3D2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR001039. MHC_I_a_a1/a2.
[Graphical view]
PfamPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
[Graphical view]
SMARTSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMSSF54452. SSF54452. 1 hit.
PROSITEPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSFCGRT. human.
EvolutionaryTraceP55899.
GeneWikiFCGRT.
GenomeRNAi2217.
NextBio8991.
PROP55899.
SOURCESearch...

Entry information

Entry nameFCGRN_HUMAN
AccessionPrimary (citable) accession number: P55899
Secondary accession number(s): Q5HYM5, Q9HBV7, Q9NZ19
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: April 16, 2014
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM